Patents Assigned to OPKO Diagnostics, LLC
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Publication number: 20160305938Abstract: Fluidic connectors, methods, and devices for performing analyses (e.g., immunoassays) in microfluidic systems are provided. In some embodiments, a fluidic connector having a fluid path is used to connect two independent channels formed in a substrate so as to allow fluid communication between the two independent channels. One or both of the independent channels may be pre-filled with reagents (e.g., antibody solutions, washing buffers and amplification reagents), which can be used to perform the analysis. These reagents may be stored in the channels of the substrate for long periods amounts of time (e.g., 1 year) prior to use.Type: ApplicationFiled: June 29, 2016Publication date: October 20, 2016Applicant: OPKO Diagnostics, LLCInventors: Vincent Linder, David Steinmiller, Samuel K. Sia
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Publication number: 20160305937Abstract: Fluidic systems and methods for analyses are provided. In some embodiments, systems and methods for improved measurement of absorbance/transmission through fluidic systems are described. Specifically, in one set of embodiments, optical elements are fabricated on one side of a transparent fluidic device opposite a series of fluidic channels. The optical elements may guide incident light passing through the device such that most of the light is dispersed away from specific areas of the device, such as intervening portions between the fluidic channels. By decreasing the amount of light incident upon these intervening portions, the amount of noise in the detection signal can be decreased when using certain optical detection systems.Type: ApplicationFiled: June 29, 2016Publication date: October 20, 2016Applicant: OPKO Diagnostics, LLCInventors: David Steinmiller, Vincent Linder
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Publication number: 20160305878Abstract: Fluidic systems and methods for analyses are provided. In some embodiments, systems and methods for improved measurement of absorbance/transmission through fluidic systems are described. Specifically, in one set of embodiments, optical elements are fabricated on one side of a transparent fluidic device opposite a series of fluidic channels. The optical elements may guide incident light passing through the device such that most of the light is dispersed away from specific areas of the device, such as intervening portions between the fluidic channels. By decreasing the amount of light incident upon these intervening portions, the amount of noise in the detection signal can be decreased when using certain optical detection systems.Type: ApplicationFiled: June 29, 2016Publication date: October 20, 2016Applicant: OPKO Diagnostics, LLCInventors: David Steinmiller, Vincent Linder
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Publication number: 20160282349Abstract: Aspects of the disclosure relate to improved methods for predicting whether a prostate tissue biopsy obtained from a subject will contain detectable prostate cancer. In some embodiments, the disclosure provides improved prostate antigen standards for quantifying levels of prostate antigens.Type: ApplicationFiled: March 25, 2016Publication date: September 29, 2016Applicant: OPKO Diagnostics, LLCInventors: Vincent Linder, Christina Higgins
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Publication number: 20160207042Abstract: Fluidic devices and methods involving incubation and/or mixing of assay components are provided. In some embodiments, a biological and/or chemical assay may be performed in fluidic device. The fluidic device may be designed to allow for controlled incubation and/or mixing of two or more assay components. In some such embodiments, the fluidic device may comprise an incubation channel having a relatively large cross-sectional dimension in fluid communication with a detection channel. The incubation channel may allow for adequate mixing and/or incubation of two or more assay components prior to analysis of the assay. In certain embodiments, the detection channel may be used to provide feedback on the extent of incubation and/or mixing. Based on the feedback, one or more component of the fluidic system may be regulated to allow the requisite degree of mixing and/or incubation to be achieved.Type: ApplicationFiled: December 11, 2015Publication date: July 21, 2016Applicant: OPKO Diagnostics, LLCInventors: Matthew Dirckx, Jason Taylor, Vincent Linder
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Publication number: 20160077087Abstract: Fluidic connectors, methods, and devices for performing analyses (e.g., immunoassays) in microfluidic systems are provided. In some embodiments, a fluidic connector having a fluid path is used to connect two independent channels formed in a substrate so as to allow fluid communication between the two independent channels. One or both of the independent channels may be pre-filled with reagents (e.g., antibody solutions, washing buffers and amplification reagents), which can be used to perform the analysis. These reagents may be stored in the channels of the substrate for long periods amounts of time (e.g., 1 year) prior to use.Type: ApplicationFiled: November 24, 2015Publication date: March 17, 2016Applicant: OPKO Diagnostics, LLCInventors: Vincent Linder, David Steinmiller, Samuel K. Sia
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Patent number: 9255866Abstract: Fluidic devices and methods associated with mixing of fluids in fluidic devices are provided. In some embodiments, a method may involve the mixing of two or more fluids in a channel segment of a fluidic device. The fluids may be in the form of, for example, at least first, second and third fluid plugs, composed of first, second, and third fluids, respectively. The second fluid may be immiscible with the first and third fluids. In certain embodiments, the fluid plugs may be flowed in series in the channel segment, e.g., in linear order, causing the first and third fluids to mix without the use of active components such as mixers. The mixing of fluids in a channel segment as described herein may allow for improved performance and simplification in the design and operations of fluidic devices that rely on mixing of fluids.Type: GrantFiled: July 30, 2014Date of Patent: February 9, 2016Assignee: OPKO Diagnostics, LLCInventors: Matthew Dirckx, Vincent Linder, Jason Taylor
