Patents Assigned to Ortho-McNeil Pharmaceutical, Inc.
  • Combination therapy comprising anti-diabetic and anticonvulsant agents
    Patent number: 6686337
    Abstract: Combination therapy comprising anti-diabetic agents and anticonvulsant derivatives useful for the treatment of Type II diabetes mellitus and Syndrome X are disclosed.
    Type: Grant
    Filed: October 25, 2001
    Date of Patent: February 3, 2004
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventor: Gregory S. Connor
  • Substituted tetracyclic pyrroloquinolone derivatives useful as phosphodiesterase inhibitors
    Patent number: 6686349
    Abstract: The invention relates to novel tetracyclic pyrroloquinolone derivatives of the formula (I) or (II): wherein all variables are as herein defined, pharmaceutical compositions containing the compounds and their use for the treatment of sexual dysfunction.
    Type: Grant
    Filed: November 12, 2002
    Date of Patent: February 3, 2004
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Weiqin Jiang, Zhihua Sui
  • Method for synthesis of substituted azole libraries
    Patent number: 6683191
    Abstract: The invention relates to methods of synthesizing libraries of diverse and complex 2-substituted azole compounds of the general formula (I) or (II) wherein X, R2 and the ring components are as described herein, novel intermediates useful for synthesizing such substituted azole compounds and methods for identifying and isolating the compounds.
    Type: Grant
    Filed: May 22, 2001
    Date of Patent: January 27, 2004
    Assignee: Ortho-McNeil Pharmaceuticals, Inc.
    Inventors: Yijun Deng, Dennis Hlasta
  • Process of preparing 3S-3-amino-3-aryl proprionic acid and derivatives thereof
    Patent number: 6673926
    Abstract: The present invention is directed to a process for preparing 3S-3-amino-3-aryl propionic acid and derivatives thereof.
    Type: Grant
    Filed: October 29, 2001
    Date of Patent: January 6, 2004
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Lorraine Scott, Frank John Villani, Jr., Donald G. Walker
  • Apparatus and method for transferring and weighing powder materials using pipette transfer devices
    Patent number: 6674022
    Abstract: The present invention provides an apparatus for automatically transferring and weighing a powder material. The apparatus comprises a weigh station including a device for weighing the powder material in a container. A transfer device for collecting and dispensing the powder material is provided in which the device has a hollow body having a first end and a second end. The first end being operatively connected to a vacuum source so that a vacuum is selectively formed in the body. A collecting/dispensing tip is detachably coupled to the second end of the body. The tip is a hollow member with a tip orifice at one end so that a vacuum is formed in the tip upon actuation of the vacuum source. A controller for causing the selective actuation of the vacuum source and movement of at least one of the transfer device and the container is provided.
    Type: Grant
    Filed: March 23, 2001
    Date of Patent: January 6, 2004
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Adam M. Fermier, John Troisi, James V. Weber
  • Cyclobutene derivatives useful as antagonists of the motilin receptor
    Patent number: 6667309
    Abstract: The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.
    Type: Grant
    Filed: March 12, 2002
    Date of Patent: December 23, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Robert H. Chen, Min A. Xiang
  • Methods for the synthesis of complex reduced isoindole, isooxyindole and isooxyquinoline libraries
    Patent number: 6667406
    Abstract: Disclosed are methods of synthesizing libraries of diverse complex hexahydroisoindole, hexahydroisooxyindole and octahydroisooxyquinoline compounds through the use of a facile intramolecular Diels Alder reaction. The invention is further directed to methods for synthesizing the libraries on solid supports. The invention is further directed to methods for identifying and isolating such hexahydroisoindole, hexahydroisooxyindole and octahydroisooxyquinoline compounds with useful and diverse activities from such libraries.
    Type: Grant
    Filed: March 7, 2000
    Date of Patent: December 23, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Sengen Sun, William V. Murray
  • Substituted pyrazoles
    Publication number: 20030225062
    Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S are described.
    Type: Application
    Filed: March 28, 2003
    Publication date: December 4, 2003
    Applicant: Ortho McNeil Pharmaceutical, Inc.
    Inventors: Hui Cai, James P. Edwards, Steven P. Meduna, Barbara A. Pio, Jianmei Wei
  • Substituted pyrazoles
    Publication number: 20030225063
    Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S are described.
    Type: Application
    Filed: March 28, 2003
    Publication date: December 4, 2003
    Applicant: Ortho McNeil Pharmaceutical, Inc.
    Inventors: Hui Cai, James P. Edwards, Steven P. Meduna, Barbara A. Pio, Jianmei Wei
  • Method and apparatus for obtaining molecular data from a pharmaceutical specimen
    Patent number: 6654118
    Abstract: This invention relates to a method and apparatus for the analysis of pharmaceutical specimens by nondestructively obtaining the molecular data for a chemical component on the surface or within the matrix of a pharmaceutical specimen.
