Patents Assigned to Oregon State University
  • Patent number: 6720005
    Abstract: An expanding tablet is described comprising a drug release controlling membrane material. After swallowing, the tablet hydrates and expands such that the membrane ruptures to directly expose some surfaces of the core tablet to hydrating and eroding liquids, thus generating in situ a tablet which is platform supported on non-exposed surfaces, and which releases active ingredient in approximately zero order fashion. More particularly, the dosage form is adapted for controlled release of various pharmaceuticals. A working embodiment of the tablet was a spray-coated tablet comprising a core having greater than 25% of an expandable material which expands upon exposure to an aqueous environment and at least one active ingredient, e.g., glipizide, and an outer rupturable coating surrounding the core comprising a rate release modifying membrane and a water-soluble modifier. A method for administering an active ingredient also is described.
    Type: Grant
    Filed: June 21, 2001
    Date of Patent: April 13, 2004
    Assignee: The State of Oregon acting by and through the State Board of Higher Education on behalf of Oregon State University
    Inventor: James W. Ayres
  • Publication number: 20040037906
    Abstract: An adhesive composition made by reacting a soy protein with at least one compound under conditions sufficient for introducing additional phenolic hydroxyl functional groups, amine functional groups, and/or thiol functional groups into the soy protein structure.
    Type: Application
    Filed: May 13, 2003
    Publication date: February 26, 2004
    Applicants: State of Oregon Acting By and Through the Oregon State, Board of Higher Education on Behalf of Oregon State University
    Inventors: Kaichang Li, Yuan Liu
  • Patent number: 6688381
    Abstract: Thermal management devices and methods include branching networks comprising flow channels of varying cross-sectional area. The branching networks can be fractal-like in nature with an increase in the total flow area following a flow channel bifurcation. In representative embodiments, the branching networks are defined in a channel pattern that is laminated between cover plates to form a thermal management device. The channel pattern includes bridging portions so that the branching network is defined with a single pattern piece. The branching networks can exhibit radial symmetry or be aligned with respect to one or more axes. Heat exchangers and diffusive mixers that include such networks are also provided.
    Type: Grant
    Filed: June 5, 2001
    Date of Patent: February 10, 2004
    Assignee: The State of Oregon Acting by and through the State Board of Higher Education on Behalf of Oregon State University
    Inventors: Deborah V. Pence, Jose N. Reyes, Jr., Nathan Phillips, Qiao Wu, John T. Groome
  • Patent number: 6672502
    Abstract: A method and system for making a monolithic intermetallic structure are presented. The structure is made from lamina blanks which comprise multiple layers of metals which are patternable, or intermetallic lamina blanks that are patternable. Lamina blanks are patterned, stacked and registered, and processed to form a monolithic intermetallic structure. The advantages of a patterned monolithic intermetallic structure include physical characteristics such as melting temperature, thermal conductivity, and corrosion resistance. Applications are broad, and include among others, use as a microreactor, heat recycling device, and apparatus for producing superheated steam. Monolithic intermetallic structures may contain one or more catalysts within the internal features.
    Type: Grant
    Filed: November 28, 2001
    Date of Patent: January 6, 2004
    Assignee: The State of Oregon acting by and through the State Board of Higher Education on behalf of Oregon State University
    Inventors: Brian Kevin Paul, Richard Dean Wilson, David Eli Alman
  • Patent number: 6657173
    Abstract: A food product is heated by maintaining the food product in an AC electrical field generated by an RF signal. As the heating takes place, maximum energy is delivered to the food product using automatic impedance matching to adjust the rate of the process.
    Type: Grant
    Filed: August 23, 2001
    Date of Patent: December 2, 2003
    Assignees: State Board of Higher Education on Behalf of Oregon State University
    Inventors: Benjamin A. Flugstad, Qingyue Ling, Edward R. Kolbe, John Henry Wells, Yanyun Zhao, Jae W. Park
  • Publication number: 20030218222
    Abstract: Enhancement mode, field effect transistors wherein at least a portion of the transistor structure may be substantially transparent. One variant of the transistor includes a channel layer comprising a substantially insulating, substantially transparent, material selected from ZnO, SnO2, or In2O3. A gate insulator layer comprising a substantially transparent material is located adjacent to the channel layer so as to define a channel layer/gate insulator layer interface. A second variant of the transistor includes a channel layer comprising a substantially transparent material selected from substantially insulating ZnO, SnO2 or In2O3, the substantially insulating ZnO, SnO2, or In2O3 being produced by annealing. Devices that include the transistors and methods for making the transistors are also disclosed.