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Publication number: 20160025732Abstract: Aspects of the disclosure relate to improved methods for predicting whether a prostate tissue biopsy obtained from a subject will contain detectable prostate cancer.Type: ApplicationFiled: March 27, 2015Publication date: January 28, 2016Applicant: OPKO Diagnostics, LLCInventors: Vincent Linder, David Steinmiller, Kim Pettersson, Timo Lovgren, Hans Lilja, Andrew J. Vickers, Peter T. Scardino
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Patent number: 9234888Abstract: Fluidic connectors, methods, and devices for performing analyses (e.g., immunoassays) in microfluidic systems are provided. In some embodiments, a fluidic connector having a fluid path is used to connect two independent channels formed in a substrate so as to allow fluid communication between the two independent channels. One or both of the independent channels may be pre-filled with reagents (e.g., antibody solutions, washing buffers and amplification reagents), which can be used to perform the analysis. These reagents may be stored in the channels of the substrate for long periods amounts of time (e.g., 1 year) prior to use.Type: GrantFiled: November 26, 2014Date of Patent: January 12, 2016Assignee: OPKO Diagnostics, LLCInventors: Vincent Linder, David Steinmiller, Samuel K. Sia
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Publication number: 20150343443Abstract: Systems and methods for controlling fluids in microfluidic systems are generally described. In some embodiments, control of fluids involves the use of feedback from one or more processes or events taking place in the microfluidic system. For instance, a detector may detect one or more fluids at a measurement zone of a microfluidic system and one or more signals, or a pattern of signals, may be generated corresponding to the fluid(s). In some cases, the signal or pattern of signals may correspond to an intensity, a duration, a position in time relative to a second position in time or relative to another process, and/or an average time period between events. Using this data, a control system may determine whether to modulate subsequent fluid flow in the microfluidic system. In some embodiments, these and other methods can be used to conduct quality control to determine abnormalities in operation of the microfluidic system.Type: ApplicationFiled: July 20, 2015Publication date: December 3, 2015Applicant: OPKO Diagnostics, LLCInventors: Vincent Linder, David Steinmiller
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Publication number: 20150251178Abstract: The specification generally discloses systems and methods for mixing and delivering fluids in microfluidic systems. The fluids can contain, in some embodiments reagents that can participate in one or more chemical or biological reactions.Type: ApplicationFiled: May 19, 2015Publication date: September 10, 2015Applicant: OPKO Diagnostics, LLCInventors: Enqing Tan, Vincent Linder
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Patent number: 9116124Abstract: Systems and methods for controlling fluids in microfluidic systems are generally described. In some embodiments, control of fluids involves the use of feedback from one or more processes or events taking place in the microfluidic system. For instance, a detector may detect one or more fluids at a measurement zone of a microfluidic system and one or more signals, or a pattern of signals, may be generated corresponding to the fluid(s). In some cases, the signal or pattern of signals may correspond to an intensity, a duration, a position in time relative to a second position in time or relative to another process, and/or an average time period between events. Using this data, a control system may determine whether to modulate subsequent fluid flow in the microfluidic system. In some embodiments, these and other methods can be used to conduct quality control to determine abnormalities in operation of the microfluidic system.Type: GrantFiled: October 2, 2013Date of Patent: August 25, 2015Assignee: OPKO Diagnostics, LLCInventors: Vincent Linder, David Steinmiller
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Publication number: 20150196908Abstract: Systems and methods for improved measurement of absorbance/transmission through fluidic systems are described. Specifically, in one set of embodiments, optical elements are fabricated on one side of a transparent fluidic device opposite a series of fluidic channels. The optical elements may guide incident light passing through the device such that most of the light is dispersed away from specific areas of the device, such as intervening portions between the fluidic channels. By decreasing the amount of light incident upon these intervening portions, the amount of noise in the detection signal can be decreased when using certain optical detection systems.Type: ApplicationFiled: June 26, 2014Publication date: July 16, 2015Applicant: OPKO Diagnostics, LLCInventors: David Steinmiller, Vincent Linder
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Patent number: 9075051Abstract: The specification generally discloses systems and methods for mixing and delivering fluids in microfluidic systems. The fluids can contain, in some embodiments reagents that can participate in one or more chemical or biological reactions. Some embodiments relate to systems and methods employing one or more vent valves to controllably flow and/or mix portions of fluid within the microfluidic system. Advantageously, fluid control such as a sequence of fluid flow and/or a change in flow rate, can be achieved by opening and closing one or more vent valves and by applying a single source of fluid flow (e.g., a vacuum) operated at a substantially constant pressure. This can simplify the operation and use of the device by an intended user.Type: GrantFiled: April 22, 2013Date of Patent: July 7, 2015Assignee: OPKO Diagnostics, LLCInventors: Enqing Tan, Vincent Linder
