Patents Assigned to Optonol Ltd.
  • Patent number: 9173774
    Abstract: The disclosure provides an intraocular implant for allowing fluid flow from the anterior chamber of an eye, the implant comprising a tube having an inlet end, an outlet end, and a tube passage, wherein the inlet end is adapted to extend into the anterior chamber of the eye, and wherein the outlet end is adapted to be implanted adjacent scleral tissue of the eye. The implant may be adapted to drain aqueous humor into a suprachoroidal space or a juxta-uveal space. The disclosure also provides associated delivery devices, methods of use, and methods of manufacture.
    Type: Grant
    Filed: September 11, 2012
    Date of Patent: November 3, 2015
    Assignee: OPTONOL LTD.
    Inventors: Ira Yaron, Oded Nissan, Gal Goren
  • Patent number: 8961600
    Abstract: A fiber matrix is provided for maintaining space in soft tissue, for example for use in procedures for assisting drainage of aqueous humor from an eye to treat glaucoma. The fiber matrix comprises a plurality of crossing fibers forming a mesh with a plurality of void spaces. The fibers and void spaces are sized and arranged so as to permit passage of fluid through the fiber matrix and to inhibit formation of scar tissue through the fiber matrix. The fibers may comprise a polymeric material, and the fiber matrix may be manufactured by electrospinning. The fibers may comprise a biostable and/or a biodegradable material. In one method of using a fiber matrix, the fiber matrix is positioned under a scleral flap, with at least part of the fiber matrix under the scleral flap.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: February 24, 2015
    Assignee: Optonol Ltd.
    Inventors: Oded Nissan, Ira Yaron, Jonathan Ben-Zvi
  • Patent number: 8486086
    Abstract: An implant includes a tube for permitting fluid flow. A flow controlling rod may be inserted within the tube passage. One or more holes around the circumference of the tube may be selectively permanently or temporarily occluded to give desired flow characteristics. A delivery device for implanting the implant may include a central bore in which a retractable wire is located. The retractable wire penetrates a tube passage of the implant. After the implant is in position in the eye, the retention wire is retracted out of the implant. In a method for manufacturing an implant, two tubes of different diameters are utilized. The smaller tube fits inside the longitudinal bore of the larger tube. When the tubes are cut, the smaller tube forms the tube of the implant and the remaining portions of the larger tube form the retention projection and/or disk of the implant.
    Type: Grant
    Filed: November 7, 2011
    Date of Patent: July 16, 2013
    Assignee: Optonol, Ltd
    Inventors: Ira Yaron, Orit Yarden
  • Publication number: 20130006164
    Abstract: The disclosure provides an intraocular implant for allowing fluid flow from the anterior chamber of an eye, the implant comprising a tube having an inlet end, an outlet end, and a tube passage, wherein the inlet end is adapted to extend into the anterior chamber of the eye, and wherein the outlet end is adapted to be implanted adjacent scleral tissue of the eye. The implant may be adapted to drain aqueous humor into a suprachoroidal space or a juxta-uveal space. The disclosure also provides associated delivery devices, methods of use, and methods of manufacture.
    Type: Application
    Filed: September 11, 2012
    Publication date: January 3, 2013
    Applicant: OPTONOL LTD.
    Inventors: Ira YARON, Oded NISSAN, Gal GOREN
  • Patent number: 8313454
    Abstract: The disclosure provides an intraocular implant for allowing fluid flow from the anterior chamber of an eye, the implant comprising a tube having an inlet end, an outlet end, and a tube passage, wherein the inlet end is adapted to extend into the anterior chamber of the eye, and wherein the outlet end is adapted to be implanted adjacent scleral tissue of the eye. The implant may be adapted to drain aqueous humor into a suprachoroidal space or a juxta-uveal space. The disclosure also provides associated delivery devices, methods of use, and methods of manufacture.
    Type: Grant
    Filed: March 26, 2010
    Date of Patent: November 20, 2012
    Assignee: Optonol Ltd.
