Patents Assigned to OCEANS CO., LTD.
  • Patent number: 4152209
    Abstract: New purine nucleoside 5'-phosphate (mono, di or tri) 3'(2' )-diphosphates and the sodium, lithium and potassium salts thereof are elaborated by the enzymatic transfer of pyrophosphoryl group from ATP (adenosine triphosphate), dATP (deoxyadenosine triphosphate) and pppApp (adenosine 5'-triphosphate 3'(2') diphosphate) to specified 5'-purine nucleotides, and a new nucleotide pyrophosphotransferase used for this enzyme reaction is produced by actinomycetes and other microorganisms and recovered from the culture filtrate and mycelium by the conventional methods for recovering enzymes.
    Type: Grant
    Filed: April 27, 1977
    Date of Patent: May 1, 1979
    Assignee: Sanraku-Ocean Co., Ltd.
    Inventors: Toyokazu Nishino, Yasutaro Hamagishi, Toshikazu Oki, Sawao Murao
  • Patent number: 4148689
    Abstract: Immobilization of microorganisms is carried out by mixing a water soluble-polymer selected from polyvinylalcohol, gelatin and carboxymethylcellulose with a tetraalkoxysilane, hydrolyzing the resulting mixture by the addition of acid to form a homogeneous complex sol, dispersing microbial cells homogeneously in the sol and gelling the mixture of the sol and microbial cells.
    Type: Grant
    Filed: May 5, 1977
    Date of Patent: April 10, 1979
    Assignee: Sanraku-Ocean Co., Ltd.
    Inventors: Tsunetoshi Hino, Hideaki Yamada, Seizo Okamura
  • Patent number: 4141972
    Abstract: New purine nucleoside 5'-phosphate (mono, di or tri) 3'(2')-diphosphates and the sodium, lithium and potassium salts thereof are elaborated by the enzymatic transfer of pyrophosphoryl group from ATP (adenosine triphosphate), dATP (deoxyadenosine triphosphate) and pppApp (adenosine 5'-triphosphate 3'(2') diphosphate) to specified 5'-purine nucleotides, and a new nucloetide pyrophosphotransferase used for this enzyme reaction is produced by actinomycetes and other microorganisms and recovered from the culture filtrate and mycelium by the conventional methods for recovering enzymes. These compounds are useful for treating leukemia L1210 in mice.
    Type: Grant
    Filed: April 27, 1977
    Date of Patent: February 27, 1979
    Assignee: Sanraku-Ocean Co., Ltd.
    Inventors: Toyokazu Nishino, Yasutaro Hamagishi, Toshikazu Oki, Sawao Murao
  • Patent number: 4092473
    Abstract: New tylosin derivatives having at least one acyl group at the 3- and 4"-positions of tylosin, and the acid addition salts thereof, which inhibit the growth of various microorganisms including drug-resistant bacterial isolants and which produce high blood levels through oral administration are produced by a biochemical reaction using the microorganisms of the genus Streptomyces which are selected for their newly-found ability to acylate at least one of the 3- and 4"-positions of macrolide antibiotics; they are recovered from the reacted mixture by conventional methods for recovering macrolide antibiotics.
    Type: Grant
    Filed: July 23, 1976
    Date of Patent: May 30, 1978
    Assignee: Sanraku Ocean Co., Ltd.
    Inventors: Rokuro Okamoto, Tsumoru Fukumoto, Akira Takamatsu, Tomio Takeuchi
  • Patent number: 4070458
    Abstract: A novel physiologically active peptide Val-X-Ala-X, in which X is 4-amino-3-hydroxy-6-methylheptanoic acid, which is prepared from R-Val-Val-X-Ala-X by the action of a microbial enzyme, N-acyl derivatives thereof which are produced by acylating said new peptide, and the processes for producing thereof and the microbial enzyme are disclosed.
    Type: Grant
    Filed: November 3, 1976
    Date of Patent: January 24, 1978
    Assignee: Sanraku-Ocean Co., Ltd.
    Inventors: Hamao Umezawa, Tomio Takeuchi, Takaaki Aoyagi, Akira Takamatsu, Taiji Inui, Hiroshi Tone, Hajime Morishama
  • Patent number: 4059487
    Abstract: New purine nucleoside 5'-phosphate (mono, di or tri) 3'(2')-diphosphates and the sodium, lithium and potassium salts thereof are elaborated by the enzymatic transfer of pyrophosphoryl group from ATP (adenosine triphosphate), dATP (deoxyadenosine triphosphate) and pppApp (adenosine 5'-triphosphate 3'(2')diphosphate) to specified 5'-purine nucleotides, and a new nucleotide pyrophosphotransferase used for this enzyme reaction is produced by actinomycetes and other microorganisms and recovered from the culture filtrate and mycelium by the conventional methods for recovering enzymes.
    Type: Grant
    Filed: March 18, 1975
    Date of Patent: November 22, 1977
    Assignee: Sanraku-Ocean Co., Ltd.
    Inventors: Toyokazu Nishino, Yasutaro Hamagishi, Toshikazu Oki, Sawao Murao
  • Patent number: 4055468
    Abstract: A novel physiologically active peptide Val--X--Ala--X, in which X is 4-amino-3-hydroxy-6-methylheptanoic acid, which is prepared from R--Val--Val--X--Ala--X by the action of a microbial enzyme, N-acyl derivatives thereof which are produced by acylating said new peptide, and the processes for producing thereof and the microbial enzyme are disclosed.
    Type: Grant
    Filed: November 3, 1976
    Date of Patent: October 25, 1977
    Assignee: Sanraku-Ocean Co., Ltd.
    Inventors: Hamao Umezawa, Tomio Takeuchi, Takaaki Aoyagi, Akira Takamatsu, Taiji Inui, Hiroshi Tone, Hajime Morishima
  • Patent number: 3963579
    Abstract: A process for producing pepstatins by means of a microorganism belonging to Streptomyces and producing pepstatins, wherein at least one amino acid selected from the group consisting of L-leucine, L-valine, L-alanine, L-aspartic acid, L-glutamic acid, and L-lysine is added to the reaction medium, which also contains an energy source.
    Type: Grant
    Filed: October 10, 1974
    Date of Patent: June 15, 1976
    Assignee: Sanraku-Ocean Co., Ltd.
    Inventors: Hamao Umezawa, Takaaki Aoyagi, Akira Takamatsu, Taiji Inui
  • Patent number: 3943135
    Abstract: Oligoethylenepiperazines and their derivatives of the formula ##SPC1##Whereinn is a positive integer of 1 to 7 inclusive;m is zero or one when n=1, or m is one when n=2.about.7R.sub.1 is hydrogen, benzenesulfonyl or benzenesulfonyl ring substituted by at least one member selected from the group consisting of lower alkyl of 1-4 carbon atoms, nitro and amino;R.sub.2 is halogen when m=zero and hydrogen, benzenesulfonyl or benzenesulfonyl ring substituted by at least one member selected from the group consisting of lower alkyl of 1-4 carbon atoms, nitro and amino when m=one; and the cationic salts thereof are useful as anion exchange oligomers, antihelmintic compounds, and intermediates for the preparation of polymers and fine industrial chemicals.
    Type: Grant
    Filed: September 12, 1973
    Date of Patent: March 9, 1976
    Assignee: Sanraku-Ocean Co., Ltd.
    Inventor: Kouki Fujii