Patents Assigned to Orion Genomics LLC
  • Differential enzymatic fragmentation
    Patent number: 7771936
    Abstract: The present invention provides methods for detecting the presence of methylation at a locus within a population of nucleic acids.
    Type: Grant
    Filed: October 21, 2004
    Date of Patent: August 10, 2010
    Assignee: Orion Genomics LLC
    Inventors: Jeffrey A. Jeddeloh, Nathan D. Lakey
  • GENE METHYLATION IN BLADDER CANCER DIAGNOSIS
    Publication number: 20090170081
    Abstract: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with bladder cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of bladder cancer.
    Type: Application
    Filed: February 1, 2008
    Publication date: July 2, 2009
    Applicant: Orion Genomics LLC
    Inventors: Muhammad A. Budiman, Jeffrey A. Jeddeloh, Rebecca Maloney, Yulia Korshunova
  • GENE METHYLATION IN BREAST CANCER
    Publication number: 20090170084
    Abstract: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with breast cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of breast cancer.
    Type: Application
    Filed: February 1, 2008
    Publication date: July 2, 2009
    Applicant: Orion Genomics LLC
    Inventors: Muhammad A. Budiman, Jeffrey A. Jeddeloh, Rebecca Maloney, Yulia Korshunova
  • GENE METHYLATION IN RENAL CANCER DIAGNOSIS
    Publication number: 20090170082
    Abstract: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with renal cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of renal cancer.
    Type: Application
    Filed: February 1, 2008
    Publication date: July 2, 2009
    Applicant: Orion Genomics LLC
    Inventors: Muhammad A. Budiman, Jeffrey A. Jeddeloh, Rebecca Maloney, Yulia Korshunova
  • GENE METHYLATION IN DIAGNOSIS OF MELANOMA
    Publication number: 20090170083
    Abstract: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with melanoma. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of melanoma.
    Type: Application
    Filed: February 1, 2008
    Publication date: July 2, 2009
    Applicant: Orion Genomics LLC
    Inventors: Muhammad A. Budiman, Jeffrey A. Jeddeloh, Rebecca Maloney, Yulia Korshunova
  • Gene Methylation in Colon Cancer Diagnosis
    Publication number: 20090098542
    Abstract: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with colon cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of colon cancer.
    Type: Application
    Filed: February 1, 2008
    Publication date: April 16, 2009
    Applicant: Orion Genomics LLC
    Inventors: Muhammad A. Budiman, Jeffrey A. Jeddeloh, Rebecca Maloney, Yulia Korshunova
  • Gene Methylation In Endometrial Cancer Diagnosis
    Publication number: 20090075262
    Abstract: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with endometrial cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of endometrial cancer.
    Type: Application
    Filed: February 1, 2008
    Publication date: March 19, 2009
    Applicant: Orion Genomics LLC
    Inventors: Muhammad A. Budiman, Jeffrey A. Jeddeloh, Rebecca Maloney, Yulia Korshunova
  • GENE METHYLATION IN OVARIAN CANCER DIAGNOSIS
    Publication number: 20090075263
    Abstract: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with ovarian cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of ovarian cancer.
    Type: Application
    Filed: February 1, 2008
    Publication date: March 19, 2009
    Applicant: Orion Genomics LLC
    Inventors: Muhammad A. Budiman, Jeffrey A. Jeddeloh, Rebecca Maloney, Yulia Korshunova
  • GENE METHYLATION IN THYROID CANCER DIAGNOSIS
    Publication number: 20090075265
    Abstract: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with thyroid cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of thyroid cancer.
    Type: Application
    Filed: February 1, 2008
    Publication date: March 19, 2009
    Applicant: Orion Genomics LLC
    Inventors: MUHAMMAD A. BUDIMAN, JEFFREY A. JEDDELOH, REBECCA MALONEY, YULIA KORSHUNOVA
  • GENE METHYLATION IN LIVER CANCER DIAGNOSIS
    Publication number: 20090075264
    Abstract: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with liver cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of liver cancer.
    Type: Application
    Filed: February 1, 2008
    Publication date: March 19, 2009
    Applicant: Orion Genomics LLC
    Inventors: Muhammad A. Budiman, Jeffrey A. Jeddeloh, Rebecca Maloney, Yulia Korshunova
  • Differential enzymatic fragmentation by whole genome amplification
    Patent number: 7459274
    Abstract: The present invention provides methods for detecting the presence of methylation at a locus within a population of nucleic acids.
    Type: Grant
    Filed: March 2, 2005
    Date of Patent: December 2, 2008
    Assignee: Orion Genomics LLC
    Inventors: Nathan D. Lakey, Jeffrey A. Jeddeloh, Yulia Korshunova
  • Gene methylation in cancer diagnosis
    Publication number: 20070298506
    Abstract: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use in detecting and diagnosing cancer.
    Type: Application
    Filed: May 30, 2007
    Publication date: December 27, 2007
    Applicant: Orion Genomics LLC
    Inventors: Jared Ordway, Jeffrey Jeddeloh, Joseph Bedell
  • Comprehensive DNA methylation profiling in a human cancer genome identifies novel epigenetic targets
    Publication number: 20070224626
    Abstract: The present invention provides DNA marker sequences that are differentially methylated in samples from normal individuals and individuals with brain cancer. The invention further provides methods of identifying differentially methylated DNA marker sequences and their use the detection and diagnosis of gliomas.
    Type: Application
    Filed: March 8, 2007
    Publication date: September 27, 2007
    Applicant: Orion Genomics LLC
    Inventors: Jeffrey Jeddeloh, Jared Ordway
  • Differential enzymatic fragmentation by whole genome amplification
    Publication number: 20050272065
    Abstract: The present invention provides methods for detecting the presence of methylation at a locus within a population of nucleic acids.
    Type: Application
    Filed: March 2, 2005
    Publication date: December 8, 2005
    Applicant: Orion Genomics LLC
    Inventors: Nathan Lakey, Jeffrey Jeddeloh, Yulia Korshunova
  • Methods for quantitative determination of methylation density in a DNA locus
    Publication number: 20050153316
    Abstract: The present invention is a novel method of determining the average DNA methylation density of a locus of interest within a population of DNA fragments.
    Type: Application
    Filed: October 21, 2004
    Publication date: July 14, 2005
    Applicant: Orion Genomics LLC
    Inventors: Jeffrey Jeddeloh, Nathan Lakey