Patents Assigned to Orchid Chemicals & Pharmaceuticals Limited
  • Patent number: 9404139
    Abstract: A mutant hydroxylase with increased activity and greater substrate specificity towards phenylacetyl-7-ADCA derivatives for the production of phenylacetyl-7-HACA derivatives, which carries one or more amino acid modification at residue positions when compared with certain wild type hydroxylase from certain groups of residues. Also disclosed is a process for the preparation of deacetyl cephalosporanic acid from the corresponding deacetoxy cephalosporanic acid that includes an enzyme of the present invention. Also provided is a method for the production and processing of such enzymes.
    Type: Grant
    Filed: January 9, 2013
    Date of Patent: August 2, 2016
    Assignee: ORCHID CHEMICALS & PHARMACEUTICALS LIMITED
    Inventors: Micheal Durairaaj, Ramanan Thirumoorthy, Kanhu Charan Mishra, Thangadurai Chinnathambi, Cavery Manian Krishnan, Padma Rajasekaran, Sugumar Subramani, Kavitha Daffrose Selvaraj, Nataraj Balakrishnan, Sathish Ravikumar Chakravarthy, Arulmozhi Natrajan Madhiyazhagan
  • Patent number: 8828999
    Abstract: Pyrimidine compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof, are useful are useful as PDE4 inhibitors and are useful for treating PDE4 mediated diseases and in the treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; atherosclerosis; cancer; cachexia; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; ARDS; psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; asthma; COPD; bone resorption diseases; multiple sclerosis; sepsis; septic shock; toxic shock syndrome and fever.
    Type: Grant
    Filed: February 26, 2013
    Date of Patent: September 9, 2014
    Assignee: Orchid Chemicals & Pharmaceuticals Limited
    Inventors: Ganapavarapu Sharma, Venkatesan Parameswaran, Gopalan Balasubramanian, Santosh Vishwakarma, Sanjeev Saxena
  • Patent number: 8580795
    Abstract: Compounds of the formula (I), their derivatives, analogs, tautomeric forms, regioisomers, stereoisomers, polymorphs, solvates, intermediates, pharmaceutically acceptable salts, pharmaceutical compositions, N-oxides, metabolites and prodrugs thereof. These compounds are phosphodiesterase type 4 (PDE4) inhibitors. They are useful in the treatment of a variety of allergic or inflammatory diseases including asthma, COPD, chronic bronchitis, atopic dermatitis, allergic rhinitis, allergic conjunctivitis, vernal conjuctivitis, psoriasis, rheumatoid arthritis, ulcerative colitis, Crohn's disease, uveitis, NASH and lupus.
    Type: Grant
    Filed: January 21, 2010
    Date of Patent: November 12, 2013
    Assignee: Orchid Chemicals & Pharmaceuticals Limited
    Inventors: Gopalan Balasubramanian, Sukunath Narayanan, Ganapavarapu Veera Raghava Sharma, Lavanya Andiappan, Shridhar Narayanan, Sanjeev Saxena, Sridharan Rajagopal, Santosh Lolaknath Vishwakarma, Saravanan Thirunavukkarasu
  • Publication number: 20130172350
    Abstract: Pyrimidine compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof, are useful are useful as PDE4 inhibitors and are useful for treating PDE4 mediated diseases and in the treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; atherosclerosis; cancer; cachexia; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; ARDS; psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; asthma; COPD; bone resorption diseases; multiple sclerosis; sepsis; septic shock; toxic shock syndrome and fever.
    Type: Application
    Filed: February 26, 2013
    Publication date: July 4, 2013
    Applicant: Orchid Chemicals and Pharmaceuticals Limited
    Inventor: Orchid Chemicals and Pharmaceuticals Limited
  • Patent number: 8476255
    Abstract: Provided herein are novel, stilbene like compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, metabolites, prodrugs, solvates, pharmaceutically acceptable salts and compositions thereof. These compounds can inhibit HDACs and are useful as a therapeutic or ameliorating agent for diseases that are involved in cellular growth such as malignant tumors, autoimmune diseases, skin diseases, infections, inflammation, etc.
    Type: Grant
    Filed: October 8, 2008
    Date of Patent: July 2, 2013
    Assignee: Orchid Chemicals & Pharmaceuticals Limited
    Inventors: Sridharan Rajagopal, Virendra Kachhadia, Thanasekaran Ponpandian, Abdul Raheem Keeri, Umamaheswari Mani, Suresh Rathinasamy, Praveen Rajendran, Kamaraj Mani, Balaji Ramachandran, Punthalir Narayanaswamy, Sriram Rajagopal
  • Patent number: 8470809
    Abstract: The present invention relates to novel polymorph of Ceftiofur sodium as a crystalline product. The present invention also provides a process for the preparation of novel polymorphs of crystalline Ceftiofur sodium of formula (I).
