Patents Assigned to Optonol Ltd.
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Patent number: 9173774Abstract: The disclosure provides an intraocular implant for allowing fluid flow from the anterior chamber of an eye, the implant comprising a tube having an inlet end, an outlet end, and a tube passage, wherein the inlet end is adapted to extend into the anterior chamber of the eye, and wherein the outlet end is adapted to be implanted adjacent scleral tissue of the eye. The implant may be adapted to drain aqueous humor into a suprachoroidal space or a juxta-uveal space. The disclosure also provides associated delivery devices, methods of use, and methods of manufacture.Type: GrantFiled: September 11, 2012Date of Patent: November 3, 2015Assignee: OPTONOL LTD.Inventors: Ira Yaron, Oded Nissan, Gal Goren
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Patent number: 8961600Abstract: A fiber matrix is provided for maintaining space in soft tissue, for example for use in procedures for assisting drainage of aqueous humor from an eye to treat glaucoma. The fiber matrix comprises a plurality of crossing fibers forming a mesh with a plurality of void spaces. The fibers and void spaces are sized and arranged so as to permit passage of fluid through the fiber matrix and to inhibit formation of scar tissue through the fiber matrix. The fibers may comprise a polymeric material, and the fiber matrix may be manufactured by electrospinning. The fibers may comprise a biostable and/or a biodegradable material. In one method of using a fiber matrix, the fiber matrix is positioned under a scleral flap, with at least part of the fiber matrix under the scleral flap.Type: GrantFiled: June 25, 2010Date of Patent: February 24, 2015Assignee: Optonol Ltd.Inventors: Oded Nissan, Ira Yaron, Jonathan Ben-Zvi
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Patent number: 8486086Abstract: An implant includes a tube for permitting fluid flow. A flow controlling rod may be inserted within the tube passage. One or more holes around the circumference of the tube may be selectively permanently or temporarily occluded to give desired flow characteristics. A delivery device for implanting the implant may include a central bore in which a retractable wire is located. The retractable wire penetrates a tube passage of the implant. After the implant is in position in the eye, the retention wire is retracted out of the implant. In a method for manufacturing an implant, two tubes of different diameters are utilized. The smaller tube fits inside the longitudinal bore of the larger tube. When the tubes are cut, the smaller tube forms the tube of the implant and the remaining portions of the larger tube form the retention projection and/or disk of the implant.Type: GrantFiled: November 7, 2011Date of Patent: July 16, 2013Assignee: Optonol, LtdInventors: Ira Yaron, Orit Yarden
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Publication number: 20130006164Abstract: The disclosure provides an intraocular implant for allowing fluid flow from the anterior chamber of an eye, the implant comprising a tube having an inlet end, an outlet end, and a tube passage, wherein the inlet end is adapted to extend into the anterior chamber of the eye, and wherein the outlet end is adapted to be implanted adjacent scleral tissue of the eye. The implant may be adapted to drain aqueous humor into a suprachoroidal space or a juxta-uveal space. The disclosure also provides associated delivery devices, methods of use, and methods of manufacture.Type: ApplicationFiled: September 11, 2012Publication date: January 3, 2013Applicant: OPTONOL LTD.Inventors: Ira YARON, Oded NISSAN, Gal GOREN
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Patent number: 8313454Abstract: The disclosure provides an intraocular implant for allowing fluid flow from the anterior chamber of an eye, the implant comprising a tube having an inlet end, an outlet end, and a tube passage, wherein the inlet end is adapted to extend into the anterior chamber of the eye, and wherein the outlet end is adapted to be implanted adjacent scleral tissue of the eye. The implant may be adapted to drain aqueous humor into a suprachoroidal space or a juxta-uveal space. The disclosure also provides associated delivery devices, methods of use, and methods of manufacture.Type: GrantFiled: March 26, 2010Date of Patent: November 20, 2012Assignee: Optonol Ltd.Inventors: Ira Yaron, Oded Nissan, Gal Goren
