Patents Assigned to Oregon Health Sciences University
  • Publication number: 20240158784
    Abstract: The present disclosure relates to molecular barcodes comprising a set of one or more identimers. Methods of using the molecular barcodes, such as to classify a material, are disclosed. Methods of making the molecular barcodes and systems for using the molecular barcodes are disclosed herein.
    Type: Application
    Filed: March 4, 2022
    Publication date: May 16, 2024
    Applicant: Oregon Health & Science University
    Inventor: Corey M. Dambacher
  • Patent number: 11974811
    Abstract: This disclosure describes systems, devices, and techniques for training neural networks to identify avascular and signal reduction areas of Optical Coherence Tomography Angiography (OCTA) images and for using trained neural networks. By identifying signal reduction areas in OCTA images, the avascular areas can be detected with high accuracy, even when the OCTA images include artifacts and other types of noise. Accordingly, various implementations described herein can accurately identify avascular areas from real-world clinical OCTA images. In various implementations, a method can include identifying images of retinas. The images may include thickness images, reflectance intensity maps, and OCTA images of the retinas. Avascular maps corresponding to the OCTA images can be identified. A neural network can be trained based on the images and the avascular maps.
    Type: Grant
    Filed: April 24, 2020
    Date of Patent: May 7, 2024
    Assignee: OREGON HEALTH & SCIENCE UNIVERSITY
    Inventors: Yali Jia, Yukun Guo
  • Patent number: 11944382
    Abstract: Disclosed are methods and systems correcting bulk-motion artifacts in phase-based functional OCT images. The disclosed methods and systems are based on the use of the standard deviation of the phase shift signal present in phase-based OCT imaging. When applied with functional OCT techniques such as OCT angiography, Doppler OCT, and OCT elastography, the disclosed methods provide improved image quality and decreased computational cost compared to other methods of bulk motion compensation.
    Type: Grant
    Filed: April 2, 2019
    Date of Patent: April 2, 2024
    Assignee: OREGON HEALTH & SCIENCE UNIVERSITY
    Inventors: Yali Jia, Xiang Wei
  • Patent number: 11945855
    Abstract: Recombinant polypeptides comprising a modified DR?1 domain are provided. In some embodiments, the polypeptides include the modified DR?1 domain, an antigenic peptide, and optionally a linker sequence. Pharmaceutical compositions comprising the recombinant polypeptides, methods of treating inflammatory disease using said recombinant polypeptides or pharmaceutical compositions, and expression constructs comprising nucleic acids that encode the recombinant polypeptides are also provided.
    Type: Grant
    Filed: October 4, 2019
    Date of Patent: April 2, 2024
    Assignees: Oregon Health & Science University, The United States Government as represented by the Department of Veterans Affairs
    Inventors: Roberto Meza-Romero, Arthur A. Vandenbark, Halina Offner
  • Patent number: 11937878
    Abstract: Disclosed herein are methods and systems for optical coherence tomography (OCT) angiography (OCTA). An interleaved scanning pattern is described herein for both raster and bidirectional scanning methods. The interleaved scanning pattern provides B-scans with different scanning intervals. OCTA images based on the B-scans may be combined to obtain a high dynamic range (HDR) OCTA image. Other embodiments may be described and claimed.
    Type: Grant
    Filed: November 13, 2020
    Date of Patent: March 26, 2024
    Assignee: OREGON HEALTH & SCIENCE UNIVERSITY
    Inventors: Xiang Wei, Yali Jia
  • Patent number: 11932626
    Abstract: The present disclosure is concerned with 2-pyrimidone compounds that are capable of inhibiting a viral infection and methods of treating alphavirus viral infections such as, for example, chikungunya, Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), and Venezuelan equine encephalitis using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: December 13, 2022
    Date of Patent: March 19, 2024
    Assignees: Southern Research Institute, Oregon Health and Science University
    Inventors: Ashish Kumar Pathak, Corinne E. Augelli-Szafran, Atefeh Garzan, Daniel Steblow, Nicole Haese
  • Publication number: 20240075128
    Abstract: Disclosed are immunogenic constructs including: a nanoparticle; a cationic polymer electrostatically bound to an exterior surface of the nanoparticle and a stabilizer bound to the cationic polymer or the exterior surface of the nanoparticle; and an antigen or antigen producing agent. Optionally, the constructs may include adjuvant and/or one or more functional oligonucleotide(s) (e.g., siRNA or pDNA). Also disclosed are methods of using the provided immunogenic constructs for co-delivering an adjuvant, antigen, and optionally siRNA to a cell, inducing immune response in a subject, and treating or preventing an infectious disease in a subject.
    Type: Application
    Filed: August 18, 2023
    Publication date: March 7, 2024
    Applicants: Oregon Health & Science University, PDX Pharmaceuticals, Inc.
