Patents Assigned to Northwestern University
  • Peptide conjugated particles
    Patent number: 11160851
    Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles. In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).
    Type: Grant
    Filed: March 8, 2017
    Date of Patent: November 2, 2021
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Lonnie D. Shea, Stephen D. Miller, Jonathan Woon Teck Yap, Daniel R. Getts, Derrick McCarthy
  • LIPID NANOPARTICLES FOR MEASURING CHRONIC AND ACUTE RESPONSE TO EXERCISE
    Publication number: 20210332404
    Abstract: The invention relates to biosensor for detecting and/or quantifying exercise and disease-risk associated enzymes in a biological sample and related methods. The biosensor includes a solid support and a nanostructure with a metallic core and a phospholipid shell capable of binding to a lecithin:cholesterol acyltransferase (LCAT) activator (BL-NP).
    Type: Application
    Filed: June 21, 2018
    Publication date: October 28, 2021
    Applicant: Northwestern University
    Inventors: C. Shad Thaxton, Rohun U. Palekar
  • Rigid chiral redox-active isosceles triangular materials
    Patent number: 11155554
    Abstract: Provided herein are rigid macrocycles comprising a first redox-active subunit and a second redox-active subunit, wherein the first redox-active unit and the second redox-active unit are different subunits. Also provided herein are methods of preparation of the rigid macrocycles and use thereof, for example, in the first of energy generation and storage.
    Type: Grant
    Filed: March 16, 2017
    Date of Patent: October 26, 2021
    Assignees: Northwestern University, KING ABDULAZIZ CITY FOR SCIENCE AND TECHNOLOGY (KACST)
    Inventors: James Fraser Stoddart, Siva Krishna Mohan Nalluri, Zhichang Liu
  • Flexible light sheet generation by field synthesis
    Patent number: 11156818
    Abstract: A light sheet microscopy apparatus has a light source, a spatial light filter, a scanning device positioned between the light source and the spatial light filter, an imaging device, a computer readable medium, and a computer processor coupled to the light source, the scanning device, the imaging device, and the computer-readable medium. The computer processor is configured to operate the light source to generate a light beam, control the scanning device to scan the light beam across the spatial light filter to generate the light sheet, and utilize the imaging device to capture one or more images of light emitted by a sample illuminated by the one or more light sheets.
    Type: Grant
    Filed: August 13, 2019
    Date of Patent: October 26, 2021
    Assignees: The Board of Regents of The University of Texas System, Northwestern University
    Inventors: Reto Fiolka, Mark Kittisopikul, Bo-Jui Chang
  • MAP kinase modulators and uses thereof
    Patent number: 11149020
    Abstract: The invention provides for novel MAP kinase inhibitors and compositions comprising the same. In some embodiments, the MAP kinase inhibitors are p38? MAP kinase inhibitors. The invention further provides for methods for treatment of diseases comprising administration of MAP kinase inhibitors or compositions comprising MAP kinase inhibitors. In some embodiments, the disease is Alzheimer's Disease, ALS, Huntington's Disease or Parkinson's Disease.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: October 19, 2021
    Assignees: The Trustees of Columbia University in the City of New York, Northwestern University
    Inventors: Ottavio Arancio, Daniel Martin Watterson, Jeffrey Claude Pelletier, Saktimayee Mitra Roy
  • Control of the electrostatic potential of nanoparticles
    Patent number: 11150185
    Abstract: The present technology is directed to the nanoparticles for use as molecular environmental sensors. The nanoparticles comprise a photoluminescence core and a plurality of ligands bound to the core and forming a quencher permeable ligand shell. The ligands comprise a reactive or charged moiety capable of being modulated between a first stand and a second state, and the proportion of ligands in each state determine the permeability of the ligand shell to a photoluminescence quencher.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: October 19, 2021
    Assignee: Northwestern University
    Inventors: Chen He, David J. Weinberg, Emily A. Weiss, Jeremiah Yoonsung Kim, Chen Wang, Andrew Lee
  • Substituted heterocycles as c-MYC targeting agents
    Patent number: 11142504
    Abstract: Disclosed are substituted heterocycle compounds including substituted pyrazoles, substituted pyrimidines, and substitute triazoles. The substituted heterocycles disclosed herein are shown to be useful in inhibiting c-MYC and may be utilized as therapeutics for treating cancer and cell proliferative disorders.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: October 12, 2021
    Assignee: Northwestern University
    Inventors: Gary E. Schiltz, Rama K. Mishra, Huiying Han, Sarki A. Abdulkadir, Javier Izquierdo-Ferrer, Atul D. Jain
  • Retinoic acid receptor gamma agonists to attenuate anthracycline-induced cardiotoxicity
    Patent number: 11135236
    Abstract: Disclosed are methods, pharmaceutical compositions, kits, and systems for treating or preventing cardiotoxicity in a subject undergoing treatment with an anthracycline chemotherapeutic agent. The methods, pharmaceutical compositions, kits, and systems typically include or utilize an agonist of the retinoic acid receptor gamma (RARG).