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Publication number: 20120053505Abstract: An implant includes a tube for permitting fluid flow. A flow controlling rod may be inserted within the tube passage. One or more holes around the circumference of the tube may be selectively permanently or temporarily occluded to give desired flow characteristics. A delivery device for implanting the implant may include a central bore in which a retractable wire is located. The retractable wire penetrates a tube passage of the implant. After the implant is in position in the eye, the retention wire is retracted out of the implant. In a method for manufacturing an implant, two tubes of different diameters are utilized. The smaller tube fits inside the longitudinal bore of the larger tube. When the tubes are cut, the smaller tube forms the tube of the implant and the remaining portions of the larger tube form the retention projection and/or disk of the implant.Type: ApplicationFiled: November 7, 2011Publication date: March 1, 2012Applicant: OPTONOL LTD.Inventors: Ira YARON, Orit YARDEN
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Patent number: 8109896Abstract: Devices and procedures for assisting drainage of aqueous humor from the eye are provided. In accordance with some embodiments, an implant sized to fit within the Schlemm's Canal is provided. The implant has a plurality of penetrating members having an unextended position in which the penetrating members lie generally close to the longitudinal axis of the implant and an extended position in which the penetrating members are extended outward. In use, the implant is advanced around at least a substantial portion of the Schlemm's Canal with the penetrating members in the first unextended position. After the implant is positioned within the Schlemm's Canal, the penetrating members are caused to move from the first unextended position to the second extended position, wherein the penetrating members penetrate the wall of the Schlemm's Canal. This creates fluid passageways in the wall of the Schlemm's Canal. The implant can also serve to keep the Schlemm's Canal open.Type: GrantFiled: February 11, 2008Date of Patent: February 7, 2012Assignee: Optonol Ltd.Inventors: Oded Nissan, Jonathan Ben-Zvi, Ira Yaron
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Patent number: 8034016Abstract: A flow regulating implant is provided with one or more grooves for allowing fluid flow. One or more grooves may have a constant or varying cross-section along its length. One or more grooves may have in it biodegradable material, absorbable material, and/or threads or sutures. A resilient band or coating may be placed around the implant or one or more grooves, to act as a pressure regulator. The implant may have a side projection, such as a side pin, for engaging tissue. The implant may comprise two or more parts that are held at a distance from each other to allow fluid flow between the parts.Type: GrantFiled: December 7, 2007Date of Patent: October 11, 2011Assignee: Optonol, Ltd.Inventors: Ira Yaron, Elie Dahan
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Patent number: 7862531Abstract: A flow regulating implant is provided with one or more grooves for allowing fluid flow. One or more grooves may have a constant or varying cross-section along its length. One or more grooves may have in it biodegradable material, absorbable material, and/or threads or sutures. A resilient band or coating may be placed around the implant or one or more grooves, to act as a pressure regulator. The implant may have a side projection, such as a side pin, for engaging tissue. The implant may comprise two or more parts that are held at a distance from each other to allow fluid flow between the parts.Type: GrantFiled: June 25, 2004Date of Patent: January 4, 2011Assignee: Optonol Ltd.Inventors: Ira Yaron, Elie Dahan
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Publication number: 20100331975Abstract: A fiber matrix is provided for maintaining space in soft tissue, for example for use in procedures for assisting drainage of aqueous humor from an eye to treat glaucoma. The fiber matrix comprises a plurality of crossing fibers forming a mesh with a plurality of void spaces. The fibers and void spaces are sized and arranged so as to permit passage of fluid through the fiber matrix and to inhibit formation of scar tissue through the fiber matrix. The fibers may comprise a polymeric material, and the fiber matrix may be manufactured by electrospinning. The fibers may comprise a biostable and/or a biodegradable material. In one method of using a fiber matrix, the fiber matrix is positioned under a scleral flap, with at least part of the fiber matrix under the scleral flap.Type: ApplicationFiled: June 25, 2010Publication date: December 30, 2010Applicant: OPTONOL LTD.Inventors: Oded NISSAN, Ira YARON, Jonathan BEN-ZVI
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Publication number: 20100274259Abstract: The disclosure provides an intraocular implant for allowing fluid flow from the anterior chamber of an eye, the implant comprising a tube having an inlet end, an outlet end, and a tube passage, wherein the inlet end is adapted to extend into the anterior chamber of the eye, and wherein the outlet end is adapted to be implanted adjacent scleral tissue of the eye. The implant may be adapted to drain aqueous humor into a suprachoroidal space or a juxta-uveal space. The disclosure also provides associated delivery devices, methods of use, and methods of manufacture.Type: ApplicationFiled: March 26, 2010Publication date: October 28, 2010Applicant: OPTONOL LTD.Inventors: Ira YARON, Oded NISSAN, Gal GOREN
