Abstract: The invention relates to a method for separating a mixture in an installation comprising a first system comprising a plurality of chromatography columns, a second system downstream of the first system and a tank fed by an outlet line of the first system and feeding the second system with a continuous stream, the method successively comprising, in a cyclical manner, in a given part of the first system, steps of collecting a raffinate, injecting the mixture to be separated, collecting an extract and injecting a mobile phase; wherein the method further comprises the measurement of the purity and/or yield of at least one collected fraction, comprising: the determination of the concentration of at least two species of the mixture to be separated in the fraction collected in the tank; and the determination of the purity and/or yield of at least one species of the fraction collected in the tank.

Abstract: The invention relates to a method for purifying a mixture to be separated, in a multicolumn chromatography system, the method comprising successively and cyclically: a step of collecting a raffinate, a step of injecting the mixture to be separated, a step of collecting an extract and an eluent injection step, at an operating temperature; wherein the mixture to be separated has a viscosity at 20° C. greater than or equal to 3 mPa·s; and wherein the dry matter mass concentration of the mixture to be separated is equal, within 5%, to a threshold concentration, said threshold concentration is such that: the viscosity of the mixture to be treated at a dry matter mass concentration equal to the threshold concentration and at the operating temperature, is equal to twice the viscosity of the mixture to be treated, at a dry matter mass concentration equal to 85% of the threshold concentration and at the operating temperature.

Abstract: The invention relates to a method for separating a mixture in a system comprising a plurality of chromatography columns, the method successively comprising, in a cyclical manner, in a given part of the system: a step of collecting a raffinate; a step of injecting the mixture to be separated; a step of collecting an extract; and a step of injecting a mobile phase; the method further comprising: determining, in a node of the system, the history of a variable representing the concentration of at least one species contained in the mixture to be separated; detecting, within said history, a characteristic point between the beginning of a step of collecting the extract and the end of the following step of collecting the raffinate; comparing the position of the characteristic point in relation to a target position; and adjusting the carrier volume of the characteristic point, modifying the position of the characteristic point in order to bring the position of the characteristic point closer to the target position; th

Abstract: A method for purifying a mixture in a multicolumn chromatography system. The method successively and cyclically collects a raffinate, injects the mixture to be separated, collects an extract, and injects eluent. The mixture to be separated contains fructose and has a dry matter mass concentration of 45 to 55%. The method is carried out at a temperature of 50 to 62° C.

Abstract: A method for purifying an amino acid from an initial mixture is disclosed, in which the amino acid includes an aromatic ring and has an acidity constant Ka, the method including: a first step of putting the initial mixture into contact with a strong cation resin, at a pH greater than or equal to pKa; and a second elution step with an aqueous solution of eluent having a pH greater than the pH of the first step, giving the possibility of collecting a flow enriched in the amino acid.

Abstract: The invention concerns a purification method comprising: providing a flow comprising a glycol, monovalent ions and multivalent ions; treating this flow with ion exclusion chromatography comprising: injecting the flow into a chromatographic unit comprising an ion exchange stationary phase; injecting an eluent into the chromatographic unit; collecting a fraction at the outlet of the chromatographic unit; the collected fraction being enriched with glycol and depleted of monovalent ions and multivalent ions relative to the flow. The invention also concerns an installation adapted to implement this method, and its application to the regeneration of an anti-hydrate agent.

Abstract: The invention relates to a method for purifying a solution, the method comprising the following successive steps: —bringing a solution to be purified into contact with an ion exchange resin by suspending the ion exchange resin in the solution to be purified, the ion exchange resin having the form of particles having a size Dv50 smaller than or equal to 200 ?m; —separating the solution into a purified solution and a loaded resin; —regenerating the loaded resin by passing at least one regenerating solution through a compact bed of loaded resin. The invention also relates to an assembly for implementing the method.

Abstract: The invention relates to a fluid distributor (9, 10) for a column (1) comprising at least one cell (2) containing a bed of particles (3), the fluid distributor (9, 10) comprising: —a floor (11, 21) comprising at least one injection point (15, 25) providing a fluidic connection on either side thereof; —a layer of a resistive medium (12, 22) fixed on one face of the floor (11, 21), the resistive medium being permeable to the fluid; —a spacing device (13, 23) inserted between the floor (11, 21) and the layer of resistive medium (12, 22) and maintaining a space for the circulation of the fluid between the floor (11, 21) and the layer of resistive medium (12, 22). The invention also relates to a column, in particular a chromatography column, provided with this fluid distributor.

