Patents Assigned to Orchid Chemicals & Pharmaceuticals Limited
  • Process for the preparation of thiazole intermediate
    Publication number: 20030204095
    Abstract: The present invention provides a process for the preparation of 4-methyl-5-formyl-thiazole of the formula (I) 1
    Type: Application
    Filed: December 5, 2002
    Publication date: October 30, 2003
    Applicant: Orchid Chemicals & Pharmaceuticals Limited
    Inventors: Pandurang Balwant Deshpande, Parven Kumar Luthra, Rajesh Vyas, Ramakrishna Kamma
  • Process for the preparation of cephalosporin intermediate and its use for the manufacture of cephalosporin compounds
    Publication number: 20030199712
    Abstract: The present invention relates to a process for the preparation of 4-halogeno-2-substitutedimino-3-oxo-butyric acid of formula (I) 1
    Type: Application
    Filed: September 18, 2002
    Publication date: October 23, 2003
    Applicant: Orchid Chemicals and Pharmaceuticals Limited
    Inventors: Pandurang Balwant Deshpande, Parven Kumar Luthra, Pratik Ramesh Sathe, Sivakumaran Sundaravadivelan, Praveen Nagesh Ganesh
  • Thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds
    Patent number: 6610845
    Abstract: The present invention provides new thioester derivatives of thiazolyl acetic acid of the general formula (I), wherein, R1 represents H, trityl, CH3, CRaRbCOOR2 (Ra and Rb independently of one another represents hydrogen or methyl and R2 represents H or C1-C4 alkyl). also, the invention provides a method by which the said thioester derivatives can be prepared by reacting thiazolyl acetic acid of the general formula (IV) with 1,2,5,6 tetrahdro-2-methyl-5,6 dioxo-1,2,4-triazin-3-thiol of the formula (VI) in a solvent, in presence of an organic base and with the help of Vilsmeier reagent of the formula (V). The so obtained thioester derivatives are reacted with 7-amino-cephem carboxylic acids of the general formula (III) to produce cephalosporin antibiotic compounds having the general formula (II).
    Type: Grant
    Filed: January 4, 2002
    Date of Patent: August 26, 2003
    Assignee: Orchid Chemicals & Pharmaceuticals Limited, India
    Inventors: Pandurang Balwant Deshpande, Pramod Narayan Deshpande, Shanmugam Srinivasan, Parven Kumar Luthra, Gautam Kumar Das
  • Synthesis of ceftiofur intermediate
    Publication number: 20030135041
    Abstract: The present invention provides an improved process for the preparation of 7-amino-3-[2-(furylcarbonyl)thiomethyl]-3-cephem-4-carboxylic acid represented by formula (I) 1
    Type: Application
    Filed: January 4, 2002
    Publication date: July 17, 2003
    Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LIMITED, INDIA
    Inventors: Pramod Narayan Deshpande, Bhausaheb Pandharinath Khadangale, Surulichamy Senthil Kumar, Gautam Kumar Das
  • Synthesis of ceftiofur intermediate
    Publication number: 20030130502
    Abstract: The present invention relates to a process for preparation of 7-amino-3-[2-(furylcarbonyl)thiomethyl]-3-cephem-4-carboxylic acid (I) by the condensation of 7-aminocephalosporanic acid (II) with furyl-2-carbonylthiol (III) in the presence of borontrifluoride or its complex, in an organic solvent or mixture of solvents at 0-50° C.
    Type: Application
    Filed: August 1, 2002
    Publication date: July 10, 2003
    Applicant: Orchid Chemicals and Pharmaceuticals Limited
    Inventors: Pramod Narayan Deshpande, Bhausaheb Pandharinath Khadangale, Surulichamy Senthil Kumar, Gautam Kumar Das
  • Stereoselective route to produce tris-O-substituted-(E)-1-(3,5-dihydroxyphenyl)-2-(4-hydroxyphenyl)ethene, an intermediate in the synthesis of trans-resveratrol
    Patent number: 6552213
    Abstract: The present invention relates to a new stereoselective method for the preparation of tris-O-substituted-(E)-1-(3,5-dihydroxyphenyl)-2-(4-hydroxyphenyl)ethene derivative of the formula (I) which is a key intermediate in the synthesis of trans-resveratrol (I, R2=R2=R3=H). The invention also provides a method for the exclusive synthesis of trans-isomer of compounds of formula (I) without any contamination of cis-isomer.
    Type: Grant
    Filed: May 24, 2002
    Date of Patent: April 22, 2003
    Assignee: Orchid Chemicals & Pharmaceuticals Limited, India
    Inventors: Pandurang Balwant Deshpande, Udayampalayam Palanisamy Senthilkumar, Gnanaprakasam Andrew