Abstract: Disclosed herein are antibody-drug conjugates (ADCs) comprising an antibody conjugated via a linker to an oxazaphosphorine drug moiety and methods of using the antibody drug conjugates. Included are methods of treating undesirable or aberrant cell proliferation or hyperproliferative disorders, such as non-metastatic and metastatic neoplasia, cancer, stem cells and malignancies that express targets that bind to such antibodies, or fragments antibodies, antibody heavy and light chains or nanobodies.

Abstract: A method for celebrity-based advertising includes storing, in a server, a likeness of subject and a corresponding booking that includes parameters outlining availability of the subject for digital advertising. The method further includes receiving or creating, by the server, a pitch that falls within the parameters of the booking, the pitch corresponding to the subject. The method further includes receiving, by the server and from a first user device, a first image of the likeness of the subject or another likeness of the subject. The method further includes determining, by the server, that the image matches the likeness of the subject. The method further includes transmitting, by the server, the pitch to the first user device to be output by the first user device.

Abstract: Systems, devices, and methods are disclosed for generating an authenticity score for a creative work using digital image data of one or more creative works. A system receives, via a network, first digital image data of a first creative work. The system determines from the first digital image data, a first set of feature variables, each corresponding to a characteristic of the first creative work. The system determines, via an artificial intelligence model and with input including the first set of feature variables and a comparison dataset, an authenticity score for the first creative work. The artificial intelligence model generates, based on the portion of first feature variables of the first creative work that match corresponding portions of the comparison dataset, an output indicative of an authenticity score. The system communicates, via the network, an authenticity score of the first creative work to a client device.

Abstract: An electronic device (e.g., a smartphone or tablet) can be connected to another electronic device that is typically a computing device (e.g., a mobile device such as a laptop or a non-mobile device such as a desktop computer or workstation), allowing the electronic devices to be used together. This connection can be a wired connection or a wireless connection. When the electronic device and the computing device are connected, and optionally also when a universal control mode is activated, the electronic device automatically operates in a non-gesture-based input style, allowing a single input control device (e.g., a trackpad on a laptop) to control user input for both devices.

Abstract: Methods, systems, and apparatus for automatically obtaining tax documents. The system includes a taxpayer client device and a server configured to automatically identify tax return items associated with the taxpayer by analyzing a prior year tax return. The server is configured to generate a list of tax return items including the automatically identified tax return items. The server is configured to receive, from the taxpayer client device, authentication data for a third party database. The server is configured to access the third party database using the authentication data. The server is configured to receive a document from the third party database and automatically determine whether the document corresponds to a tax return item from the list of tax return items. The server is configured to automatically store the document when the document corresponds to one of the tax return items from the list of tax return items.

Abstract: A surgical instrument system including an endoscope having an elongated housing extending between a proximal instrument end and a distal instrument end. The surgical instrument system may further include an irrigation sleeve having a sleeve body extending between a proximal sleeve end and a distal sleeve end. The irrigation sleeve may further have a first lumen and a second lumen spaced out of fluid communication with the first lumen, the first lumen formed in the sleeve body for receiving at least a portion of the elongated housing of the endoscope with the distal instrument end arranged adjacent to the distal sleeve end. The second lumen may be formed in the sleeve body and extend between a lumen inlet adapted for fluid communication with an irrigation source and a lumen outlet arranged to direct irrigation fluid toward the distal instrument end.

Abstract: The invention relates to analog forms of ambroxol and related compounds, compositions comprising same, and methods of preventing and/or treating various diseases and medical conditions involving the administration of analogs of ambroxol and related compounds.

Abstract: Compositions which are fragrant and contain at least a member set culled from a library of compositions, each being comprised of sub-combinations of selected terpenes. Fragrances that mimic that of various states of organic and synthetic aromatics including products, processes and those from non-combusted plant products, among other things, uniquitous products, processes, medicinals, and related moieties leverage databases of all known terpene groupings are offered for consideration, and have been provided, according to the instant teachings.

Abstract: The invention comprises a method of making lime, dolomitic lime, hydraulic cement such as portland cement clinker and co-products such as pozzolan, acids, alumina, silica and the like while producing reduced amounts of carbon dioxide. The method comprises combining hyaloclastite with a first acid to form a first salt, combining the first salt with a second acid to form a second salt and heating the second salt to form an oxide.

Abstract: An air vent device for a vehicle includes an air guide configured to protrude towards a passage through which air flows, wherein a length of the air guide protruding into the passage is adjustable by rotation with respect to the passage.