    Inventors: Ira Yaron, Oded Nissan, Gal Goren
  • Publication number: 20120053505
    Abstract: An implant includes a tube for permitting fluid flow. A flow controlling rod may be inserted within the tube passage. One or more holes around the circumference of the tube may be selectively permanently or temporarily occluded to give desired flow characteristics. A delivery device for implanting the implant may include a central bore in which a retractable wire is located. The retractable wire penetrates a tube passage of the implant. After the implant is in position in the eye, the retention wire is retracted out of the implant. In a method for manufacturing an implant, two tubes of different diameters are utilized. The smaller tube fits inside the longitudinal bore of the larger tube. When the tubes are cut, the smaller tube forms the tube of the implant and the remaining portions of the larger tube form the retention projection and/or disk of the implant.
    Type: Application
    Filed: November 7, 2011
    Publication date: March 1, 2012
    Applicant: OPTONOL LTD.
    Inventors: Ira YARON, Orit YARDEN
  • Patent number: 8109896
    Abstract: Devices and procedures for assisting drainage of aqueous humor from the eye are provided. In accordance with some embodiments, an implant sized to fit within the Schlemm's Canal is provided. The implant has a plurality of penetrating members having an unextended position in which the penetrating members lie generally close to the longitudinal axis of the implant and an extended position in which the penetrating members are extended outward. In use, the implant is advanced around at least a substantial portion of the Schlemm's Canal with the penetrating members in the first unextended position. After the implant is positioned within the Schlemm's Canal, the penetrating members are caused to move from the first unextended position to the second extended position, wherein the penetrating members penetrate the wall of the Schlemm's Canal. This creates fluid passageways in the wall of the Schlemm's Canal. The implant can also serve to keep the Schlemm's Canal open.
    Type: Grant
    Filed: February 11, 2008
    Date of Patent: February 7, 2012
    Assignee: Optonol Ltd.
    Inventors: Oded Nissan, Jonathan Ben-Zvi, Ira Yaron
  • Patent number: 8034016
    Abstract: A flow regulating implant is provided with one or more grooves for allowing fluid flow. One or more grooves may have a constant or varying cross-section along its length. One or more grooves may have in it biodegradable material, absorbable material, and/or threads or sutures. A resilient band or coating may be placed around the implant or one or more grooves, to act as a pressure regulator. The implant may have a side projection, such as a side pin, for engaging tissue. The implant may comprise two or more parts that are held at a distance from each other to allow fluid flow between the parts.
    Type: Grant
    Filed: December 7, 2007
    Date of Patent: October 11, 2011
    Assignee: Optonol, Ltd.
    Inventors: Ira Yaron, Elie Dahan
  • Patent number: 7862531
    Abstract: A flow regulating implant is provided with one or more grooves for allowing fluid flow. One or more grooves may have a constant or varying cross-section along its length. One or more grooves may have in it biodegradable material, absorbable material, and/or threads or sutures. A resilient band or coating may be placed around the implant or one or more grooves, to act as a pressure regulator. The implant may have a side projection, such as a side pin, for engaging tissue. The implant may comprise two or more parts that are held at a distance from each other to allow fluid flow between the parts.
    Type: Grant
    Filed: June 25, 2004
    Date of Patent: January 4, 2011
    Assignee: Optonol Ltd.
    Inventors: Ira Yaron, Elie Dahan
  • Publication number: 20100331975
    Abstract: A fiber matrix is provided for maintaining space in soft tissue, for example for use in procedures for assisting drainage of aqueous humor from an eye to treat glaucoma. The fiber matrix comprises a plurality of crossing fibers forming a mesh with a plurality of void spaces. The fibers and void spaces are sized and arranged so as to permit passage of fluid through the fiber matrix and to inhibit formation of scar tissue through the fiber matrix. The fibers may comprise a polymeric material, and the fiber matrix may be manufactured by electrospinning. The fibers may comprise a biostable and/or a biodegradable material. In one method of using a fiber matrix, the fiber matrix is positioned under a scleral flap, with at least part of the fiber matrix under the scleral flap.
    Type: Application
    Filed: June 25, 2010
    Publication date: December 30, 2010
    Applicant: OPTONOL LTD.
