Patents Assigned to Nycomed GmbH
  • Process for preparing optically pure active compounds
    Patent number: 7452998
    Abstract: The invention relates to a novel process for preparing an optically pure PPI having a sulfinyl structure using a chiral zirconium complex or a chiral hafnium complex.
    Type: Grant
    Filed: December 3, 2003
    Date of Patent: November 18, 2008
    Assignee: Nycomed GmbH
    Inventors: Bernhard Kohl, Bernd Müller, Ralf Steffen Weingart
  • Process For the Production of Intermediates For the Preparation of Tricyclic Benzimidazoles
    Publication number: 20080280855
    Abstract: The invention relates to a process for the synthesis of compounds of the formula 1-a and compounds of the formula 1-b. The compounds of the formula 1-a and the compounds of the formula 1-b, in which the substituents R1, R2, R3, and Ar have the meanings indicated in the description, are valuable intermediates for the preparation of pharmaceutically active compounds.
    Type: Application
    Filed: June 20, 2006
    Publication date: November 13, 2008
    Applicant: NYCOMED GmbH
    Inventors: Maria Vittoria Chiesa, Andreas Palmer, Wilm Buhr, Peter Jan Zimmermann, Christof Brehm, Wolfgang-Alexander Simon, Stefan Postius, Wolfgang Kromer, Antonio Zanotti-Gerosa
  • Topically applicable pharmaceutical preparation
    Publication number: 20080280958
    Abstract: A topical pharmaceutical preparation for administering a slightly soluble PDE4 inhibitor is described. A surprisingly good systemic bioavailability is observed with this dosage form.
    Type: Application
    Filed: April 29, 2008
    Publication date: November 13, 2008
    Applicant: NYCOMED GmbH
    Inventors: Christina Bolle, Rudolf Linder
  • Aerosol Container
    Publication number: 20080257339
    Abstract: The present invention relates to an aerosol container with an RFID unit applied to a spacer connected to the base of the aerosol container.
    Type: Application
    Filed: June 8, 2006
    Publication date: October 23, 2008
    Applicant: NYCOMED GMBH
    Inventors: Rango Dietrich, Gabriele Emser, Jutta Pfeiffer, Michael Lange
  • Novel Tetrahydropyridothiophenes
    Publication number: 20080260749
    Abstract: Compounds of a certain formula (I) in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.
    Type: Application
    Filed: May 24, 2006
    Publication date: October 23, 2008
    Applicant: NYCOMED GmbH
    Inventors: Klaus Pekari, Mathias Schmidt, Thomas Bar, Thomas Beckers, Petra Gimmnich
  • Combination of a NSAID and a PDE-4 inhibitor
    Publication number: 20080255209
    Abstract: The invention relates to the combined use of a PDE4 inhibitor and a conventional NSAID in the treatment of an inflammatory disease and/or an inflammation-associated disorder while minimizing gastrointestinal side effects, such as gastric erosions and ulcer, which are frequently associated with the use of conventional NSAIDs. A preferred PDE 4 inhibitor for this combination is roflumilast or a derivative thereof. A preferred conventional NSAID for this combination is diclofenac or a derivative thereof.
    Type: Application
    Filed: December 20, 2007
    Publication date: October 16, 2008
    Applicant: NYCOMED GMBH
    Inventors: Thomas Klein, Hans-Peter Kley
  • Oral administration form for pyridin-2-ylmethylsulfinyl-1H benzimidazoles
    Publication number: 20080226712
    Abstract: The invention relates to an oral administration form for pyridin-2-ylmethylsulfinyl-1H-benzimidazoles and their salts, which comprises the active compound together with tablet disintegrants and is provided with a film coating customary per se for sustained-release compositions.
    Type: Application
    Filed: May 21, 2008
    Publication date: September 18, 2008
    Applicant: NYCOMED GmbH
    Inventors: Rango Dietrich, Hartmut Ney
  • Combination of a Pd4 Inhibitor and a Tetrahydrobiopterin Derivative
    Publication number: 20080221111
    Abstract: The invention describes the use of a PDE4 inhibitor in combination with BH4 or a BH4 derivative for the prevention and/or treatment of respiratory diseases.
    Type: Application
    Filed: May 8, 2006
    Publication date: September 11, 2008
    Applicant: NYCOMED GmbH
    Inventors: Christian Hesslinger, Christian Schudt, Degenhard Marx, Clemens Braun
  • 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors
    Patent number: 7423046
    Abstract: Compounds of formula (I), in which R1, R2, R3, R4, R5, R6 and R7 have the meaning indicated in the description, are novel effective PDE4 inhibitors.
    Type: Grant
    Filed: August 29, 2003
    Date of Patent: September 9, 2008
    Assignee: Nycomed GmbH
    Inventors: Ulrich Kautz, Beate Schmidt
  • Amido-Substituted 6-Phenylphenanthridines
    Publication number: 20080214536
    Abstract: Compounds of a certain formula (I) in which R1, R2, R3, R31, R4, R5, R51, R6 and R7 have the meanings indicated in the description, are novel effective PDE4 inhibitors.