Abstract: Vacuum insulating glass units, vacuum insulating glass unit assemblies, and methods for making and using the same are disclosed. An example vacuum insulating glass unit may include a generally planar first lite of glass and a generally planar second lite of glass, each having a perimeter surface. At least one pillar array may be arranged between the first lite of glass and the second lite of glass. A metallic sealing component, or a ceramic frit sealing component, may be provided around a perimeter of the first lite of glass and the second lite of glass. A gasket may be provided adjacent to the perimeter surface of the first lite of glass and the perimeter surface of the second lite of glass. The vacuum insulating glass unit assembly with the gasket may be configured to be installed within a window frame.

Abstract: Method for the separation of Zinc and Iron from electric arc furnace baghouse dust Provided are new and improved novel processes and continuous ion exchange/continuous ion chromatography (CIX/CIC) systems for the separation of iron and zinc from electric arc furnace baghouse dust.

Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

Abstract: Aspects of the disclosure include methods, apparatuses, and non-transitory computer-readable storage mediums for video encoding/decoding. An apparatus includes processing circuitry that decodes prediction information of a current block that is a part of a current picture in a video bitstream. The prediction information indicates a reference block for the current block. The processing circuitry generates filter coefficients of a filter operation based on neighboring reconstructed samples of the current block and neighboring reconstructed samples of the reference block that are co-located with the neighboring reconstructed samples of the current block. The filter operation compensates local changes to the current picture, such as illumination change or motion blur. The processing circuitry determines a prediction block for the current block based on the filter operation being performed on the reference block of the current block.

Abstract: A decoder may receive, for a block, an indication that an intra prediction mode is to be determined at the decoder to decode the block. The decoder may generate, based on the indication, a plurality of reconstructed blocks for a plurality of intra prediction modes. Each of the plurality of reconstructed blocks is generated based on a prediction block generated using a respective intra prediction mode of the plurality of intra prediction modes. The decoder may further select, based on a visual quality of each of the plurality of reconstructed blocks, a prediction mode, from the plurality of intra prediction modes, as the intra prediction mode of the block. The decoder may decode the block based on the intra prediction mode.

Abstract: A method and a system for monitoring an optical transmission path in an optical transmission system. A signal is transmitted on a portion of the optical transmission path. The optical transmission path includes a plurality of portions. A clock synchronization signal in a plurality of clock synchronization signals is assigned to the transmitted signal. A backscattered signal is received. The backscattered signal is generated by the portion of the optical transmission path in response to the signal being transmitted on the portion of the optical transmission path. Based on the assigned clock synchronization signal, the portion of the optical transmission path is monitored by analyzing the backscattered signal to determine a presence of an interference on the portion of the optical transmission path.

Abstract: A die-attach process that creates a bond strength sufficient to hold a die to a substrate while it is handled before being permanently attached is disclosed. The die-attach process includes forming locking features in a metal layer of a substrate so a bond at the die-substrate interface is strengthened. The locking features may include a plurality of cavities or slots formed in a metal layer of the substrate. The cavities and slots can increase a surface area and provide anchor points for a die-attach film placed between the die and the substrate.

Abstract: An electrolyzer stack, an electrolysis system, and a method for operating an electrolysis system are provided. In one example, the electrolyzer stack includes a cell block that includes a plurality of cells configured to receive and convert water to form a hydrogen product stream. The electrolyzer stack includes a force applicator, when pressurized, configured to apply a force to the cell block to counter dimensional changes (e.g., expansion or contraction) to the electrolyzer stack. The force applied by the force applicator is based on the pressure of the hydrogen product stream.

Abstract: A supplemental fuel system for a machine with an engine is configured to monitor a voltage of a power supply of the machine based on voltage data acquired by a voltage sensor where the power supply is configured to receive power from an alternator driven by the engine, compare the voltage to a voltage threshold, and control an electronic lock off valve positioned between a supplemental fuel tank and an air supply system for the engine such that the electronic lock off valve is (i) closed to prevent a supplemental fuel from being provided from the supplemental fuel tank to the to the air supply system in response to the voltage being less than the voltage threshold and (ii) open or openable to permit the supplemental fuel to be provided to the air supply system in response to the voltage being greater than the voltage threshold.

Abstract: A mechanical design of a rechargeable battery cell (e.g., a Lithium-ion battery) disposed inside of a prismatic can, for use in electric vehicles and other electric-powered devices. The improved design uses a thermally conductive insert to divide the battery cell into two adjacent volumes that each hold a pair of stacked layers of a battery cell. This thermally conductive insert conducts heat from the center of the battery cell during battery recharging to actively-cooled channels disposed in a pair of cooling manifolds that are disposed on two vertical sides of the battery cell. Alternatively, or additionally, an actively-cooled bottom cold plate can be used. The pair of stacked battery layers can each be wound in a “jelly-roll” geometric configuration. The thermally conductive insert may be made of aluminum, aluminum alloy, copper, or copper alloy, and combinations thereof.