Patents Assigned to Oregon State University
-
Publication number: 20230338575Abstract: Disclosed herein are embodiments of a nanoparticle suitable for use in providing hyperthermia treatment. The nanoparticle may be a cobalt-doped iron oxide nanoparticle. Also disclosed are compositions comprising the nanoparticle. The composition may further comprise a polymer and/or a targeting moiety. Further disclosed and methods for making the nanoparticle and the composition, and embodiments of a method for using the nanoparticle or a composition thereof. The nanoparticle may be useful for treating cancer, and/or endometriosis.Type: ApplicationFiled: March 20, 2023Publication date: October 26, 2023Applicants: Oregon State University, Oregon Health & Science UnivesityInventors: Olena Taratula, Oleh Taratula, Ananiya A. Demessie, Ov Slayden, Youngrong Park
-
Patent number: 11793210Abstract: Disclosed herein are embodiments of a composition for use in forming films or coatings that prevent damage in foodstuffs, including plants, fruits, and vegetables. The disclosed compositions comprise a cellulose nanomaterial and can further comprise a nanoscale mineral compound and one or more additional components. Also disclosed are films or coatings made using the disclosed compositions, as well as methods for making the disclosed compositions and methods for using the disclosed compositions.Type: GrantFiled: July 23, 2021Date of Patent: October 24, 2023Assignee: Oregon State UniversityInventors: Yanyun Zhao, John Simonsen, George Cavender, Jooyeoun Jung, Leslie H. Fuchigami
-
Publication number: 20230320683Abstract: Described herein is a technique (e.g., apparatus and method) to improve consistency of lumbar lordosis (LL) and disc height index (DHI) measurements. In at least one embodiment, one or more processors are to measure lumber spine based, at least in part, on cross-sectional area and optical center of mass of segmented intervertebral discs (IVDs).Type: ApplicationFiled: April 6, 2023Publication date: October 12, 2023Applicant: Oregon State UniversityInventors: Morgan B. Giers, Sonia Ahrens
-
Publication number: 20230313180Abstract: Embodiments of the claimed invention describe methods for making a multimeric nanobody assembly. In some embodiments, a method for making a multimeric nanobody assembly comprises providing polynucleic acids that encode for nanobodies, wherein the polynucleic acids each further comprise at least one selector codon at a preselected position, providing a non-peptide linker comprising a strained alkene functional group, and providing a translational system, wherein the polynucleic acids are translated by the translational system to encode the nanobodies, and wherein the tetrazine amino acids react with the strained alkene functional group to produce the multimeric nanobody assembly.Type: ApplicationFiled: December 2, 2022Publication date: October 5, 2023Applicant: Oregon State UniversityInventors: Ryan A. Mehl, Elise M. Van Fossen, Riley M. Bednar
-
Patent number: 11739337Abstract: Disclosed is a synthetic gene cluster for producing gadusol derivatives, expression vectors and host cells containing the same, methods of producing gadusol derivatives, and compositions thereof. In an example, the synthetic gene cluster includes a valA nucleotide sequence capable of expressing ValA protein; a nucleotide sequence capable of expressing methyltransferase/oxidoreductase (MT-Ox) protein; a mysC nucleotide sequence capable of expressing a MysC protein; and a mysD nucleotide sequence capable of expressing a MysD protein. In this way, gadusol derivatives can be produced in amounts sufficient for use in a variety of applications.Type: GrantFiled: September 4, 2020Date of Patent: August 29, 2023Assignee: OREGON STATE UNIVERSITYInventors: Taifo Mahmud, Andrew Robert Osborn
-
Patent number: 11723370Abstract: Provided herein are synthetic peptides developed from slug and insect neuropeptides. Peptides described can be used to repel, control or deter slugs, including the gray garden slug (Deroceras reticulatum), from feeding on agricultural and horticultural plants. The peptides can be combined with bait materials, or applied directly to plants or areas, or produced by genetically modified plants.Type: GrantFiled: August 25, 2020Date of Patent: August 15, 2023Assignees: The United States of America, as represented by The Secretary Agriculture, Oregon State UniversityInventors: Man Y. Choi, Ruth C. Martin, Seungjoon Ahn, Rory McDonnell, Sujaya Rao
-
Publication number: 20230241196Abstract: Methods are disclosed for inducing an immune response to Neisseria gonorrhoeae in a mammalian subject. These methods include administering to the mammalian subject an effective amount of a MetQ protein and an effective amount of a K-type CpG oligodeoxynucleotide, thereby inducing the immune response. Also disclosed are immunogenic compositions including an effective amount of a MetQ protein and an effective amount of a K-type CpG oligodeoxynucleotide.Type: ApplicationFiled: January 26, 2021Publication date: August 3, 2023Applicants: Oregon State University, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.Inventors: Aleksandra E. Sikora, Ryszard A. Zielke, Ann E. Jerse
