Abstract: The present disclosure relates to a gastrointestinal delivery device of a dressing, where the delivery device is capable of fitting through a narrow channel before expanding and applying the dressing. The gastrointestinal delivery device may be used in all gastrointestinal bleeding applications and can be used with a biocompatible, foldable, thin profile, chitosan dressing. Various aspects of the device and its uses are provided herein.
Type:
Grant
Filed:
December 28, 2018
Date of Patent:
January 31, 2023
Assignees:
Tricol Biomedical, Inc., Oregon Health & Science University
Inventors:
Kenneth E. Perry, Kenneth P. Perry, Hua Xie, Brintha Enestvedt, Simon J. McCarthy
Abstract: An anatomical sensing system-guided prostate procedure device that includes a housing having a proximal end and a distal end. The housing may be divided into a distal housing section, amid housing section, and a proximal housing section, wherein the distal housing section is configured for insertion into the anus and retention in the rectum of a subject. The device further includes an instrument convergence point disposed between the proximal end and the distal end, the convergence point configured to allow an instrument pass though the instrument convergence point at a variable angle; and an instrument angle orienting system at the proximal end of the housing, the angle orienting system directing an orientation of the variable angle about the convergence point. Methods of the using an anatomical sensing system-guided prostate procedure device and system including the same.
Type:
Application
Filed:
October 5, 2022
Publication date:
January 26, 2023
Applicant:
Oregon Health & Science University
Inventors:
Fergus Coakley, Stevan Wittenbrock, Forrest Seitz, Christopher J. Jensen, Daniel R. Baker
Abstract: Disclosed are implantable ocular drainage devices that include a reversible switch mechanism to control flow through the drainage device. The devices include a drainage tube and a reversible, bi-stable switch mechanism that includes first and second stationary magnets spaced apart from one another and a magnetic or ferromagnetic mobile element moveably disposed in a channel in the housing.
Abstract: Provided herein are HIV-1 vaccines comprising a carrier and a population episensus antigen determined using the EpiGraph approach. Also provided are HIV-1 vaccines comprising a carrier, a population episensus antigen, and a tailored antigen. Also provided are methods of designing and producing an HIV-1 vaccine for a subject comprising designing vaccine antigens to optimally cover the diversity within a geographic area using an antigen amino acid sequence generated using the EpiGraph approach, and producing said designed vaccine antigen. Also provided are methods of inducing an effector memory T cell response comprising designing the one or more EpiGraph amino acid sequences, producing a vaccine comprising the one or more EpiGraph amino acid sequences and a vector, and administering the vaccine to a subject. Further provided are methods of treating HIV-1 in a subject comprising administering an effective amount of the described HIV-1 vaccines to the subject in need thereof.
Type:
Grant
Filed:
August 31, 2020
Date of Patent:
January 17, 2023
Assignees:
Vir Biotechnology, Inc., Triad National Security, LLC, Oregon Health & Science University
Inventors:
Eric Bruening, Klaus Frueh, Louis Picker, Bette T. M. Korber, James Theiler, Emily Marshall
Abstract: Methods, computer-readable storage devices, and systems are described for reducing movement of a patient undergoing a magnetic resonance imaging (MRI) scan by aligning MRI data, the method implemented on a Framewise Integrated Real-time MRI Monitoring (“FIRMM”) computing device including at least one processor in communication with at least one memory device. Aspects of the method comprise receiving a data frame from the MRI system, aligning the received data frame to a preceding data frame, calculating motion of a body part between the received data frame and the preceding data frame, calculating total frame displacement, and excluding data frames with a cutoff above a pre-identified threshold of the total frame displacement.
Type:
Grant
Filed:
October 20, 2021
Date of Patent:
January 3, 2023
Assignees:
Washington University, Oregon Health & Science University
Inventors:
Nico Dosenbach, Jonathan Koller, Andrew Van, Abraham Snyder, Amy Mirro, Damien Fair, Eric Earl, Rachel Klein, Oscar Miranda Dominguez, Anders Perrone
Abstract: Provided herein are methods for preparing a sequencing library that includes nucleic acids from a plurality of single cells. In one embodiment, the sequencing library includes whole genome nucleic acids from the plurality of single cells. In one embodiment, the method includes generating nucleosome-depleted nuclei by chemical treatment while maintaining integrity of the nuclei. Also provided herein are compositions, such as compositions that include chemically treated nucleosome-depleted isolated nuclei.
Type:
Grant
Filed:
July 21, 2017
Date of Patent:
December 27, 2022
Assignees:
Illumina, Inc., Oregon Health & Science University
Inventors:
Andrew C. Adey, Sarah A. Vitak, Frank J. Steemers
Abstract: Mutant mono ADP-ribose-polymerases (mono-PARP) proteins and small molecule compound substrates specific for the mutant mono-PARP proteins as well as methods of using these compositions to identify protein targets of the mono-PARPs and to screen for antagonists of the mono-PARPs are described.
Type:
Grant
Filed:
December 16, 2019
Date of Patent:
December 20, 2022
Assignee:
Oregon Health & Science University
Inventors:
Michael Cohen, Ian Carter-O'Connell, Rory Morgan, Haihong Jin
Abstract: Methods of treating a subject having or at risk of developing a neurodegenerative disease or condition associated with demyelination, insufficient myelination, or underdevelopment of myelin sheath are described. The methods include administration of a therapeutically effective amount of sobetirome, or a pharmaceutically acceptable salt thereof.
