Patents Assigned to OCEANS CO., LTD.
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Patent number: 4474945Abstract: New anthracycline compounds, 2-hydroxyaclacinomycin B having potent antitumor activity and lower toxicity, and a process for producing 2-hydroxyaclacinomycins A, B, and N by fermentation.Type: GrantFiled: August 6, 1982Date of Patent: October 2, 1984Assignee: Sanraku-Ocean Co., Ltd.Inventors: Akihiro Yoshimoto, Hiroyasu Tobe, Tomoyuki Ishikura, Hamao Umezawa, Tomio Takeuchi
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Patent number: 4463171Abstract: Compounds of the following general formula ##STR1## wherein R.sup.1 and R.sup.2 represent a hydrogen atom or a lower alkanoyl group;R.sup.3 represents a hydrogen atom or the group --COCH.sub.2 R.sup.5 in which R.sup.5 represents a lower alkyl group or an aryl or pyridyl group bonded through a sulfur atom;R.sup.4 represents a methyl group which may be substituted by aryl, pyridyl, pyridylthio, hydroxyl or arylthioamino, an aryl group, a nitrile group, a 5- or 6-membered heterocyclic group having 1 to 4 hetero atoms selected from nitrogen and sulfur atoms, or a tetrahydropyranyl group which may be substituted by methoxy;A represents the group --OCO--, --OSO.sub.2 --, --O-- or --S--, or A and R.sup.4, taken together, represent a halogen atom, a nitrile group or a group of the formula ##STR2## in which R.sup.Type: GrantFiled: June 9, 1983Date of Patent: July 31, 1984Assignee: Sanraku-Ocean Co., Ltd.Inventors: Hamao Umezawa, Tomio Takeuchi, Kuniaki Tatsuta, Tomoyuki Ishikura, Rokuro Okamoto, Masao Yamamoto, Kohki Kiyoshima
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Patent number: 4451401Abstract: A compound represented by the following formula ##STR1## wherein R represents a hydrogen atom or a methyl group,R.sup.1 represents a hydrogen atom or an ester residue, andR.sup.2 and R.sup.3 represent hydrogen atoms respectively, or taken together, a group of the formula ##STR2## in which each of R.sup.4 and R.sup.5 represents a hydrogen atom, a lower alkyl group or a phenyl group,and its salt; and a process for the production thereof.Type: GrantFiled: July 1, 1982Date of Patent: May 29, 1984Assignee: Sanraku-Ocean Co., Ltd.Inventors: Mitsuyasu Okabe, Takeo Yoshioka, Yasuo Fukagawa, Rokuro Okamoto, Kageaki Kouno, Tomoyuki Ishikura
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Patent number: 4439603Abstract: New anthracycline derivatives, .beta.-rhodomycinone-RDA, .beta.-rhodomycinone-RDRs and .beta.-rhodomycinone-RD having potent anticancer activities and lower toxicities and a process for the production thereof by reduction or hydrolysis of .beta.-rhodomycinone-RDC are disclosed.Type: GrantFiled: October 25, 1982Date of Patent: March 27, 1984Assignee: Sanraku-Ocean Co., Ltd.Inventors: Hamao Umezawa, Tomio Takeuchi, Tomoyuki Ishikura, Akihiro Yoshimoto, Yasue Matsuzawa, Yukio Takatsuki
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Patent number: 4438201Abstract: A novel enzyme, amidohydrolase, having the ability to depantothenylate antibiotic OA-6129A represented by the following formula ##STR1## but no substantial ability to deacetylate antibiotic PS-5 represented by the following formula ##STR2##Type: GrantFiled: July 1, 1982Date of Patent: March 20, 1984Assignee: Sanraku-Ocean Co., Ltd.Inventors: Katsuro Kubo, Yasuo Fukagawa, Tomoyuki Ishikura
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Patent number: 4426390Abstract: A compound of the formula ##STR1## wherein R.sub.1 represents a hydrogen atom, --OH or --OSO.sub.3 H, and R.sub.2 represents a hydrogen atom or an unsubstituted or substituted benzyl group; and a salt thereof; processes for production thereof by fermentation; and uses thereof as antimicrobial agents.Type: GrantFiled: September 29, 1981Date of Patent: January 17, 1984Assignee: Sanraku-Ocean Co., Ltd.Inventors: Mitsuyasu Okabe, Takeo Yoshioka, Yasuo Fukagawa, Rokuro Okamoto, Kageaki Kouno, Tomoyuki Ishikura
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Patent number: 4424342Abstract: Disclosed are an antitumor compound having the chemical structure ##STR1## or its acid addition salts; and its preparation method which consists of treating a compound represented by the chemical structure ##STR2## whereinR is a COCH.sub.3 or CH(OH)CH.sub.3 group,by a streptomycetes strain or its mutants.Type: GrantFiled: March 24, 1982Date of Patent: January 3, 1984Assignee: Sanraku-Ocean Co., Ltd.Inventors: Toshikazu Oki, Akihiro Yoshimoto, Yasue Matsuzawa, Tomoyuki Ishikura, Hamao Umezawa, Tomio Takeuchi
