Patents Assigned to Orchid Chemical & Pharmaceuticals Limited
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Patent number: 6936711Abstract: The present invention relates to a process for preparing 2?-methyl-2?-substituted methyl penam derivatives from cepham derivatives, more particularly the present invention provides a novel process for preparing 2?-heterocyclyl methyl penam derivatives of the formula (I) by reacting a cepham compound with a heterocylic amine to form an intermediate compound, and oxidizing the intermediate compound to produce the 2?-heterocyclyl methyl penam derivatives of the formula (I), wherein R1 represents carboxylic acid protecting group; R2 and R3 may be same or different and independently represent hydrogen, halogen, NH2, acylamino, phthalimido with a proviso that both R2 and R3 are not NH2, acylamino, phthalimido; Het represents a 5 or 6 membered nitrogen containing heterocycle ring system having one or more heteroatoms selected from O, S, or N.Type: GrantFiled: December 4, 2002Date of Patent: August 30, 2005Assignee: Orchid Chemicals and Pharmaceuticals LimitedInventors: Pandurang Balwant Deshpande, Senthil Kumar Udayampalayam Palanisamy, Gnanaprakasam Andrew
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Patent number: 6919449Abstract: The present invention relates to a method for the preparation of cephalosporin antibiotic of the formula (II), which comprises hydrolyzing and halogenating the ester of formula (III) by photochemical irradiation in one pot using a halogenating agent in the absence or presence of a solvent, to produce compound of formula (I), activating the 4-halogeno-2-substitutedimino-3-oxo-butyric acid of formula (I) using conventional activation agents gives compound of formula (IV), condensing the activated compound of the formula (IV) with 7-amino cephem derivative of the formula (V) to produce a compound of formula (VI), and cyclizing the compound of formula (VI) with thiourea to give cephalosporin compounds of the formula (II).Type: GrantFiled: September 18, 2002Date of Patent: July 19, 2005Assignee: Orchid Chemicals and Pharmaceuticals LimitedInventors: Pandurang Balwant Deshpande, Parven Kumar Luthra, Pratik Ramesh Sathe, Sivakumaran Sundaravadivelan, Praveen Nagesh Ganesh
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Patent number: 6903211Abstract: The present invention relates to an improved process for the preparation of cefprozil DMF solvate of formula (I), which is useful for the preparation of cefprozil, comprising: i) reacting a compound of formula (VIII) with acetaldehyde to produce a compound of formula (IX), ii) deesterifying the carboxy protecting group of the compound of formula (IX) using an acid to yield a compound of formula (X), iii) converting the compound of formula (X) to a compound of formula (XI), iv) neutralizing the compound of formula (XI) followed by enzymatic hydrolysis to produce an APCA of formula (V), v) silylating the APCA using a mixture of trimethylsilylchloride and hexamethyldisilazane to produce silylated APCA of formula (XII), and vi) condensing the silylated APCA with a mixed anhydride to produce the DMF solvate compound of formula (I).Type: GrantFiled: December 10, 2002Date of Patent: June 7, 2005Assignee: Orchid Chemicals & Pharmaceuticals LimitedInventors: Pandurang Balwant Deshpande, Bhausaheb Pandharinath Khadangale, Kumar Gurusamy, Ramesh Athmaram Konda
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Patent number: 6844471Abstract: A method of converting (Z)-1-(3,5-disubstituted phenyl)-2-(4-substituted phenyl)ethene of general formula (II) to (E)-1-(3,5-disubstituted phenyl)-2-(4-substituted phenyl)ethene of general formula (I) wherein R1, R2, and R3 are the same or different and independently represent (C1-C4)alkyl, (C1-C4)alkoxy(C1-C4)alkyl, (C1-C4)alkoxy(C1-C4)alkoxy(C1-C4)alkyl, allyl, vinyl, silyl, formyl, acyl, aryl(C1-C4)alkyl or substituted aryl(C1-C4)alkyl group. The present invention also provides a process for the conversion of (E)-(3,5-disubstituted phenyl-2-(4-substituted phenyl)ethene of general formula (I) to E-resveratrol of formula (III).Type: GrantFiled: December 5, 2002Date of Patent: January 18, 2005Assignee: Orchid Chemicals and Pharmaceuticals LimitedInventors: Pandurang Balwant Deshpande, Senthil Kumar Udayampalayam Palanisamy, Gnanaprakasam Andrew
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Publication number: 20040259891Abstract: The present invention relates to novel pyrimidones of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The present invention more particularly novel pyrimidones of the general formula (I).Type: ApplicationFiled: April 20, 2004Publication date: December 23, 2004Applicant: Orchid Chemical & Pharmaceuticals LimitedInventors: Shiv Kumar Agarwal, Ravikumar Tadiparthi, Pawan Aggarwal, Savithiri Shivakumar, Debendranath Dey, Biswajit Nag