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: October 5, 2021
    Assignee: Northwestern University
    Inventor: Paul W. Burridge
  • Methods for in vitro ribosome synthesis and evolution
    Patent number: 11136574
    Abstract: Disclosed are methods, components, compositions, and kits for preparing and identifying engineered E. coli ribosomes. The E. coli ribosomes may be prepared and identified under a set of defined conditions, such as in the presences of antibiotics, in order to obtain an engineered ribosome that is resistant to the antibiotic.
    Type: Grant
    Filed: October 7, 2019
    Date of Patent: October 5, 2021
    Assignee: Northwestern University
    Inventors: Michael Christopher Jewett, Brian R. Fritz
  • Heparin Conjugated to Collagen-Binding Peptides for Targeting to Biological and Synthetic Tissues
    Publication number: 20210299158
    Abstract: Disclosed are heparin conjugates comprising heparin conjugated to a peptide that binds to a protein of the extracellular matrix (ECM) of cellular tissue, such as a collagen-binding peptide that binds to collagen of the ECM. The disclosed heparin conjugates may be utilized in methods that include treating ECM material to incorporate the heparin conjugates and impart anticoagulant activity to the ECM. The disclosed heparin conjugates also may be formulated as pharmaceutical compositions for treating and/or preventing vascular injuries and conditions.
    Type: Application
    Filed: October 11, 2018
    Publication date: September 30, 2021
    Applicant: Northwestern University
    Inventors: Guillermo A. Ameer, Jason A. Wertheim, Bin Jiang
  • Peptide conjugated particles
    Patent number: 11129881
    Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles. In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).
    Type: Grant
    Filed: April 13, 2020
    Date of Patent: September 28, 2021
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Lonnie D. Shea, Stephen D. Miller, Jonathan Woon Teck Yap, Daniel R. Getts, Derrick McCarthy
  • Facile assembly of soft nanoarchitectures and co-loading of hydrophilic and hydrophobic molecules via flash nanoprecipitation
    Patent number: 11124612
    Abstract: Described herein are flash nanoprecipitation methods capable of encapsulating hydrophobic molecules, hydrophilic molecules, bioactive protein therapeutics, or other target molecules in amphiphilic copolymer nanocarriers.
    Type: Grant
    Filed: April 10, 2020
    Date of Patent: September 21, 2021
    Assignee: Northwestern University
    Inventors: Evan A. Scott, Sean D. Allen
  • Compositions and methods for the detection of zinc
    Patent number: 11125741
    Abstract: The invention relates generally to compositions and methods for the detection of zinc. In particular, compositions and methods are provided to detect changes in cellular zinc concentration and to correlate them to cellular phenomena.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: September 21, 2021
    Assignee: Northwestern University
    Inventors: Emily L. Que, Thomas V. O'Halloran, Teresa K. Woodruff
  • Stochastic memristive devices based on arrays of magnetic tunnel junctions
    Patent number: 11127446
    Abstract: Embodiments of a Stochastic memristive array (SMA) device based on arrays of voltage-controlled magnetic tunnel junctions (MTJs) are disclosed. The SMA device is based on an array of stochastic (low energy barrier) magnetic tunnel junctions that are connected in parallel which simultaneously exhibits features that include (i) stochasticity and (ii) memristive behavior. The energy barrier of the MJTs may be tuned by an applied voltage (electric field). SMA devices may find applications in emerging computing concepts such as probabilistic computing and memcomputing, among others, providing a pathway towards intelligent hybrid CMOS-spintronic systems.
