Patents Assigned to Ohio University
  • Patent number: 10799884
    Abstract: A fluid processing system and method of processing a fluid includes a tank having an outer wall, a heating element, and an insulating element. The heating element is situated within the tank and includes a first electrode and a second electrode. The insulating element is positioned between the first electrode and the second electrode. As such, powering the heating element directs an electric current through the fluid within the tank for heating the fluid, while the insulating element provides electrical and thermal insulation to the outer wall of the tank.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: October 13, 2020
    Assignee: Ohio University
    Inventors: Khairul Alam, Hajrudin Pasic
  • Patent number: 10787665
    Abstract: The present disclosure relates to antisense oligomers targeting the long non-coding RNA HOXB-AS3 and methods of treating acute myeloid leukemia.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: September 29, 2020
    Assignees: Ohio State Innovation Foundation, Aalborg University
    Inventors: Ramiro Garzon, Adrienne Dorrance, Dimitrios Papaioannou, Robert Lee, Sakari Kauppinen, Andreas Petri, Charlotte AlbÆk Thrue
  • Patent number: 10770794
    Abstract: A single element antenna with the ability to have pattern control by placing multiple feeds on opposite ends of the antenna element and controlling the amplitude and phase distribution of each of the feed ports.
    Type: Grant
    Filed: January 20, 2016
    Date of Patent: September 8, 2020
    Assignee: Ohio University
    Inventors: Chris G. Bartone, Joel L. Schopis
  • Patent number: 10760643
    Abstract: A passive variable negative stiffness device (passive VNSD) configured to facilitate a transition to zero stiffness by using elastic devices (e.g., springs) combined with translating and rotating components. An exemplary embodiment of a passive VNSD may comprise at least one pretensioned and/or precompressed elastic device to produce the desired force-displacement profiles. For instance, an exemplary embodiment of a passive VNSD may be adapted to produce force-displacement profiles that transition from zero stiffness, to negative stiffness, and then to positive stiffness (ZNP) and from zero stiffness, to negative stiffness, and then back to zero stiffness (ZNZ).
    Type: Grant
    Filed: October 8, 2018
    Date of Patent: September 1, 2020
    Assignee: Ohio University
    Inventor: Kenneth K. Walsh
  • Patent number: 10759820
    Abstract: Stable monomeric phosphaplatins, namely, (pyrophosphato)platinum(II) or platinum(IV) complexes containing a cis-cyclohexanediamine ligand or enantiomerically enriched or enantiopure trans-cyclohexanediamine ligands, and synthesis of these complexes, are provided. Efficacies and toxicities of the phosphaplatin compounds are determined toward a variety of cancers, including sensitive and resistant ovarian cancers, head and neck, and colon cancers. Compositions comprising the platinum complexes, and methods for treatment of proliferative diseases or disorders by means of the complexes or the compositions comprising them are disclosed.
    Type: Grant
    Filed: June 26, 2019
    Date of Patent: September 1, 2020
    Assignee: Ohio University
    Inventor: Rathindra N. Bose
  • Patent number: 10738387
    Abstract: An electrochemical cell 10 is provided that includes first and second electrodes 13, 15, an electrolyte medium 17 in electrolytic communication with the first and second electrodes 13, 15, a chemical substance capable of undergoing an electrochemical reaction, and a voltage source 19 in electrolytic communication with the first and second electrodes 13, 15. The first electrode 13 includes a layer of an active catalyst material 25, and graphene coating 27 at least partially covering the layer of the active catalyst material 25. Methods for making and using the graphene coated electrode are further provided.
    Type: Grant
    Filed: October 27, 2014
    Date of Patent: August 11, 2020
    Assignee: Ohio University
    Inventors: Gerardine G. Botte, Santosh Vijapur
  • Publication number: 20200245924
    Abstract: Parametric model based computer implemented methods for determining the stiffness of a bone and systems for estimating the stiffness of a bone in vivo. The computer implemented methods include determining a complex compliance frequency response function Y(f) and an associated complex stiffness frequency response function H(f) and independently fitting a parametric mathematical model to Y(f) and to H(f). The systems include a device for measuring the stiffness of the bone in vivo and a data analyzer to determine a complex compliance frequency response function Y(f) and an associated complex stiffness frequency response function H(f).