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Patent number: 6833459Abstract: The present invention provides a process for the preparation of 4-methyl-5-formyl-thiazole of the formula (I) which comprises reducing the thiazole ester of the formula (III) to thiazole alcohol of the formula (IV), using sodium borohydride in the presence of AlCl3 in a solvent and oxidising using an oxidizing agent the thiazole alcohol of the formula (IV) to obtain 4-methyl-5-formyl-thiazole of the formula (I).Type: GrantFiled: December 5, 2002Date of Patent: December 21, 2004Assignee: Orchid Chemicals & Pharmaceuticals LimitedInventors: Pandurang Balwant Deshpande, Parven Kumar Luthra, Rajesh Vyas, Ramakrishna Kamma
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Patent number: 6803461Abstract: The present invention relates to a process for preparation of 7-amino-3-[2-(furylcarbonyl)thiomethyl]-3-cephem-4-carboxylic acid (I) by the condensation of 7-aminocephalosporanic acid (II) with furyl-2-carbonylthiol (III) in the presence of borontrifluoride or its complex, in an organic solvent or mixture of solvents at 0-50° C.Type: GrantFiled: August 1, 2002Date of Patent: October 12, 2004Assignee: Orchid Chemicals and Pharmaceuticals LimitedInventors: Pramod Narayan Deshpande, Bhausaheb Pandharinath Khadangale, Surulichamy Senthil Kumar, Gautam Kumar Das
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Patent number: 6800755Abstract: The present invention provides an improved process for the preparation of cefixime of formula (I), with an improved quality having/possessing better color and solubility: the process includes the steps of dissolving the compound of formula (II) in water/water immisible solvent using sodium bicarbonate at a temperature in the range of 0° C. to the 35° C., hydrolyzing with sodium hydroxide at a temperature in the range of 0° C. to 25° C., and acidifying the resultant mass to 2.3 to 3.0 with dilute acid in the presence or absence of solvent at a temperature in the range of 10° C. to 45° C.Type: GrantFiled: December 5, 2002Date of Patent: October 5, 2004Assignee: Orchid Chemicals and Pharmaceuticals LimitedInventors: Pandurang Balwant Deshpande, Gautam Kumar Das, Pramod Narayan Deshpande, Ramasubbu Chandrasekaran, Padmanabhan Ramar, John Muthiah Raja Jeyakumar
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Publication number: 20040096496Abstract: Sustained release pharmaceutical compositions comprising at least a cephalosporin antibiotic, a mixture of polymers comprising of galactomannans and neutral swellable polymers, and other pharmaceutically acceptable excipients are described. The composition comprises about 30% to about 90% by weight of a cephalosporin antibiotic; about 1% to about 30% by weight of said mixture of polymers comprising from about 0.1% to about 15% by weight of galactomannans, and about 0.1% to about 15% of neutral swellable polymer by weight of sustained release composition.Type: ApplicationFiled: August 18, 2003Publication date: May 20, 2004Applicant: Orchid Chemicals & Pharmaceuticals LimitedInventors: Rajesh Suresh Kshirsagar, Sanjay Parbhatrao Boldhane, Kour Chand Jindal
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Publication number: 20040092735Abstract: The present invention relates to an improved process for the preparation of the sterile cefuroxime sodium of formula (I).Type: ApplicationFiled: December 5, 2002Publication date: May 13, 2004Applicant: Orchid Chemicals & Pharmaceuticals LimitedInventors: Pandurang Balwant Deshpande, Pramod Narayan Deshpande, Bhausaheb Pandharinath Khadangale, Gautam Kumar Das, John Muthiah Raja Jeyakumar
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Publication number: 20040087786Abstract: The present invention relates to an improved process for the preparation of 3-propenyl cephalosporin DMF solvate, more particularly, the present invention relates to an improved process for the preparation of cefprozil DMF solvate of the formula (I), which is useful for the preparation of cefprozil of the formula (XIV).Type: ApplicationFiled: December 10, 2002Publication date: May 6, 2004Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LIMITEDInventors: Pandurang Balwant Deshpande, Bhausaheb Pandharinath Khadangale, Kumar Gurusamy, Ramesh Athmaram Konda
