Patents Assigned to Novo Industri A/S
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Patent number: 4478854Abstract: Hydrolysis of plant kingdom polysaccharides by treatment with SPS-ase preparations.SPS-ase is an enzyme adapted to hydrolyzing the water-soluble protein binding polysaccharide present in soy flour decomposed by use of conventional pectinases, which polysaccharide is believed to be widespread in plant kingdom substances. Treatment with an SPS-ase preparation can clarify juices, wines and beers, hydrolyze process wastes such as sugar beet pulp, pomace, and soy milk remanence, improve the digestability of silage, and reduce the viscosity of wort.Type: GrantFiled: May 3, 1983Date of Patent: October 23, 1984Assignee: Novo Industri A/SInventors: Jens L. Adler-Nissen, Henrik Gurtler, Georg W. Jensen, Hans A. S. Olsen, Steen Riisgaard, Martin Schulein
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Patent number: 4476118Abstract: Novel pharmaceutical solutions of dissolved insulin having improved physical stability prepared by incorporating therein an essentially ionized zinc salt in a concentration corresponding to a content of zinc ions at the disposal of the insulin of more than 4 Zn.sup.2+ /hexamer insulin preferably 4.2-4.5 Zn.sup.2+ /hexamer insulin. The solutions exhibit a stability factor exceeding 5.The novel insulin solutions are particularly adapted for use in continuous insulin delivery equipment.Type: GrantFiled: February 4, 1983Date of Patent: October 9, 1984Assignee: Novo Industri A/SInventors: Jens J. V. Brange, Svend Havelund
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Patent number: 4472385Abstract: Novel pharmaceutical preparations of dissolved insulin having improved physical stability particularly adapted for use in continuous insulin delivery equipment prepared by incorporating therein a calcium or magnesium salt so as to provide a solution containing essentially ionized calcium or magnesium in insulin stabilizing concentrations.The magnesium or calcium ions concentrations are with the range of about 0.4.times.10.sup.-3 to 10.sup.-2 molar.Type: GrantFiled: March 9, 1982Date of Patent: September 18, 1984Assignee: Novo Industri A/SInventors: Jens J. V. Brange, Svend Havelund
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Patent number: 4462980Abstract: Novel plasmin compositions, conditioned for labelling with technetium-99m by containing a pertechnetate reducing reagent, and plasmin admixed with a plasmin stabilizing agent.The novel compositions are particularly suited for the preparation of technetium-99m labelled plasmin used as a scintigraphic scanning agent for the detection of venous thrombosis.Type: GrantFiled: January 4, 1982Date of Patent: July 31, 1984Assignee: Novo Industri A/SInventors: Allan Diedrichsen, Marie Johannessen, Peter Tang
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Patent number: 4455375Abstract: A stabilized solution of rennet; the stabilizing agent being methionine. The stabilizing agent is added in an amount corresponding to a concentration of between 0.1% (w/w) and saturation calculated on the total weight of the solution.Type: GrantFiled: September 14, 1982Date of Patent: June 19, 1984Assignee: Novo Industri A/SInventors: Palle Schneider, Sven Branner-Jorgensen
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Patent number: 4439455Abstract: The filterability of wine and must obtained from grapes infected with the mold Botrytis cinerea is improved by treatment thereof with an enzyme product produced by cultivating the microorganism Trichoderma harzianum. The enzyme product exhibits both alpha- and beta-glucanase activity.Type: GrantFiled: June 10, 1982Date of Patent: March 27, 1984Assignee: Novo Industri A/SInventor: Jean-Claude Villettaz
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Patent number: 4435307Abstract: A harshness reducing, enzymatic additive for a main wash detergent based on a fungal cellulase, i.e., a cellulase produced by means of Humicola insolens. The enzymatic additive can be produced in high yields and has an extraordinarily high activity at alkaline pH values, whereby it is possible to mix the additive with a main wash detergent and perform the harshness reduction and the washing as a single operation.Type: GrantFiled: April 23, 1981Date of Patent: March 6, 1984Assignee: Novo Industri A/SInventors: Peder O. Barbesgaard, Georg W. Jensen, Poul Holm