-
Patent number: 11708506Abstract: Disclosed herein are embodiments of a composition comprising at least one cellulose material (such as a cellulose nanomaterial) and an optional inorganic salt component. Some embodiments of the composition can further comprise additional components, with some embodiments further comprising a non-starch polysaccharide (e.g., methyl cellulose carboxymethyl cellulose or other cellulose derivative, chitosan, or the like), a surfactant, a plasticizer, an antimicrobial component, or any combination thereof. The disclosed compositions are useful for forming edible coatings/films on plants, plant parts, and other objects. The disclosed compositions and coatings/films made using the compositions are effective at protecting fresh and processed produce and other substances and products, from various different types of food processing damage (and the deleterious effects associated therewith).Type: GrantFiled: May 26, 2021Date of Patent: July 25, 2023Assignee: Oregon State UniversityInventors: Yanyun Zhao, John Simonsen, George Cavender, Jooyeoun Jung, Leslie H. Fuchigami
-
Patent number: 11708377Abstract: Disclosed herein are embodiments of a compound having a Formula I or a salt, solvate, N-oxide, prodrug, diastereomer or enantiomer thereof. Also disclosed are derivative compounds made from the compound of Formula I. Certain derivative compounds have a Formula V-2, or a salt, solvate, N-oxide, prodrug, diastereomer or enantiomer thereof. Also disclosed are method for making and using the disclosed compounds. Certain disclosed embodiments are useful for treating and/or preventing certain diseases and/or disorders, including proliferation diseases, such as leukemia.Type: GrantFiled: September 9, 2021Date of Patent: July 25, 2023Assignee: Oregon State UniversityInventors: Christopher M. Beaudry, Xuan Ju
-
Publication number: 20230212583Abstract: Disclosed herein are embodiments of a compound useful for treating or preventing SARS-Cov-2 infections. Also disclosed is a method for administering the compound to a subject, particularly a human subject, to treat or prevent a SARS-CoV-2 infection in the subject. The compound may comprise an oligomer comprising a nucleic acid base sequence that is antisense to a gene, pre-mRNA or mRNA in the subject, such as a gene, pre-mRNA or mRNA of transmembrane serine protease 2 (TMPRSS2). The compound also may comprise a peptide sequence. In some embodiments, the compound is a peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO).Type: ApplicationFiled: October 13, 2022Publication date: July 6, 2023Applicants: Oregon State University, Philipps-Universität MarburgInventors: Eva Friebertshäuser, Hong M. Moulton, David A. Stein
-
Publication number: 20230203492Abstract: Disclosed herein are embodiments of a compound useful for treating or preventing betacoronavirus infections such as SARS-Cov-2 infections. Also disclosed is a method for administering the compound to a subject, particularly a human subject, to treat or prevent a betacoronavirus infection in the subject. The compound can comprise an oligomer comprising a nucleic acid base sequence that is antisense to at least a portion of a SARS-CoV-2 genomic RNA, and can comprise a sequence present in the 5? UTR and first 20 nt of coding sequence of the SARS-CoV-2 genomic RNA. The compound also can contain a peptide sequence. In some embodiments, the compound is a peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO).Type: ApplicationFiled: November 7, 2022Publication date: June 29, 2023Applicants: Oregon State University, The U.S.A., as Represented by the Secretary, Department of Health and Human ServicesInventors: Hong M. Moulton, David Adam Stein, Heinrich Ulrich Feldmann, Kyle Ture Rosenke
-
Patent number: 11672898Abstract: A microfluidic photoreactor for treating excess bilirubin in blood, having: a microfluidic channel module; an illumination module comprising one or more illumination sources disposed about the microfluidic channel module and configured to illuminate blood passing through at least one microfluidic channel of the microfluidic channel module; and a heat exchanger module coupled to the at least one microfluidic channel module, wherein the heat exchanger module is configured to extract heat from the at least one microfluidic channel. A system including a microfluidic photoreactor and a method of treating excess bilirubin in blood.Type: GrantFiled: June 5, 2019Date of Patent: June 13, 2023Assignee: OREGON STATE UNIVERSITYInventors: John Lahmann, Adam Z. Higgins
-
