Patents Assigned to Ortho Pharmaceutical Corporation
  • Monoclonal antibody to a human T cell antigen and methods of preparing same
    Patent number: 4364937
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on essentially all normal human T cells and on approximately 95% of normal human thymocytes. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: January 8, 1980
    Date of Patent: December 21, 1982
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Monoclonal antibody to human cytotoxic and suppressor T cells and methods of preparing same
    Patent number: 4364932
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on normal human cytotoxic and suppressor T cells. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: October 9, 1979
    Date of Patent: December 21, 1982
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Monoclonal antibody to human T cells, and methods for preparing same
    Patent number: 4363799
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on all normal human T cells. The hybrid is formed by fusing splenocytes from immunized Balb/cJ mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: March 20, 1979
    Date of Patent: December 14, 1982
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Complement-fixing monoclonal antibody to human suppressor T cells and methods of preparing same
    Patent number: 4361550
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on normal human suppressor T cells. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: December 4, 1979
    Date of Patent: November 30, 1982
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Complement-fixing monoclonal antibody to human T cells, and methods of preparing same
    Patent number: 4361549
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on all normal human T cells and cutaneous T lymphoma cells. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8Ul myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: April 26, 1979
    Date of Patent: November 30, 1982
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Process for preparing 8-oxabicyclo[3.2.1]-octane-1-acetic acids
    Patent number: 4360467
    Abstract: The preparation of racemic 1R, 4R, 5R-5-(4', 8'-dimethyl-5'-hydroxy-7'-nonenyl)-5-methyl-8-oxabicyclo[3.2.1]-octane-1-a cetic acid is described. The cycloheptane compounds are active uteroevacuant agents.
    Type: Grant
    Filed: September 8, 1981
    Date of Patent: November 23, 1982
    Assignee: Ortho Pharmaceutical Corporation
    Inventor: Ramesh M. Kanojia
  • Immunoregulatory diketopiperazine compounds
    Patent number: 4331595
    Abstract: Immunoregulatory 2,5-diketopiperazine compounds of formula: ##STR1## wherein m is 1 or 2 and n is 3 or 4 possess the ability to regulate the immune system of humans and animals. Administration of the compounds will return to a normal state an immune system in need of regulation.
    Type: Grant
    Filed: March 30, 1981
    Date of Patent: May 25, 1982
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: George Heavner, Foe-Siong Tjoeng, Gideon Goldstein
  • ( 1RS,4SR,5RS)-4-(5-Hydroxy-4,8-dimethyl-8-nonenyl)-4-methyl-3,8-dioxabicyc lo[3.2.1]octane-1-acetic acid
    Patent number: 4329288
    Abstract: The synthesis of 1RS,4SR,5RS-4-(4,8-dimethyl-5-hydroxy-7-nonen-1-yl)-4-methyl-3,8-dioxabicy clo[3.2.1]octane-1-acetic acid and related compounds is described. The above acetic acid compound and its isomer are contragestational agents.
    Type: Grant
    Filed: December 29, 1980
    Date of Patent: May 11, 1982
    Assignee: Ortho Pharmaceutical Corporation
    Inventor: Zoltan G. Hajos
  • Synthesis of dioxabicyclo(3.2.1)octanes and oxepanes
    Patent number: 4322353
    Abstract: The synthesis of C-4 alkyl homologs of racemic (1RS, 4SR,5RS)-4-(4,8-dimethyl-5-hydroxy-7-nonenyl)-4-methyl-3,8-dioxabicyclo[3. 2.1]octane-1-acetic acid and the corresponding (1RS,4RS,5RS) - derivative is described. The dioxabicylo[3.2.1]octanes are useful as contragestational agents.
    Type: Grant
    Filed: April 18, 1980
    Date of Patent: March 30, 1982
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Zoltan G. Hajos, Michael P. Wachter
  • Vaginal suppository
    Patent number: 4322399
    Abstract: A spermicidally active suppository comprising an alkylphenoxypolyethoxyethanol as the spermicide, a mixture of water-soluble polyethylene glycols as the suppository base, a mixture of an organic acid and an inorganic bicarbonate as the foaming agents and a mixture of an amphoteric surfactant and a water-soluble film-forming agent as the foam-stabilizing agent.
    Type: Grant
    Filed: October 19, 1979
    Date of Patent: March 30, 1982
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Nawaz Ahmad, Leonard Kaplan, George Ziets
  • Novel cycloheptanes
    Patent number: 4322357
    Abstract: The preparation of racemic 1R, 4R, 5R-5-(4', 8'-dimethyl-5'-hydroxy-7'-nonenyl)-5-methyl-8-oxabicyclo[3.2.1]-octane-1-a cetic acid is described. The cycloheptane compounds are active uteroevacuant agents.