    Type: Application
    Filed: January 24, 2003
    Publication date: November 27, 2003
    Applicants: The State of Oregon acting and through the oregon State Board of Higher Education on behalf of, Oregon State University
    Inventors: John F. Wager, Randy L. Hoffman
  • Publication number: 20030187273
    Abstract: A method for making epothilones and epothilone analogs is described, as are novel compounds made by the method. One embodiment of the method was used to synthesize epothilone B by a convergent approach that entailed Wittig coupling of an ylide derived from phosphonium bromide with an aldehyde. The former was prepared from propargyl alcohol by a nine-step pathway which installed both trisubstituted double bonds with clean Z configuration. Macrolactonization of a resulting seco acid provided the following intermediate diene epothilone analog. Selective saturation of the 9,10-olefin and subsequent epoxidation provided epothilone B.
    Type: Application
    Filed: January 27, 2003
    Publication date: October 2, 2003
    Applicant: Oregon State University
    Inventors: James David White, Rich Garrett Carter, Kurt Frederick Sundermann
  • Patent number: 6600091
    Abstract: Isolated nucleic acids encoding zeatin O-glucosyltransferase are disclosed. These nucleic acid molecules are useful, among other things, to produce transgenic plants having modified zeatin O-glucosyltransferase activity.
    Type: Grant
    Filed: October 4, 2000
    Date of Patent: July 29, 2003
    Assignee: The State of Oregon acting by and through the State Board of Higher Education on behalf of Oregon State University
    Inventors: David W. S. Mok, Machteld C. Mok, Ruth C. Martin
  • Patent number: 6596323
    Abstract: Meadowfoam seedmeal used for plant growth enhancement. Experiments with meadowfoam seedmeal, genus Limnanthes, indicated significant growth enhancement when combined with a growing medium at certain rates. Nutrient exclusion experiments suggested that enhanced growth was not from nutrient supplementation, but hormone induced growth exogenously mediated by the seedmeal. Various target plants and application rates and methods are discussed as are various fertilizer application rates.
    Type: Grant
    Filed: February 22, 2002
    Date of Patent: July 22, 2003
    Assignee: State of Oregon acting by and through the State Board of Higher Education on behalf of Oregon State University
    Inventor: Wes A. Deuel
  • Patent number: 6593080
    Abstract: Caliciviruses are herein recognized as potentially important human pathogens, infecting a large percentage (18%) of a sampled human population. A new calicivirus isolate called “San Miguel sea lion virus 5 serotype Homosapien-1” (SMSV-5 Hom-1) is also disclosed. Compositions and methods are disclosed that allow diagnosis, prevention and treatment of calicivirus (including SMSV-5 Hom-1) infection in humans.
    Type: Grant
    Filed: February 1, 2000
    Date of Patent: July 15, 2003
    Assignee: The State of Oregon Acting by and through the State Board of Higher Education on Behalf of Oregon State University
    Inventor: Alvin W. Smith
  • Patent number: 6495586
    Abstract: Disclosed are compounds having a scytoneman skeleton, such as scytonemin, and methods of using thereof. Methods of using a compound having a scytoneman skeleton to inhibit, modulate, attenuate, or prevent cell-cycle progression, cell proliferation, kinase activity, or induce apoptosis are disclosed. Also disclosed are methods of treating, preventing, or inhibiting diseases and disorders associated with cell cycle progression, cell proliferation, kinase activity, tissue hyperplasia or angiogenesis, such as cancer or an inflammatory disease.
    Type: Grant
    Filed: February 23, 2001
    Date of Patent: December 17, 2002
    Assignees: The Regents of the University of California, Oregon State University, GlaxoSmithKline
    Inventors: Robert S. Jacobs, Lisa A. Marshall, William H. Gerwick, Christopher Stevenson
  • Patent number: 6495588
    Abstract: Disclosed are compounds having a scytoneman skeleton, such as scytonemin, and methods of using thereof. Methods of using a compound having a scytoneman skeleton to inhibit, modulate, attenuate, or prevent cell-cycle progression, cell proliferation, kinase activity, or induce apoptosis are disclosed. Also disclosed are methods of treating, preventing, or inhibiting diseases and disorders associated with cell cycle progression, cell proliferation, kinase activity, tissue hyperplasia or angiogenesis, such as cancer or an inflammatory disease.
    Type: Grant
    Filed: September 24, 2001
    Date of Patent: December 17, 2002
    Assignees: The Regents of the University of California, State of Oregon c/o Oregon State University, GlaxoSmithKline
    Inventors: Robert S. Jacobs, Lisa A. Marshall, William H. Gerwick, Christopher Stevenson
  • Patent number: 6489610
    Abstract: A tandem time-of-flight mass spectrometer includes an ion source, a velocity selector downstream of the ion source, a dissociation cell downstream of the velocity selector, and an ion accelerator downstream of the dissociation cell, the accelerator being capable of focusing ions at a space focal plane, and an ion-reflector (reflectron) downstream of the accelerator. The accelerator allows the ions to subsequently separate according to their m/z ratios and the reflectron to subsequently space-focus the ions over a broad mass range at a detector. A velocity selector includes a pair of ion defectors each having multiple electrically conductive strips, the strips including alternate positive voltage strips and alternate negative voltage strips.