Abstract: This application relates to methods for purification of proteins such as antibodies using a hydrophilic polymer (e.g., PEG), a fatty acid (e.g., caprylic acid), and/or another agent (e.g., calcium chloride).

Abstract: It is an object of the invention to provide a process for producing an organic acid, comprising: providing an incoming stream containing an organic acid and impurities; subjecting said incoming stream to a step of chromatographic separation, using a solution of mineral acid as an eluent, so as to collect an extract and a raffinate, the organic acid being recovered in the extract; and subjecting the raffinate to an electrodialysis step, so as to collect a diluate and a concentrate, the mineral acid being concentrated in the concentrate. The invention also provides an installation for implementing this process.

Abstract: The invention relates to a fluid distributor (9,10)for a column (1)comprising at least one cell (2) containing a bed of particles (3), the fluid distributor (9, 10) comprising: - a floor (11, 21) comprising at least one injection point (15, 25) providing a fluidic connection on either side thereof; - a layer of resistive medium (12, 22) fixed on one face of the floor(11, 21), the resistive medium being permeable to the fluid; - a spacing device (13, 23) inserted between the floor (11, 21) and the layer of reistive medium (12, 22) and maintaining a space for the circulation of the fluid between the floor (11, 21) and the layer of resistive medium (12, 22). The invention also relates to a column, in particular a chromatography column, provided with this fluid distributor.

Abstract: The invention relates to a method for purifying a first fatty acid, in particular a first polyunsaturated fatty acid, using an initial mixture further comprising at least one second fatty acid and a third fatty acid, with the method comprising at least: a first step of chromatographic separation in liquid phase, using the initial mixture, making it possible to recover on the one hand a first flow enriched with a first fatty acid and on the other hand a flow enriched with a second fatty acid; a second step of chromatographic separation in liquid phase, using the first flow enriched with a first fatty acid, making it possible to recover on the one hand a second flow enriched with a first fatty acid and on the other hand a flow enriched with a third fatty acid, with the second step of chromatographic separation being carried out in a static bed chromatographic separation unit.

Abstract: The invention related to a method for purifying a first fatty acid, preferably polyunsaturated, using an initial mixture further comprising at least one second fatty acid, optionally a third fatty acid and optionally a fourth fatty acid, with the method comprising: a first step of chromatographic separation in liquid phase, using the initial mixture, carried out in a first unit for chromatographic separation, making it possible to recover on the one hand a first flow enriched with a first fatty acid and on the other hand a flow enriched with a second fatty acid, optionally, a second step of chromatographic separation in liquid phase, using the first flow enriched with a first fatty acid, carried out in a second chromatographic separation unit, making it possible to recover on the one hand a second flow enriched with a first fatty acid and on the other hand a flow enriched with a third fatty acid; optionally, a third step of chromatographic separation in liquid phase, using the third flow enriched with a fi

Abstract: A read circuit for an electrical signal produced by a POSFET device is disclosed which comprises a transconductance amplifier (4) connected at its inverting input to the output of the POSFET device (1), at least one neuron (8a, 8b) connected to the output of said transconductance amplifier, said amplifier being adapted to receive a signal from the POSFET device representative of a force or pressure exerted on it and to produce at its output at least one current signal (I0?, I0+) representative of such force or pressure, the at least one neuron being adapted to receive said current signal and to produce an output signal (12a, 12b) being a pulse train with frequency proportional to said current signal.

Abstract: A method for purifying an amino acid from an initial mixture is disclosed, in which the amino acid includes an aromatic ring and has an acidity constant Ka, the method including: a first step of putting the initial mixture into contact with a strong cation resin, at a pH greater than or equal to pKa; and a second elution step with an aqueous solution of eluent having a pH greater than the pH of the first step, giving the possibility of collecting a flow enriched in the amino acid.

Abstract: The invention related to a method for purifying a first fatty acid, preferably polyunsaturated, using an initial mixture further comprising at least one second fatty acid, optionally a third fatty acid and optionally a fourth fatty acid, with the method comprising: a first step of chromatographic separation in liquid phase, using the initial mixture, carried out in a first unit for chromatographic separation, making it possible to recover on the one hand a first flow enriched with a first fatty acid and on the other hand a flow enriched with a second fatty acid, optionally, a second step of chromatographic separation in liquid phase, using the first flow enriched with a first fatty acid, carried out in a second chromatographic separation unit, making it possible to recover on the one hand a second flow enriched with a first fatty acid and on the other hand a flow enriched with a third fatty acid; optionally, a third step of chromatographic separation in liquid phase, using the third flow enriched with a fi