Patents Assigned to OPKO Diagnostics, LLC
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Patent number: 9770715Abstract: Systems and methods for improved measurement of absorbance/transmission through fluidic systems are described. Specifically, in one set of embodiments, optical elements are fabricated on one side of a transparent fluidic device opposite a series of fluidic channels. The optical elements may guide incident light passing through the device such that most of the light is dispersed away from specific areas of the device, such as intervening portions between the fluidic channels. By decreasing the amount of light incident upon these intervening portions, the amount of noise in the detection signal can be decreased when using certain optical detection systems.Type: GrantFiled: June 26, 2014Date of Patent: September 26, 2017Assignee: OPKO Diagnostics, LLCInventors: David Steinmiller, Vincent Linder
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Publication number: 20170238857Abstract: Articles and methods for collecting and/or facilitating transfer of fluids are generally provided. In some embodiments, an article comprises a fluid collection region for introducing a fluid, such as a sample (e.g., blood sample) or a reagent, into a fluidic system. The articles and methods described herein may be useful for facilitating the filling of relatively small channels with a fluid, such as channels of a microfluidic device. The articles and methods may, for example, interface with a patient sample (e.g., a droplet of blood), or with a macroscopic fluid source such as a pipette or syringe. In certain embodiments, articles and methods described herein may increase the ease of collecting a fluidic sample from a patient, prevent or reduce spillage of the fluidic sample, reduce contamination of a fluidic sample, and/or prevent or reduce air from entering a fluidic sample or device compared to certain existing fluid collection devices.Type: ApplicationFiled: April 24, 2017Publication date: August 24, 2017Applicant: OPKO Diagnostics, LLCInventors: JASON TAYLOR, Hardeep Singh, Matthew Dirckx
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Publication number: 20170239656Abstract: Systems and methods for analysis of samples, and in certain embodiments, microfluidic sample analyzers configured to receive a cassette containing a sample therein to perform an analysis of the sample are described. The microfluidic sample analyzers may be used to control fluid flow, mixing, and sample analysis in a variety of microfluidic systems such as microfluidic point-of-care diagnostic platforms. Advantageously, the microfluidic sample analyzers may be, in some embodiments, inexpensive, reduced in size compared to conventional bench top systems, and simple to use. Cassettes that can operate with the sample analyzers are also described.Type: ApplicationFiled: May 5, 2017Publication date: August 24, 2017Applicant: OPKO Diagnostics, LLCInventors: Vincent Linder, David Steinmiller, Jason Taylor
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Patent number: 9731291Abstract: The specification generally discloses systems and methods for mixing and delivering fluids in microfluidic systems. The fluids can contain, in some embodiments reagents that can participate in one or more chemical or biological reactions.Type: GrantFiled: May 19, 2015Date of Patent: August 15, 2017Assignee: OPKO Diagnostics, LLCInventors: Enqing Tan, Vincent Linder
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Patent number: 9682376Abstract: Systems and methods for analysis of samples, and in certain embodiments, microfluidic sample analyzers configured to receive a cassette containing a sample therein to perform an analysis of the sample are described. The microfluidic sample analyzers may be used to control fluid flow, mixing, and sample analysis in a variety of microfluidic systems such as microfluidic point-of-care diagnostic platforms. Advantageously, the microfluidic sample analyzers may be, in some embodiments, inexpensive, reduced in size compared to conventional bench top systems, and simple to use. Cassettes that can operate with the sample analyzers are also described.Type: GrantFiled: May 1, 2014Date of Patent: June 20, 2017Assignee: OPKO Diagnostics, LLCInventors: Vincent Linder, David Steinmiller, Jason Taylor
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Patent number: 9683993Abstract: The present invention relates generally to microfluidic structures, and more specifically, to microfluidic structures and methods including meandering and wide channels. Microfluidic systems can provide an advantageous environment for performing various reactions and analyses due to a reduction in sample and reagent quantities that are required, a reduction in the size of the operating system, and a decrease in reaction time compared to conventional systems. Unfortunately, the small size of microfluidic channels can sometimes result in difficulty in detecting a species without magnifying optics (such as a microscope or a photomultiplier). A series of tightly packed microchannels, i.e., a meandering region, or a wide channel having a dimension on the order of millimeters, can serve as a solution to this problem by creating a wide measurement area.Type: GrantFiled: April 10, 2013Date of Patent: June 20, 2017Assignees: President and Fellows of Harvard College, OPKO Diagnostics, LLCInventors: Vincent Linder, Samuel K. Sia, George M. Whitesides, Max Narovlyansky, Adam Carlyn Siegel
