Patents Assigned to Nycomed Pharma AS
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Publication number: 20130028973Abstract: The present invention relates to a particulate material and a solid dosage form notably tablets comprising a regularly shaped calcium-containing compound such as a calcium salt as a therapeutically and/or prophylactically active substance and a pharmaceutically acceptable sugar alcohol such as, e.g., sorbitol and/or isomalt that has a micro structure as evidenced by SEM. The invention also relates to a process for the preparation of the particulate material and solid dosage form. The process involves agglomeration of the calcium-containing compound and the pharmaceutically acceptable sugar alcohol by means of roller compaction. The particulate material obtained by roller compaction is suitable for use in the further processing of the particulate material into e.g. tablets such as chewing tablets.Type: ApplicationFiled: September 26, 2012Publication date: January 31, 2013Applicant: NYCOMED PHARMA ASInventor: NYCOMED PHARMA AS
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Publication number: 20110287098Abstract: The present invention relates to a method for the preparation of a tablet comprising at least 50% w/w of calcium carbonate, the method comprising i) providing a particulate composition comprising a) calcium carbonate, b) a binding sugar alcohol selected from sorbitol or isomalt, or combinations thereof, c) a non-binding sugar alcohol selected from mannitol, maltitol or xylitol, or combinations thereof, and ii) compressing said composition using a tabletting machine equipped with at least one pair of punches and dies, wherein the pair of punches and die before filling the die with said particulate composition is sprayed with a composition comprising a lubricant selected from magnesium stearate, calcium stearate or stearic acid or combinations thereof.Type: ApplicationFiled: November 17, 2009Publication date: November 24, 2011Applicant: NYCOMED PHARMA ASInventors: Peder Mohr Olsen, Poul Egon Bertelsen, Thomas Thisted, Henrik Ravn Aage
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Patent number: 8007752Abstract: A process for the preparation of an orally administrable calcium composition comprising the steps of: (i) obtaining a physiologically tolerable particulate calcium compound having a mean particle size in the range of 3 to 40 ?m, having a crystalline structure and having a surface area of 0.1 to 1.2 m2/g; (ii) mixing the calcium compound with a water-soluble diluent and an aqueous solution of a water soluble binder in a fluid bed granulation apparatus and dying the resulting mixture to produce a first granulate; (iii) optionally mixing the first granulate with one or more further components to produce a second granulate; and (iv) optionally compressing the first or second granulate to form tablets.Type: GrantFiled: November 13, 2009Date of Patent: August 30, 2011Assignee: Nycomed Pharma AsInventors: Jan Yngvar Piene, Dina Dogger Schmidt
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Publication number: 20110142928Abstract: The present invention discloses a process for producing a particulate material comprising a calcium-containing compound, the process comprises granulating and/or coating a powder mixture, which comprises the calcium-containing compound together with one or more pharmaceutically acceptable excipients in a continuous fluid bed apparatus.Type: ApplicationFiled: March 6, 2006Publication date: June 16, 2011Applicants: Nycomed Pharma AS, Nycomed Danmark A/SInventors: Jan Y. Piene, Kjell Tomas Lunde
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Publication number: 20100119621Abstract: A process for the preparation of an orally administrable calcium composition comprising the steps of: (i) obtaining a physiologically tolerable particulate calcium compound having a mean particle size in the range of 3 to 40 ?m, having a crystalline structure and having a surface area of 0.1 to 1.2 m2/g; (ii) mixing the calcium compound with a water-soluble diluent and an aqueous solution of a water soluble binder in a fluid bed granulation apparatus and dying the resulting mixture to produce a first granulate; (iii) optionally mixing the first granulate with one or more further components to produce a second granulate; and (iv) optionally compressing the first or second granulate to form tablets.Type: ApplicationFiled: November 13, 2009Publication date: May 13, 2010Applicant: Nycomed Pharma ASInventors: Jan Yngvar Piene, Dina Dogger Schmidt
