Abstract: The invention relates to a synthetic, biologically active molecule for fixing an active ingredient to the virus protein 1 (VP1) of the polyoma virus. According to the invention, an amino acid sequence A1 which is derived from the C-terminal end of virus protein 2 (VP2) or 3 (VP3) of the polyoma virus is bonded to an active ingredient at one of its ends.

Abstract: The invention relates to a method for conducting the parallel identification of different nucleic acids S. When nucleic acids S are present, primers are lengthened each of which having an intermediate segment z. The intermediate segment z is amplified by using a second primer pair and is specifically identified by hybridizing with a probe So.

Abstract: The invention relates to a device for receiving and discharging a given amount of liquid, comprising agitating means (2) arranged on one end (E1) of a capillary (1) and a diaphragm (3) in the vicinity of the other end (E2).

Abstract: The invention relates to a device for conducting biochemical and microbiological reactions, comprising a support (2) for receiving at least one reaction vessel (3) and a device (5) for pressing a closing means (11, 12) sealing the reaction vessel (3), wherein the closing means (11, 12) project in closed position in the area surrounded by the reaction vessel (3). According to the invention, in order to accelerate and simplify reaction, an inner wall of the closing means opposite the reaction vessel (3) is coated with a molecule (14) on which a molecule to be detected can be bonded or deposited, wherein the molecule (14) contains a nucleic acid, an amino acid or a synthetic derivative of a nucleic or amino acid.

Abstract: A cap adapted to be secured on a neck of a container wherein the cap includes a top wall and a depending annular skirt having an inner annular projection. A fluid seal having a central transverse wall, an outer annular shoulder and a inner annular bead rests on the inner annular projection so as to define a space between the cap and the fluid seal into which the fluid seal is pushed when the cap is secured to the neck of the container to make a seal between the outer annular shoulder of the seal and the inner annular projection.

Abstract: A method for perforating skin including a lancet (1) held in a lancet holder (2) which, by means of a spring-loaded element (9), can be locked in a housing and moved out of the housing. To improve hygiene the invention provides for the lancet holder to be housed in a cup (5), which can be attached to the housing (8), and slidably guided in the cup.

Abstract: The invention relates to an agent for detecting chemical substances, comprising: a first polynucleotide or peptide sequence having a first fluorophore molecule, the first end of said sequence being bonded on a solid phase and a second polynucleotide or peptide sequence having a second fluorophore molecule, the second end of said sequence having a group that is sensitive to the chemical substance to be detected. The first polynucleotide or peptide sequence can be hybridized to the second polynucleotide or peptide sequence in such a way that a spatial relationship enabling an interaction betweeen the first and the second fluorophore molecule is produced. When the chemical substance including a physical property is attached to the group and the influence of an external force is exerted on the physical property, the spatial relation can be eliminated, thereby generating or abolishing a fluorescent reaction.

Abstract: The invention relates to a process for recombinantly preparing picornavirus particles, in particular hepatitis A virus particles, their precursors and particles which are derived therefrom, with a structural protein precursor molecule (P1-2A or P1) and the corresponding P3 region (3ABCD) being coexpressed in cis or in trans.

Abstract: A method for preparing samples for detecting a nucleotide sequence by polymerase chain reaction (PCR) according to which a) an analysis solution is filled into at least one cavity (2) provided for in a support (1); b) a lid (3) configured complementary to the shape of the cavity (2) is placed onto the support (1) in such a way that the analysis solution is pushed at least partly into a gap (S) formed between the cavity (2) and the lid (3); and c) the gap (S) is sealed by means of at least one seal (5, 12) provided for near an opening in the cavity (2).

Abstract: A push-pull closure which includes a base for securing to a container and which base includes an upper plug which seats within an opening in a valve lifter which is moveable with respect thereto between a closed position and an open position and wherein a cap is provided for covering the valve lifter when in a closed position. A tamper indicating seal is applied over a portion of the top of the valve lifter and the plug of the base in order to provide a seal therebetween and to provide evidence of tampering or of first opening of the valve lifter from the closed position to the open position.

