Patents Assigned to Orchid Chemical & Pharmaceuticals Limited
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Patent number: 8129536Abstract: The present invention relates to an improved process for the preparation of Lansoprazole of formula (I). More particularly, the present invention relates to a method for the purification of crude Lansoprazole in a solvent in presence of an alkali salt of an organic acid or in presence of an organic base such as piperidine or imidazole.Type: GrantFiled: September 21, 2007Date of Patent: March 6, 2012Assignee: Orchid Chemicals & Pharmaceuticals LimitedInventors: Thangavel Arulmoli, Siripragada Mahender Rao, Krishna Sumanth Peraka, Ariyamuthu Sundara Selvan
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Publication number: 20110136777Abstract: Polymorphs of Ceftiofur sodium as a crystalline product and a process for the preparation of polymorphs of crystalline Ceftiofur sodium of formula (I).Type: ApplicationFiled: August 20, 2009Publication date: June 9, 2011Applicant: Orchid Chemicals and Pharmaceuticals LimitedInventors: Senthilkumar Udayampalayam Palanisamy, Sivakumar Balasubramanian, Manimaran Arasappan, Meenakshi Sundaram Soma Sundaram, Sureshkumar Kanagaraj, Mohan Singaravel
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Publication number: 20110059933Abstract: The present invention relates to novel polymorph of Ceftiofur sodium as a crystalline product. The present invention also provides a process for the preparation of novel polymorphs of crystalline Ceftiofur sodium of formula (I).Type: ApplicationFiled: October 13, 2010Publication date: March 10, 2011Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LIMITEDInventors: Sureshkumar KANAGARAJ, Sivakumar BALASUBRAMANIAN, Senthilkumar UDAYAMPALAYAM PALANISAMY
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Publication number: 20100311984Abstract: An improved process for the preparation of carbapenem antibiotic of formula (I) or its hydrate is provided.Type: ApplicationFiled: September 30, 2008Publication date: December 9, 2010Applicant: Orchid Chemicals & Pharmaceuticals LimitedInventors: Senthilkumar Udayampalayam Palanisamy, Mohan Singaravel, Vignesh Babu Heeralal
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Publication number: 20100298566Abstract: A process for the preparation of a psychotropic agent Paliperidone. Preferably, this invention relates to a method for the purification of Paliperidone by making its acid addition salts.Type: ApplicationFiled: November 7, 2008Publication date: November 25, 2010Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LIMITEDInventors: Arulmoli Thangavel, Arunagiri Muthulingam, Thirugnanasambandan Shanmuganathan, Rengasamy Vadivelan, Gurusamy Kasiyappan Saravanakumar, Rao Siripragada Mahender
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Publication number: 20100292341Abstract: The present invention relates to quick dissolve pharmaceutical compositions. More particularly the invention relates to quick dissolve pharmaceutical compositions of memantine hydrochloride capable of dissolving in the oral cavity and process for preparing such compositions. The quick dissolve pharmaceutical compositions of memantine hydrochloride contain at least one water-soluble diluent in particular a mono- or disaccharide and at least one disintegrant and optionally other pharmaceutically acceptable excipients.Type: ApplicationFiled: June 26, 2008Publication date: November 18, 2010Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LIMITEDInventors: Ramakrishnan Sankar, Chidambaram Seshadri Venkateswaran, Praveen Reddy Billa
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Publication number: 20100267968Abstract: The present invention relates to an improved process for the preparation of Duloxetine and its intermediates (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine by reacting (S)-(+)-N,N-dimethyl-3-(2-thienyl)-3-hydroxypropanamine with 1-fluoronaphthalene in the presence of a base; wherein the improvement lies in conducting the reaction in the absence of solvent.Type: ApplicationFiled: December 26, 2008Publication date: October 21, 2010Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LIMITEDInventors: Mahender Rao Siripragada, Arulmoli Thangavel, Muthulingham Arunagiri, Prasadachari Yarroju, Kiranmye Tayyala