    Type: Grant
    Filed: September 24, 1999
    Date of Patent: December 3, 2002
    Assignee: The State of Oregon acting by and through the State Board of Higher Education on Behalf of Oregon State University
    Inventors: Douglas F. Barofsky, Per Håkansson, Daniel Louis Katz, C. K. Gamini Piyadasa
  • Patent number: 6472198
    Abstract: Bioremediation methods and kits for degrading environmental contaminants, such as chlorinated hydrocarbons, in a sample containing microorganisms uses at least one slow release compound having at least one hydrolyzable organic group capable of forming at least one alcohol, at least one organic acid, or a combination thereof, upon hydrolysis. The hydrolysis occurs over an extended period of time to provide alcohols and/or organic acids, which are used by the microorganisms to degrade the environmental contaminants.
    Type: Grant
    Filed: May 14, 1999
    Date of Patent: October 29, 2002
    Assignee: The State of Oregon Acting by and through the State Board of Higher Education on Behalf of Oregon State University
    Inventors: Lewis Semprini, Sanjay Vancheeswaran
  • Patent number: 6459017
    Abstract: Methods of transformation and regeneration of Iris germanica cell suspensions are disclosed. Also disclosed are transgenic Iris germanica cells and plants made by the disclosed methods.
    Type: Grant
    Filed: June 29, 2000
    Date of Patent: October 1, 2002
    Assignees: The State of Oregon Acting By and Through the State Board of Higher Education on Behalf of Oregon State University, Cooley's Gardens, Inc.
    Inventors: Zoran Jeknic, Richard C. Ernst, Tony H. H. Chen
  • Patent number: 6419855
    Abstract: Phosphor compositions of the formula Zn1-3x/2MxX:Mn, wherein M is selected from the group consisting of the trivalent cations of Al, In, Ga, and mixtures thereof, and X is selected from the group consisting of S, Se, Te, and mixtures thereof are disclosed. Also disclosed are phosphor compositions of the formula, MX:Cu,L,A wherein M is selected from the divalent ions of Sr, Mg, Ca, Ba, X is selected from the group consisting of S, Se, Te, and mixtures thereof, and mixtures thereof, L is selected from the group consisting of the trivalent cations of the lanthanides, Al, In, Ga, Sc, and mixtures thereof, and A is selected from the alkali metal ions or mixtures thereof. Emission chromaticity of the phosphors is controlled by varying codopant concentrations. Electroluminescent devices comprising the phosphors also are disclosed.
    Type: Grant
    Filed: September 16, 1999
    Date of Patent: July 16, 2002
    Assignee: The State of Oregon Acting by and through the State Board of Higher Education on behalf of Oregon State University
    Inventors: Douglas A. Keszler, Dong Li, John F. Wager, Benjamin L. Clark, Paul D. Keir
  • Patent number: 6395892
    Abstract: Four floral homeotic genes from Poplar are disclosed. The disclosed nucleic acid molecules are useful for producing transgenic plants having modified fertility characteristics, particularly sterility.
    Type: Grant
    Filed: October 1, 1999
    Date of Patent: May 28, 2002
    Assignee: The State of Oregon Acting by and through the State Board of Higher Education on Behalf of Oregon State University
    Inventors: Steven H. Strauss, William Rottmann, Amy Brunner, Lorraine Sheppard
  • Patent number: 6343305
    Abstract: Methods and apparatus for multiplication in the Galois field GF(2m) are provided. The methods transform elements of the Galois field into a basis obtained by a permutation of an optimal normal basis. In an embodiment, a multiplier is provided that includes m2 AND gates and 1.5(m2−m) XOR gates. The methods are implemented in hardware such as integrated circuits or in software instructions stored in a computer readable medium such as a hard disk.
    Type: Grant
    Filed: September 14, 1999
    Date of Patent: January 29, 2002
    Assignee: The State of Oregon Acting by and through the State Board of Higher Education on Behalf of Oregon State University
    Inventors: etin Kaya Koç, Berk Sunar
  • Patent number: 6316034
    Abstract: The growth of spoilage bacteria in yeast preparations and in fermentation products is inhibited by addition of lysozyme at various steps in the production process.
    Type: Grant
    Filed: January 15, 1999
    Date of Patent: November 13, 2001
    Assignee: The State of Oregon acting by and through the State Board of Higher Education on behalf of Oregon State University
    Inventors: Mark A. Daeschel, Linda D. Bruslind
  • Patent number: D455776
    Type: Grant
    Filed: December 1, 2000
    Date of Patent: April 16, 2002
    Assignee: The State of Oregon Acting by and through the State Board of Higher Education on Behalf of Oregon State University
    Inventor: John A. Gardner