Abstract: A method is disclosed for detecting a nucleotide sequence by a polymerase chain reaction, the nucleotide sequence is a constituent of a double-stranded nucleic acid molecule which is in solution and formed of a strand and a counter-strand. A first primer is added to the solution and is complementary to a first segment of the strand located at the 5′-terminus of a central segment. A second primer is added and is complementary to a 5′-terminal second segment of the counter-strand. The solution is brought into contact with a third primer whose 5′-terminal end is bound to a solid phase. The third primer is complementary to the central segment of the strand containing the nucleotide sequence. A reaction vessel is closed which contains the solution. The solution is repeatedly heated and cooled and the nucleic acid molecule is detected in the closed reaction vessel.

Abstract: The invention relates to a method for preparing samples for detecting a nucleotide sequence by polymerase chain reaction (PCR), according to which a) an analysis solution is filled into at least one cavity (2) provided for in a support (1); b) a lid (3) configured complementary to the shape of the cavity (2) is placed onto the support (1) in such a way that the analysis solution is pushed at least partly into a gap (S) formed between the cavity (2) and the lid (3); and c) the gap (S) is sealed by means of at least one seal (5, 12) provided for near an opening in the cavity (2).

Abstract: The invention relates to a device for the contamination-free delivery and discharge of liquid into and from a reaction vessel 15, having a tube 1, one end of which [lacuna] designed as a first connection fitting 2 for connection to a pipette or the like and the other end of which has a first opening 3. In order to avoid contamination when the reaction vessel is filled with and drained of liquids, it is proposed that a second connection fitting 4, which is in communication with at least a second opening 8, is provided in the vicinity of the first end.

Abstract: The invention refers to a cap for containers for holding a mixture to be produced from two components, having a cylinder (5) with an open end and an end closed by a partition (6) which can be perforated, a piston (1) having a gripping piece (2) of larger design than the cylinder diameter being inserted into the open end of the cylinder, such that a first chamber (K1) having a height (h) is formed between a lower side (KU) of the piston lying opposite the gripping piece (2) and the partition (6), characterized in that two incisions (7) extending from the open end of the cylinder and lying opposite each other are provided in the cylinder wall, and in that the gripping piece (2) is designed in such a manner that it can be displaced in the incisions (7) in order to move the piston (1) in the direction of the partition (6).

Abstract: The invention relates to a method of detecting and identifying nucleic aicd (NA) molecules within a population (I) of NA molecules of identical, similar or different sequence, in which: (a) the single-stranded or duplex ribonucleic acid (RNA) molecules or single-stranded deoxyribonucleic aicd (DNA) molecules contained in a population (I) iare convereted into a population (II) of duplex DNA molecules; b) the population (II) of duplex DNA molecules is subjected to denaturation and subsequent renaturation, so that a mixture of homo- and heteroduplex DNA molecules is present; c) heteroduplexes formed in the population (II) where unpaired of incorrectly paired nucleotides are present are reacted chemically with a carbodiimide compound; and d) the resulting carboddimide reactions products are characterized and quantified, characterized in that a chromatographic purification method is carried out between each of the steps a to d.

Abstract: The invention relates to a method for marking solid, liquid or gaseous substances, whereby the substance to be marked is provided with at least one synthetically produced nucleic acid sequence. Said nucleic acid sequence contains a first sequence section constructed with the 5′ terminal end, a second sequence comprised of at least two bases and connected to said nucleic acid sequence, and a third sequence section constructed with the 3′ terminal end and connected to the said nucleic acid sequence. In order to simplify the identification of the marking, the invention provides that a first primer group is used with a first primer section corresponding to the first sequence section and a second primer group is used with a third primer section corresponding to the third sequence section.

Abstract: A fitting for anchoring an aircraft seat to a track mounted to the floor of the aircraft is provided. The fitting is removably mounted to the seat and includes a generally rectangular elongate base having flange-like extensions running longitudinally thereof. The base has symmetric slide bearings affixed thereto, one at each end thereof, and overlaying the base, dimensioned so that the base with attached bearings is slidably insertable into the slot of the track. When the seat is mounted to the track, the symmetric bearings are in contact with the upper inside surfaces of the slot within the track, providing relative ease of slidable movement thereof when required.