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Patent number: 4431629Abstract: Method of producing an egg white substitute material from soy protein. The method comprises extraction of a defatted soy bean material at a pH between about 6.0 and 10.5, separation, subjection of the supernatant to one or more ultrafiltrations and proteolytic hydrolysis of the supernatant or some fraction thereof to a DH between 1 and 8. The hydrolyzed soy material exhibits both a superior whipping or emulsifying ability and a good nutritional value, and it has no bitter taste.Type: GrantFiled: May 6, 1981Date of Patent: February 14, 1984Assignee: Novo Industri A/SInventor: Hans A. S. Olsen
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Patent number: 4405608Abstract: A novel, purified peptide having the following amino acid sequence:Arg-Ser-Leu-Gln-Asn-Thr-Glu-Glu-Lys-Ser-Arg-Ser-Phe-Pro-Ala-Pro-Gln-Thr-Asp -Pro-Leu-Asp-Asp-Pro-Asp-Gln-Met-Thr-Glu-Asp.The peptide may be used as medicament, e.g., in the treatment of gastroduodenal ulcers.Type: GrantFiled: August 27, 1981Date of Patent: September 20, 1983Assignee: Novo Industri A/SInventors: Alister J. Moody, Lars Thim, Karin D. Jorgensen
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Patent number: 4386160Abstract: Bacillus serine proteases are acylated with an acyl radical of a monocarboxylic or dicarboxylic acid of about 1 to 6 carbon atoms to thermally destabilize the proteases at least about 3.degree. C. The acylated proteases have at least about 50% of their activity before acylation, and are advantageous in processes where it is desired to inactivate the proteases at a certain point in the process.Type: GrantFiled: March 9, 1981Date of Patent: May 31, 1983Assignee: Novo Industri A/SInventor: Sven Branner-Jorgensen
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Patent number: 4380552Abstract: Deacidifying wine by passage through an alginate gel containing living cells of Leuconostoc oenos therein. To ensure maximum viability, the alginate gel is stored in a resting medium, preferably sterile grape juice containing 5-12% ethanol. Before deacidifying wine the immobilized cells are conditioned to a wine milieu.Type: GrantFiled: October 27, 1980Date of Patent: April 19, 1983Assignee: Novo Industri A/SInventors: Stina M. Gestrelius, Jorgen H. Kjaer
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Patent number: 4371552Abstract: The disintegration process for prune juice production is improved through cooking prunes until substantial disintegration has taken place followed by treatment with cellulase, e.g., the cellulase of Trichoderma reesei, and optionally with a pectinase, which allows for good yield recovery of prune juice through centrifugal separation.Type: GrantFiled: September 8, 1981Date of Patent: February 1, 1983Assignee: Novo Industri A/SInventor: Laurence H. Posorske
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Patent number: 4370317Abstract: The invention relates to a novel purified polypeptide which is recoverable from porcine pancreas glands. The amino acid composition of the said polypeptide has been determined to be as follows:Trp (2), Lys (4), His (1), Arg (5), Asx (10), Thr (3), Ser (9), Glx (12), Pro (12), Gly (6), Ala (6), Cys 1/2 (14), Val (7), Met (2), Ile (3), Leu (1), Try (2), Phe (7), wherein the determinations are subjected to the usual error of .+-.10 percent of the indicated figures. The partial amino acid sequence comprising a total of 45 amino acids from the N-terminal, is believed to be: ##STR1## wherein pyrGlu (residue 1) stands for pyroglutamic acid. The purified polypeptide is of utility as a medicament, for example as a spasmolytic agent, as an agent for treatment of gastroduodenal ulcers and as a diagnostic aid.Type: GrantFiled: March 9, 1981Date of Patent: January 25, 1983Assignee: Novo Industri A/SInventors: Klavs H. Jorgensen, Karin D. Jorgensen, Lars Thim
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Patent number: 4357357Abstract: Microbial rennet such as from Mucor miehei is thermally destabilized by treatment of the rennet in an aqueous medium with oxidizing agents containing active chlorine such as hypochlorites. The thermally destabilized rennet is advantageous for cheese making where absence of rennet activity in pasteurized whey is desired.Type: GrantFiled: November 20, 1979Date of Patent: November 2, 1982Assignee: Novo Industri A/SInventors: Sven Branner-Jorgensen, Palle Schneider, Peter Eigtved