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Publication number: 20040082560Abstract: The present invention provides an improved process for the preparation of cefixime of formula (I), with an improved quality having/possessing better color and solubility.Type: ApplicationFiled: December 5, 2002Publication date: April 29, 2004Applicant: ORCHID CHEMICALS AND PHARMACEUTICALS LIMITEDInventors: Pandurang Balwant Deshpande, Gautam Kumar Das, Pramod Narayan Deshpande, Ramasubbu Chandrasekaran, Padmanabhan Ramar, John Muthiah Raja Jeyakumar
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Publication number: 20040077849Abstract: The present invention relates to an improved process for the preparation of cefadroxil of the formula (I), more particularly, the present invention relates to an improved process for the preparation of cefadroxil having water content in the range of 4-5%.Type: ApplicationFiled: December 5, 2002Publication date: April 22, 2004Applicant: Orchid Chemicals & Pharmaceuticals LimitedInventors: Pramod Narayan Deshpande, Gautam Kumar Das, Rajendra Janardan Sarangdhar, Peter Xavier Tharial
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Publication number: 20040015020Abstract: A method of converting (Z)-1-(3,5-disubstituted phenyl)-2-(4-substituted phenyl)ethene of general formula (II) to (E)-1-(3,5-disubstituted phenyl)-2-(4-substituted phenyl)ethene of general formula (I) 1Type: ApplicationFiled: December 5, 2002Publication date: January 22, 2004Applicant: ORCHID CHEMICALS AND PHARMACEUTICALS LIMITEDInventors: Pandurang Balwant Deshpande, Senthil Kumar Udayampalayam Palanisamy, Gnanaprakasam Andrew
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Publication number: 20040009975Abstract: Pyrimidinedione derivatives of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them are useful for the treatment of inflammation and immunological diseases.Type: ApplicationFiled: April 9, 2003Publication date: January 15, 2004Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LIMITEDInventors: Shiv Kumar Agarwal, Ravikumar Tadiparthi, Pawan Aggarwal, Savithiri Shivakumar
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Publication number: 20040002600Abstract: The present invention relates to a new process for the preparation of cephalosporin derivative of formula (I) 1Type: ApplicationFiled: July 30, 2002Publication date: January 1, 2004Applicant: Orchid Chemicals and Pharmaceuticals LimitedInventors: Pandurang Balwant Deshpande, Senthilkumar Udayampalayam Palanisamy, Padmanabhan Ramar
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Publication number: 20030232983Abstract: The present invention relates to a process for preparing 2&agr;-methyl-2&bgr;-substituted methyl penam derivatives from cepham derivatives, more particularly the present invention provides a novel process for preparing 2&bgr;-heterocyclyl methyl penam derivatives of the formula (I) 1Type: ApplicationFiled: December 4, 2002Publication date: December 18, 2003Applicant: Orchid Chemicals and Pharmaceuticals LimitedInventors: Pandurang Balwant Deshpande, Senthil Kumar Udayampalayam Palanisamy, Gnanaprakasam Andrew
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Publication number: 20030232813Abstract: The present invention relates to novel amino substituted pyrimidinone derivatives of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The present invention more particularly provides novel amino substituted pyrimidinone derivatives of the general formula (I) and a method thereof.Type: ApplicationFiled: April 9, 2003Publication date: December 18, 2003Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LIMITEDInventors: Shiv Kumar Agarwal, Ravikumar Tadiparthi, Pawan Aggarwal, Savithiri Shivakumar
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Publication number: 20030225075Abstract: The present invention relates to novel pyrimidone derivatives of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The present invention more particularly provides novel pyrimidone derivatives of the general formula (I) and a method thereof.Type: ApplicationFiled: April 9, 2003Publication date: December 4, 2003Applicant: Orchid Chemicals & Pharmaceuticals LimitedInventors: Shiv Kumar Agarwal, Ravikumar Tadiparthi, Pawan Aggarwal, Savithiri Shivakumar, Debendranath Dey, Biswajit Nag
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Publication number: 20030216567Abstract: The present invention relates to a new method for the preparation of Ceftiofur acid of formula (I), 1Type: ApplicationFiled: July 30, 2002Publication date: November 20, 2003Applicant: ORCHID CHEMICALS AND PHARMACEUTICALS LIMITEDInventors: Pandurang Balwant Deshpande, Praven Kumar Luthra, Pratik Ramesh Sathe, Sivakumaran Sundaravadivelan, Praveen Nagesh Ganesh