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Patent number: 7741478Abstract: Compounds of general formula (II), wherein R1 represents R4 represents hydrogen or —CHO group, R5 represents hydrogen or trityl, R2 represents hydrogen or methoxy group, R3 represents —CH?CH2 or and M represents a dialkyl or dicycloalkyl ethylenediamine group selected from N,N?-diisobutylethylenediamine, N,N?-dicyclohexylethylenediamine, and N,N?-dicyclopentylethylenediamine, are useful in a process to make cephalosporin antibiotics of formula (I) wherein R represents hydrogen or pharmaceutically acceptable esters or alkali metals salts.Type: GrantFiled: July 4, 2005Date of Patent: June 22, 2010Assignee: Orchid Chemicals & Pharmaceuticals LimitedInventors: Udayampalayam Palanisamy Senthilkumar, Venu Sanjeevi Lakshmipathi, Gnanaprakasam Andrew, Ramasubbu Chandrasekaran, Dindigala Nagender Rao, Gaddam Om Reddy
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Patent number: 7667034Abstract: This invention relates to an improved process for the industrial manufacture of S-adenosyl-L-methionine (SAMe) of formula (I), which consists of stereo-selective methylation of S-adenosyl-L-homocysteine (SAH) with the enrichment of active (S,S)-isomer.Type: GrantFiled: June 22, 2005Date of Patent: February 23, 2010Assignee: Orchid Chemicals & Pharmaceuticals LimitedInventors: Udayampalayam Palanisamy Senthilkumar, Ramar Padmanabhan, Venugopal Sivasankaran, Singaravel Mohan
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Publication number: 20100010230Abstract: The present invention relates to an improved process for the preparation of Lansoprazole of formula (I). More particularly, the present invention relates to a method for the purification of crude Lansoprazole in a solvent in presence of an alkali salt of an organic acid or in presence of an organic base such as piperidine or imidazole.Type: ApplicationFiled: September 21, 2007Publication date: January 14, 2010Applicant: Orchid Chemicals & Pharmaceuticals LimitedInventors: Thangavel Arulmoli, Siripragada Mahender Rao, Krishna Sumanth Peraka, Ariyamuthu Sundara Selvan
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Publication number: 20090312539Abstract: The present invention provides a process for the preparation of the carbapenem antibiotic of formula (I) or its salt in amorphous form. Formula (I) wherein R represents hydrogen or COOM and M represents hydrogen or sodium.Type: ApplicationFiled: November 20, 2007Publication date: December 17, 2009Applicant: Orchid Chemicals & Pharmaceuticals LimitedInventors: Andrew Gnanaprakasam, Nagappan Arumugam, Palanisamy Senthilkumar Udayampalayam, Pandi Suresh Pandian, Venugopal Sivasankaran, Ganapathy Veeramani, Henry Syril Sudhan, Gollapalli Venkateswara Rao
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Publication number: 20090143614Abstract: The present invention relates to an improved process for the preparation of Cilastatin Sodium of formula (I). The present invention also provides an isolation technique for Cilastatin acid from the reaction mixture.Type: ApplicationFiled: November 3, 2006Publication date: June 4, 2009Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LIMITED ORCHID TOWERSInventors: Ganapathy Panchapakesan, Nagappan Arumugam, Pandi Suresh Pandian, Gollapalli Venkateswara Rao, Subramaniam Ganesan
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Publication number: 20090093423Abstract: Novel 2-substituted methyl penam derivatives include the formula (I), their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their solvates, their pharmaceutically acceptable salts, and pharmaceutical compositions containing them; wherein A=C or N; Het is a three- to seven-membered heterocyclic ring; R1 represents carboxylate anion, or —COOR4 where R4 represents hydrogen, carboxylic acid protecting group or a pharmaceutically acceptable salt; R2 and R3 may be same or different and independently represent hydrogen, halogen, amino, alkyl, protected amino, optionally substituted alkyl, alkenyl, alkynyl and the like; R represents substituted or unsubstituted alkyl, alkenyl, aryl, aralkyl, cycloalkyl, heterocyclyl or heterocyclylalkyl.Type: ApplicationFiled: July 11, 2007Publication date: April 9, 2009Applicant: Orchid Chemicals and Pharmaceuticals LimitedInventors: Senthilkumar UDAYAMPALAYAMPALANISAMY, Andrew GNANAPRAKASAM, Panchapakesan GANAPATHY, Mukut GOHAIN, Venkatasubramanian HARIHARAN, Sriram RAJAGOPAL, Maneesh PAUL-SATYASEELA, Shakti SINGH SOLANKI, Sathishkumar DEVARAJAN