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Patent number: 4343898Abstract: A process for converting insulin compounds containing the human insulin moiety ##STR1## into h-In-Thr.sup.B30 esters through transpeptidation of such insulin compounds with a threonine ester in solution of water and a water miscible solvent in the presence of trypsin and optionally an acid.Yields in excess of 60% are obtained by limiting water content to less than 50% v/v of the reaction mixture and controlling reaction temperature, with below ambient temperature and extended reaction times being preferred.A preferred starting material is the crude porcine insulin recovered from insulin salt cake and contaminated by proinsulin and degradation products thereof which contaminants convert into the h-In-Thr.sup.B30 ester.Type: GrantFiled: February 10, 1981Date of Patent: August 10, 1982Assignee: Novo Industri A/SInventor: Jan Markussen
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Patent number: 4335208Abstract: Saccharifying starch hydrolysate to a high DX glucose syrup at pH 3-5 by the enzyme mixture of a glucoamylase and an acidophilic iso-amylase. A lower dosage level than the heretofore conventional glucoamylase dosage may be employed and higher DX glucose syrups can be obtained.Type: GrantFiled: March 11, 1980Date of Patent: June 15, 1982Assignee: Novo Industri A/SInventor: Barrie E. Norman
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Patent number: 4324805Abstract: A method for producing soy protein hydrolysate involving water washing fat-containing soy material at a pH of 3.5-5.5 thereby partially defatting the soy material; then hydrolyzing the partially defatted soy material with a proteolytic enzyme in the presence of water and a base to a DH in the range of 1-20; and recovering the aqueous soy protein hydrolysate from soy derived oil and solids in the hydrolysis mixture. The oil is recovered from the wash water and from the hydrolysate mixture.Type: GrantFiled: July 7, 1980Date of Patent: April 13, 1982Assignee: Novo Industri A/SInventor: Hans A. S. Olsen
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Patent number: 4316956Abstract: This invention relates to a novel fermentation process and in particular, to fermentative production of ethanol producing in the presence of non-gelled, or granular, starch particles, alpha-amylase and a glucoamylase; characteristic of the present process is recycle of enzymes for renewed use in fermentation, usually through termination of the fermentation prior to complete disappearance of the granular starch particles, and recovery for use anew of the unconsumed starch, along with enzymes thereon. Fermentation according to practice of this invention proceeds at a near to linear rate in the main.Type: GrantFiled: February 6, 1980Date of Patent: February 23, 1982Assignee: Novo Industri A/SInventor: Niels W. Lutzen
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Patent number: 4288552Abstract: Intracellular glutaraldehyde sensitive enzymes are immobilized by reacting microbial cell material with glutaraldehyde in the presence of a polyamine which is preferably a branched polyethylene imine.Type: GrantFiled: April 11, 1979Date of Patent: September 8, 1981Assignee: Novo Industri A/SInventor: Stina M. Gestrelius
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Patent number: 4266029Abstract: An immobilized enzyme granular product suitable for use in expanded and fluidized bed operations is formed by gelatine coating a dense particulate material, e.g., a mineral oxide, and hardening the coating with glutaraldehyde, then treating the coated particles with a pasty mixture of an enzyme substance and polyethylene imine, and thereafter treating the mixture with glutaraldehyde, followed by granulating and drying. Sand and titanium dioxide are preferred particulate materials. Lactase, urease, and inulinase are preferred enzymes, preferably in the form of whole or homogenized microbial cells.Type: GrantFiled: August 10, 1979Date of Patent: May 5, 1981Assignee: Novo Industri A/SInventor: Sven Branner-Jorgensen