Abstract: A micro-electro-mechanical-systems (MEMS) device is disclosed that is configured to operate as a reservoir computer including performing sensing and computing co-locally. The MEMS device includes circuitry for: generating a modulated input signal based on an input signal; generating a MEMS deflection signal based on the modulated input signal and a time-delayed MEMS deflection signal; sampling the MEMS deflection signal N times during a time internal T to generate a MEMS deflection matrix, wherein MEMS deflection matrix has a size M×N, wherein N corresponds to a number of virtual nodes of the reservoir computer and M is a number of time steps of time interval T; receiving a trained weight matrix, wherein the trained weight matrix is trained by linear regression; and multiplying the MEMS deflection matrix by the trained weight matrix to generate an output signal that classifies the input signal.

Abstract: The present disclosure relates to materials and methods for extracellular vesicle (e.g., exosome)-mediated delivery of cargo (e.g., endogenous and/or exogenous) to non-bovine mammalian (e.g., human) cells. For example, exosomes isolated from bovine milk for delivering cargo to non-bovine mammalian (e.g., human) cells are provided.

Abstract: A cell expansion system for culturing and expanding cells in hydrogel tubes is disclosed herein. The cell expansion system includes a cap having an extruder located within the cap and a tubular housing in fluid connection with the cap. The extruder has at least a first and second inlet. The tubular housing includes a cell compatible buffer. The extruder extends from within the cap into the tubular housing. The cell expansion system allows for expanding cells that can significantly reduce the production time and cost, while increasing the production capacity.

Abstract: The present disclosure describes methods of generating three-dimensional skin tissue constructs comprising a basal-to-suprabasal transition.

Abstract: The present disclosure is directed to a tactile stimulation device. The tactile stimulation device can include at least one pneumatic switch, an applicator connected to the at least one pneumatic switch, and a controller operatively connected to the at least one pneumatic switch. The controller is configured to control the at least one pneumatic switch to connect the applicator to at least one of high pressure, vacuum pressure, and atmospheric pressure to stimulate a nerve ending of a user.

Abstract: An overhead support system includes a plurality of posts; a plurality of beams configured to connect to and span between the posts; a counterbalance system configured to be attached to the plurality of posts; a harness configured to be worn by and support a patient; a plurality of pulleys configured to be disposed on the plurality of posts; a plurality of cables, each cable including a first end configured to be operatively connected to the harness and a second end configured to be operatively connected to a counterbalance system, each cable passing over one of the pulleys; and a mechanism configured to selectively adjust a tension in at least one of the plurality of cables to support some or all of the weight of the patient. The counterbalance system compensates to maintain support while the patient is located between the posts and the harness is lower than the pulleys.

Abstract: Systems and methods for treatment of squamous cell carcinoma or other cancer utilizing targeting peptides are described. The targeting peptides interact with SCC cells or other cancerous cells to block or interfere with 14-3-3? heterodimerization or CDC25A binding to 14-3-3?. A peptide composition embodiment includes, but is not limited to, at least one of a first targeting peptide comprising a structure of Trp-Tyr-Trp-Lys-NH2 (SEQ ID NO: 1), a second targeting peptide comprising a structure of phospho-Ser178; Ac-Thr-Gln-Arg-Gln-Asn-Ser-(PO32?)-Ala-Pro-Arg-Met-Leu-Ser-Ser-Asn-NH2 (SEQ ID NO: 2), and a third targeting peptide comprising a structure of phospho-Thr507 residue; Ac-Arg-Thr-Lys-Ser-Arg-Thr(PO32?)-Trp-Ala-Gly-Glu-Lys-Ser-Lys-Arg-NH2 (SEQ ID NO: 3).

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for simulating heat transfer in additive manufacturing. Implementations disclosed herein convert a model of an object into a node representation of the object, and generate an adjacency matrix of the object based on the node representation. For each layer of nodes in the node representation, implementations apply a simulated heat to the layer of nodes, and estimating a diffusion of heat to other nodes based on the adjacency matrix. Implementations generate a representation of an estimated heat distribution within the object.

Abstract: Provided here are methods of detecting compromised cerebrovascular reactivity in a subject and treating such subject. The method includes acquiring transcranial Doppler signals and cardiac measurements from the subject following a breath-hold maneuver and recording a test set of CBFV measurements. A breath-hold acceleration index is calculated based on a linear regression correlation of temporal variations of the mean velocity across all cardiac cycles during the breath-hold maneuver. The presence of compromised cerebrovascular reactivity in the subject is detected in response to variations in the breath-hold acceleration index of the subject as compared to a healthy individual performing breath-hold maneuver under similar conditions. If the subject has compromised cerebrovascular reactivity, a therapeutically effective compound is administered to the subject along with provision of behavioral modification regimen.