    Type: Application
    Filed: October 18, 2018
    Publication date: August 6, 2020
    Applicant: Ohio University
    Inventors: Lyn Bowman, Joseph Oberhauser
  • Patent number: 10722115
    Abstract: Devices and methods for determining a propensity to diabetic and/or macular degeneration in a subject by measuring certain featured from a captured retinal image from a subject are described.
    Type: Grant
    Filed: August 16, 2016
    Date of Patent: July 28, 2020
    Assignee: Ohio University
    Inventors: Mehmet Celenk, H. Bryan Riley, Nikita Gurudath, Frank Schwartz
  • Publication number: 20200222502
    Abstract: FSP27 compositions and methods for treating cancers are described.
    Type: Application
    Filed: September 17, 2018
    Publication date: July 16, 2020
    Applicant: Ohio University
    Inventors: John Kopchick, Vishwajeet Puri, Vishva Sharma, Reetobrata Basu
  • Publication number: 20200179483
    Abstract: Methods and FSP27 compositions for treating and/or preventing metabolic disease and conditions associated insulin resistance, obesity, inflammation and dyslipidemia are described.
    Type: Application
    Filed: June 14, 2018
    Publication date: June 11, 2020
    Applicant: Ohio University
    Inventors: Vishwajeet Puri, John Kopchick, Vishva Sharma
  • Publication number: 20200146616
    Abstract: Methods of patient-specific modeling of the mechanical properties of bone and related systems. The methods include obtaining a bending stiffness (K) of a bone specimen non-invasively and non-destructively in a dynamic 3-point bending test, creating a mathematical mechanical model of the bone specimen, assigning an elastic modulus (E) to the bone specimen of the mathematical mechanical model, determining the flexural rigidity of the bone specimen from simulating the mathematical mechanical model, determining a discrepancy between the flexural rigidity of the bone specimen from the simulated mechanical model and based on the obtained K, adjusting the elastic modulus of the simulated mechanical model to minimize the discrepancy, adjusting the elastic modulus until an optimized elastic modulus is determined where the discrepancy is reduced below a predetermined threshold, and applying the optimized elastic modulus to the simulated mechanical model to determine a strength of the bone.
    Type: Application
    Filed: May 10, 2018
    Publication date: May 14, 2020
    Applicant: Ohio University
    Inventors: Lyn Bowman, John R. Cotton
  • Patent number: 10647654
    Abstract: Compounds that inhibit or reduce glucose transport and methods of using the compounds to treat cancer are provided herein.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: May 12, 2020
    Assignee: Ohio University
    Inventors: Stephen Bergmeier, Xiaozhuo Chen
  • Patent number: 10633377
    Abstract: Compounds having General Formula (I) or General Formula (II): in which R1 is chosen from C1 to C10 aliphatic or heteroaliphatic groups, optionally substituted with one or more aryl groups, substituted aryl groups, heteroaryl groups, substituted heteroaryl groups, or combination thereof, R2 is chosen from aromatic moieties, substituted aromatic moieties, heteroaromatic moieties, substituted heteroaromatic moieties, and coumarin; R3 is chosen from —H, C1 to C10 aliphatic or heteroaliphatic groups, phenyl, or substituted phenyl, wherein the aliphatic or heteroaliphatic groups are optionally substituted with one or more phenyl groups, aryl groups, heteroaryl groups, substituted heteroaryl groups, or combination thereof, and wherein the aliphatic or heteroaliphatic groups are optionally bonded to R2 to form a ring; X is S or O; and Y is S or NH, may be used in pharmaceutical compositions that modify of biological signaling processes or as reagents for biological assays.