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Publication number: 20170167958Abstract: Fluidic devices and methods associated with mixing of fluids in fluidic devices are provided. In some embodiments, a method may involve the mixing of two or more fluids in a channel segment of a fluidic device. The fluids may be in the form of, for example, at least first, second and third fluid plugs, composed of first, second, and third fluids, respectively. The second fluid may be immiscible with the first and third fluids. In certain embodiments, the fluid plugs may be flowed in series in the channel segment, e.g., in linear order, causing the first and third fluids to mix without the use of active components such as mixers. The mixing of fluids in a channel segment as described herein may allow for improved performance and simplification in the design and operations of fluidic devices that rely on mixing of fluids.Type: ApplicationFiled: February 27, 2017Publication date: June 15, 2017Applicant: OPKO Diagnostics, LLCInventors: Matthew Dirckx, Vincent Linder, Jason Taylor
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Publication number: 20170165664Abstract: The specification generally discloses systems and methods for mixing and delivering fluids in microfluidic systems. The fluids can contain, in some embodiments reagents that can participate in one or more chemical or biological reactions. Some embodiments relate to systems and methods employing one or more vent valves to controllably flow and/or mix portions of fluid within the microfluidic system. Advantageously, fluid control such as a sequence of fluid flow and/or a change in flow rate, can be achieved by opening and closing one or more vent valves and by applying a single source of fluid flow (e.g., a vacuum) operated at a substantially constant pressure. This can simplify the operation and use of the device by an intended user.Type: ApplicationFiled: December 20, 2016Publication date: June 15, 2017Applicant: OPKO Diagnostics, LLCInventors: Enqing Tan, Vincent Linder, Jason Taylor, David Steinmiller
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Publication number: 20170168077Abstract: Fluidic devices and methods involving incubation and/or mixing of assay components are provided. In some embodiments, a biological and/or chemical assay may be performed in a fluidic device. The fluidic device may be designed to allow for controlled incubation and/or mixing of two or more assay components. In some such embodiments, the fluidic device may comprise an incubation channel having a relatively large cross-sectional dimension in fluid communication with a detection channel. The incubation channel may allow for adequate mixing and/or incubation of two or more assay components prior to analysis of the assay. In some embodiments, fluidic devices for performing a vitamin D assay are provided.Type: ApplicationFiled: December 8, 2016Publication date: June 15, 2017Applicant: OPKO Diagnostics, LLCInventors: DOUGLAS M. HADDAD, Gary J. Fagan, Yi Dong, Matthew Dirckx, Vincent Linder
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Publication number: 20170168060Abstract: Methods and apparatuses for predicting risk of prostate cancer and/or prostate gland volume are provided. More particularly, this disclosure relates to methods and apparatuses for providing the models and employing the models for predicting risk of prostate cancer and/or predicting prostate gland volume. The methods and apparatuses for predicting risk of prostate cancer and/or prostate gland volume are provided using, at least in part, information from a panel of kallikrein markers.Type: ApplicationFiled: February 27, 2017Publication date: June 15, 2017Applicants: OPKO Diagnostics, LLC, Oy Arctic Partners AbInventors: Andrew J. Vickers, Peter T. Scardino, Hans Lilja, Vincent Linder, David Steinmiller
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Publication number: 20170165665Abstract: Microfluidic systems and methods including those that provide control of fluid flow are provided. Such systems and methods can be used, for example, to control pressure-driven flow based on the influence of channel geometry and the viscosity of one or more fluids inside the system.Type: ApplicationFiled: February 27, 2017Publication date: June 15, 2017Applicant: OPKO Diagnostics, LLCInventors: Vincent Linder, David Steinmiller
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Publication number: 20170165661Abstract: Fluidic devices and methods including those that provide storage and/or facilitate fluid handling of reagents are provided. Fluidic devices described herein may include channel segments positioned on two sides of an article, optionally connected by an intervening channel passing through the article. The channel segments may be used to store reagents in the device prior to first use by an end user. The stored reagents may include fluid plugs positioned in linear order so that during use, as fluids flow to a reaction site, they are delivered in a predetermined sequence. The specific geometries of the channel segments and the positions of the channel segments within the fluidic devices described herein may allow fluid reagents to be stored for extended periods of time without mixing, even during routine handling of the devices such as during shipping of the devices, and when the devices are subjected to physical shock or vibration.Type: ApplicationFiled: December 22, 2016Publication date: June 15, 2017Applicant: OPKO Diagnostics, LLCInventors: Jason Taylor, Vincent Linder
