Patents Assigned to Nycomed GmbH
  • 6-BENZYL-2,3,4,7-TETRAHYDRO-INDOLO [2,3-C] QUINOLINE COMPOUNDS USEFUL AS PDE5 INHIBITORS
    Publication number: 20100120730
    Abstract: The compounds of formula (I) wherein R1 to R8 and R11 have the meanings as given in the description, the salts thereof, the N-oxides of the compounds and the salts thereof, and the stereoisomers of the compounds, the salts, the N-oxides of the compounds and the N-oxides of the salts thereof are effective inhibitors of the type 5 phosphodiesterase.
    Type: Application
    Filed: January 30, 2008
    Publication date: May 13, 2010
    Applicant: NYCOMED GmbH
    Inventors: Steffen Weinbrenner, Torsten Dunkern, Degenhard Marx, Beate Schmidt, Thomas Stengel, Dieter Flockerzi, Ulrich Kautz, Daniela Hauser, Jörg Diefenbach, Johannes A.M. Christiaans, Wiro M.P.B. Menge
  • PYRAZOLONE DERIVATIVES AS PDE4 INHIBITORS
    Publication number: 20100120757
    Abstract: The compounds of a certain formula 1, in which R1, R7, R8, R9 and n have the meanings as given in the description, are novel effective inhibitors of the type 4 phosphodiesterase.
    Type: Application
    Filed: May 14, 2008
    Publication date: May 13, 2010
    Applicant: NYCOMED GmbH
    Inventors: Beate Schmidt, Christian Scheufler, Juergen Volz, Martin Feth, Rolf-Peter Hummel, Armin Hatzelmann, Christof Zitt, Andrea Wohlsen, Degenhard Marx, Hans-Peter Kley, Deborah Ockert, Anke Heuser, Johannes A.M. Christiaans, Geert Jan Sterk, Wiro M.P.B. Menge
  • Combination of HMG-COA Reductase Inhibitors with Phosphodiesterase 4 Inhibitors for the Treatment of Inflammatory Pulmonary Disease
    Publication number: 20100069392
    Abstract: The invention relates to the combined use of a PDE4 inhibitor with a HMG-CoA reductase inhibitor for the preventive and curative treatment of an inflammatory pulmonary disease.
    Type: Application
    Filed: July 3, 2007
    Publication date: March 18, 2010
    Applicant: Nycomed GmbH
    Inventor: Stefan-Lutz Wollin
  • N-(alkoxyalkyl) carbamoyl-substituted 6-phenyl-benzonaphthyridine derivatives and their use as PDE ¾ inhibitors
    Patent number: 7671068
    Abstract: Compounds of the formula I in which the substitutents have the definitions provided in the specification, are novel, effective PDE 3/4 inhibitors.
    Type: Grant
    Filed: March 16, 2005
    Date of Patent: March 2, 2010
    Assignee: NYCOMED GmbH
    Inventor: Dieter Flockerzi
  • Triazolophthalazines
    Patent number: 7671050
    Abstract: The compounds of formula (I) in which R1, R2 and R3 have the meanings as given in the description are novel effective PDE2 inhibitors.
    Type: Grant
    Filed: January 4, 2006
    Date of Patent: March 2, 2010
    Assignee: NYCOMED GmbH
    Inventors: Beate Schmidt, Steffen Weinbrenner, Dieter Flockerzi, Raimund Külzer, Hermann Tenor, Hans-Peter Kley
  • Use for PDE5 inhibitors
    Patent number: 7666872
    Abstract: The present invention is concerned with the use of PDE5 inhibitors in medicine.
    Type: Grant
    Filed: March 3, 2005
    Date of Patent: February 23, 2010
    Assignee: NYCOMED GmbH
    Inventors: Torsten Dunkern, Christian Schudt, Friedrich Grimminger, Hossein Ardeschir Ghofrani, Manfred Kaps, Bernhard Rosengarten
  • Novel guanidinyl-substituted hydroxy-6-phenylphenanthridines as effective phosphodiestrase (PDE) 4 inhibitors
    Publication number: 20100035913
    Abstract: The compounds of a certain formula (1), in which R1, R2, R3, R31, R4, R5, R6 and R7 have the meanings as given in the description, are novel effective PDE4 inhibitors.