    Type: Application
    Filed: March 9, 2006
    Publication date: September 4, 2008
    Applicant: NYCOMED Gmbh
    Inventors: Ulrich Kautz, Beate Schmidt, Dieter Flockerzi, Maria Vittoria Chiesa, Armin Hatzelmann, Christof Zitt, Johannes Barsig, Degenhard Marx, Hans-Peter Kley
  • Taste Masked Dosage Form Containing Roflumilast
    Publication number: 20080193544
    Abstract: Taste masked dosage forms for oral administration of roflumilast are described.
    Type: Application
    Filed: March 14, 2006
    Publication date: August 14, 2008
    Applicant: Nycomed GmbH
    Inventors: Antje Bruck-Scheffler, Alexander Pontius
  • Novel Salts of 6-Heterocycle Substituted Hexahydrophenanthridine Derivatives
    Publication number: 20080194587
    Abstract: The invention relates to salts of 6-heteroaryl substituted hexahydrophenanthridine PDE4-inhibiting compounds, which can be used in the pharmaceutical industry for the production of pharmaceutical compositions for use, e.g., in treatment of airway disorders.
    Type: Application
    Filed: March 1, 2006
    Publication date: August 14, 2008
    Applicant: NYCOMED GmbH
    Inventors: Ulrich Kautz, Matthias Webel, Christian Scheufler, Rolf-Peter Hummel
  • N-Sulphonylpyrroles and Their Use as Histone Deacetylase Inhibitors
    Publication number: 20080176848
    Abstract: Compounds of a certain formula (I) in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, are novel effective HDAC inhibitors.
    Type: Application
    Filed: March 14, 2006
    Publication date: July 24, 2008
    Applicant: Nycomed GmbH
    Inventors: Thomas Maier, Thomas Bar, Thomas Beckers, Astrid Zimmermann, Siegfried Schneider, Volker Gekeler
  • Oral administration form for pyridin-2-ylmethylsulfinyl-1H-benzimidazoles
    Patent number: 7402321
    Abstract: The invention relates to an oral administration form for pyridin-2-ylmethylsulfinyl-1H-benzimidazoles and their salts, which comprises the active compound together with tablet disintegrants and is provided with a film coating customary per se for sustained-release compositions.
    Type: Grant
    Filed: March 17, 2006
    Date of Patent: July 22, 2008
    Assignee: Nycomed GmbH
    Inventors: Rango Dietrich, Hartmut Ney
  • Isotopically substituted proton pump inhibitors
    Publication number: 20080146610
    Abstract: The invention relates to compounds of formula 1 and formula 10 and to compositions comprising these compounds and methods of treating gastrointestinal disorders by administering these compounds.
    Type: Application
    Filed: December 12, 2007
    Publication date: June 19, 2008
    Applicant: NYCOMED GmbH
    Inventors: Bernhard Kohl, Bernd Muller, Dieter Haag, Wolfgang-Alexander Simon, Karl Zech, Michael David, Oliver Von Richter, Felix Huth
  • Pharmaceutical preparation in the form of a suspension comprising an acid-labile active ingredient
    Patent number: 7357943
    Abstract: The present invention relates to the field of pharmaceutical technology and describes a novel pharmaceutical preparation in the form of a suspension comprising an acid-labile active ingredient, in particular an acid-labile proton pump inhibitor. The invention also relates to processes for producing the suspension. The suspension is particularly suitable for administering acid-labile active ingredients to people who have difficulty taking solid dosage forms such as tablets or capsules.
    Type: Grant
    Filed: December 5, 2001
    Date of Patent: April 15, 2008
    Assignee: Nycomed GmbH
    Inventors: Rudolf Linder, Rango Dietrich
  • Freeze-dried pantoprazole preparation and pantoprazole injection
    Patent number: 7351723
    Abstract: Lyophilized pantoprazole preparations which are obtainable by freeze-drying of an aqueous solution of pantoprazole, ethylenediamine tetraacetic acid and/or a suitable salt thereof, and sodium hydroxide and/or sodium carbonate are disclosed. The preparations have advantageous properties when reconstituted for injection.
    Type: Grant
    Filed: May 28, 2004
    Date of Patent: April 1, 2008
    Assignee: Nycomed GmbH
    Inventors: Rudolf Linder, Rango Dietrich
  • Novel Pyrrolodihydroisoquinolines
    Publication number: 20080064714
    Abstract: The invention relates to novel pyrrolodihydroisoquinoline derivatives which are efficacious inhibitors of cellular (hyper)proliferation and/or inducers of apoptosis in cancer cells.
    Type: Application
    Filed: January 11, 2006
    Publication date: March 13, 2008
    Applicant: NYCOMED GMBH
    Inventors: Matthias Vennemann, Thomas Bar, Juergen Braunger, Volker Gekeler, Petra Gimmnich, Paola Ciapetti, Jean-Marie Contreras, Camille Wermuth
  • 2-hydroxy-6-phenylphenanthridines as PDE-4 inhibitors
    Patent number: 7329676
    Abstract: The compounds of formula I in which R1, R2, R3, R31, R4, R5, R6 and R7 have the meanings as indicated in the description, are novel effective PDE4 inhibitors.
    Type: Grant
    Filed: August 28, 2003
    Date of Patent: February 12, 2008
    Assignee: Nycomed GmbH
    Inventors: Ulrich Kautz, Beate Schmidt
  • Tablet
    Patent number: D580547
    Type: Grant
    Filed: July 31, 2007
    Date of Patent: November 11, 2008
    Assignee: NYCOMED GmbH
    Inventors: James Lolis, Ralf Ritter