Abstract: A method of pushing a message notification to a message recipient comprises capturing a message that is sent to a message recipient. The method further comprises extracting a first set of one or more message keywords from the message. The method further comprises extracting a second set of one or more recipient keywords from one or more digital resources associated with the message recipient. The method further comprises evaluating a correspondence between the first set and the second set. The method further comprises pushing, to the message recipient, at a notification time, a notification of the message. The notification time depends on the evaluated correspondence.

Abstract: An insulated metal panel (IMP) assembly system includes a panel assembly table and a boom IMP attachment. The panel assembly table allows for assembly of a panel module at ground level. The boom IMP attachment features a quick-coupler couplable to the boom of a telehandler, a swivel coupler column, one or more tilt linear actuators configured to tilt the orientation of a panel module, and one or more hydraulic rotation linear actuators configured to rotate the orientation of the panel module. The boom IMP attachment also includes a jib frame, a plurality of jib arms spanning outwards from the jib frame, and one or more clamp header rails having a plurality of clamp assemblies, each configured to grip a frame member of the panel frame of the panel module. The boom IMP attachment may hoist, tilt, and rotate the panel module.

Abstract: A dynamic controlling framework that is adapted to dynamically optimize existing routing decisions in an optimized link state routing (OLSR) platform to favor higher-bandwidth, lower-latency links in the active link database. The dynamic controlling framework includes a link probing tool that is in communication with OLSR platform where the link probing tool is adapted to dynamically measure estimated bandwidth, latency scores, or both estimated bandwidth and latency scores of active links in the active link database of the OLSR platform. The dynamic controlling framework includes a plug-in framework that is in communication with the OLSR platform and the link probing tool where the plugin framework is adapted to receive at least one link quality multiplier (LQM) metric computed by the link probing tool and to combine the at least one LQM metric with the OLSR platform's existing link quality (LQ) metric for enhancing route selection by the OLSR platform.

Abstract: Methods of coating a substrate are provided. In an exemplary embodiment, a coating composition is applied to the substrate with a high transfer efficiency applicator to produce a coating layer, where the high transfer efficiency applicator and the substrate remain spatially separate while the coating composition is applied. A droplet of the coating composition expelled from the high transfer efficiency applicator has a particle size of about 10 microns or greater. The coating composition has a viscosity of from about 1,000 to about 1,000,000 centipoise when the coating composition is subject to a shear rate of about 0.1 reciprocal seconds (s?1). However, the coating composition is non-Newtonian such that a coating composition viscosity decreases when the shear rate is increased to the coating composition. The coating layer is impinged with a gas such that a coating layer surface moves upon impingement with the gas.

Abstract: A ballistically enhanced projectile 360, 460 includes a body having a distal ogive section with external ballistic effect uniforming surface discontinuity (e.g., nose ring groove 369, 469) defined therein to provide an unsupported gap in the ogive profile which affects the flow of air over the front half of the ogive to provide greater aerodynamic uniformity and shot-to-shot consistency with more uniform observed external ballistics and superior terminal ballistics. The bullet's external surface discontinuity feature (369 or 469) creates effects in the flowfield that dominate any dynamic effects from bullet-to-bullet manufacturing inconsistency and resultant differences in dynamic behavior.

Abstract: Provided herein are methods for the treatment of pancreatitis and/or the prevention of pancreatic cancer. The treatment may comprise the administration of an inducer of acinar-to-ductal metaplasia (ADM), such as an agonist of the mitogen-activated protein kinase (MAPK) signaling pathway, such as a BRAF inhibitor, or an epigenetic modifier, such as a bromodomain extra-terminal motif (BET) inhibitor.

Abstract: The disclosure relates to a method and a control unit to control a marine vessel comprising two or more drive units. The method involving the steps of registering an operating command indicating a requested vessel direction and plotting a course represented by a reference line for the requested vessel direction from an initial position. It is then monitored if the vessel has deviated from the reference line and if a deviation from the reference line is detected, then a value for current vessel speed is detected. The detected vessel speed value is compared to a predetermined reference speed value to determine if the current vessel speed value is within a high speed interval or a low speed interval relative to the reference speed value. Depending on the determined speed interval the vessel is controlled according a low speed control strategy; or a high speed control strategy in order to move the vessel from a current vessel heading to the reference line and the requested vessel direction.

Abstract: Methods and devices for the prevention, treatment and diagnosis of cancer include assessing and quantifying imperfect dsDNA break repair. The methods may include determining a deletion signal for a DNA-containing sample of a subject, wherein the deletion signal comprises distributions of deletions (frequencies) of deletions with microhomologies of different lengths at the deletion sites in a DNA sequence or genome of the subject or sample thereof. The method may further include decomposing the deletion signal into components corresponding to changes arising from: (1) DNA repair processes, (2) systematic effects due to mapping personal deletion variants to reference genomes, and (3) false positive deletions generated during sample preparation, sequencing, and analysis, and quantifying these components to produce mutational signatures of defective HRR.

Abstract: This disclosure provides for engineered T cell Receptors (TCRs), cells comprising the TCRs, and methods of making and using the TCRs. The current disclosure relates to TCRs that specifically recognize cancer testis (CT) antigens of the MAGE-A4 antigen. Accordingly, aspects of the disclosure relate to an engineered T-cell Receptors (TCRs), nucleic acids encoding the TCRs, and cells comprising the nucleic acids and TCRs. Also provided are compositions comprising the cells, nucleic acids, or engineered TCRs of the disclosure, methods of making the cells and methods of using the embodiments of the disclosure for therapeutic treatments.