    Type: Grant
    Filed: July 25, 2019
    Date of Patent: April 28, 2020
    Assignee: Ohio University
    Inventors: Douglas Goetz, Stephen C. Bergmeier, Mark C. McMills, Crina M. Orac
  • Patent number: 10625197
    Abstract: A vibrating wet precipitator is designed to remove particulates from particulate-laden hot gas. The precipitator includes an array of vertical wet cords stretched within a duct. The cords are tuned to vibrate due to the gas flow by controlling key parameters such as gas flow, velocity, cord length and diameter so that particulate collection and heat transfer efficiency are maximized. The cords are part of sieves. A plurality of these sieves are arranged to define a plurality of gaps, through which the exhaust flows. The sieves and thus the cords are space so that a vortex from a first cord affects an adjacent cord and subsequently cord. The particles are then absorbed in liquid, which can be passed through a heat exchanger filtered and subsequently reused. Preferably the cord arrangement is designed to allow the cords to vibrate at high frequencies, typically 10 to 100 Hz, to maximize particulate collection.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: April 21, 2020
    Assignee: Ohio University
    Inventors: Hajrudin Pasic, Khairul Alam
  • Patent number: 10591017
    Abstract: A resetting semi-passive stiffness damper (RSPSD) triggering assembly and a RSPSD and method of use for damping movement of an object. Exemplary embodiments of a RSPSD triggering assembly include, for example, a rotatable disc and a spring-loaded lever arranged between the disc and a slotted channel. A sensor is provided and communicates with a bypass valve on the cylinder. A change in the direction of movement of the disc causes reciprocation of the lever in the channel, which causes the sensor to send open and close signals to the bypass valve. In some embodiments, a single disc may be replaced with two interacting discs. A RSPSD equipped with such a triggering assembly is usable to damp movement of an object of interest.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: March 17, 2020
    Assignee: Ohio University
    Inventor: Kenneth K. Walsh
  • Patent number: 10577699
    Abstract: Lignin is electro-oxidized to commercially useful products using a binary transition metal catalyst. In particular, the transition metal catalyst includes nickel or cobalt as a first metal and any other transition metal as a second metal. The binary catalyst system prevents poisoning of the catalyst, extending the useful life of the catalyst.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: March 3, 2020
    Assignee: Ohio University
    Inventors: John Adams Staser, Omar Movil-Cabrera
  • Publication number: 20200055058
    Abstract: A hybrid composite discharge electrode (HCDE) (20) includes at least one metal layer (22) and at least one carbon fiber layer (26). The HCDE (20) improves the stability and uniformity of the corona while being corrosion-resistant, lightweight, and compact. Additionally, a method of making a HCDE (20) is provided. In another aspect, an electrostatic precipitator (60) is provided and includes a hybrid composite discharge electrode (62).
    Type: Application
    Filed: February 21, 2018
    Publication date: February 20, 2020
    Applicant: Ohio University
    Inventors: Khairul Alam, Muhammad Ali
  • Patent number: 10550945
    Abstract: A bypass feature and an emergency shutdown valve that includes such a bypass feature, which is selectively operable to permit a flow of material to pass through the emergency shutdown valve when a shutoff element thereof is closed so as to otherwise prohibit flow through the valve, as well as an associated method of testing an emergency shutdown valve.
    Type: Grant
    Filed: April 24, 2014
    Date of Patent: February 4, 2020
    Assignee: Ohio University
    Inventor: Azamat Orazbayev
  • Patent number: 10544503
    Abstract: Graphene can be produced from the byproducts formed during electrolysis of coal. These byproducts may be electrolyzed coal particles, gelatinous film formed on the electrolyzed coal particles, or the electrolyzed coal particles together with the gelatinous film. The electrolyzed coal byproduct is deposited as a thin layer onto a surface, or carrier substrate 50, which is heated to a temperature effective to form graphite while a reductant gas, such as hydrogen, flows over the heated coal product. The reductant gas flow carries the carbon particles and deposits them onto a surface 66, forming a layer of graphene thereon.
    Type: Grant
    Filed: April 8, 2013
    Date of Patent: January 28, 2020
    Assignee: Ohio University
    Inventor: Gerardine G. Botte
  • Publication number: 20200017489
    Abstract: Compounds having General Formula (I) or General Formula (II): in which R1 is chosen from C1 to C10 aliphatic or heteroaliphatic groups, optionally substituted with one or more aryl groups, substituted aryl groups, heteroaryl groups, substituted heteroaryl groups, or combination thereof, R2 is chosen from aromatic moieties, substituted aromatic moieties, heteroaromatic moieties, substituted heteroaromatic moieties, and coumarin; R3 is chosen from —H, C1 to C10 aliphatic or heteroaliphatic groups, phenyl, or substituted phenyl, wherein the aliphatic or heteroaliphatic groups are optionally substituted with one or more phenyl groups, aryl groups, heteroaryl groups, substituted heteroaryl groups, or combination thereof, and wherein the aliphatic or heteroaliphatic groups are optionally bonded to R2 to form a ring; X is S or O; and Y is S or NH, may be used in pharmaceutical compositions that modify of biological signaling processes or as reagents for biological assays.
    Type: Application
    Filed: July 25, 2019
    Publication date: January 16, 2020
    Applicant: Ohio University
    Inventors: Douglas Goetz, Stephen C. Bergmeier, Mark C. McMills, Crina M. Orac