    Type: Grant
    Filed: January 9, 2003
    Date of Patent: November 25, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventor: Richard David Bruce
  • Substituted benzimidazol-2-ones as vasopressin receptor antagonists and neuropeptide Y modulators
    Patent number: 6653478
    Abstract: The invention is directed to substituted benzimidazol-2-ones of Formula I, wherein A, X, Y, m, n, R1, R2, R3, R4, and R5 are as described in the specification, which are useful as vasopressin receptor antagonists or Neuropeptide Y Modulators for treating conditions such as aggression, obsessive-compulsive disorders, hypertension, dysmenorrhea, congestive heart failure/cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, renal vasospasm, renal failure, edema, ischemia, stroke, thrombosis, water retention, nephrotic syndrome, central nervous injuries, obesity, anorexia, hyperglycemia, diabetes, anxiety, depression, asthma, memory loss, sexual dysfunction, disorders of sleep and other circadian rhythms, and Cushing's disease.
    Type: Grant
    Filed: October 23, 2001
    Date of Patent: November 25, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Maud J. Urbanski, Joseph W. Gunnet, Jr., Keith T. Demarest
  • Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors
    Patent number: 6635638
    Abstract: The invention relates to novel pyrrolopyridinone derivatives of the formula (I) or (II): pharmaceutical compositions containing the compounds and their use for the treatment of sexual dysfunction.
    Type: Grant
    Filed: May 2, 2001
    Date of Patent: October 21, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Zhihua Sui, Mark J. Macielag, Jihua Guan, Weiqin Jiang, James C. Lanter
  • Aminopyrrolidine sulfonamides as serine protease inhibitors
    Patent number: 6630505
    Abstract: The present invention is directed to compounds useful as selective serine protease or dual-serine protease inhibitors, compositions thereof and methods for treating serine protease or dual-serine protease mediated disorders.
    Type: Grant
    Filed: November 25, 2002
    Date of Patent: October 7, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Michael N. Greco, Bruce E. Maryanoff, Michael J. Hawkins, Robert E. Boyd
  • Process for coating stents and other medical devices using super-critical carbon dioxide
    Patent number: 6627246
    Abstract: This invention provides an improved process for coating medical and surgical devices and the like using super-critical fluids.
    Type: Grant
    Filed: April 17, 2001
    Date of Patent: September 30, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Deepak B. Mehta, Michael Corbo
  • Anticonvulsant derivatives useful for the treatment of depression
    Patent number: 6627653
    Abstract: Anticonvulsant derivatives useful for treating depression as monotherapy or combination therapy are disclosed.
    Type: Grant
    Filed: July 27, 2001
    Date of Patent: September 30, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Carlos R. Plata-Salaman, Josue Bacaltchuk, Pedro A. S. Prado-Lima
  • Cyclopentene derivatives useful as antagonists of the motilin receptor
    Patent number: 6624165
    Abstract: The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.
    Type: Grant
    Filed: April 9, 2002
    Date of Patent: September 23, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Robert H. Chen, Min A. Xiang
  • Anticonvulsant derivatives useful in treating psychosis
    Patent number: 6620819
    Abstract: The anticonvulsant derivative topiramate useful in treating dementia and/or behavioral and psychotic disturbances in dementia is disclosed.
    Type: Grant
    Filed: May 13, 2002
    Date of Patent: September 16, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventor: David B. Marcotte
  • 6-O-carbamoyl ketolide antibacterials
    Patent number: 6613747
    Abstract: 6-O-Carbamoyl ketolide antibacterials of the formula: wherein R1, R2, R3, R4, R5, R6, X, X′, Y, and Y′ are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.
    Type: Grant
    Filed: December 5, 2001
    Date of Patent: September 2, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Todd C. Henninger, Xiaodong Xu
  • Process for preparing 1, 5-diaryl-3-substituted pyrazoles
    Patent number: 6613914
    Abstract: A process for making a compound of formula I wherein the substituents are as described in the specification comprising reacting a ketone of formula II with succinic anhydride and an alkoxide base to form a compound of formula III which is reacted with a compound of formula IV to form a compound of V and reacting with an alcohol to form the corresponding ester of formula VI and reacting the ester with N-methylhydroxylamine.
    Type: Grant
    Filed: March 1, 2002
    Date of Patent: September 2, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Ahmed F. Abdel-Magid, Bruce D. Harris, Cynthia A. Maryanoff
  • Substituted 2-aryl-3-(heteroaryl)-imidazo[1,2-a]pyrimidines, and related pharmaceutical compositions and methods
    Patent number: 6610697
    Abstract: This invention relates to a series of imidazopyrimidines of Formula I, and pharmaceutical compositions containing them. The compounds of the invention inhibit the production of a number of inflammatory cytokines and are useful in the treatment and prevention of diseases associated with the overproduction thereof.
    Type: Grant
    Filed: October 27, 2000
    Date of Patent: August 26, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: John H. Dodd, James R. Henry, Kenneth C. Rupert