Abstract: The present invention is directed to certain 2-aminoquinzaoline derivatives of Formula (I): Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, and R3 are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.

Abstract: A Web3 identity is created with a digital residency platform and verification system using a user's root legal identity. The digital residency platform and verification system and methods associated therewith include a blockchain-native digital residency platform that bridges the privacy and security of Web3 identity with the capabilities and validity of global sovereignties.

Abstract: A rail assembly for a medical examination table. The medical examination table having a main body including a side surface. The rail assembly having a support frame, a connecting rail, and a mount. The support frame having a set of rails. The connecting rail extending from the support frame to a distal end. The connecting rail being couplable to the side surface.

Abstract: The invention is a method for treating patients with Parkinson's disease, primary parkinsonism/idiopathic parkinsonism, post-encephalitic parkinsonism, parkinsonism that may follow carbon monoxide intoxication, or parkinsonism that may follow manganese intoxication and provides an improvement of a patient's total post-dose “On” time or “Good On” time compared to post-dose of treatment regimens with oral immediate release levodopa tablets.

Abstract: The present disclosure recites techniques for content delivery in an MABR system.

Abstract: A system for software download compatibility.

Abstract: Aspects of present disclosure relates to a brain-like in-pixel intelligent processing system having in-pixel processing array, feature vector generator, neural network processor, and region and object of interest identifier. Each in-pixel processing unit includes photogate sensor to acquire image, average circuit to generate P element, subtraction circuit to generate F element, and absolute circuit to generate LGN element. Feature vector generator generates P, F, and LGN feature vectors from certain selected in-pixel processing units of in-pixel processing array selected according to saccadic eye movement algorithm. Neural network processor processes P, F, and LGN feature vectors and detects object, recognizes object, and determines location of object.

Abstract: Provided is a method for generating a personalized content suggestion in response to a query from a user. The method may be performed by a system comprising one or more processors. The method may include receiving the query from the user, generating one or more user parameters associated with the user, determining a predicted content topic of the query, and generating the content suggestion based on the predicted content topic and the one or more user parameters.

Abstract: An automatic swimming pool cleaner generally includes a body and one or more turbines. The one or more turbines may be positionable on a bottom portion of the automatic swimming pool cleaner. In certain aspects, each turbine of the one or more turbines includes a plurality of blades arranged around a center axis of the turbine. Each turbine of the one or more turbines may include a non-uniform height, and a maximum height of the plurality of blades is at the center axis.

Abstract: Disclosed are methods for detecting a target polynucleotide comprising a genetic alteration relative to a reference polynucleotide in a sample comprising a mixture of the target polynucleotide and the reference polynucleotide. The methods may be utilized for detecting with high selectivity a target polynucleotide in a mixture of the reference polynucleotide and the target polynucleotide in which the target polynucleotide represents a low percentage of the mixture. The methods may be adapted for diagnosing, prognosing, and treating subjects having a disease or disorder associated with the genetic alteration.

Abstract: Apparatus and associated methods relate to a catheter manipulation handle with user interface controls for steering a catheter in situ while providing an augmented (e.g., motorized, powered and tunable precision steering, and perforation safeguards) control and feedback user experience. In an illustrative example, the catheter manipulation handle may provide motor assisted operation to automatically rotate and/or deflect a distal tip of the catheter to steer and guide the distal tip to a target location in the patient's vasculature system. The augmented feedback may include, for example, haptic feedback via the handle. Haptic, audible, and/or visual feedback via the handle may indicate, for example, proximity or engagement of the distal tip with sensitive tissue. In some examples, the handle's augmented operation may advantageously amplify feedback signals to enhance the user's perception of the patient's safety with respect to the safe passage of the distal tip through the patient's vasculature.