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Patent number: 7638143Abstract: A process for the preparation of an orally administrable calcium composition comprising the steps of: (i) obtaining a physiologically tolerable particulate calcium compound having a mean particle size in the range 3 to 40 ?m, having a crystalline structure and having a surface area of 0.1 to 1.2 m2/g; (ii) mixing the calcium compound with a water-soluble diluent and an aqueous solution of a water soluble binder in a fluid bed granulation apparatus and drying the resulting mixture to produce a first granulate; (iii) optionally mixing the first granulate with one or more further components to produce a second granulate; and (iv) optionally compressing the first or second granulate to form tablets.Type: GrantFiled: May 15, 2007Date of Patent: December 29, 2009Assignee: Nycomed Pharma ASInventors: Jan Yngvar Piene, Dina Dogger Schmidt
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Publication number: 20090252805Abstract: Calcium-containing compounds have been at least partly film-coated and/or granulated with a water-soluble substance and a water-soluble polymeric substance and use of such coated compounds in pharmaceutical compositions. The at least partly film-coated and/or granulated calcium-containing compounds have proved suitable for the preparation of tablets having a very high load of elemental calcium and a conveniently small size. A drug load of about 96% or more is obtained in tablets of the invention that have sufficient mechanical and organoleptic properties.Type: ApplicationFiled: December 7, 2006Publication date: October 8, 2009Applicants: NYCOMED PHARMA AS, NYCOMED DANMARK APSInventor: Jan Y. Piene
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Publication number: 20090068268Abstract: A novel method for the preparation of a tablet comprising a calcium-containing compound, the method involves a melt granulation process by which a sugar alcohol is melted and embeds the calcium-containing compound so that a sufficient taste masking of the chalkiness is substantially achieved and an unpleasant mouth feel of the calcium-containing compound is substantially avoided, while at the same time obtaining a low tablet volume. The method of the invention is especially suitable for the manufacturing of tablets having a high load of a calcium-containing compound.Type: ApplicationFiled: February 2, 2006Publication date: March 12, 2009Applicant: NYCOMED PHARMA ASInventors: Poul E. Bertelsen, Peder M. Olsen, Carsten M. Nielsen, Magnus W. Tolleshaug
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Publication number: 20080175904Abstract: The present invention relates to a particulate material and a solid dosage form notably tablets comprising a regularly shaped calcium-containing compound such as a calcium salt as a therapeutically and/or prophylactically active substance and a pharmaceutically acceptable sugar alcohol such as, e.g., sorbitol and/or isomalt that has a micro structure as evidenced by SEM. The invention also relates to a process for the preparation of the particulate material and solid dosage form. The process involves agglomeration of the calcium-containing compound and the pharmaceutically acceptable sugar alcohol by means of roller compaction. The particulate material obtained by roller compaction is suitable for use in the further processing of the particulate material into e.g. tablets such as chewing tablets.Type: ApplicationFiled: May 24, 2005Publication date: July 24, 2008Applicant: Nycomed Pharma ASInventors: Jacob Mathiesen, Carsten M. Nielsen, Peder M. Olsen, Poul E. Bertelsen