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Patent number: 4418192Abstract: Disclosed are novel anthracyclinone glycosides represented by the chemical formula ##STR1## wherein R.sup.1 is hydrogen or methyl;R.sup.2 is hydrogen or hydroxyl;R.sup.3 is hydrogen or methoxycarbonyl;R.sup.4 is two hydrogen atoms or an oxygen atom;R.sup.5 is hydrogen, hydroxyl or --OCOX (wherein X is lower alkyl or aralkyl);R.sup.6 is amino, monomethylamino or dimethylamino;R.sup.7 is hydrogen or acetyl; andR.sup.8 is hydrogen or L-cinerulose A ##STR2## but, when R.sup.1 and R.sup.3 are hydrogen and methoxycarbonyl respectively, R.sup.2 is hydrogen; R.sup.4 is two hydrogen atoms; R.sup.5 is hydrogen; R.sup.6 is amino, monoethylamino or dimethylamino; R.sup.7 is acetyl; and R.sup.8 is L-cinerulose A,and their acid addition salts and a method for preparation thereof which consists of treating O-alpha-L-cinerulosyl-(1.fwdarw.4)-O-(3-O-acetyl-2-deoxy-alpha-L-fucosyl)- (1.fwdarw.4)-alpha-L-rhodosamine with corresponding aglycones.Type: GrantFiled: April 20, 1982Date of Patent: November 29, 1983Assignee: Sanraku-Ocean Co., Ltd.Inventors: Hiroshi Tanaka, Takeo Yoshioka, Yasutaka Shimauchi, Toshikazu Oki, Tomoyuki Ishikura, Tomio Takeuchi, Hamao Umezawa
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Patent number: 4386198Abstract: New anthracycline compounds, 2-hydroxyaclacinomycin A having potent antitumor activity and lower toxicity, 2-hydroxyaklavinone as an useful precursor for producing anthracycline glycosides, and a process for the production thereof by microbial conversion method are disclosed.Type: GrantFiled: September 5, 1980Date of Patent: May 31, 1983Assignee: Sanraku-Ocean Co., Ltd.Inventors: Toshikazu Oki, Akihiro Yoshimoto, Kageaki Kouno, Taiji Inui, Tomio Takeuchi, Hamao Umezawa
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Patent number: 4373094Abstract: New anthracycline compounds, 2-hydroxy-aclacinomycins M, N, S and T having potent antitumor activity and low toxicity, and the processes for the preparation thereof from 2-hydroxy-aclacinomycin A by reduction or acid hydrolysis are disclosed.Type: GrantFiled: July 29, 1981Date of Patent: February 8, 1983Assignee: Sanraku-Ocean Co., Ltd.Inventors: Toshikazu Oki, Yasue Matsuzawa, Tomoyuki Ishikura, Tomio Takeuchi, Hamao Umezawa
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Patent number: 4368203Abstract: A novel antibiotic substance of the formula ##STR1## wherein R.sub.1 is CH.sub.3 and R.sub.2 is --CH.sub.2 --CH.sub.2 -- or R.sub.1 is H and R.sub.2 is --CH.dbd.CH--; and R.sub.3 represents hydrogen, lower alkyl or triphenylmethyl,and including the salts of the compound of formula (I) wherein R.sub.3 is hydrogen, said antibiotic substance having strong antibiotic activity and .beta.-lactamase inhibiting effect, and a method for producing the same by aerobic cultivation of Streptomyces A271.Type: GrantFiled: October 10, 1978Date of Patent: January 11, 1983Assignee: Sanraku-Ocean Co., Ltd.Inventors: Kazuhiko Okamura, Shoji Hirata, Yasushi Okumura, Yasuo Fukagawa, Yasutaka Shimauchi, Tomoyuki Ishikura, Kageaki Kouno, Joseph Lein
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Patent number: 4355112Abstract: A group of novel depsipeptide antibiotics, neoviridogriseins I, II and III are produced by fermentation of Streptomyces sp. P8648 (FERM-P 3562; ATCC 31289). The antibiotics are highly active against Gram-positive bacteria and mycoplasmas.Type: GrantFiled: June 6, 1977Date of Patent: October 19, 1982Assignees: Sanraku-Ocean Co., Ltd., Panlabs, Inc.Inventors: Yasushi Okumura, Kazuhiko Okamura, Yasuo Fugakawa, Tomoyuki Ishikura, Kageaki Kouno, Joseph Lein
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Patent number: 4337199Abstract: Novel antibiotic .beta.-lactam compounds, i.e. 7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives of the following formula ##STR1## wherein R.sub.1 represents a hydrogen atom, a methyl group or a hydroxyl group,R.sub.2 represents a lower alkyl group, a hydroxy lower alkyl group, a lower alkoxy-lower alkyl group, a lower alkanoyloxy-lower alkyl group, a cyclohexyl group, a phenyl group or a 5- or 6-membered aromatic heterocyclic group containing 1 or 2 nitrogen atoms, andR.sub.3 represents a hydrogen atom, a lower alkyl group, or a substituted or unsubstituted aralkyl group containing 7 to 20 carbon atoms,and the salts thereof; processes for production thereof; use thereof as antimicrobial agents; and novel intermediates for production of the compounds of formula (I).Type: GrantFiled: May 6, 1980Date of Patent: June 29, 1982Assignee: Sanraku-Ocean Co., Ltd.Inventors: Takeo Yoshioka, Kenichi Yamamoto, Kaoru Yamada, Yasuyuki Kato, Yasutaka Shimauchi, Tomoyuki Ishikura
