Patents Assigned to Nucletron Operations B.V.
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Patent number: 11383099Abstract: Embodiments of the disclosure may be drawn to wireless afterloaders. Exemplary afterloaders may include a central processing unit, a first complex programmable logic device having a memory, a transceiver operably connected to the complex programmable logic device, wherein the transceiver is configured to wirelessly receive data from a second complex programmable logic device separate from the wireless afterloader, and a battery.Type: GrantFiled: December 18, 2018Date of Patent: July 12, 2022Assignee: Nucletron Operations B.V.Inventors: Cor van de Wardt, Johan Henning
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Publication number: 20220161056Abstract: Embodiments of the disclosure may be drawn to brachytherapy applicators. Exemplary applicators may include an interstitial tube having a body with a proximal end and a distal end and a central conduit extending from the distal end of the body, wherein the central conduit includes a proximal opening, a distal opening, and a channel extending from the proximal opening to the distal opening, and wherein the proximal opening is offset from an axis of the body. The proximal opening may be configured to fluidly connect to a brachytherapy guide tube, and the channel of the central conduit may be dimensioned to receive at least one of a needle or a catheter therethrough.Type: ApplicationFiled: February 27, 2020Publication date: May 26, 2022Applicant: NUCLETRON OPERATIONS B.V.Inventors: Jan Willem VAN MANEN, Eylem ARIKAN, Wilko VAN ERP
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Patent number: 10933255Abstract: A source guide apparatus for brachytherapy application, wherein the source guide apparatus is provided with a source capsule, a guidewire for moving the source capsule through a catheter, a mechanical connection between the guidewire and the source capsule, wherein the source guide apparatus is provided with a sleeve which is attached on the capsule, wherein the sleeve envelops at least a part of the mechanical connection.Type: GrantFiled: October 22, 2007Date of Patent: March 2, 2021Assignee: Nucletron Operations B.V.Inventors: Eric van't Hooft, Libbe van Zwol
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Patent number: 10806369Abstract: The invention relates to a method for determining the position of a surgical tool relative to a target volume inside an animal body according to a pre-plan comprising the steps of i) obtaining a plurality of two-dimensional images of said target volume using imaging means, each 2D-image being represented by an image data slice I(x,y,z); ii) reconstructing from said plurality of image data slices I(x,y,z) a three-dimensional image of said target volume using transformation means, said 3D-image being represented by a volumetric image data array V(x,y,z); iii) displaying said three-dimensional image of said target volume to an user using displaying means.Type: GrantFiled: July 10, 2017Date of Patent: October 20, 2020Assignee: NUCLETRON OPERATIONS B.V.Inventors: Wilco Van Der Lugt, Jeroen Schuurman, Johan Henning, Stefan Kwa, Johann Kindlein
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Patent number: 10758745Abstract: Systems and methods for generating a radiation therapy treatment plan by using ultrasound images are disclosed. The method includes obtaining a first set of image data representing a first image of an anatomical region that includes a treatment applicator inserted into the anatomical region. The method further includes receiving tracking information indicating a position of the treatment applicator as represented in the first set of image data, obtaining a second set of image data representing a second image of the anatomical region, and combining at least a portion of the first set of image data with the second set of image data. One of the first set and the second set of image data is used to identify a target tissue portion in the anatomical region. The method further includes generating, based on the combined image data, treatment plan information for treating the target tissue portion in the anatomical region.Type: GrantFiled: May 28, 2015Date of Patent: September 1, 2020Assignee: NUCLETRON OPERATIONS B.V.Inventors: Cor Van de Wardt, Paulus Cornelis Hendrikus Maria Krechting, Jan Frans Lodewijk De Becker, Nicole Nesvacil, Christian Kirisits, Richard Pötter, Maximilian Paul Schmid
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Publication number: 20200188690Abstract: Embodiments of the disclosure may be drawn to wireless afterloaders. Exemplary afterloaders may include a central processing unit, a first complex programmable logic device having a memory, a transceiver operably connected to the complex programmable logic device, wherein the transceiver is configured to wirelessly receive data from a second complex programmable logic device separate from the wireless afterloader, and a battery.Type: ApplicationFiled: December 18, 2018Publication date: June 18, 2020Applicant: NUCLETRON OPERATIONS B.V.Inventors: Cor van de WARDT, Johan Henning