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Patent number: 7399483Abstract: The present invention relates to a solid composition useful for tissue gluing, tissue sealing and haemostasis consisting essentially of a) a carrier which has at least one of the following physical properties: elasticity module in the range of 5-100 N/cm, density of 1-10 mg/cm3, chamber diameter of more than 0.75 mm and less than 4 mm and/or having a chamber diameter average below 3 mm and evenly distributed and fixed upon said carrier, b) solid fibrinogen, and c) solid thrombin. The carrier is a biodegradable polymer such as a polyhyaluronic acid, polyhydroxy acid, e.g. lactic acid, glucolic acid, hydroxybutanoic acid, a cellulose, gelatine or collagen, such as a collagen sponge, e.g. a collagen sponge consisting essentially of collagen type I fibres. The fibrinogen and thrombin are preferably human, purified from a natural source, or transgenic or recombinant human fibrinogen and/or thrombin.Type: GrantFiled: August 26, 2005Date of Patent: July 15, 2008Assignee: Nycomed Pharma ASInventor: Dagmar Stimmeder
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Publication number: 20070224268Abstract: A process for the preparation of an orally administrable calcium composition comprising the steps of: (i) obtaining a physiologically tolerable particulate calcium compound having a mean particle size in the range 3 to 40 ?m, having a crystalline structure and having a surface area of 0.1 to 1.2 m2/g; (ii) mixing the calcium compound with a water-soluble diluent and an aqueous solution of a water soluble binder in a fluid bed granulation apparatus and drying the resulting mixture to produce a first granulate; (iii) optionally mixing the first granulate with one or more further components to produce a second granulate; and (iv) optionally compressing the first or second granulate to form tablets.Type: ApplicationFiled: May 15, 2007Publication date: September 27, 2007Applicant: Nycomed Pharma ASInventors: Jan Piene, Dina Schmidt
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Patent number: 7098315Abstract: A method of preparing a collagen sponge comprises mixing air into a collagen gel, so as to obtain a collagen foam which is dried. From the dried product thereby obtained, collagen sponge is obtained by isolating parts of sponge with a chamber diameter of more than 0.75 mm and less than 4 mm, or parts with an average chamber diagonal dimension of 3 mm. The collagen sponge may be used as a material for sealing wounds, possibly with a coating comprising a fibrin glue, such as a combination of fibrinogen, thrombin and aprotinin. A device for extracting a part of a collagen foam and for degenerating another part of the collagen foam to a collagen gel is disclosed. An elongated collagen sponge having a through-going hole or bore and a flexible wall may be used for re-establishing walls in a mammalian gastrointestinal funnel or trachea system.Type: GrantFiled: January 25, 2002Date of Patent: August 29, 2006Assignee: Nycomed Pharma ASInventor: Alfred Schaufler
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Patent number: 7052713Abstract: The present invention relates to a solid composition useful for tissue gluing, tissue sealing and hemostasis consisting essentially of a) a carrier which has at least one of the following physical properties: elasticity module in the range of 5-100 N/cm, density of 1-10 mg/cm3, chamber diameter of more than 0.75 mm and less than 4 mm and/or having a chamber diameter average below 3 mm and evenly distributed and fixed upon said carrier, b) solid fibrinogen, and c) solid thrombin. The carrier is a biodegradable polymer such as a polyhyaluronic acid, polyhydroxy acid, e.g. lactic acid, glucolic acid, hydroxybutanoic acid, a cellulose, gelatine or collagen, such as a collagen sponge, e.g. a collagen sponge consisting essentially of collagen type I fibers. The fibrinogen and thrombin are preferably human, purified from a natural source, or transgenic or recombinant human fibrinogen and/or thrombin.Type: GrantFiled: November 7, 2003Date of Patent: May 30, 2006Assignee: Nycomed Pharma ASInventor: Dagmar Stimmeder