    Type: Application
    Filed: July 27, 2009
    Publication date: February 11, 2010
    Applicant: NYCOMED GmbH
    Inventor: Ulrich Kautz
  • Ciclesonide-containing sterile aqueous suspension
    Publication number: 20100034696
    Abstract: The present invention provides methods of manufacturing a sterile ciclesonide-containing aqueous suspension comprising the step of sterilization by autoclaving a ciclesonide-containing aqueous suspension.
    Type: Application
    Filed: August 19, 2009
    Publication date: February 11, 2010
    Applicant: NYCOMED GmbH
    Inventors: Yoshihisa Nishibe, Atsuhiro Nagano, Kazuya Takanashi, Yasuhide Uejima
  • Isotopically substituted proton pump inhibitors
    Publication number: 20100022779
    Abstract: The invention relates to compounds of formula 1 and formula 10 and to compositions comprising these compounds and methods of treating gastrointestinal disorders by administering these compounds.
    Type: Application
    Filed: July 21, 2009
    Publication date: January 28, 2010
    Applicant: NYCOMED GMBH
    Inventors: Bernhard Kohl, Bernd Müller, Dieter Haag, Wolfgang-Alexander Simon, Karl Zech, Michael David, Oliver Von Richter, Felix Huth
  • Medicine pack
    Patent number: 7641050
    Abstract: The present invention relates to a novel type of medicine pack comprising a plurality of blister units (1), said blister units (1) each having a protective case (6), with a blister strip (4) located therein, the blister strip (4) being fixedly connected to the protective case (6), and the protective case being able to be unfolded or opened out, and also, if appropriate, an outer package (5, 5a) for receiving the blister units (1).
    Type: Grant
    Filed: October 22, 2004
    Date of Patent: January 5, 2010
    Assignee: NYCOMED GmbH
    Inventors: Andreas Klatt, Klaus Hinderegger
  • 2-hydroxy-6-phenylphenanthridines as PDE-4 inhibitors
    Patent number: 7632844
    Abstract: The compounds of formula I in which R1, R2, R3, R31, R4, R5, R6 and R7 have the meanings as indicated in the description, are novel effective PDE4 inhibitors.
    Type: Grant
    Filed: December 17, 2007
    Date of Patent: December 15, 2009
    Assignee: Nycomed GmbH
    Inventors: Ulrich Kautz, Beate Schmidt
  • Salt of (S)-pantoprazole and its hydrates
    Patent number: 7629361
    Abstract: The invention relates to (?)-pantoprazole magnesium and its hydrates and to medicaments comprising these compounds.
    Type: Grant
    Filed: July 26, 2003
    Date of Patent: December 8, 2009
    Assignee: NYCOMED GmbH
    Inventors: Wolfgang Kromer, Bernd Müller, Stefan Postius, Wolfgang-Alexander Simon, Ernst Sturm, Guido Hanauer
  • Sulphonylpyrrole Hydrochloride Salts as Histone Deacetylases Inhibitors
    Publication number: 20090297473
    Abstract: Compounds of a certain formula 1, in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, as well as salts thereof are novel effective HDAC inhibitors.
    Type: Application
    Filed: September 8, 2006
    Publication date: December 3, 2009
    Applicant: Nycomed GmbH
    Inventors: Thomas Maier, Thomas Beckers, Rolf-Peter Hummel, Martin Feth, Matthias Müller, Thomas Bär
  • NOVEL TETRAHYDROPYRIDOTHIOPHENES
    Publication number: 20090270378
    Abstract: Compounds of a certain formula (I), in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and/or apoptosis inducing activity.