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Patent number: 10668299Abstract: A brachytherapy system includes a brachytherapy applicator. The brachytherapy applicator includes an applicator tube and a radiation source configured to deliver radiation to a tumor. At least a portion of the applicator tube is configured to conform to at least a portion of a patient's anatomy. At least one ultrasound element or probe is coupled to or embedded with the applicator tube.Type: GrantFiled: April 11, 2016Date of Patent: June 2, 2020Assignee: Nucletron Operations B.V.Inventors: Paulus Cornelis Hendrikus Maria Krechting, Wilhelmus Petrus Martinus Maria Van Erp, Jan F. L. De Becker, Anton J. G. Welberg
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Patent number: 10596390Abstract: Systems, methods, and apparatuses are provided for an advanced gynecological applicator. In accordance with some embodiments, a brachytherapy applicator head and assembly is provided. The assembly may include two ovoid tubes configured to receive radiation sources, the two ovoid tubes combining to form a rounded applicator having a middle opening and comprising a plurality of needle holes to guide interstitial needles. The assembly may also include a central applicator tube configured to receive a radiation source that is located within the middle opening. Additionally, the assembly may include a vaginal cap that includes a tool-free connection to the two ovoid tubes and includes needle guides that align with the needle holes of the two ovoid tubes. The assembly may include a one-piece template for securing interstitial needles. The assembly may further include a tool-free connector to secure the two ovoid tubes to the central applicator tube.Type: GrantFiled: December 4, 2015Date of Patent: March 24, 2020Assignee: NUCLETRON OPERATIONS B.V.Inventors: Hendrik Steller, Wilhelmus Van Erp, Jan Willem Van Manen, Norbert Johan Lukas Geheniau
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Patent number: 10293178Abstract: In one embodiment, a verification system for confirming the position of a conduit inserted within a patient may include an elongate control element dimensioned for insertion within the conduit. The control element has a proximal end and a distal end, and a verification element coupled to a distal region. The verification element may be configured to detect the presence of a reference marker associated with the conduit and communicate a signal indicative of the position of the reference marker relative to the verification element. The control element may also be configured to maneuver the verification element along a length of the conduit.Type: GrantFiled: December 10, 2014Date of Patent: May 21, 2019Assignee: Nucletron Operations B.V.Inventors: Frits De Vries, Adriaan Van Appeldoorn
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Patent number: 10226232Abstract: The invention relates to a brachytherapy instrument comprising a body, wherein the body is provided with at least one marker comprising a material suitable to be visualized using an ultrasonic and/or magnetic resonance imaging technique. The invention further relates to an image acquisition system and a method of image acquisition.Type: GrantFiled: December 11, 2013Date of Patent: March 12, 2019Assignee: Nucletron Operations B.V.Inventors: Cor Van de Wardt, Wilhelmus Petra Martinus Maria Van Erp, Luite Visscher
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Patent number: 10195460Abstract: A system for transporting a source for brachytherapy may include a source guide, a detector, and a controller. The source guide may be configured to guide a source transport for transporting the source, wherein the source guide includes at least one electronic tag. The detector may be configured to detect a frequency signal generated by the at least one electronic tag, wherein the frequency signal varies when the source transport is proximate to the at least one electronic tag. The controller may be configured to receive the frequency signal from the detector and determine a path of the source transport based on the frequency signal. A method for transporting a source used for brachytherapy may include detecting a frequency signal generated by at least one electronic tag associated with a source guide configured to guide a source transport for transporting the source. The frequency may vary when the source transport is proximate to the at least one electronic tag.Type: GrantFiled: May 18, 2016Date of Patent: February 5, 2019Assignee: Nucletron Operations B.V.Inventors: Bas Woudstra, Johan Henning