Abstract: A sensor assembly includes a housing shaped to be mounted to a vehicle. The sensor assembly includes a first nozzle positioned on the housing and below the sensor and is positioned to dispense a fluid in an upward direction to a surface of the sensor. The sensor assembly includes a second nozzle positioned below the sensor, in which the second nozzle is positioned to dispense airflow to the surface of the sensor. The sensor assembly further includes a ram air structure positioned to receive airflow during forward travel of the vehicle and to dispense airflow to the surface of the sensor.

Abstract: A computer includes a processor and a memory, and the memory stores instructions executable by the processor to determine a quantity of relative motion between a host vehicle and a target vehicle; in response to the quantity of relative motion being below a threshold, determine a pose of the host vehicle subject to a constraint on motion of the host vehicle; and in response to the quantity of relative motion being above the threshold, determine the pose of the host vehicle without the constraint.

Abstract: A medical services kiosk supporting private and secure telemedicine sessions between a patient and a remote network terminal utilized by a remote health care professional. The medical services kiosk comprising at least one privacy chamber having at least one door and at least one window. Each privacy chamber may include a user interactive display terminal that includes a display device, an input device, and a centralized processor, wherein the centralized processor is electronically communicable with the remote network terminal and a cloud based system. Each patient station may each include at least one documentation receiving device, at least one biometric device for obtaining biometric health measurements of the patient utilizing the at least one patient station, an arm mechanism, a seating mechanism, a camera, a retractable diagnostic camera device, a lighting mechanism that lights the privacy chamber, and a purification system.

Abstract: An all-natural argan oil blend hair treatment is provided that includes a natural oil combination, and an essential oils combination, where the natural oil combination includes argan oil in an amount of about 3% to about 20% by weight of the overall hair treatment formulation. Each of the natural oil combination and the essential oil combination includes multiple all-natural ingredients that work together to moisturize and repair dry, brittle hair and contribute to a shiny, luscious appearance. The argon oil blend hair treatment can be used in combination with an all-natural shampoo and rinse for optimal results.

Abstract: A method and system for performing blackstart functionality from renewable generation and battery energy storage systems are disclosed. A plant may include a microgrid that includes one or more customer loads and that may provide power to a utility grid. Blackstart may be performed to restore operations to part or all of the plant or to external loads such as microgrid customer loads or part of the utility grid. In practice, blackstart may be performed in order to restore operation to the one or more feeders in the plant, such as to the generation sources within the plant, to restore power to the plant auxiliary loads, customer loads in the microgrid, and to provide power to different sections of the grid when transitioning from shutdown mode of operation. In this way, the method and system may automatically transition from a shutdown mode of operation to an islanded mode of operation.

Abstract: In examples, systems and methods are described for edge computing recommendations and implementation. A service request is received from a client computing device that includes information about a location of a customer site and latency requirements of the customer, among other information. The system provides recommendations for particular provider computing site(s) based on, e.g., rough and/or fine latency estimates, and implements the requested computing services at selected provider computing site(s).

Abstract: An example portable heating device includes a container, one or more heating elements, an electronic device, one or more temperature sensors, a controller, a power supply, and a power supply controller. The one or more heating elements are in thermal contact with the container. The electronic device is configured to receive a user input selecting a target temperature to heat a substance in the container to and to display the target temperature. The controller is configured to cause the one or more heating elements to heat the substance to the target temperature in response to determining the current temperature of the substance measured by the one or more temperature sensors is less than the target temperature. The power supply is configured to provide power to the one or more heating elements, the electronic device, the one or more temperature sensors, and the controller.

Abstract: The present invention is directed to substituted Pyrazole and Imidazole derivatives of compounds that are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved or implicated. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

Abstract: An online blockchain platform that allows users to sell and purchase tokens stored on the blockchain that are associated with a particular collectible. These tokens reflect 100 percent ownership of the collectible and entitle the holders to certain rights relating to the collectible including a percentage of any future sale or insurance proceeds of the collectible. The tokens include descriptions and attributes of the collectible, media files including digital images and videos, insurance documents, and appraisal documents. Storage on the blockchain provides a shared, immutable ledger that facilitates the process of recording transactions and tracking assets in a decentralized network.