    Type: Grant
    Filed: July 2, 2020
    Date of Patent: September 21, 2021
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Pedram Khalili Amiri, Giovanni Finocchio
  • High speed/low dose multi-objective autonomous scanning materials imaging
    Patent number: 11120968
    Abstract: Aspects of the present disclosure involve applying a Multi-Objective Autonomous Dynamic Sampling algorithm in an electron or other radiation/charged-particle microscope for the characterization of elemental, chemical, and crystallographic information with over an order of magnitude improvement in time and exposure.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: September 14, 2021
    Assignee: Northwestern University
    Inventors: Karl A. Hujsak, Vinayak P. Dravid
  • Anti-inflammatory treatment via inhibition of endothelial cell kinesin light chain 1, variant 1 (KLC1C)
    Patent number: 11118180
    Abstract: Provided herein are compositions and methods for the inhibition of endothelial cell kinesin light chain 1, variant 1 (KLC1C) expression and/or activity, and treatment or prevention of inflammation therewith.
    Type: Grant
    Filed: July 23, 2019
    Date of Patent: September 14, 2021
    Assignee: Northwestern University
    Inventors: William A. Muller, Bita F. Cyrus
  • Micro resolution imaging range sensor system
    Patent number: 11119193
    Abstract: A system configured to generate images includes one or more narrowband electromagnetic sources configured to emit a first radiation and a second radiation. The system also includes a detector configured to detect first reflected radiation off of an object and second reflected radiation off of the object, where the first reflected radiation results from the first radiation and the second reflected radiation results from the second radiation. The system further includes a processor operatively coupled to the detector and configured to generate an image of the object based at least in part on a first amplitude of the first reflected radiation and a second amplitude of the second reflected radiation. The processor is also configured to determine a depth profile of the object based at least in part on the first reflected radiation and the second reflected radiation detected by the detector.
    Type: Grant
    Filed: March 28, 2019
    Date of Patent: September 14, 2021
    Assignees: Northwestern University, Southern Methodist University
    Inventors: Oliver Strider Cossairt, Fengqiang Li, Florian Willomitzer, Prasanna V. Rangarajan
  • COMBINED CYCLE POWER SYSTEM
    Publication number: 20210277524
    Abstract: The present disclosure generally relates in certain embodiments to a combined cycle power plant system comprising an electrochemical compressor. For instance, in one set of embodiments, the electrochemical compressor is may separate oxygen from a flow of air from an air source to provide a pressurized flow of oxygen to a combustor. In some embodiments, the resulting combustion products may only include oxygen and water without any substantial fraction of other combustion products or contaminants which may facilitate the separation of carbon dioxide (CO2) for subsequent processes including compression and/or storage.
    Type: Application
    Filed: March 4, 2021
    Publication date: September 9, 2021
    Applicants: Massachusetts Institute of Technology, Northwestern University
    Inventors: Asegun Henry, Ahmed Fouad Ghoniem, Michael Bichnevicius, Mehdi Pishahang, Sossina Haile
  • Epidermal virtual reality devices
    Patent number: 11112869
    Abstract: Provided are actuation devices, virtual reality devices formed from the actuation devices, and related virtual reality methods. The devices may comprise a plurality of spatially distributed actuators, each actuator configured for interacting with a biological skin surface; a wireless controller configured to receive operative command signals to control each of the actuators; and a wireless power system to power the actuators. Also provided are unique layouts of multiple interconnected devices to achieve large area coverage.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: September 7, 2021
    Assignees: NORTHWESTERN UNIVERSITY, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: John A. Rogers, Shuai Xu, In Hwa Jung, Ha Uk Chung, Xinge Yu, Yu Yang, Jungyup Lee, Rujie Sun
  • System and method for integrated circuit usage tracking circuit with fast tracking time for hardware security and re-configurability
    Patent number: 11115022
    Abstract: An accelerated aging circuit is described to shorten the required stress time to a few seconds of operation. Due to the challenges posed by process variation in advanced CMOS technology, a stochastic processing methodology is also described to reduce the failure rate of the tracking and detection. Combining both circuit and system level acceleration, the creation of a silicon marker can be realized within seconds of usage in contrast with days of operation from previously reported aging monitor.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: September 7, 2021
    Assignee: NORTHWESTERN UNIVERSITY
    Inventor: Jie Gu