    Type: Grant
    Filed: October 13, 2010
    Date of Patent: June 25, 2013
    Assignee: Orchid Chemicals & Pharmaceuticals Limited
    Inventors: Sureshkumar Kanagaraj, Sivakumar Balasubramanian, Senthilkumar Udayampalayam Palanisamy
  • Patent number: 8466145
    Abstract: Described are novel compounds of the Formula (I), their derivatives, analogs, tautomeric forms, regioisomers, stereoisomers, polymorphs, solvates, intermediates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof. These compounds are effective in lowering blood glucose, serum insulin, free fatty acids, cholesterol, triglyceride levels; treatment of obesity, inflammation, autoimmune diseases such as multiple sclerosis, rheumatoid arthritis; treatment and/or prophylaxis of type II diabetes. These compounds are more particularly dipeptidyl peptidase (DPP IV) inhibitors.
    Type: Grant
    Filed: January 7, 2010
    Date of Patent: June 18, 2013
    Assignee: Orchid Chemicals & Pharmaceuticals Limited
    Inventors: Gopalan Balasubramanian, Sukumar Sakamuri, Gajendra Singh, Sivanesan Dharmalingam, Franklin Pooppady Xavier, Shridhar Narayanan, Jeyamurugan Mookkan, Jeganatha Sivakumar Balasubramanian, Agneeswari Rajalingam, Jayanarayan Kulathingal
  • Patent number: 8450525
    Abstract: Novel compounds of the general formula (I), having histone deacetylase (HDAC) inhibiting enzymatic activity, their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, intermediates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof. The present invention more particularly provides novel compounds of the general formula (I). Also included is a method for treatment of cancer, psoriasis, proliferative conditions and conditions mediated by HDAC, in a mammal comprising administering an effective amount of a novel compound of formula (I).
    Type: Grant
    Filed: October 21, 2008
    Date of Patent: May 28, 2013
    Assignee: Orchid Chemicals & Pharmaceuticals Limited
    Inventors: Sridharan Rajagopal, Virendra Kachhadia, Thanasekaran Ponpandian, Abdul Raheem Keeri, Karnambaram Anandhan, Sriram Rajagopal, Rajendran Praveen, Prabhu Daivasigamani
  • Patent number: 8431562
    Abstract: Polymorphs of Ceftiofur sodium as a crystalline product and a process for the preparation of polymorphs of crystalline Ceftiofur sodium of formula (I).
    Type: Grant
    Filed: August 20, 2009
    Date of Patent: April 30, 2013
    Assignee: Orchid Chemicals & Pharmaceuticals Limited
    Inventors: Senthilkumar Udayampalayam Palanisamy, Sivakumar Balasubramanian, Manimaran Arasappan, Meenakshi Sundaram Soma Sundaram, Sureshkumar Kanagaraj, Mohan Singaravel
  • Patent number: 8420653
    Abstract: Described are novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof. These compounds are useful in the treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; atherosclerosis; cancer; cachexia; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; ARDS; psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; asthma; COPD; bone resorption diseases; multiple sclerosis; sepsis; septic shock; toxic shock syndrome and fever. More particularly these compounds are useful as PDE4 inhibitors and are useful for treating PDE4 mediated diseases.
    Type: Grant
    Filed: January 30, 2009
    Date of Patent: April 16, 2013
    Assignee: Orchid Chemicals & Pharmaceuticals Limited
    Inventors: Visweswara Akella Satya Surya Srinivas, Ravikumar Tadiparthi, Ganapavarapu Veera Raghava Sharma, Thirunavukkarasu Sappanimuthu, Durairaj Peter Bhakiaraj, Virendra Kachhadia, Kilambi Narasimhan, Sathya Narayana Thara, Sriram Rajagopal, Sukunath Narayanan, Venkatesan Parameswaran, Venkatesan Janarthanam, Maruthikumar Narayanam, Sathyanarayana Gadde, Uma Ramachandran, Gopalan Balasubramanian, Narayanan Surendran, Shridhar Narayanan, Lolaknath Santosh Vishwakarma, Sanjeev Saxena, Nishikanth Reddy Gaddam
  • Publication number: 20130012714
    Abstract: The present invention provides novel solvate of dexlansoprazole (or R-lansoprazole), particularly diol solvate and its hydrate form of dexlansoprazole (or R-lansoprazole) which is chemically known as (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole compound of the formula (I), as well as processes for the preparation thereof. The said solvates are useful in the preparation of dexlansoprazole with enhanced chiral purity and better HPLC purity with less sulphone impurity content.
    Type: Application
    Filed: February 4, 2011
    Publication date: January 10, 2013
    Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LIMITED
    Inventors: Buchi Reddy Reguri, Sampath kumar Upparapalli, Thirumurugan Kunchithapatham, Sabarinathan Natarajan, Thiyagarajan Sambashivam, Suresh Munuswamy, Susi Swaminathan
  • Patent number: 8293924
    Abstract: An improved process for the preparation of carbapenem antibiotic of formula (I) or its hydrate is provided.
