Abstract: A foot abduction brace is disclosed herein. The foot abduction brace can include a crossbar having a planar bottom end. The foot abduction brace can also include a first end disposed on one side of the crossbar. The foot abduction brace can further include a first locking hub removably coupled to the first end in a first position of a plurality of positions, where the first locking hub is disposed in the first keyhole and includes a first coupling feature disposed at a top end of the first locking hub. The foot abduction brace can also include a first footplate having a first complementary coupling feature that removably couples to the first coupling feature of the first locking hub. The foot abduction brace can further include a first foot restraint mechanically coupled to the first footplate.

Abstract: Compounds, pharmaceutical compositions, and methods of using such compounds and compositions to treat or prevent Alzheimer's disease and related tauopathies through the inhibition of USP-9X and/or enhancement of SCF(?-TrCP).

Abstract: Engineered fusion proteins comprising photochromic protein domains are disclosed. In particular, the inventors have constructed fusion proteins containing photoswitchable photochromic fluorescent protein domains linked to selected proteins and shown that such fusion proteins can be used to control the activity or localization of selected proteins with light.

Abstract: The present disclosure provides novel oligo phenylene ethynylene (OPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various OPEs show antibacterial, antiviral and anti-fungal activity.

Abstract: This invention relates to a method for characterizing the pores of reticulated framework structures and using these characteristics to predict the actual performance characteristics of the reticulated framework structures as membranes for gas separation, and other purposes.

Abstract: Provided herein are methods for dehydrating single-walled metal oxide nanotubes by heating the SWNT under vacuum at 250-300° C.; methods of dehydroxylating SWNT, comprising heating the SWNT under vacuum at 300-340° C., and methods for maximizing the pore volume of a SWNT, comprising heating the SWNT at 300° C. under vacuum to partially dehydroxylate and dehydrate the SWNT; methods of modifying the inner surface of a single walled aluminosilicate nanotube (SWNT), comprising dehydration or dehydration and dehydroxylation, followed by reacting the SWNT with a derivative under anhydrous conditions to produce a SWNT that is derivatized on its inner surface. The invention also includes single-walled nanotubes produced by the methods of the invention.

Abstract: A method of determining a number of a solution constituent includes introducing a first number of solution constituents to a first test location, establishing a first binding environment for the introduced first number of solution constituents, creating a first residual number of solution constituents by binding a first plurality of solution constituents, establishing a second binding environment for the first residual number of solution constituents, creating a second residual number of solution constituents by binding a second plurality of solution constituents from the first residual number of solution constituents, obtaining a first signal associated with the bound first plurality of solution constituents, obtaining a second signal associated with the bound second plurality of solution constituents, and determining a second number of a constituent of interest based upon the obtained first signal and the obtained second signal.

Abstract: The present invention provides an apparatus for fluidics-based automated orientation of plant embryos. The apparatus comprises flow channels, flow direction means, an orientation detector and a control unit. The orientation of embryos suspended in liquid flowing individually through the flow channels is constrained to cotyledon-first or cotyledon-last orientation by dimensional constraints. The orientation is determined by the orientation detector. Embryos not oriented as desired are directed into a reservoir tube by the flow direction means, after which the flow is directed from the reservoir tube to the outlet thereby having reoriented the embryo. Means of sorting viable embryos from other objects are optionally included in the apparatus.

Abstract: A method of detecting a biomarker in one embodiment includes identifying a quantity of biomolecule types in a sample, exposing the sample to a plurality of test sites, wherein the number of test sites in the plurality of test sites is equal to or greater than the identified quantity of biomolecule types, establishing, for each of the plurality of test sites, a respective test environment, wherein the test environment for each of the plurality of test sites is different from the test environment for each of the other of the plurality of test sites, obtaining a detection signal associated with each of the plurality of test sites, and determining the concentration of one of the biomolecule types based upon the obtained detection signals.

Abstract: Methods and devices for dispersion of clusters of somatic plant embryos suspended in a liquid are disclosed. The methods comprise i) subjecting the clusters of embryos to fluid dynamics forces causing axially extensional strain and radially compressional strain and ii) subjecting the clusters of embryos to fluid dynamics forces causing axially compressional strain and radially extensional strain fluid dynamics and iii) repeating said steps in sequence until the individual embryos are separated from each other. The devices may comprise a flow channel including at least one constriction, such that clusters of embryos flowing through the flow channel are first subjected to axially extensional strain and radially compressional strain, and then to axially compressional strain and radially extensional strain from fluid dynamics forces.