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Patent number: 10029119Abstract: The invention relates to a brachytherapy applicator device for insertion in a body cavity. The applicator device comprises an applicator shaped for insertion in the body cavity; the applicator comprising connectable segments; at least one connectable part having a form following wall surface shaped to follow the body cavity, the wall surface having a multichannel groove structure, so as to guide a plurality of catheters along the grooves in the groove structure along the wall surface.Type: GrantFiled: August 5, 2015Date of Patent: July 24, 2018Assignee: NUCLETRON OPERATIONS B.V.Inventors: René Gerard Willem Mäkel, Pieter Morssink, Hendrik Steller, Arie Luite Visscher, Cor van de Wardt, Franciscus Antonius Maria Kuipers
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Publication number: 20180071549Abstract: A brachytherapy system includes a brachytherapy applicator. The brachytherapy applicator includes an applicator tube and a radiation source configured to deliver radiation to a tumor. At least a portion of the applicator tube is configured to conform to at least a portion of a patient's anatomy. At least one ultrasound element or probe is coupled to or embedded with the applicator tube.Type: ApplicationFiled: April 11, 2016Publication date: March 15, 2018Applicant: Nucletron Operations B.V.Inventors: Paulus Cornelis Hendrikus Maria KRECHTING, Wilhelmus Petrus Martinus Maria VAN ERP, Jan F. L. DE BECKER, Anton J. G. WELBERG
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Patent number: 9827443Abstract: A modular applicator for enabling a brachytherapy treatment comprising a central element and one or more of peripheral elements, wherein the central element is adapted with a fixation mechanism having a core for affixing the said peripheral elements thereto, wherein the fixation mechanism prevents a rotational displacement of the peripheral elements attached to the core of the fixation element with respect to the central element.Type: GrantFiled: October 25, 2013Date of Patent: November 28, 2017Assignee: Nucletron Operations B.V.Inventors: Wilhelmus Petrus Martinus Maria van Erp, Tommy Robert Oscar Martens, Gaetan Stephan Marie van Wijck, Cor van de Wardt
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Patent number: 9795804Abstract: An afterloading device for effectuating a brachytherapy treatment, comprising a first elongated flexible transport element, arranged to maneuver a radiation source between a storage position inside the afterloading device and a treatment position outside the afterloading device, the afterloading device further comprising a second elongated flexible transport element, having at least one transducer, the second transport element being arranged to move the at least one transducer between a first transducer position and a second transducer position.Type: GrantFiled: May 21, 2014Date of Patent: October 24, 2017Assignee: Nucletron Operations B.V.Inventors: Adriaan Van Appeldoorn, Jeroen Schuurman, Martin Van Beek, Finn Sollen, Johan Henning, Arie Luite Visscher
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Patent number: 9737729Abstract: Embodiments of the present disclosure relate to a modular applicator for enabling a brachytherapy treatment, comprising a central core and an outer sleeve, wherein the central core is adapted with a fixation mechanism for affixing the outer sleeve to the central core, wherein the outer sleeve is manufactured from a substantially rigid or shapeable material.Type: GrantFiled: October 25, 2013Date of Patent: August 22, 2017Assignee: Nucletron Operations B.V.Inventors: Wilhelmus Petrus Martinus Maria van Erp, Tommy Robert Oscar Martens, Gaetan Stephan Marie van Wijck, Cor van de Wardt
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Patent number: 9730608Abstract: The invention relates to a method for determining the position of a surgical tool relative to a target volume inside an animal body according to a pre-plan comprising the steps of i) obtaining a plurality of two-dimensional images of said target volume using imaging means, each 2D-image being represented by an image data slice I(x,y,z); ii) reconstructing from said plurality of image data slices I(x,y,z) a three-dimensional image of said target volume using transformation means, said 3D-image being represented by a volumetric image data array V(x,y,z); iii) displaying said three-dimensional image of said target volume to an user using displaying means.Type: GrantFiled: January 10, 2012Date of Patent: August 15, 2017Assignee: Nucletron Operations, B.V.Inventors: Wilco Van Der Lugt, Jeroen Schuurman, Johan Henning, Stefan Kwa, Johann Kindlein
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Patent number: D939706Type: GrantFiled: February 27, 2020Date of Patent: December 28, 2021Assignee: Nucletron Operations B.V.Inventor: Jan Willem Van Manen
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Patent number: D954956Type: GrantFiled: February 27, 2020Date of Patent: June 14, 2022Assignee: Nucletron Operations B.V.Inventor: Jan Willem Van Manen
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Patent number: D966521Type: GrantFiled: November 18, 2021Date of Patent: October 11, 2022Assignee: Nucletron Operations B.V.Inventor: Jan Willem Van Manen