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Patent number: 9672329Abstract: Methods and apparatuses for predicting risk of prostate cancer and/or prostate gland volume are provided. More particularly, this disclosure relates to methods and apparatuses for providing the models and employing the models for predicting risk of prostate cancer and/or predicting prostate gland volume. The methods and apparatuses for predicting risk of prostate cancer and/or prostate gland volume are provided using, at least in part, information from a panel of kallikrein markers.Type: GrantFiled: March 5, 2013Date of Patent: June 6, 2017Assignees: OPKO Diagnostics, LLC, Oy Arctic Partners AbInventors: Andrew J. Vickers, Peter T. Scardino, Hans Lilja, Vincent Linder, David Steinmiller
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Patent number: 9643182Abstract: Systems and methods for analysis of samples, and in certain embodiments, microfluidic sample analyzers configured to receive a cassette containing a sample therein to perform an analysis of the sample are described. The microfluidic sample analyzers may be used to control fluid flow, mixing, and sample analysis in a variety of microfluidic systems such as microfluidic point-of-care diagnostic platforms. Advantageously, the microfluidic sample analyzers may be, in some embodiments, inexpensive, reduced in size compared to conventional bench top systems, and simple to use. Cassettes that can operate with the sample analyzers are also described.Type: GrantFiled: November 26, 2014Date of Patent: May 9, 2017Assignee: OPKO Diagnostics, LLCInventors: Vincent Linder, David Steinmiller, Jason Taylor
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Publication number: 20170091379Abstract: Methods and apparatuses for conducting analyses are provided.Type: ApplicationFiled: June 29, 2016Publication date: March 30, 2017Applicants: OPKO Diagnostics, LLC, Oy Arctic Partners AbInventors: Andrew J. Vickers, Peter T. Scardino, Hans Lilja, Vincent Linder, David Steinmiller
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Publication number: 20170089904Abstract: Aspects of the disclosure relate to improved methods and systems for active surveillance of subject having non-aggressive prostate cancer.Type: ApplicationFiled: April 29, 2016Publication date: March 30, 2017Applicant: OPKO Diagnostics, LLCInventors: Yan Dong, Andrew J. Vickers, Daniel Sjoberg, Peter T. Scardino, Hans Lilja
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Patent number: 9592505Abstract: Microfluidic systems and methods including those that provide control of fluid flow are provided. Such systems and methods can be used, for example, to control pressure-driven flow based on the influence of channel geometry and the viscosity of one or more fluids inside the system.Type: GrantFiled: June 6, 2012Date of Patent: March 14, 2017Assignee: OPKO Diagnostics, LLCInventors: Vincent Linder, David Steinmiller
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Patent number: 9561506Abstract: Fluidic devices and methods including those that provide storage and/or facilitate fluid handling of reagents are provided. Fluidic devices described herein may include channel segments positioned on two sides of an article, optionally connected by an intervening channel passing through the article. The channel segments may be used to store reagents in the device prior to first use by an end user. The stored reagents may include fluid plugs positioned in linear order so that during use, as fluids flow to a reaction site, they are delivered in a predetermined sequence. The specific geometries of the channel segments and the positions of the channel segments within the fluidic devices described herein may allow fluid reagents to be stored for extended periods of time without mixing, even during routine handling of the devices such as during shipping of the devices, and when the devices are subjected to physical shock or vibration.Type: GrantFiled: September 24, 2013Date of Patent: February 7, 2017Assignee: OPKO Diagnostics, LLCInventors: Jason Taylor, Vincent Linder
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Patent number: 9555408Abstract: The specification generally discloses systems and methods for mixing and delivering fluids in microfluidic systems. The fluids can contain, in some embodiments reagents that can participate in one or more chemical or biological reactions. Some embodiments relate to systems and methods employing one or more vent valves to controllably flow and/or mix portions of fluid within the microfluidic system. Advantageously, fluid control such as a sequence of fluid flow and/or a change in flow rate, can be achieved by opening and closing one or more vent valves and by applying a single source of fluid flow (e.g., a vacuum) operated at a substantially constant pressure. This can simplify the operation and use of the device by an intended user.Type: GrantFiled: October 23, 2014Date of Patent: January 31, 2017Assignee: OPKO Diagnostics, LLCInventors: Enqing Tan, Vincent Linder, Jason Taylor, David Steinmiller
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Publication number: 20160320394Abstract: Aspects of the disclosure relate to improved methods and systems for active surveillance of subject having non-aggressive prostate cancer.Type: ApplicationFiled: April 29, 2016Publication date: November 3, 2016Applicant: OPKO DIAGNOSTICS, LLCInventors: YAN DONG, ANDREW J. VICKERS, DANIEL SJOBERG, PETER T. SCARDINO, HANS LILJA