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Patent number: 6733774Abstract: The present invention relates to a solid composition useful for tissue gluing, tissue sealing and haemostasis consisting essentially of a) a carrier which has at least one of the following physical properties: elasticity module in the range of 5-100 N/cm, density of 1-10 mg/cm3, chamber diameter of more than 0.75 mm and less than 4 mm and/or having a chamber diameter average below 3 mm and evenly distributed and fixed upon said carrier, b) solid fibrinogen, and c) solid thrombin. The carrier is a biodegradable polymer such as a polyhyaluronic acid, polyhydroxy acid, e.g. lactic acid, glucolic acid, hydroxybutanoic acid, a cellulose, gelatine or collagen, such as a collagen sponge, e.g. a collagen sponge consisting essentially of collagen type I fibres. The fibrinogen and thrombin are preferably human, purified from a natural source, or transgenic or recombinant human fibrinogen and/or thrombin.Type: GrantFiled: January 25, 2002Date of Patent: May 11, 2004Assignee: Nycomed Pharma ASInventor: Dagmar Stimmeder
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Patent number: 5830867Abstract: The invention provides compounds of the general formula (I):A.sup.1 --B.sup.1 --X.sup.1 --(CH.sub.2).sub.m --(CON(R.sub.1)).sub.r --(CH.sub.2).sub.s --Y.sup.1 --(CH.sub.2).sub.s --(N(R.sub.1)CO).sub.r --(CH.sub.2).sub.n --X.sup.1 --B.sup.1 --A.sup.1The compounds of this invention are also illustrated by the Formula (II):A.sup.2 --B.sup.2 --X.sup.2 --(CH.sub.2).sub.m --(N(R.sub.1)CO).sub.r --(CH.sub.2).sub.s --Y.sup.2 --(CH.sub.2).sub.s --(CON(R.sub.1)).sub.r --(CH.sub.2).sub.n --X.sup.2 --B.sup.2 --A.sup.2The compounds have hemoregulatory activities and can be used to stimulate haematopoiesis and for the prevention and treatment of viral, fungal and bacterial infectious diseases.Type: GrantFiled: January 30, 1996Date of Patent: November 3, 1998Assignees: SmithKline Beecham Corporation, Nycomed Pharma ASInventors: Pradip Kumar Bhatnagar, Dirk Heerding, Peter Martin Fischer
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Patent number: 5810711Abstract: A device for endoscopic or laparoscopic application of surgical material has a hand grip 1 and a shaft 2 surrounded by a movable tube 3, at a end of which shaft 2 there is a closure for an appliance for securing the wound-healing or wound-sealing material or a surgical instrument. The closure has two branches 6 which are of different lengths and are connected in a U-shape, a notch 7 being provided on the longer branch. An a raised portion 8 is provided on the appliance for securing the wound-healing or wound-sealing material or on the surgical material, which raised portion 8 can be inserted with an exact fit into the notch in the longer branch.Type: GrantFiled: May 7, 1996Date of Patent: September 22, 1998Assignee: Hafslund Nycomed Pharma AktiengesellschaftInventor: Mathias Scheyer
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Patent number: 5811250Abstract: The present invention provides a method of diagnosing haemostatic disorders in a human or non-human subject wherein the presence and/or concentration of platelet-derived microvesicles in a sample of body fluid of the subject is assessed.Type: GrantFiled: October 4, 1995Date of Patent: September 22, 1998Assignee: Nycomed Pharma A/SInventors: Nils Olay Solum, Frank Brosstad, Pal Andre Holme, Geir Olay Gogstad
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Patent number: 5691207Abstract: Methods of assaying samples for the presence of an analyte involving immobilization of a gold sol, and optionally an enzyme capable of generating a reaction product, on a solid phase. The gold sol has a mean particle size of less than 20 nm for at least 75% by weight of the particles and is formed into a novel superaggregated complex with at least one protein.Type: GrantFiled: April 29, 1993Date of Patent: November 25, 1997Assignee: Nycomed Pharma ASInventors: Jostein Holtlund, Geir Olav Gogstad
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Patent number: 5650333Abstract: Methods of assaying samples for the presence or quantity of an analyte involving immobilization of a gold sol, and optionally an enzyme capable of generating a reaction product, on a solid phase. The gold sol has a mean particle size of less than 20 nm for at least 75% by weight of the particles and is formed into a novel superaggregated complex with at least one protein.Type: GrantFiled: June 7, 1995Date of Patent: July 22, 1997Assignee: Nycomed Pharma ASInventors: Jostein Holtlund, Geir Olav Gogstad
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Patent number: D564086Type: GrantFiled: November 29, 2005Date of Patent: March 11, 2008Assignee: Nycomed Pharma A/SInventors: Carsten Martini Nielsen, Peder Mohr Olsen