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Patent number: 4337312Abstract: The invention is to provide a new process for producing daunomycin and baumycins having potent antitumor activity and low toxicity by microbial conversion of anthracyclinones such as aklavinone and .epsilon.-rhodomycinone.Type: GrantFiled: August 26, 1980Date of Patent: June 29, 1982Assignee: Sanraku-Ocean Co., Ltd.Inventors: Toshikazu Oki, Akihiro Yoshimoto, Kageaki Kouno, Taiji Inui, Tomio Takeuchi, Hamao Umezawa
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Patent number: 4318916Abstract: A novel antibiotic substance and derivatives thereof, having strong antibiotic activity and .beta.-lactamase inhibiting effect and a method for producing the same by aerobic cultivation of Streptomyces A 271.Type: GrantFiled: March 2, 1978Date of Patent: March 9, 1982Assignee: Sanraku-Ocean Co., Ltd.Inventors: Kazuhiko Okamura, Shoji Hirata, Yasushi Okumura, Yasuo Fukagawa, Yasutaka Shimauchi, Tomoyuki Ishikura, Kageaki Kouno, Joseph Lein
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Patent number: 4317881Abstract: A process for producing cyclodextrins which comprises using cultured medium of the strains belonging to genus Micrococcus, filtrate thereof or enzyme preparation obtained therefrom, especially, the process in which the ratio of .alpha.-cyclodextrin to .beta.-cyclodextrin can be desirably varied by regulating the condition of the reaction mixture, is disclosed.Type: GrantFiled: March 26, 1980Date of Patent: March 2, 1982Assignee: Sanraku-Ocean Co., Ltd.Inventors: Yoshiaki Yagi, Kageaki Kouno, Taiji Inui
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Patent number: 4316011Abstract: New anthracycline glycoside derivatives of rhodomycin-group, .epsilon.-rhodomycin RDC, .epsilon.-isorhodomycin RDC, .beta.-rhodomycin RDC, .gamma.-rhodomycin RDC, .gamma.-rhodomycin RDRs and .beta.-pyrromycin RDC having potent anticancer activities and lower toxicities and a process for the production thereof by microbiological conversion method are disclosed.Type: GrantFiled: June 30, 1980Date of Patent: February 16, 1982Assignee: Sanraku-Ocean Co., Ltd.Inventors: Toshikazu Oki, Akihiro Yoshimoto, Yasue Matsuzawa, Taiji Inui, Tomio Takeuchi, Hamao Umezawa
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Patent number: 4267312Abstract: New anthracycline derivatives, 1-hydroxy-13-dihydrodaunomycin and N-formyl-1-hydroxy-13-dihydrodaunomycin are produced by microbial transformation of .epsilon.-pyrromycinone and .epsilon.-isorhodomycinone with daunomycin-producing streptomyces and their mutants. The derivatives herein are useful as cancer chemotherapeutic agents.Type: GrantFiled: September 12, 1979Date of Patent: May 12, 1981Assignee: Sanraku-Ocean Co., Ltd.Inventors: Toshikazu Oki, Akihiro Yoshimoto, Taiji Inui, Tomio Takeuchi, Hamao Umezawa
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Patent number: 4205163Abstract: A number of 4"-acyl derivatives of tylosin and acetyltylosin which are prepared by first protectively acylating at the 2'-hydroxyl group of tylosin or acetyltylosin, secondly at the 4'"-hydroxyl group thereof, thirdly at the 4"-hydroxyl group thereof and finally deacylating the 2'- and 4'"-acyl groups to produce new 4"-acyl derivatives of tylosin or acetyltylosin which effect high blood level compared to those tylosin derivatives heretofore are disclosed.Type: GrantFiled: October 23, 1978Date of Patent: May 27, 1980Assignee: Sanraku-Ocean Co., Ltd.Inventors: Shunro Mori, Rokuro Okamoto, Taiji Inui, Tomio Takeuchi
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Patent number: 4201843Abstract: New tylosin derivatives having at least one acyl group at the 3- and 4"-positions of tylosin, and the acid addition salts thereof, which inhibit the growth of various microorganisms including drug-resistant bacterial isolants and which produce high blood levels through oral administration are produced by a biochemical reaction using the microorganisms of the genus Streptomyces which are selected for their newly-found ability to acylate at least one of the 3- and 4"-positions of macrolide antibiotics; they are recovered from the reacted mixture by conventional methods for recovering macrolide antibiotics.Type: GrantFiled: February 27, 1978Date of Patent: May 6, 1980Assignee: Sanraku Ocean Co., Ltd.Inventors: Rokuro Okamoto, Tsumoru Fukumoto, Akira Takamatsu, Tomio Takeuchi