Abstract: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease encompassing chronic bronchitis, emphysema and remodeling of small airways that can be treated by the caveolin-1 peptide CSP7 (SEQ ID NO:1). Chronic tobacco smoke exposure (TSE)-induced lung injury includes increased alveolar and airway inflammation, type II alveolar epithelial cells (A2Cs) senescence and apoptosis, and mucus hypersecretion by AECs. Interleukin 17A-mediated induction of plasminogen activator inhibitor-1 (PAI-1) expression through caveolin-1 led to TSE-induced lung injury, which was abrogated by CSP7 treatment which abolished A2Cs senescence and apoptosis, and AECs mucus hypersecretion in TSE wild type (WT) mice. Ex vivo CSP7 treatment of lung tissue of COPD patients decreased A2C apoptosis and AEC mucus hypersecretion. Lung injury induced by PAI-1 expression in COPD lung tissue and WT mice (20 weeks TSE), with A2Cs senescence and apoptosis, and AEC mucus hypersecretion was abolished by CSP7.

Abstract: A wire harness unit including: a conductive path for conducting electricity between in-vehicle devices, the conductive path including a conductive hollow tubular conductor, a flexible conductor that is more flexible than the tubular conductor, and a terminal; and a cooling tube through which a coolant is flowable for cooling the conductive path and that is separate from the tubular conductor, wherein: the tubular conductor is more rigid than the cooling tube, the flexible conductor includes a first end that is electrically connected to the tubular conductor, and a second end that is electrically connected to the terminal, and the cooling tube extends through the tubular conductor, and further extends through the flexible conductor between the first end and the second end of the flexible conductor.

Abstract: Provided is a technique by which each nuclide is optimized in terms of energy and number of particles and pre-accelerated so as to be injected into a main accelerator in charged particle beam irradiation by the combined use of different nuclides. A charged particle beam injector includes: a first ion source that generates first nuclide ions; a first linear accelerator that linearly accelerates the generated first nuclide ions to form a first charged particle beam; a second ion source that generates second nuclide ions; a second linear accelerator that linearly accelerates the generated second nuclide ions to form a second charged particle beam; and a switching electromagnet that injects one of the first charged particle beam and the second charged particle beam into an inflector of a main accelerator.

Abstract: An electronic tracking tag that attaches a battery to the tag's circuitry by folding over a portion of the flexible PCB on top of the battery to secure it between two conductive pads. This configuration eliminates the need for a battery holder, thereby reducing weight, cost, and thickness and enabling a label containing the electronics to be fed through a printer without damaging the circuit. The battery may be attached to conductive pads using a conductive adhesive such as a conductive tape, avoiding the use of rigid or brittle tabs or epoxies that may break under the stress of going through the printer. An illustrative configuration with the electronic components, the battery, the fold-over battery attachment, and a label front and liner backing may be less than 2100 micrometers thick.

Abstract: A magnetic resonance imaging apparatus according to an embodiment includes a gantry, a first illuminating unit, and processing circuitry. The gantry has a hollow bore. The first illuminating unit illuminates the hollow bore. The processing circuitry identifies the position of a predetermined region of the subject inside the hollow bore, and controls the illumination state of the first illuminating unit based on the identified position of the predetermined region.

Abstract: A method and system for classifying field of view (FOV) images of histological slides into various categories that include certain stain patterns, artifacts, and/or other features of interest are provided herein. Few-shot learning (e.g., a prototypical network) techniques are used to train a deep convolutional neural network using a small number of training samples for a small number of image classes for classifying stain images belonging to a larger number of image classes.

Abstract: A projectile for short firing ranges includes as a cylinder with a nose having a substantially flat surface arranged with a threaded socket allowing for the arrangement of, for example, a fuze a rear section designed with a substantially flat surface, as well as a projectile body arranged with energetic material enclosed by a casing.

Abstract: According to one embodiment, a Vacuum interrupter includes a pair of electrodes provided such that their electrode opposed surfaces face each other, and an undulating structure provided in at least one of the electrode opposed surfaces. The undulating structure includes one or more projections which project from the electrode opposed surface, and depressions provided so as to be adjacent to the projections, respectively. The projections and the depressions are alternately provided in a direction crossing the electrode opposed surface. In a conducting state in which the electrodes are in contact with each other, the projections are in contact with the opposite electrode opposed surface.

Abstract: A logic unit in an array of processing units is configurable to consume source tokens and a status signal and to produce barrier tokens and an enable signal based on the source tokens and the status signal.

Abstract: Systems and methods for circulating air in an enclosed environment are disclosed. In some embodiments, the system includes an inlet to receive air from outside of the enclosed environment and an air handling unit coupled to the inlet and also configured to receive circulated air from the enclosed environment. The air handling unit can be configured to affect a temperature of at least one of the received outside air and the received circulated air. Based on the received outside air and the received circulated air, the air handling unit can be further configured to generate air for supplying to the enclosed environment.

Abstract: Method of reducing multipath effects on phase measurements, including receiving radio signals with different pseudo-random codes transmitted by at least four base stations, each at particular frequency received by one channel; measuring delay difference and phase difference from different pairs of base stations; calculating a current position of the receiver based on the measured phase differences and delay differences, wherein the base stations differ in pseudo-random codes at same frequencies or differ in carrier frequency or polarization type if using the same pseudo-random codes, and wherein a number of channels in the receiver exceeds a number of channels needed for the calculating of the current position; detecting anomalous jumps in phase of one or more channels, based on first or second derivative of the phase, as being indicative of multipath signal reception; removing those channels from calculation of current position; and calculating current position based on remaining channels.