    Type: Grant
    Filed: September 30, 2008
    Date of Patent: October 23, 2012
    Assignee: Orchid Chemicals & Pharmaceuticals Limited
    Inventors: Senthilkumar Udayampalayam Palanisamy, Mohan Singaravel, Vignesh Babu Heeralal
  • Patent number: 8293894
    Abstract: A process for the preparation of a carbapenem of formula (I): in amorphous form wherein R represents hydrogen or COOM and M represents hydrogen or sodium the process including condensing a compound of formula (II): wherein P? denotes a carboxy protecting group, with a compound of formula (III): wherein P? denotes a carboxy protecting group, in the presence of a base to yield a compound of formula (IV): deprotecting both the protecting groups in the compound of formula (IV) in the presence or absence of a sodium ion source, a solvent and in the presence or absence of CO2, gas, extracting the product into an aqueous medium, quenching the aqueous layer of into an alcohol at a temperature, and isolating the carbapenem compound of formula (I) in amorphous form.
    Type: Grant
    Filed: November 20, 2007
    Date of Patent: October 23, 2012
    Assignee: Orchid Chemicals & Pharmaceuticals Limited
    Inventors: Andrew Gnanaprakasam, Nagappan Arumugam, Palanisamy Senthilkumar Udayampalayam, Pandi Suresh Pandian, Venugopal Sivasankaran, Ganapathy Veeramani, Henry Syril Sudhan, Gollapalli Venkateswara Rao
  • Publication number: 20120253066
    Abstract: The present invention relates to an improved process for the preparation of Cilastatin Sodium of formula (I), having mesityl oxide content less than 2000 ppm and more than 1 ppm.
    Type: Application
    Filed: December 16, 2010
    Publication date: October 4, 2012
    Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LIMITED
    Inventors: Khadangale Bhausaheb Pandharinath, Kahandal Bhimraj Suryabhan, Suresh Pandian Pandi, Senthilkumar Udayampalayam Palanisamy, Sureshkumar Kanagaraj, Pandiarajan Sivasubramanian
  • Patent number: 8247606
    Abstract: An improved process for preparing Cilastatin Sodium including dissolving Cilastatin acid in a solvent using an organic base, adding sodium salt of a week acid and isolating Cilastatin Sodium.
    Type: Grant
    Filed: December 2, 2011
    Date of Patent: August 21, 2012
    Assignee: Orchid Chemicals & Pharmaceuticals Limited
    Inventors: Ganapathy Panchapakesan, Nagappan Arumugam, Pandi Suresh Pandian, Gollapalli Venkateswara Rao, Subramaniam Ganesan
  • Publication number: 20120178937
    Abstract: The present invention provides an improved process for the preparation of Alosetron of formula (I) and its pharmaceutically acceptable salts.
    Type: Application
    Filed: January 12, 2012
    Publication date: July 12, 2012
    Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LIMITED
    Inventors: Buchi Reddy REGURI, Sampathkumar UPPARAPALLI, Nilam SAHU, Karunakara Rao JAVVAJI, Brahma Reddy GADE
  • Publication number: 20120095210
    Abstract: The present invention provides a novel process for the preparation of the meropenem trihydrate of formula (I).
    Type: Application
    Filed: December 29, 2011
    Publication date: April 19, 2012
    Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LIMITED
    Inventors: Senthilkumar SURULICHAMY, Selvakumar SEKAR, Pramod Narayan DESHPANDE, Panchapakesan GANPATHY, Rajendra Janardan SARANGDHAR, Syril Sudhan HENRY, Sanjay Nivruti KARALE, Arvind Atmaram JANGALE, Ram Dattatray KALDATE
  • Patent number: 8148520
    Abstract: A process for preparing purified Meropenem trihydrate that involves the dissolution of Meropenem in water in presence of base, adjusting the pH to 4.0-7.0, and adding solvent to yield Meropenem trihydrate.
    Type: Grant
    Filed: September 15, 2006
    Date of Patent: April 3, 2012
    Assignee: Orchid Chemicals and Pharmaceuticals Limited
    Inventors: Senthilkumar Surulichamy, Selvakumar Sekar, Pramod Narayan Deshpande, Panchapakesan Ganpathy, Rajendra Janardan Sarangdhar, Syril Sudhan Henry, Sanjay Nivruti Karale, Arvind Atmaram Jangale, Ram Dattatray Kaldate
  • Publication number: 20120078009
    Abstract: An improved process for preparing Cilastatin Sodium including dissolving Cilastatin acid in a solvent using an organic base, adding sodium salt of a week acid and isolating Cilastatin Sodium.
    Type: Application
    Filed: December 2, 2011
    Publication date: March 29, 2012
    Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LIMITED
    Inventors: Ganapathy PANCHAPAKESAN, Nagappan ARUMUGAM, Pandi Suresh PANDIAN, Gollapalli Venkateswara RAO, Subramaniam GANESAN
  • Patent number: 8134026
    Abstract: The present invention relates to an improved process for the preparation of Cilastatin Sodium of formula (I). The present invention also provides an isolation technique for Cilastatin acid from the reaction mixture.
    Type: Grant
    Filed: November 3, 2006
    Date of Patent: March 13, 2012
    Assignee: Orchid Chemicals & Pharmaceuticals Limited
    Inventors: Ganapathy Panchapakesan, Nagappan Arumugam, Pandi Suresh Pandian, Gollapalli Venkateswara Rao, Subramaniam Ganesan