    Inventors: Oded NISSAN, Ira YARON, Jonathan BEN-ZVI
  • Publication number: 20100274259
    Abstract: The disclosure provides an intraocular implant for allowing fluid flow from the anterior chamber of an eye, the implant comprising a tube having an inlet end, an outlet end, and a tube passage, wherein the inlet end is adapted to extend into the anterior chamber of the eye, and wherein the outlet end is adapted to be implanted adjacent scleral tissue of the eye. The implant may be adapted to drain aqueous humor into a suprachoroidal space or a juxta-uveal space. The disclosure also provides associated delivery devices, methods of use, and methods of manufacture.
    Type: Application
    Filed: March 26, 2010
    Publication date: October 28, 2010
    Applicant: OPTONOL LTD.
    Inventors: Ira YARON, Oded NISSAN, Gal GOREN
  • Publication number: 20100185138
    Abstract: An implant includes a tube for permitting fluid flow. A flow controlling rod may be inserted within the tube passage. One or more holes around the circumference of the tube may be selectively permanently or temporarily occluded to give desired flow characteristics. A delivery device for implanting the implant may include a central bore in which a retractable wire is located. The retractable wire penetrates a tube passage of the implant. After the implant is in position in the eye, the retention wire is retracted out of the implant. In a method for manufacturing an implant, two tubes of different diameters are utilized. The smaller tube fits inside the longitudinal bore of the larger tube. When the tubes are cut, the smaller tube forms the tube of the implant and the remaining portions of the larger tube form the retention projection and/or disk of the implant.
    Type: Application
    Filed: January 21, 2010
    Publication date: July 22, 2010
    Applicant: OPTONOL LTD.
    Inventors: Ira YARON, Orit YARDEN
  • Patent number: 7670310
    Abstract: An implant includes a tube for permitting fluid flow. A flow controlling rod may be inserted within the tube passage. One or more holes around the circumference of the tube may be selectively permanently or temporarily occluded to give desired flow characteristics. A delivery device for implanting the implant may include a central bore in which a retractable wire is located. The retractable wire penetrates a tube passage of the implant when the implant is attached to the delivery device. A hook on the delivery device prevents the implant from moving down the wire. After the implant is in position in the eye, the retention wire is retracted out of the implant. With the retention wire retracted, the implant is then free to slide away from the hook, allowing the delivery device to be withdrawn, leaving the implant in place. In a method for manufacturing an implant, two tubes of different diameters are utilized. The smaller tube fits inside the longitudinal bore of the larger tube.
    Type: Grant
    Filed: December 7, 2007
    Date of Patent: March 2, 2010
    Assignee: Optonol Ltd
    Inventors: Ira Yaron, Orit Yarden
  • Publication number: 20090204053
    Abstract: Devices and procedures for assisting drainage of aqueous humor from the eye are provided. In accordance with some embodiments, an implant sized to fit within the Schlemm's Canal is provided. The implant has a plurality of penetrating members having an unextended position in which the penetrating members lie generally close to the longitudinal axis of the implant and an extended position in which the penetrating members are extended outward. In use, the implant is advanced around at least a substantial portion of the Schlemm's Canal with the penetrating members in the first unextended position. After the implant is positioned within the Schlemm's Canal, the penetrating members are caused to move from the first unextended position to the second extended position, wherein the penetrating members penetrate the wall of the Schlemm's Canal. This creates fluid passageways in the wall of the Schlemm's Canal. The implant can also serve to keep the Schlemm's Canal open.
    Type: Application
    Filed: February 11, 2008
    Publication date: August 13, 2009
    Applicant: OPTONOL LTD.
    Inventors: Oded Nissan, Jonathan Ben-Zvi, Ira Yaron
  • Patent number: 7481816
    Abstract: An ophthalmic implant for treatment of glaucoma, a delivery device for implanting such an implant, and a method of implanting such an implant. The implant includes a tube having an inlet end, an outlet end, and a tube passage therebetween, and a flange connected to the tube at the outlet end of the tube. The tube at its inlet end may have a beveled surface facing away from the iris and one or more circumferential holes. The implant may be implanted by use of a delivery device comprising a handle and rodlike instrument,with a tip for insertion into the tube passage of the implant.
    Type: Grant
    Filed: October 27, 2003
    Date of Patent: January 27, 2009
    Assignee: Optonol Ltd.
