Patents Assigned to Ortho-McNeil Pharmaceutical, Inc.
  • Assays for compounds modulating human serine protease C-E
    Patent number: 6849421
    Abstract: Here we describe the molecular identification of a cDNA encoding a novel serine protease we have termed protease C-E. The deduced amino acid sequence, and it alignment with other well-characterized serine proteases indicates that it is a member of the S1 serine protease family. We have found that the protease C-E mRNA is expressed in pancreas, placenta, prostate, small intestine, stomach, spleen, fibroblasts and epidermis, as well as in certain regions of the brain i.e., cerebellum, cerebral cortex, pituitary and hippocampus. Enzymatically active protease C-E, as produced using the methodologies described herein, is amenable to further biochemical analyses for the identification of physiological substrates and specific modulators.
    Type: Grant
    Filed: January 7, 2002
    Date of Patent: February 1, 2005
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Andrew Darrow, Jenson Qi, Patricia Andrade-Grodon
  • Indazolyl-substituted pyrroline compounds as kinase inhibitors
    Patent number: 6849643
    Abstract: The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: February 1, 2005
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, Bruce Conway, Kimberly White, Hong Ye, Leonard Robert Hecker, David F. McComsey
  • DNA encoding the human serine protease EOS
    Patent number: 6846920
    Abstract: Here we describe the molecular identification of a cDNA encoding a novel serine protease we have termed protease EOS. The deduced amino acid sequence, and it alignment with other well-characterized serine proteases indicates that it is a member of the S1 serine protease family. We have found that the protease EOS mRNA is expressed in platelets and leukocytes and more specifically eosinophils. Although this protease is abundantly expressed in ovary, retina and stomach, where it may perform important functions, its expression in platelets and certain cells of the immune system suggests that it may play roles in thrombosis and in the immune process. Enzymatically active protease EOS is amenable to further biochemical analyses for the identification of physiological substrates and specific modulators.
    Type: Grant
    Filed: January 8, 2002
    Date of Patent: January 25, 2005
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Andrew Darrow, Jenson Qi, Patricia Andrade-Gordon
  • 3a,4,5,9b-tetrahydro-1H-benz[e]indol-2-yl amine-derived neuropeptide Y receptors ligands useful in the treatment of obesity and other disorders
    Patent number: 6841552
    Abstract: Compounds of the formula: are disclosed as ligands for neuropeptide Y receptors and as such are useful in the treatment of obesity and disorders of the central nervous system.
    Type: Grant
    Filed: April 20, 2000
    Date of Patent: January 11, 2005
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Scott Dax, James McNally
  • Combination therapy comprising glucose reabsorption inhibitors and retinoid-X receptor modulators
    Patent number: 6838442
    Abstract: Combination therapy comprising RXR modulators and glucose reabsorption inhibitors useful for the treatment of diabetes and Syndrome X are disclosed.
    Type: Grant
    Filed: April 3, 2002
    Date of Patent: January 4, 2005
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Jacqueline C. Bussolari, Xiaoli Chen, Bruce R. Conway, Keith T. Demarest, Hamish N. M. Ross, Rafael Severino
  • Substituted amino acids as erythropoietin mimetics
    Publication number: 20040248815
    Abstract: This invention relates to a series of substitituted amino acids of Formula I 1
    Type: Application
    Filed: March 12, 2004
    Publication date: December 9, 2004
    Applicant: Ortho McNeil Pharmaceutical, Inc.
    Inventors: Peter J. Connolly, Victor T. Bandurco, Steven K. Wetter, Sigmond Johnson, Jacqueline Bussolari, William V. Murray
  • DNAs encoding mammalian histamine receptor of the H4 subtype
    Publication number: 20040248252
    Abstract: DNAs encoding the mammalian histamine H4 receptors have been cloned and characterized. These recombinant molecules are capable of expressing biologically active histamine H4 receptor protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The pharmacology of known histamine ligands is demonstrated. The recombinant protein may be purified from the recombinant host cells. In addition, recombinant host cells are utilized to establish methods to identify modulators of the receptor activity, and receptor modulators are identified.
    Type: Application
    Filed: July 23, 2003
    Publication date: December 9, 2004
    Applicant: ORTHO MCNEIL PHARMACEUTICAL, INC.
    Inventors: Timothy Lovenberg, Changlu Liu
  • Pharmaceutical compositions of erythropoietin
    Publication number: 20040248797
    Abstract: The present invention provides aqueous pharmaceutical formulations of erytropoietin that are free of human serum blood products, stabilized with a quantity of an amino acid and a sorbitan mono-9-octadecenoate poly(oxy-1,2-ethanediyl) derivative. The present invention also provides aqueous stable, preserved pharmaceutical formulations of erythropoietin that contain an antimicrobial quantity of cresol and a quantity of an amino acid.
    Type: Application
    Filed: February 10, 2004
    Publication date: December 9, 2004
    Applicant: Ortho McNeil Pharmaceutical, Inc.
    Inventors: Wing K. Cheung, Jaya Natarajan, Marilyn Sanders, Els Vercammen, Selima Begum, Basant Sharma
  • Macroheterocylic compounds useful as kinase inhibitors
    Patent number: 6828327
    Abstract: This invention is directed to macroheterocyclic compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: December 7, 2004
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Gee-Hong Kuo, Han-Cheng Zhang, Catherine Prouty, Alan DeAngelis, Peter Connolly, William V. Murray, Lan Shen, Bruce Conway, Keith Demarest, Chandra R. Shah, Bruce E. Maryanoff, Kimberly B. White
  • 6-O-acyl ketolide antibacterials
    Patent number: 6825170
    Abstract: 6-O-Acyl ketolide antibacterials of the formula: wherein R1, R2, R3, R4, W, X, X′, Y, and Y′ are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.