    Type: Application
    Filed: March 26, 2009
    Publication date: October 29, 2009
    Applicant: NYCOMED GMBH
    Inventors: Klaus PEKARI, Thomas BAER, Bjoern BARTELS, Mathias SCHMIDT, Thomas BECKERS
  • Novel Sulphonylpyrroles as Inhibitors of Hdac S Novel Sulphonylpyrroles
    Publication number: 20090263353
    Abstract: Compounds of a certain formula I, in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, as well as salts thereof are novel effective HDAC inhibitors.
    Type: Application
    Filed: September 8, 2006
    Publication date: October 22, 2009
    Applicant: Nycomed GmbH
    Inventors: Thomas Maier, Thomas Beckers, Rolf-Peter Hummel, Martin Feth, Matthias Muller, Thomas Bar, Jurgen Volz
  • Isotopically substituted proton pump inhibitors
    Patent number: 7601737
    Abstract: The invention relates to compounds of formula 1 and formula 10 and to compositions comprising these compounds and methods of treating gastrointestinal disorders by administering these compounds.
    Type: Grant
    Filed: December 12, 2007
    Date of Patent: October 13, 2009
    Assignee: Nycomed GmbH
    Inventors: Bernhard Kohl, Bernd Müller, Dieter Haag, Wolfgang-Alexander Simon, Karl Zech, Michael David, Oliver Von Richter, Felix Huth
  • Novel 3-thia-10-aza-phenanthrene derivatives
    Publication number: 20090239895
    Abstract: The compounds of formula I in which A, R1, R2 and R3 have the meanings as given in the description, are novel effective PDE4 inhibitors.
    Type: Application
    Filed: May 28, 2009
    Publication date: September 24, 2009
    Applicant: Nycomed GmbH
    Inventors: Dieter Flockerzi, Ulrich Kautz, Armin Hatzelmann, Christof Zitt, Andrea Wohlsen, Degenhard Marx, Hans-Peter Kley, Jens Christoffers, Anna Rosiak
  • 3-thia-10-aza-phenanthrene derivatives
    Patent number: 7589205
    Abstract: The compounds of formula I in which A, R1, R2 and R3 have the meanings as given in the description, are novel effective PDE4 inhibitors.
    Type: Grant
    Filed: September 5, 2005
    Date of Patent: September 15, 2009
    Assignee: NYCOMED GmbH
    Inventors: Dieter Flockerzi, Ulrich Kautz, Armin Hatzelmann, Christof Zitt, Andrea Wohlsen, Degenhard Marx, Hans-Peter Kley, Jens Christoffers, Anna Rosiak
  • Guanidinyl-substituted hydroxy-6-phenylphenanthridines as effective phosphodiesterase (PDE) 4 inhibitors
    Patent number: 7585872
    Abstract: The compounds of a certain formula (1), in which R1, R2, R3, R31, R4, R5, R6 and R7 have the meanings as given in the description, are novel effective PDE4 inhibitors.
    Type: Grant
    Filed: February 17, 2005
    Date of Patent: September 8, 2009
    Assignee: NYCOMED GmbH
    Inventor: Ulrich Kautz
  • Roflumilast for the Treatment of Pulmonary Hypertension
    Publication number: 20090215836
    Abstract: The invention relates to the use of Roflumilast, Roflumilast N-Oxide or a pharmaceutically acceptable salt of either for the treatment of pulmonary hypertension. The invention additionally relates to the use of Roflumilast, Roflumilast N-oxide or a pharmaceutically acceptable salt of either in combination with a PDE5 inhibitor or a pharmaceutically acceptable salt thereof for the treatment of pulmonary hypertension.
    Type: Application
    Filed: April 12, 2006
    Publication date: August 27, 2009
    Applicant: NYCOMED GMBH
    Inventors: Rolf Beume, Armin Hatzelmann, Degenhard Marx, Christian Schudt, Hermann Tenor, Saadia Eddahibi, Serge Adnot