Abstract: This document describes a number of different polypeptide sequences, and the nucleic acid sequences encoding such polypeptide sequences, that can be used alone or in combination as universal vaccines against viruses including influenza A or influenza B in humans or influenza in swine.

Abstract: Microfluidic gradient generators that can create robust platforms that can not only be used for creating co-cultures of cells with various ratios, but also can simultaneously generate gradients of mechanical and chemical stresses. A chip utilizes microchambers embedded within channels to provide space for 3D cell culture and exposes these cells to gradients of mechanical shear stress and a chemical treatment.

Abstract: A thin film molecular memory is provided that satisfies criteria needed to make a molecular spintronic device, based on spin crossover complexes, competitive with silicon technology. These criteria include, device implementation, a low coercive voltage (less than 1V) and low write peak currents (on the order of 104 A/cm2), a device on/off ratio >10, thin film quality, the ability to “lock” the spin state (providing nonvolatility), the ability to isothermally “unlock” and switch the spin state with voltage, conductance change with spin state, room temperature and above room temperature operation, an on-state device resistivity less than 1 ?·cm, a device fast switching speed (less than 100 ps), device endurance (on the order of 1016 switches without degradation), and the ability of having a device with a transistor channel width of 10 nm or below.

Abstract: A method for preparing keratin-based composites includes mixing polysaccharide nanoparticles and a keratin solution to form a nanoparticle-keratin solution; and solvent casting the nanoparticle-keratin solution to form the keratin-based composites.

Abstract: The use of mitochondrial protease OMA1 as a theranostic marker for breast cancer, tumor progression, metastatis and drug responsiveness is disclosed herein.

Abstract: A crash impact attenuator system for deployment in front of a structure includes a rail and a plurality of diaphragms initially disposed in spaced relation along the length of the rail. Each of the plurality of diaphragms moves along the rail, so that when a front end of the crash attenuator system receives an impact force from a vehicle, a first one of the diaphragms moves rearwardly along the rail and impacts a second one of the diaphragms so that both the first and second diaphragms move further rearwardly along the rail, this process continuing with additional ones of the diaphragms until the impact forces have been fully attenuated. A tearing member on the crash attenuator system engages material forming a side or fender panel of the crash attenuator system, the tearing member tearing material forming the side panel to attenuate the impact force.

Abstract: A method of forming a photoactive device includes steps of: forming a photoactive layer, the photoactive layer comprising a perovskite material and a dopant; wherein the photoactive device comprises a positive electrode and a negative electrode; wherein said photoactive layer is directly or indirectly in electronic communication with the positive electrode and directly or indirectly in electronic communication with the negative electrode; and wherein the photoactive device is free of a hole transport layer between the photoactive layer and the positive electrode.

Abstract: The present invention provides methods for obtaining plants that exhibit useful traits by perturbation of plastid function in plant rootstocks and grafting the rootstocks to scions. Methods for identifying genetic loci that provide for useful traits in plants and plants produced with those loci are also provided. In addition, plants that exhibit the useful traits, parts of the plants including seeds, and products of the plants are provided as well as methods of using the plants. Recombinant DNA vectors and transgenic plants comprising those vectors that provide for plastid perturbation are also provided.

Abstract: In an example, a conductive concrete structure disclosed. The conductive concrete can include a plurality of conductive side structures defining an interior of the conductive concrete structure and a plurality of conductive concrete partitions disposed within the interior of the conductive concrete structure. The plurality of conductive concrete partitions are arranged to define a labyrinth within the conductive concrete structure.

Abstract: A method for desensitizing a metal alloy such as an aluminum (Al) alloy is presented. The surface of the alloy is treated by controlled laser beam irradiation. The scanning laser beam heats the alloy to reach a relative low temperature between a solvus temperature and a soften/annealing temperature of the metal alloy to controllably reduce the degree of sensitization (DOS) of the metal alloy. The locally rapid heating and cooling effects produced by scanning the laser can improve the future sensitization resistance of the metal alloy, reduce the average desensitization temperature applied, and maintain the mechanical properties of Al alloy at the same time.

Abstract: Methods and materials for treating a mammal having Alzheimer's disease (AD) are described. For example, one or more Zika virus (ZIKV) polypeptides can be administered to a mammal having, or at risk of developing, AD to treat the mammal.