    Type: Grant
    Filed: November 21, 2002
    Date of Patent: November 30, 2004
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Todd C. Henninger, Mark J. Macielag, Manomi A. Tennakoon, Xiaodong Xu
  • Child safe container
    Patent number: 6824006
    Abstract: A child safe container including a base and a cover is provided. The container includes a hinge and latch which cooperate to maintain the container in a locked position. The container is unlocked and can be opened by translating the base and the cover in a preferred direction.
    Type: Grant
    Filed: November 7, 2002
    Date of Patent: November 30, 2004
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventor: Lawrence E. Lambelet, Jr.
  • Triazepine derivatives as neurotrophic agents
    Patent number: 6821993
    Abstract: This invention relates to a series of triazepines of Formula I and II, and pharmaceutical compositions containing them. The compounds of the invention have neurotrophic activity and are useful in the treatment and prevention of neuronal disorders such as Parkinson's disease, Alzheimer's disease, stroke, multiple sclerosis, amyotrophic lateral sclerosis diabetic neuropathy and Bell's palsy.
    Type: Grant
    Filed: October 4, 2002
    Date of Patent: November 23, 2004
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Zhihua Sui, Shawn P. Walsh
  • Aqueous sustained-release formulations of proteins
    Patent number: 6818613
    Abstract: The present invention is directed to sustained-release pharmaceutical formulations of therapeutic proteins containing carboxymethyl ether cellulose polymer and methods of manufacture and use thereof.
    Type: Grant
    Filed: November 7, 2001
    Date of Patent: November 16, 2004
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Basant Sharma, Renzhe Jin, Sunitha Rudolph, Wing K. Cheung, Selima Begum, Marian Kelley
  • Carbamate compounds for use in the treatment of pain
    Patent number: 6815464
    Abstract: This invention is directed to a method for the treatment of pain comprising administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of Formula (I) and Formula (II): wherein phenyl is substituted at X with one to five halogen atoms selected from the group consisting of fluorine, chlorine, bromine and iodine; and, R1, R2, R3, R4, R5 and R6 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; wherein C1-C4 alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of halogen, C1-C4 alkyl, C1-C4 alkoxy, amino, nitro and cyano).
    Type: Grant
    Filed: February 21, 2002
    Date of Patent: November 9, 2004
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Carlos R. Plata-Salaman, Boyu Zhao, Roy E. Twyman
  • Neurotrophic pyrrolidines and piperidines, and related compositions and methods
    Patent number: 6809107
    Abstract: This invention provides compounds having the following general structures: This invention also provides pharmaceutical compositions comprising same and methods of using these compositions to treat and prevent disorders characterized by neuronal damage.
    Type: Grant
    Filed: June 14, 2000
    Date of Patent: October 26, 2004
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Ramesh M. Kanojia, Alfonzo D. Jordan, Allen B. Reitz, Mark J. Macielag, Boyu Zhao
  • Taste masked liquid pharmaceutical compositions
    Patent number: 6806256
    Abstract: This invention is directed to a taste masked liquid pharmaceutical composition comprising a pharmaceutically active agent and a taste masking composition. In particular, the taste masking composition comprises a taste masking effective amount of an artificial sweetener.
    Type: Grant
    Filed: February 26, 2002
    Date of Patent: October 19, 2004
    Assignee: Ortho -McNeil Pharmaceutical, Inc.
    Inventors: Stephen A. Ulrich, Karen R. Zimm, Marc Karel Jozef Francois, Willy Maria Albert Carlo Dries
  • Heterocyclic compounds
    Patent number: 6803362
    Abstract: Heterocyclic compounds and methods of making them and using them.
    Type: Grant
    Filed: March 8, 2002
    Date of Patent: October 12, 2004
    Assignee: Ortho-McNeil Pharmaceutical inc.
    Inventors: Nicholas I. Carruthers, Wenying Chai, Curt A. Dvorak, James P. Edwards, Cheryl A. Grice, Jill A. Jablonowski, Lars Karlsson, Haripada Khatuya, Jennifer D. Kreisberg, Annette K. Kwok, Timothy W. Lovenberg, Kiev S. Ly, Barbara Pio, Chandravadan R. Shah, Siguan Sun, Robin L. Thurmond, Jianmei Wei, Wei Xiao
  • Combination progestin oral contraceptive regimen
    Patent number: 6797282
    Abstract: An oral contraception regimen which comprises sequentially administering two or more progestational agents exhibiting different effects on the human endometrium in combination with an estrogen. The invention is also directed to an extended use oral contraception regimen comprising the sequential administration of two or more progestational agents in combination with an estrogen.
    Type: Grant
    Filed: April 12, 2001
    Date of Patent: September 28, 2004
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Michael Kafrissen, Haya Taitel
  • Method of isolating CD8+ cells, and related hybridoma cells antibodies and polypeptides
    Patent number: 6790662
    Abstract: This invention provides a method of isolating CD8+ cells which employs an antibody which specifically binds to CD8 molecules present on the surface of CD8+ cells but does not activate the CD8+ cells once bound. This invention also provides related hybridoma cell lines, monoclonal antibodies, antigenic polypeptides, isolated CD8+ cells, and kits.
    Type: Grant
    Filed: March 8, 2000
    Date of Patent: September 14, 2004
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventor: Didier Leturcq
  • Polynucleotide and polypeptide sequences of monkey cathepsin S
    Patent number: 6784288
    Abstract: DNAs encoding monkey cathepsin S have been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
    Type: Grant
    Filed: November 8, 2001
    Date of Patent: August 31, 2004
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Robin Thurmond, Lars Karlsson, Sherry Baker