    Inventors: Jacob Richter, Gregory Pinchasik, Ira Yaron
  • Publication number: 20080125691
    Abstract: An implant includes a tube for permitting fluid flow. A flow controlling rod may be inserted within the tube passage. One or more holes around the circumference of the tube may be selectively permanently or temporarily occluded to give desired flow characteristics. A delivery device for implanting the implant may include a central bore in which a retractable wire is located. The retractable wire penetrates a tube passage of the implant when the implant is attached to the delivery device. A hook on the delivery device prevents the implant from moving down the wire. After the implant is in position in the eye, the retention wire is retracted out of the implant. With the retention wire retracted, the implant is then free to slide away from the hook, allowing the delivery device to be withdrawn, leaving the implant in place. In a method for manufacturing an implant, two tubes of different diameters are utilized. The smaller tube fits inside the longitudinal bore of the larger tube.
    Type: Application
    Filed: December 7, 2007
    Publication date: May 29, 2008
    Applicant: OPTONOL LTD.
    Inventors: Ira Yaron, Orit Yarden
  • Publication number: 20080077071
    Abstract: A flow regulating implant is provided with one or more grooves for allowing fluid flow. One or more grooves may have a constant or varying cross-section along its length. One or more grooves may have in it biodegradable material, absorbable material, and/or threads or sutures. A resilient band or coating may be placed around the implant or one or more grooves, to act as a pressure regulator. The implant may have a side projection, such as a side pin, for engaging tissue. The implant may comprise two or more parts that are held at a distance from each other to allow fluid flow between the parts.
    Type: Application
    Filed: December 7, 2007
    Publication date: March 27, 2008
    Applicant: OPTONOL LTD.
    Inventors: Ira Yaron, Elie Dahan
  • Patent number: 6726664
    Abstract: An implant having a tube for permitting fluid flow has an outer flange at the outlet end and a retention projection near the inlet end. A delivery device for implanting the implant has a central bore for accommodating the implant during the implantation procedure. When the implant is loaded in the delivery device, the retention projection of the implant protrudes beyond the outside surface of the delivery device. After the delivery device and implant have penetrated the tissue through which drainage is desired, and the retention projection has fully penetrated through the tissue, the delivery device is withdrawn. The retention projection acts as a hook engaging the inside surface of the tissue, causing the implant to stay implanted in the tissue. An implant may also be provided with a mechanism for temporary occlusion, in whole or in part, of the flow passage.
    Type: Grant
    Filed: August 6, 2001
    Date of Patent: April 27, 2004
    Assignee: Optonol Ltd.
    Inventors: Ira Yaron, Orit Yarden
  • Publication number: 20030208163
    Abstract: An implant having a tube for permitting fluid flow has an outer flange at the outlet end and a retention projection near the inlet end. A delivery device for implanting the implant has a central bore for accommodating the implant during the implantation procedure. When the implant is loaded in the delivery device, the retention projection of the implant protrudes beyond the outside surface of the delivery device. After the delivery device and implant have penetrated the tissue through which drainage is desired, and the retention projection has fully penetrated through the tissue, the delivery device is withdrawn. The retention projection acts as a hook engaging the inside surface of the tissue, causing the implant to stay implanted in the tissue. An implant may also be provided with a mechanism for temporary occlusion, in whole or in part, of the flow passage.
    Type: Application
    Filed: August 6, 2001
    Publication date: November 6, 2003
    Applicant: Optonol Ltd.
    Inventors: Ira Yaron, Orit Yarden
  • Publication number: 20030093084
    Abstract: The disclosed delivery devices for flow regulating implants comprise a handle and a tube (such as a hollow needle or cannula), with a retractable wire extending through the tube. Prior to deployment, the wire extends a short distance out of the distal end of the tube. The flow regulating implant is mounted on the wire at the distal end of the tube; for example, the implant may have a central bore into which the wire extends. The implant may be held on the wire by friction, by a hook, or by other suitable means. The delivery device includes a trigger that acts on the retractable wire. Actuating the trigger retracts the wire into the tube, thereby releasing the implant.
    Type: Application
    Filed: November 13, 2001
    Publication date: May 15, 2003
    Applicant: OPTONOL LTD.
    Inventors: Oded Nissan, Sagi Ben-Rimon, Ira Yaron