Abstract: Provided are compositions relating to novel MDR1 polymorphisms, including nucleic acids, polypeptides, and recombinant cells, as well as methods for detection of MDR1 polymorphisms in biological samples and elucidation of the influence of MDR1 polymorphisms on MDR1 protein function. Also provided are a rat MRP1 cDNA and protein, stable cell lines expressing the rat MRP1 protein, and methods of assessing drug penetration or disposition in a cell line expressing a recombinant mammalian MRP1 or MDR1 protein, or a homolog thereof.

Abstract: The present invention is directed to ancestral and COT nucleic acid and amino acid sequences, methods for producing such sequences and uses thereof, including prophylactic and diagnostic uses.

Abstract: A non-resonant microwave imaging microscope and associated probe. The probe includes a sensor unit with two fixed electrodes, preferably a large outer electrode surrounding a small inner electrode which are approximately co-planar, thereby protecting the small inner electrode from an uneven topography. The outer electrode may be deposited on a conically shaped dielectric disk having a bore through which the inner electrode is placed. Non-resonant circuitry couples the inner electrode to the probe signal variably selected in the range of 10 MHz-50 GHz and to an amplifier whose output is coupled to a signal processor detector in-phase and out-of-phase components of the current or voltage across the two electrodes. A mechanical positioner moves the probe vertically towards the sample and scans it across the sample.

Abstract: Immobilized calixarenes and calixarene-related compounds are produced by a process comprising either:

Abstract: Device and method for rapid extraction of body tissue from an enclosed body cavity. Hollow entry cannula with optional core element provides entry into body tissue space such as bone marrow. Aspiration cannula is inserted through entry cannula into body tissue and is manipulated to advance directionally through body cavity. Optional stylet within aspiration cannula aids in advancing aspiration cannula through body tissue and is removed to facilitate extraction of body tissue through the aspiration cannula. Inlet openings near distal tip of aspiration cannula allow tissue aspiration, with negative pressure source at proximal end of aspiration cannula providing controlled negative pressure.

Abstract: Dimethyl ether is converted to formaldehyde using a supported catalyst comprising molybdenum and/or vanadium oxides. The surface density of the oxide(s) ranges from greater than that for the isolated monomeric oxides upwards, so long as there is a substantial absence of bulk crystalline molybdenum and/or vanadium oxide(s). Conversion and selectivity to formaldehyde are improved as compared to data reported for known catalysts. Also disclosed is a catalyst comprising molybdenum and/or vanadium oxides supported on a layer of stannic oxide that is disposed on the surface of a particulate alumina or zirconia support.

Abstract: The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also provided are probes incorporating the phthalamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.

Abstract: A technique for fabricating substrates such as a silicon-on-insulator substrate using a plasma immersion ion implantation (“PIII”) system 10. The technique includes a method, which has a step of providing a substrate 2100. Ions are implanted 2109 into a surface of the substrate to a first desired depth to provide a first distribution of the ions using a plasma immersion ion implantation system 10. The implanted ions define a first thickness of material 2101 above the implant. Global energy is then increased of the substrate to initiate a cleaving action, where the cleaving action is sufficient to completely free the thickness of material from a remaining portion of the substrate. By way of the PIII system, the ions are introduced into the substrate in an efficient and cost effective manner.

Abstract: An apparatus and method for temperature and concentration measurement at liquid surfaces using reflectance. The apparatus includes a light source which produces a measurement light beam, and also includes a detector. The measurement light beam has a measurement light beam intensity and impinges on the surface of the liquid specimen. It reflects back as a reflected light beam with a reflected light beam intensity which is related to the reflectivity R of the liquid surface and to the measurement light beam intensity. The detector receives the reflected light beam and determines the reflected light beam intensity. Either the temperature or concentration of the liquid specimen can then be determined based on the reflected light beam intensity. The light source can be a coherent light source, such as a laser. A beam splitter can be provided to split the light beam from the light source into a reference light beam and the measurement light beam.

Abstract: A part tracking system comprised of an array of photoelectric sensors positioned at various angles with respect to a conveyor transporting parts such as pieces of poultry to create a field of detection. The angle arrangements of the array of photoelectric sensors circumscribes the parts with lines of varying angles to approximate the part outline or closed line integral with a polygon. As a part is conveyed through the array of photoelectric sensors each transition of the sensors provide a side of the polygon that circumscribes the part. From this the vertices of the polygon can be determined which allows the centroid and angle of the major axis of the part to be calculated thereby providing the coordinates for the part's location on the conveyor. The coordinates are then conveyed to a robotic controller which manipulates an end effector to grasp the part.

Abstract: An apparatus for applying compressive and tensile loads on bones having a frame with a work surface and a stepper motor. The stepper motor is operably connected to a rotational force to linear force converter which is in turn connected to an articulating arm for applying force to a first pair of pads. A second pair of pads is mounted to the work surface such that a bone may be placed across the second pair of pads such that either end of the bone is supported by the second pair of pads and such that the activation of the stepper motor causes the upper pair of pads to exert compressive bending strain on the lateral surface of the bone and such that the lower pair of pads exert tensile bending strain on the medial surface of the bone. A method of modifying hard tissue morphology is also described.

Abstract: A method of removably securing a basketball net to a basketball basket ring wherein an attachment clip is provided at each loop of a conventional basketball net for securing the net to a conventional basketball basket ring. An installation disk, having substantially the same diameter as a basket ring is provided to spread the attachment clip end of the clip and net combination to the diameter of the basket ring such that the clips may be easily secured to the ring. An apparatus for practicing the before described method is also disclosed.