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Patent number: 9075047Abstract: Fluidic connectors, methods, and devices for performing analyses (e.g., immunoassays) in microfluidic systems are provided. In some embodiments, a fluidic connector having a fluid path is used to connect two independent channels formed in a substrate so as to allow fluid communication between the two independent channels. One or both of the independent channels may be pre-filled with reagents (e.g., antibody solutions, washing buffers and amplification reagents), which can be used to perform the analysis. These reagents may be stored in the channels of the substrate for long periods amounts of time (e.g., 1 year) prior to use.Type: GrantFiled: March 21, 2014Date of Patent: July 7, 2015Assignee: OPKO Diagnostics, LLCInventors: Vincent Linder, David Steinmiller, Samuel K. Sia
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Publication number: 20150086997Abstract: Systems and methods for analysis of samples, and in certain embodiments, microfluidic sample analyzers configured to receive a cassette containing a sample therein to perform an analysis of the sample are described. The microfluidic sample analyzers may be used to control fluid flow, mixing, and sample analysis in a variety of microfluidic systems such as microfluidic point-of-care diagnostic platforms. Advantageously, the microfluidic sample analyzers may be, in some embodiments, inexpensive, reduced in size compared to conventional bench top systems, and simple to use. Cassettes that can operate with the sample analyzers are also described.Type: ApplicationFiled: November 26, 2014Publication date: March 26, 2015Applicant: OPKO Diagnostics, LLCInventors: Vincent Linder, David Steinmiller, Jason Taylor
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Publication number: 20150079606Abstract: Fluidic connectors, methods, and devices for performing analyses (e.g., immunoassays) in microfluidic systems are provided. In some embodiments, a fluidic connector having a fluid path is used to connect two independent channels formed in a substrate so as to allow fluid communication between the two independent channels. One or both of the independent channels may be pre-filled with reagents (e.g., antibody solutions, washing buffers and amplification reagents), which can be used to perform the analysis. These reagents may be stored in the channels of the substrate for long periods amounts of time (e.g., 1 year) prior to use.Type: ApplicationFiled: November 26, 2014Publication date: March 19, 2015Applicant: OPKO Diagnostics, LLCInventors: Vincent Linder, David Steinmiller, Samuel K. Sia
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Publication number: 20150044760Abstract: The specification generally discloses systems and methods for mixing and delivering fluids in microfluidic systems. The fluids can contain, in some embodiments reagents that can participate in one or more chemical or biological reactions. Some embodiments relate to systems and methods employing one or more vent valves to controllably flow and/or mix portions of fluid within the microfluidic system. Advantageously, fluid control such as a sequence of fluid flow and/or a change in flow rate, can be achieved by opening and closing one or more vent valves and by applying a single source of fluid flow (e.g., a vacuum) operated at a substantially constant pressure. This can simplify the operation and use of the device by an intended user.Type: ApplicationFiled: October 23, 2014Publication date: February 12, 2015Applicant: OPKO Diagnostics, LLCInventors: Enqing Tan, Vincent Linder, Jason Taylor, David Steinmiller
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Patent number: 8932523Abstract: Systems and methods for analysis of samples, and in certain embodiments, microfluidic sample analyzers configured to receive a cassette containing a sample therein to perform an analysis of the sample are described. The microfluidic sample analyzers may be used to control fluid flow, mixing, and sample analysis in a variety of microfluidic systems such as microfluidic point-of-care diagnostic platforms. Advantageously, the microfluidic sample analyzers may be, in some embodiments, inexpensive, reduced in size compared to conventional bench top systems, and simple to use. Cassettes that can operate with the sample analyzers are also described.Type: GrantFiled: April 15, 2011Date of Patent: January 13, 2015Assignee: OPKO Diagnostics, LLCInventors: Vincent Linder, David Steinmiller, Jason Taylor
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Patent number: 8915259Abstract: The specification generally discloses systems and methods for mixing and delivering fluids in microfluidic systems. The fluids can contain, in some embodiments reagents that can participate in one or more chemical or biological reactions. Some embodiments relate to systems and methods employing one or more vent valves to controllably flow and/or mix portions of fluid within the microfluidic system. Advantageously, fluid control such as a sequence of fluid flow and/or a change in flow rate, can be achieved by opening and closing one or more vent valves and by applying a single source of fluid flow (e.g., a vacuum) operated at a substantially constant pressure. This can simplify the operation and use of the device by an intended user.Type: GrantFiled: September 27, 2013Date of Patent: December 23, 2014Assignee: OPKO Diagnostics, LLCInventors: Enqing Tan, Vincent Linder, Jason Taylor, David Steinmiller