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Publication number: 20100185138Abstract: An implant includes a tube for permitting fluid flow. A flow controlling rod may be inserted within the tube passage. One or more holes around the circumference of the tube may be selectively permanently or temporarily occluded to give desired flow characteristics. A delivery device for implanting the implant may include a central bore in which a retractable wire is located. The retractable wire penetrates a tube passage of the implant. After the implant is in position in the eye, the retention wire is retracted out of the implant. In a method for manufacturing an implant, two tubes of different diameters are utilized. The smaller tube fits inside the longitudinal bore of the larger tube. When the tubes are cut, the smaller tube forms the tube of the implant and the remaining portions of the larger tube form the retention projection and/or disk of the implant.Type: ApplicationFiled: January 21, 2010Publication date: July 22, 2010Applicant: OPTONOL LTD.Inventors: Ira YARON, Orit YARDEN
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Patent number: 7670310Abstract: An implant includes a tube for permitting fluid flow. A flow controlling rod may be inserted within the tube passage. One or more holes around the circumference of the tube may be selectively permanently or temporarily occluded to give desired flow characteristics. A delivery device for implanting the implant may include a central bore in which a retractable wire is located. The retractable wire penetrates a tube passage of the implant when the implant is attached to the delivery device. A hook on the delivery device prevents the implant from moving down the wire. After the implant is in position in the eye, the retention wire is retracted out of the implant. With the retention wire retracted, the implant is then free to slide away from the hook, allowing the delivery device to be withdrawn, leaving the implant in place. In a method for manufacturing an implant, two tubes of different diameters are utilized. The smaller tube fits inside the longitudinal bore of the larger tube.Type: GrantFiled: December 7, 2007Date of Patent: March 2, 2010Assignee: Optonol LtdInventors: Ira Yaron, Orit Yarden
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Publication number: 20090204053Abstract: Devices and procedures for assisting drainage of aqueous humor from the eye are provided. In accordance with some embodiments, an implant sized to fit within the Schlemm's Canal is provided. The implant has a plurality of penetrating members having an unextended position in which the penetrating members lie generally close to the longitudinal axis of the implant and an extended position in which the penetrating members are extended outward. In use, the implant is advanced around at least a substantial portion of the Schlemm's Canal with the penetrating members in the first unextended position. After the implant is positioned within the Schlemm's Canal, the penetrating members are caused to move from the first unextended position to the second extended position, wherein the penetrating members penetrate the wall of the Schlemm's Canal. This creates fluid passageways in the wall of the Schlemm's Canal. The implant can also serve to keep the Schlemm's Canal open.Type: ApplicationFiled: February 11, 2008Publication date: August 13, 2009Applicant: OPTONOL LTD.Inventors: Oded Nissan, Jonathan Ben-Zvi, Ira Yaron
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Patent number: 7481816Abstract: An ophthalmic implant for treatment of glaucoma, a delivery device for implanting such an implant, and a method of implanting such an implant. The implant includes a tube having an inlet end, an outlet end, and a tube passage therebetween, and a flange connected to the tube at the outlet end of the tube. The tube at its inlet end may have a beveled surface facing away from the iris and one or more circumferential holes. The implant may be implanted by use of a delivery device comprising a handle and rodlike instrument,with a tip for insertion into the tube passage of the implant.Type: GrantFiled: October 27, 2003Date of Patent: January 27, 2009Assignee: Optonol Ltd.Inventors: Jacob Richter, Gregory Pinchasik, Ira Yaron