    Inventors: Wassana Yantasee, Sherif Reda, Moataz Reda, Worapol Ngamcherdtrakul, Ruijie Wang
  • Publication number: 20240065544
    Abstract: Disclosed are methods and systems for signal attenuation-compensated projection-resolved (sacPR) optical coherence tomography angiography (OCTA). The sacPR OCTA may be free of segmentation and vascular contrast enhancement. In some embodiments, projection artifacts may be suppressed with signal compensation including flow and large vessel shadow compensation for projection removal and wavelet-based compensation for noise suppression.
    Type: Application
    Filed: August 24, 2023
    Publication date: February 29, 2024
    Applicant: OREGON HEALTH & SCIENCE UNIVERSITY
    Inventors: Yali JIA, Jie WANG
  • Patent number: 11896525
    Abstract: Disclosed is a handheld laser probe for laser thermal conjunctivoplasty, the handheld laser comprising: a forceps; and a line focused laser light source coupled to the forceps, wherein the forceps are configured to grasp a conjunctival fold and hold the fold in a light beam of the line focused laser, and wherein the line focused laser beam is configured to uniformly heat the conjunctival fold held in the forceps. Disclosed are systems for laser thermal conjunctivoplasty including the handheld laser. Disclosed are methods of conjunctivoplasty using the handheld laser probe.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: February 13, 2024
    Assignees: OREGON HEALTH & SCIENCE UNIVERSITY, BAYLOR COLLEGE OF MEDICINE
    Inventors: David Huang, Gangjun Liu, Jianlong Yang, Stephen Pflugfelder
  • Patent number: 11883099
    Abstract: Methods and systems for identifying CNV membranes and vasculature in images obtained using noninvasive imaging techniques are described. An example method includes generating, by a first model based on at least one image of a retina of a subject, a membrane mask indicating a location of a CNV membrane in the retina. The method further includes generating, by a second model based on the membrane mask and the at least one image, a vasculature mask of the retina of the subject, the vasculature mask indicating CNV vascularization in the retina.
    Type: Grant
    Filed: November 19, 2020
    Date of Patent: January 30, 2024
    Assignee: Oregon Health & Science University
    Inventors: Yali Jia, Jie Wang
  • Publication number: 20240016784
    Abstract: Provided herein are novel azopodophyllotoxin analog compounds, pharmaceutical compositions comprising them, and their use as inhibitors of Y box protein 1 (YB1 or YBX1) in treatments for conditions including gynecological, breast, bladder, kidney, head and neck, neuronal, and prostate cancers, lymphomas, and leukemias. Methods of their use in sensitizing resistant cancers to treatment with anticancer agents and radiation are also provided.
    Type: Application
    Filed: December 3, 2021
    Publication date: January 18, 2024
    Applicants: Oregon Health & Science University, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Sanjay V. Malhotra, Dhanir Tailor, Arpit Dheeraj
  • Publication number: 20240016634
    Abstract: Embodiments include a delivery device for an auxetic device. The delivery device is comprised of an outer constraining device and a longitudinal controlling device disposed concentrically within the outer constraining device and offset to form a chamber for receiving the auxetic device. A mechanism coupled to the outer constraining device and the longitudinal controlling device allows the chamber size to adjust longitudinally as the auxetic device is deployed. Other embodiments may be described and/or claimed.
    Type: Application
    Filed: October 13, 2021
    Publication date: January 18, 2024
    Applicant: OREGON HEALTH & SCIENCE UNIVERSITY
    Inventors: Ramsey Al-Hakim, Khashayar Farsad, John A. Kaufman
  • Publication number: 20240009032
    Abstract: Disclosed is a handheld laser probe for laser thermal conjunctivoplasty, the handheld laser comprising: a forceps; and a line focused laser light source coupled to the forceps, wherein the forceps are configured to grasp a conjunctival fold and hold the fold in a light beam of the line focused laser, and wherein the line focused laser beam is configured to uniformly heat the conjunctival fold held in the forceps. Disclosed are systems for laser thermal conjunctivoplasty including the handheld laser. Disclosed are methods of conjunctivoplasty using the handheld laser probe.
    Type: Application
    Filed: September 26, 2023
    Publication date: January 11, 2024
    Applicant: Oregon Health & Science University
    Inventors: David Huang, Gangjun Liu, Jianlong Yang, Stephen Pflugfelder
  • Patent number: 11866462
    Abstract: Disclosed are adeno-associated viral vectors and plasmids encoding the same. Also disclosed are methods of using adeno-associated viral vectors to deliver a protein of interest to the subject. The disclosed vectors have phenotypes including but not limited to increased retention in the blood of a subject, avoidance of the liver, and transduction of the brain and other tissues.