Abstract: Disclosed herein are autonomous molecular circuits that can function in cells. The circuits can process logical operations in which one or more input cues are among the operands and produce an appropriate output. Such circuits can be implemented in living cells, e.g., eukaryotic or prokaryotic cells that have been modified to include circuit components. The molecular circuits and cells containing the circuits can be used in a variety of applications including, e.g., diagnostics, therapeutics, and protein production.

Abstract: Photosensitive polybenzoxazine compositions include a photosensitive additive such as an o-diazoquinone and a polymer comprising a repeating unit represented by the following formula (I) wherein R1 comprises an aliphatic group, an alicyclic group, an aromatic group, a heterocyclic group, or combinations thereof, R2 comprises an aliphatic group, an alicyclic group, an aromatic group, a heterocyclic group, or combinations thereof, R4 comprises a hydrophilic group, a hydrophilic group protected by an acid-cleavable group, a hydrophilic group protected by a base-cleavable group, a cross-linkable group, or combinations thereof, and i represents an integer of 1 or more. The photosensitive compositions may be formed by combining a precursor polymer with a photosensitive additive and a solvent, patterning the precursor polymer, and heating the precursor polymer at a thermal processing temperature in a range of from about 180° C. to about 300° C. to convert the precursor polymer into the final polymer.

Abstract: The present invention provides an apparatus and a method of fabricating the apparatus. The apparatus comprises a substrate having a planar surface and first and second electrodes located on the planar surface. The first electrode has a top surface and a lateral surface, and the lateral surface has an edge near or in contact with the substrate. An electrode insulating layer is located on the top surface and a self-assembled layer located on the lateral surface. The second electrode is in contact with both the self-assembled layer and the electrode insulating layer.

Abstract: Device and method for rapid extraction of body tissue from an enclosed body cavity. Hollow entry cannula with optional core element provides entry into body tissue space such as bone marrow. Aspiration cannula is inserted through entry cannula into body tissue and is manipulated to advance directionally through body cavity. Optional stylet within aspiration cannula aids in advancing aspiration cannula through body tissue and is removed to facilitate extraction of body tissue through the aspiration cannula. Inlet openings near distal tip of aspiration cannula allow tissue aspiration, with negative pressure source at proximal end of aspiration cannula providing controlled negative pressure. Aspiration cannula may be withdrawn and its path adjusted for multiple entries through the same entry point, following different paths through tissue space for subsequent aspiration of more tissue.

Abstract: Vascular endothelial growth factor alternative splice variants and methods of their use are provided.

Abstract: Ligands having a metal binding domain and a targeting domain are provided. The ligands can be used to target, inhibit, and catalytically degrade or inactivate a desired target. Methods of treating a disease or condition using the ligands are also provided.

Abstract: Low-cost, reliable, easy to use device and method identifies potential drowning or near-drowning events (i.e. a submerged inert human) in a timely manner, provides the precise location of the event, and issues an alert that such an event is in progress. Device is optionally networked to remote monitoring station.

Abstract: A gene that is a positive mediator of tumor growth and metastasis in certain cancer types is provided. This gene and corresponding polypeptide have diagnostic and therapeutic application for detecting and treating cancers that involve expression of SCC-S2 such as renal, ovarian, head and neck, breast, prostate, brain, chronic myelogenous leukemia, lung, lymphoblastic leukemia, and colorectal adenocarcinoma cells.

Abstract: The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one salicylamidyl moiety. Also provided are probes incorporating the salicylamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.

Abstract: The present invention provides a method and apparatus for increasing the intensity of coherent population trapping (CPT) resonances, used in atomic clocks and magnetometers, by pumping the atoms with light of alternating polarization. Pumping with such light, characterized by a photon spin vector that alternates in direction at a hyperfine frequency of the atoms at the location of the atoms, is referred to as push-pull pumping. In one embodiment of the system of the present invention, alkali-metal vapor is pumped with alternating circular-polarization D1 laser light that is intensity modulated at appropriate resonance frequencies, thereby exciting CPT resonances, which can be observed as increase in the mean transmittance of the alkali-metal vapor. These resonances are substantially enhanced due to an optically-induced concentration of atoms in the resonant energy sublevels.