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Publication number: 20080125691Abstract: An implant includes a tube for permitting fluid flow. A flow controlling rod may be inserted within the tube passage. One or more holes around the circumference of the tube may be selectively permanently or temporarily occluded to give desired flow characteristics. A delivery device for implanting the implant may include a central bore in which a retractable wire is located. The retractable wire penetrates a tube passage of the implant when the implant is attached to the delivery device. A hook on the delivery device prevents the implant from moving down the wire. After the implant is in position in the eye, the retention wire is retracted out of the implant. With the retention wire retracted, the implant is then free to slide away from the hook, allowing the delivery device to be withdrawn, leaving the implant in place. In a method for manufacturing an implant, two tubes of different diameters are utilized. The smaller tube fits inside the longitudinal bore of the larger tube.Type: ApplicationFiled: December 7, 2007Publication date: May 29, 2008Applicant: OPTONOL LTD.Inventors: Ira Yaron, Orit Yarden
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Publication number: 20080077071Abstract: A flow regulating implant is provided with one or more grooves for allowing fluid flow. One or more grooves may have a constant or varying cross-section along its length. One or more grooves may have in it biodegradable material, absorbable material, and/or threads or sutures. A resilient band or coating may be placed around the implant or one or more grooves, to act as a pressure regulator. The implant may have a side projection, such as a side pin, for engaging tissue. The implant may comprise two or more parts that are held at a distance from each other to allow fluid flow between the parts.Type: ApplicationFiled: December 7, 2007Publication date: March 27, 2008Applicant: OPTONOL LTD.Inventors: Ira Yaron, Elie Dahan
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Patent number: 6726664Abstract: An implant having a tube for permitting fluid flow has an outer flange at the outlet end and a retention projection near the inlet end. A delivery device for implanting the implant has a central bore for accommodating the implant during the implantation procedure. When the implant is loaded in the delivery device, the retention projection of the implant protrudes beyond the outside surface of the delivery device. After the delivery device and implant have penetrated the tissue through which drainage is desired, and the retention projection has fully penetrated through the tissue, the delivery device is withdrawn. The retention projection acts as a hook engaging the inside surface of the tissue, causing the implant to stay implanted in the tissue. An implant may also be provided with a mechanism for temporary occlusion, in whole or in part, of the flow passage.Type: GrantFiled: August 6, 2001Date of Patent: April 27, 2004Assignee: Optonol Ltd.Inventors: Ira Yaron, Orit Yarden
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Publication number: 20030208163Abstract: An implant having a tube for permitting fluid flow has an outer flange at the outlet end and a retention projection near the inlet end. A delivery device for implanting the implant has a central bore for accommodating the implant during the implantation procedure. When the implant is loaded in the delivery device, the retention projection of the implant protrudes beyond the outside surface of the delivery device. After the delivery device and implant have penetrated the tissue through which drainage is desired, and the retention projection has fully penetrated through the tissue, the delivery device is withdrawn. The retention projection acts as a hook engaging the inside surface of the tissue, causing the implant to stay implanted in the tissue. An implant may also be provided with a mechanism for temporary occlusion, in whole or in part, of the flow passage.Type: ApplicationFiled: August 6, 2001Publication date: November 6, 2003Applicant: Optonol Ltd.Inventors: Ira Yaron, Orit Yarden
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Publication number: 20030093084Abstract: The disclosed delivery devices for flow regulating implants comprise a handle and a tube (such as a hollow needle or cannula), with a retractable wire extending through the tube. Prior to deployment, the wire extends a short distance out of the distal end of the tube. The flow regulating implant is mounted on the wire at the distal end of the tube; for example, the implant may have a central bore into which the wire extends. The implant may be held on the wire by friction, by a hook, or by other suitable means. The delivery device includes a trigger that acts on the retractable wire. Actuating the trigger retracts the wire into the tube, thereby releasing the implant.Type: ApplicationFiled: November 13, 2001Publication date: May 15, 2003Applicant: OPTONOL LTD.Inventors: Oded Nissan, Sagi Ben-Rimon, Ira Yaron