Publication number: 20230172977Abstract: Disclosed herein are compound embodiments that are useful for treating a variety of diseases, particularly neurological diseases, motor neuron diseases, copper deficiency-related diseases, and/or mitochondrial deficiencies. The compound embodiments described herein also can be used in PET methods. Also disclosed herein are embodiments of methods of making and using the compound embodiments, as well as pharmaceutical formulations comprising the disclosed compound embodiments.Type: ApplicationFiled: January 27, 2023Publication date: June 8, 2023Applicant: Oregon State UniversityInventors: Joseph Beckman, James Hurst, John Sirois, Chris Beaudry
-
Publication number: 20230175830Abstract: Described herein is a magnetic dendrometer having a frame, a spring-tension mechanism, and a magnet for moving together with the spring-tension mechanism. A magnetic sensor is attached to the frame. The magnetic sensor senses the linear motion of the magnet. This linear motion translates to trackable fluctuations in magnetic field. The magnetic fluctuations are converted to electrical signals by the magnetic sensor. A spring is attached to a free-floating wishbone-style component. The free-floating wishbone-style component is coupled to a slider which has an adjustable, single-contact point with a target (e.g., a vine, a branch, etc.). The frame is a stationary frame that carries the magnetic sensor. The frame connected via the spring to the wishbone/slider combination cooperates with each other for providing linear motion to extend or contract the spring in length directions. The length variations of the dendrometer spring are converted to linear motion of the magnet and then into electronic signals.Type: ApplicationFiled: December 2, 2021Publication date: June 8, 2023Applicant: Oregon State UniversityInventors: Cameron Clonch, Bryson Goto, Mark Huynh, John Selker, Chet Udell
-
Publication number: 20230129487Abstract: Methods for inducing growth inhibition or apoptosis of Bcl-2-expressing cells and treatments of Bcl-2 expressing cancers are provided. Additionally, assays for agents that can induce apoptosis of Bcl-2 expressing cells are disclosed.Type: ApplicationFiled: August 19, 2022Publication date: April 27, 2023Applicant: Oregon State UniversityInventors: Siva K. Kolluri, Prasad R. Kopparapu, Martin Pearce
-
Publication number: 20230117370Abstract: Disclosed herein are embodiments of a method for making substituted compounds with specific and selectable regiochemistry. Also disclosed are compounds made by the method.Type: ApplicationFiled: October 14, 2022Publication date: April 20, 2023Applicant: Oregon State UniversityInventors: Christopher M. Beaudry, Xiaojie Zhang
-
Patent number: 11629190Abstract: Disclosed are isolated single heavy chain variable (VHH) monoclonal antibodies, antigen binding fragments thereof, and bispecific antibodies include these VHH monoclonal antibodies, wherein the VHH monoclonal antibody or antigen binding fragment specifically binds a canine programmed death (PD)-1. Nucleic acid molecules encoding these VHH monoclonal antibodies and antigen binding fragments are also disclosed, as are expression vectors including these nucleic acid molecules and host cells including these expression vectors. Methods of detecting canine PD-1, and methods of increasing cytotoxic T cell activity and treating tumors are also disclosed.Type: GrantFiled: August 13, 2020Date of Patent: April 18, 2023Assignee: Oregon State UniversityInventors: Dan Vincent Mourich, Carl E. Ruby, Shay Bracha, Christopher Keith Cebra
-
Publication number: 20230112618Abstract: Compositions comprising RqSnOm(OH)x(HCO3)y(CO3)z are disclosed, where R is (i) C1—C10 hydrocarbyl or (ii) heteroaliphatic, heteroaryl, or heteroaryl-aliphatic including 1-10 carbon atoms and one or more heteroatoms; q = 0.1-1; x ? 4; y ? 4; z ? 2; m = 2 - q/2 - x/2 - y/2 - z; and (q/2 + x/2 + y/2 + z) ? 2 Methods of making a photoresist film comprising [(RSn)12O14(OH)6](OH)2 on a substrate also are disclosed. The photoresist film may be irradiated to form RqSnOm(OH)x(HCO3)y(CO3)z.Type: ApplicationFiled: February 25, 2021Publication date: April 13, 2023Applicant: Oregon State UniversityInventors: Nizan Kenane, Douglas A. Keszler
-
Publication number: 20230098480Abstract: A computer implemented scheme for a light detection and ranging (LIDAR) system where point cloud feature extraction and segmentation by efficiently is achieved by: (1) data structuring; (2) edge detection; and (3) region growing.Type: ApplicationFiled: November 16, 2022Publication date: March 30, 2023Applicant: Oregon State UniversityInventors: Erzhuo Che, Michael Olsen
-
Patent number: 11596651Abstract: Disclosed herein are compound embodiments that are useful for treating a variety of diseases, particularly neurological diseases, motor neuron diseases, copper deficiency-related diseases, and/or mitochondrial deficiencies. The compound embodiments described herein also can be used in PET methods. Also disclosed herein are embodiments of methods of making and using the compound embodiments, as well as pharmaceutical formulations comprising the disclosed compound embodiments.Type: GrantFiled: February 26, 2020Date of Patent: March 7, 2023Assignee: Oregon State UniversityInventors: Joseph Beckman, James Hurst, John Sirois, Chris Beaudry