    Type: Grant
    Filed: May 3, 2017
    Date of Patent: January 9, 2024
    Assignee: OREGON HEALTH & SCIENCE UNIVERSITY
    Inventors: Hiroyuki Nakai, Kei Adachi
  • Patent number: 11858956
    Abstract: The present disclosure is concerned with 6-aza-nucleoside prodrugs that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, human immunodeficiency virus (HIV), human papillomavirus (HPV), chicken pox, infectious mononucleosis, mumps, measles, rubella, shingles, ebola, viral gastroenteritis, viral hepatitis, viral meningitis, human metapneumovirus, human parainfluenza virus type 1, parainfluenza virus type 2, parainfluenza virus type 3, respiratory syncytial virus, viral pneumonia, yellow fever virus, tick-borne encephalitis virus, Chikungunya virus (CHIKV), Venezuelan equine encephalitis (VEEV), Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), dengue (DENV), influenza, West Nile virus (WNV), zika (ZIKV), Middle East Respiratory Syndromes (MERS), Severe Acute Respiratory Syndrome (SARS), and coronavirus disease 2019 (COVID-19), using these compounds.
    Type: Grant
    Filed: December 17, 2021
    Date of Patent: January 2, 2024
    Assignees: Southern Research Institute, Oregon Health & Science University, Washington University in St. Louis, Board of Regents, The University of Texas System
    Inventors: Omar Moukha-Chafiq, Ashish Kumar Pathak, Shuklendu D. Karyakarte, Larry D. Bratton, Corinne E. Augelli-Szafran, Michael Diamond, Pei Yong Shi, Alec Jay Hirsch, Jessica Lee Smith, Daniel Streblow, Nicole Haese, Baoling Ying
  • Publication number: 20230414094
    Abstract: Disclosed herein is a method for detecting retinal pathologies in three dimensions using structural and angiographic OCT. The method in accordance with the present disclosure may operate by detecting deviations in reflectance and perfusion from a depth-normalized standard retina created by merging and averaging scans from healthy subjects. In one example, the deviations from the standard retina highlight key pathologic features, while depth-normalization obviates the need to segment retinal layers. Additionally, a composite pathology index is disclosed herein that measures average deviation from the standard retina. The present method is amenable to automation and may be implemented in an integrated system and/or provided in the form of software encoded on a computer-readable medium.
    Type: Application
    Filed: June 16, 2023
    Publication date: December 28, 2023
    Applicant: Oregon Health & Science University
    Inventors: Shaohua Pi, Yali Jia
  • Patent number: 11846612
    Abstract: A compact material testing system is configured to expose multiple samples housed within separate sample chambers to simulated fluid, thermal, and mechanical loading conditions. The system includes multiple independent load actuators positioned to extend actuator rods into corresponding sample chambers to apply mechanical loading to the test sample within. A fluid control system is included to bathe each test sample in a fluid medium and replenish the fluid medium within its sample chamber as needed. Each sample chamber includes a gas inlet and gas outlet to provide non-turbulent circulation and control of atmospheric composition above the fluid medium inside the chamber. A logic programmable controller is provided for input of test parameters and automated simultaneous control of mechanical loading, fluid flow, and temperature in the sample chambers.
    Type: Grant
    Filed: April 21, 2022
    Date of Patent: December 19, 2023
    Assignee: Oregon Health & Science University
    Inventors: Jack Ferracane, Carmem Pfeifer, Rafael Tiago Patzlaff
  • Patent number: 11841360
    Abstract: Provided is an ex vivo system allowing for assessment of tumor and other cell responses to pluralities of agents or agent combinations using a microdose delivery microdevice implanted into an ex vivo tissue sample. The microdevice permits localized intra-tissue sample agent delivery and provides the ability to predict the drug efficacy within days after application. Systems for maintaining tissue samples ex vivo over hours to weeks are provided, which can be used to house tissue samples during exposure of the tissue to microdoses of agents applied using the delivery microdevices. Also provided are biomarkers (galectin and/or neuropilin) useful in evaluating the efficacy of agents.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: December 12, 2023
    Assignee: Oregon Health & Science University
    Inventors: Joe Gray, Zuzana Tatárová
  • Patent number: 11841109
    Abstract: A method using a specially configured computer display support structure reduces occurrences of medical errors by facilitating real-time, synchronous review of medical data by rounding professionals during patient rounds. The support structure includes an upright column assembly that has a column assembly base and six sides. Mounting brackets fixed to non-contiguous sides of the column assembly receive back plates of a system device mounting assembly, each of which includes a pivot arm that receives a system device arm. The system device arm is pivotable at opposing ends and terminates in a coupling member at its distal end. The coupling member is connected to a video display that has an angularly positionable display screen. In some embodiments, a keyboard tray, on which a keyboard and computer mouse rest, is connected to the coupling member.
    Type: Grant
    Filed: July 28, 2020
    Date of Patent: December 12, 2023
    Assignee: Oregon Health & Science University
    Inventors: Jeffrey A Gold, Vishnu Mohan
  • Patent number: D1012285
    Type: Grant
    Filed: June 3, 2020
    Date of Patent: January 23, 2024
    Assignee: Oregon Health & Science University
    Inventors: Benjamin H. Timmins, Angelo B. Lipira, Nichole Joslyn