    Type: Grant
    Filed: February 23, 1981
    Date of Patent: March 30, 1982
    Assignee: Ortho Pharmaceutical Corporation
    Inventor: Ramesh M. Kanojia
  • Drug delivery system
    Patent number: 4317447
    Abstract: A drug delivery system comprising a soluble medicated polymer in the shape of a cartridge or capsule is described. The capsule is applied over a carrier and the drug is released upon disintegration of the cartridge after insertion into the vagina.
    Type: Grant
    Filed: July 19, 1979
    Date of Patent: March 2, 1982
    Assignee: Ortho Pharmaceutical Corporation
    Inventor: Bernard L. Williams
  • Analgesic composition
    Patent number: 4315936
    Abstract: An analgesic composition comprising a mixture of a centrally-acting analgesic compound and .alpha.-methyl-4-[2-thienylcarbonyl] benzene acetic acid is described. Enhancement of the analgesic effect is observed in the combination.
    Type: Grant
    Filed: December 17, 1979
    Date of Patent: February 16, 1982
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Robert J. Capetola, John L. McGuire
  • Total synthesis of 1RS,4SR,5RS,-4-(4,8-dimethyl-5-hydroxy-7-nonen-1-yl)-4-methyl-3,8-dioxab icyclo[3.2.1]octane-1-acetic acid
    Patent number: 4307019
    Abstract: The synthesis of 1RS,4SR,5RS-4-(4,8-dimethyl-5-hydroxy-7-nonen-1-yl)-4-methyl-3,8-dioxabicy clo[3.2.1]octane-1-acetic acid is described. The bicyclo acetic acid compound is useful as a uteroevacuant agent.
    Type: Grant
    Filed: December 23, 1980
    Date of Patent: December 22, 1981
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Zoltan G. Hajos, Seymour Levine
  • Continuous process for the preparation of semisolid dispersions
    Patent number: 4299501
    Abstract: A semicontinuous or continuous process for preparing semisolid dispersions is provided wherein oil and water phases are circulated from a single vessel through a system of mixers and homogenizers until a dispersion is obtained.
    Type: Grant
    Filed: August 10, 1979
    Date of Patent: November 10, 1981
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Deepak R. Patil, Glenn A. VanBuskirk
  • Methods and compositions for preparation of H-ARG-X-Z-Y-TYR-R
    Patent number: 4298523
    Abstract: Solution phase methods and compositions for preparing H-ARG-X-Z-Y-TYR-R wherein X is LYS and Y is VAL or X and Y are both SAR, Z is ASP or GLU, and R is NH.sub.2 or OH.
    Type: Grant
    Filed: June 17, 1980
    Date of Patent: November 3, 1981
    Assignee: Ortho Pharmaceutical Corporation
    Inventor: George Heavner
  • Total synthesis of the utero-evacuant substance d,l-zoapatanol
    Patent number: 4296035
    Abstract: A method for the synthesis of racemic 2S* 3R*-6E-(2"-hydroxyethylidene)-2-methyl-2-(4',8'-dimethyl-5'-oxo-7'-nonenyl )-oxepan-3-ol is described. The naturally occurring product, 2S,3R-6E-(2"-hydroxyethylidene)-2-methyl-2-(4',8'-dimethyl-5'-oxo-7'-nonen yl)-oxepan-3-ol, is one of the active components of the zoapatle plant.
    Type: Grant
    Filed: March 17, 1980
    Date of Patent: October 20, 1981
    Assignee: Ortho Pharmaceutical Corporation
    Inventor: Vinayak V. Kane
  • Immunoregulatory diketopiperazine compounds
    Patent number: 4289759
    Abstract: Immunoregulatory 2,5-diketopiperazine compounds of formula: ##STR1## wherein m is 1 or 2 and n is 3 or 4 possess the ability to regulate the immune system of humans and animals. Administration of the compounds will return to a normal state an immune system in need of regulation.
    Type: Grant
    Filed: June 23, 1980
    Date of Patent: September 15, 1981
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: George Heavner, Foe-Siong Tjoeng, Gideon Goldstein
  • Total synthesis of 1RS,4SR,5RS-4-(4,8-dimethyl)-5-hydroxy-7-nonen-1-yl)-4-methyl-3,8-dioxab icyclo[3.2.1]octane-1-acetic acid and related compounds
    Patent number: 4284565
    Abstract: The synthesis of 1RS,4SR,5RS-4-(4,8-dimethyl-5-hydroxy-7-nonen-1-yl)-4-methyl-3,8-dioxabicy clo[3.2.1]octane-1-acetic acid and related compounds is described. The above acetic acid compound and its isomer are contragestational agents.
    Type: Grant
    Filed: May 2, 1980
    Date of Patent: August 18, 1981
    Assignee: Ortho Pharmaceutical Corporation
    Inventor: Zoltan G. Hajos
  • Tampon applicator
    Patent number: D263503
    Type: Grant
    Filed: May 17, 1979
    Date of Patent: March 23, 1982
    Assignee: Ortho Pharmaceutical Corporation
    Inventor: Ralph I. Williams