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Publication number: 20080306256Abstract: The present invention relates to an improved process for the preparation of cephalosporin antibiotics of formula (I). The present invention also provides new salts of compound of formula (II) and a process for the preparation of these new salts, where n=0.5 to 2. The present invention also provides a process for the preparation of compound of formula (I) using the new salts of formula (II).Type: ApplicationFiled: July 4, 2005Publication date: December 11, 2008Applicant: Orchid Chemicals & Pharmaceuticals LimitedInventors: Udayampalayam P. Senthilkumar, Venu S. Lakshmipathi, Gnanaprakasam Andrew, Ramasubbu Chandrasekaran, Dindigala Nagender Rao, Gaddam Om Reddy
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Publication number: 20080221076Abstract: The present invention relates to novel polymorph of Ceftiofur sodium as a crystalline product. The present invention also provides a process for the preparation of crystalline Ceftiofur sodium of formula (I).Type: ApplicationFiled: October 12, 2006Publication date: September 11, 2008Applicant: ORCHID CHEMICALS AND PHARMACEUTICALS LIMITEDInventors: Udayampalayam Palanisamy Senthilkumar, Kanagaraj Suresh Kumar, Singaravel Mohan, Lakshminarayanan Arunkumar, Bakthavachalam Ananthan
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Patent number: 7417143Abstract: An improved process for the purification of tazobactam or its derivatives of the formula (I) wherein R represents hydrogen, C1-C6alkyl, p-methoxybenzyl, o-nitrobenzyl, p-nitrobenzyl, o-chlorobenzyl, benzyl or diphenylmethyl, which comprises the steps of: i) slurrying the compound of formula (I) containing the impurity of the formula (V) using a solvent in the presence or absence of tartaric acid with or without the presence of water at 20-50° C. and ii) isolating the compound of formula (I) in pure form.Type: GrantFiled: April 5, 2005Date of Patent: August 26, 2008Assignee: Orchid Chemicals & Pharmaceuticals LimitedInventors: Andrew Gnanaprakasam, Udayampalayam Palanisamy Senthilkumar, Gaddam Om Reddy
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Publication number: 20080103303Abstract: This invention relates to an improved process for the industrial manufacture of S-adenosyl-L-methionine (SAMe) of formula (I), which consists of stereo-selective methylation of S-adenosyl-L-homocysteine (SAH) with the enrichment of active (S,S)-isomer.Type: ApplicationFiled: June 22, 2005Publication date: May 1, 2008Applicant: Orchid Chemicals & Pharmaceuticals LimitedInventors: Udayampalayam Palanisamy Senthilkumar, Ramar Padmanabhan, Venugopal Sivasankaran, Singaravel Mohan
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Publication number: 20070167414Abstract: The present invention provides novel compounds of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The present invention more particularly provides novel oxazolidinone derivatives of the general formula (I).Type: ApplicationFiled: March 30, 2007Publication date: July 19, 2007Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LIMITEDInventors: Shiv Agarwal, Mrinal Guha, Surendrakumar Pandey, Matte Samuel
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Patent number: 7217726Abstract: The present invention provides novel compounds of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them.Type: GrantFiled: August 21, 2003Date of Patent: May 15, 2007Assignee: Orchid Chemicals & Pharmaceuticals LimitedInventors: Shiv Kumar Agarwal, Mrinal Kanti Guha, Surendrakumar Satyanarayan Pandey, Matte Marianna Samuel
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Publication number: 20060009639Abstract: An improved process for the preparation of cefpodoxime proxetil of the formula (I) the said process comprises reacting cefpodoxime acid with 1-haloethyl isopropyl carbonate of the formula (VI) where X represents halogen atom such as chlorine, bromine or iodine using a base such as tetramethylguanidine, di-isopropylethyl amine, 1,5-diazabicyclo(4.3.0)non-5-ene (DBN), 1,4-diazabicyclo[2.2.2]octane (DABCO) in the presence of a solvent at a temperature in the range of ?30 ° C. to 30 ° C. to produce cefpodoxime proxetil of the formula (I) and isolating the pure cefpodoxime proxetil of the formula (I).Type: ApplicationFiled: November 19, 2003Publication date: January 12, 2006Applicant: Orchid Chemicals & Pharmaceuticals LimitedInventors: Pandurang Deshpande, Gautam Das, Parven Luthra, Pramod Deshpande, Selvraj Subramanian, Ramakrishna Kamma