Type:
Grant
Filed:
July 7, 2020
Date of Patent:
November 29, 2022
Assignees:
Oregon Health & Science University, The United States Government as represented by the Department of Veterans Affairs
Inventors:
Thomas S. Scanlan, Meredith Hartley, Andrew Placzek, Marco Righi, Dennis Bourdette, Gail Marracci, Priya Chaudhary
Abstract: Disclosed herein are methods for delivering a composition comprising an adeno-associated virus (AAV) to one or more pancreatic cells in a subject. Also disclosed are adeno-associated viral vectors for use in these methods.
Abstract: The compounds provided herein are phenoxazines that can be used as far red to near-infrared nerve-sparing fluorescent compounds in medical procedures.
Type:
Grant
Filed:
July 26, 2019
Date of Patent:
November 8, 2022
Assignee:
Oregon Health & Science University
Inventors:
Summer L. Gibbs, Lei G. Wang, Connor W. Barth
Abstract: Disclosed are systems and methods for characterizing corneal shape abnormalities. These methods may be used to differentiate corneas having subclinical keratoconus from other conditions which cause distortion of corneal shape, including warpage of the cornea due to contact lens wear. Also disclosed is classification scheme to aid diagnosis of corneal conditions and thereby guide clinical decision making regarding patient treatment. This classification scheme is based on computed properties of corneal shape, is amenable to automation, and may be implemented in an integrated system or provided in the form of software encoded on a computer-readable medium.
Abstract: An anatomical sensing system-guided prostate procedure device that includes a housing having a proximal end and a distal end. The housing may be divided into a distal housing section, a mid housing section, and a proximal housing section, wherein the distal housing section is configured for insertion into the anus and retention in the rectum of a subject. The device further includes an instrument convergence point disposed between the proximal end and the distal end, the convergence point configured to allow an instrument pass though the instrument convergence point at a variable angle; and an instrument angle orienting system at the proximal end of the housing, the angle orienting system directing an orientation of the variable angle about the convergence point. Methods of the using an anatomical sensing system-guided prostate procedure device and system including the same.
Type:
Grant
Filed:
September 1, 2017
Date of Patent:
October 11, 2022
Assignee:
OREGON HEALTH & SCIENCE UNIVERSITY
Inventors:
Fergus Coakley, Stevan Wittenbrock, Forrest Seitz, Christopher J. Jensen, Daniel R. Baker
Abstract: Methods for generating aortic heart valve leaflets are disclosed wherein the aortic sinus surfaces (the inner surfaces of the sinuses of Valsalva) are used as a template to generate geometric representations of replacement aortic heart valve leaflets. As such, sinus-matched replacement leaflets can be sized and shaped according to the patient-specific geometry of the aortic root. Patient-specific aortic valve assemblies based on aortic root and sinus geometry are also described. Methods for estimating the coaptation area of a sinus-matched valve and assessing whether the valve is functionally competent for implantation are described.
Type:
Grant
Filed:
January 31, 2019
Date of Patent:
October 11, 2022
Assignees:
Oregon Health & Science University, Iowa State University Research Foundation
Inventors:
Gary Michael Silberbach, Ming-Chen Hsu, Xiao-Yue Han
Abstract: Disclosed are systems and methods for generating wide-field optical coherence tomography angiography (OCTA) images. In embodiments, multiple OCTA scans of a sample are automatically acquired at overlapping locations. The systems and methods include functionality to adaptively control the scanning procedure such that eye blink and eye motion events are detected in real time and accounted for during 3D scan acquisition. Also disclosed are methods for detecting and correcting motion-related artifacts in OCTA datasets which allow for the longer scan times over larger fields of view required for wide-field imaging. These methods may include division of en face angiogram images into a set of motion-free parallel strips, and application of gross and fine registration methods to align overlapping strips into a motion-corrected composite image. A series of overlapping motion-corrected composite images may be combined into a larger montage to enable wide-field OCTA imaging using multiple OCTA scans.
Abstract: Disclosed are methods and systems for adaptive optics (AO)-optical coherence tomography (OCT) and OCT angiography (OCTA). Embodiments include techniques to generate one or more volumetric and/or depth-resolved figures of merit to guide optimization of ocular aberrations in sensorless AO-OCT and/or AO-OCTA. The one or more figures of merit may be generated in real-time, e.g., in parallel with the OCT scan and/or aberration optimization process. Other embodiments may be described and claimed.
Abstract: The present invention provides compounds useful as mitochondrial permeability transition pore (mtPTP) inhibitors, the compounds being of Formula (I), or a pharmaceutically acceptable salt thereof wherein R1 is selected from the group of H, halogen, and C1-C3 alkyl; and R2 is selected from the group of H, CF3, and halogen; with the proviso that at least one of R1 and R2 is halogen or CF3.
Type:
Application
Filed:
July 24, 2020
Publication date:
September 15, 2022
Applicant:
Oregon Health & Science University
Inventors:
Michael Cohen, Michael Forte, Justina Sileikyte, Aaron Nilsen, Jordan Devereaux, Paolo Bernardi
Abstract: Described herein is a method for eliminating or reducing ototoxicity in patients receiving a platinum based chemotherapeutic. In particular, are methods of reducing ototoxicity in a pediatric patient. The methods described herein include administering an effective amount of sodium thiosulfate to a patient in need thereof to reduce ototoxicity.
Abstract: Methods of treating acute myeloid leukemia, chronic lymphocytic leukemia and myeloproliferative neoplasms that involve the administration of combinations of small molecule compounds are disclosed.
Type:
Application
Filed:
April 15, 2022
Publication date:
September 8, 2022
Applicant:
Oregon Health & Science University
Inventors:
Jeffrey Tyner, Stephen Kurtz, Brian Druker, Elie Traer, Christopher Eide, Motomi Mori, Andrew Kaempf