Patents Assigned to Ortho Pharmaceutical Corporation
  • 1,5-epoxy-2,3,4,5-tetrahydro-1H-3-benzazepins and use in treatment of ulcers
    Patent number: 4761413
    Abstract: The synthesis of epoxybenzazepin compounds is described. The novel compounds have anti-ulcer activity.
    Type: Grant
    Filed: December 22, 1986
    Date of Patent: August 2, 1988
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Michael P. Wachter, Donald S. Karanewsky
  • Process for preparing 5,6-dialkoxy-4-alkyl-2(1H)-quinazolinones
    Patent number: 4751304
    Abstract: A method for preparing 5,6-dialkoxy-4-alkyl-quinazolinones is described. The 5,6-dialkoxy-4-alkyl-quinazolinones are active cardiotonic agents.
    Type: Grant
    Filed: September 26, 1984
    Date of Patent: June 14, 1988
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Victor T. Bandurco, Robert A. Mallory, Jeffery B. Press
  • Treatment of allergy with thymopentin
    Patent number: 4749690
    Abstract: A method for treating allergy by administration of the peptide thymopentin.
    Type: Grant
    Filed: January 27, 1986
    Date of Patent: June 7, 1988
    Assignee: Ortho Pharmaceutical Corporation
    Inventor: Gideon Goldstein
  • Substituted quinazoline-3-oxides providing pharmacological activity
    Patent number: 4745118
    Abstract: Novel substituted quinazoline-3-oxides are disclosed as are methods of increasing cardiotonic activity and bronchodilation in which an unit dose of a composition containing an effective amount of a cardiotonic agent or a bronchodilating agent dispersed in a pharmaceutically acceptable carrier are administered to a mammalian host.
    Type: Grant
    Filed: June 5, 1986
    Date of Patent: May 17, 1988
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Donald W. Combs, Robert Falotico
  • Hybrid cell line for producing monoclonal antibody to a human T cell antigen, antibody, and methods
    Patent number: 4743681
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on essentially all normal human T cells and on approximately 95% of normal human thymocytes. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: August 29, 1984
    Date of Patent: May 10, 1988
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Monoclonal antibody therapy
    Patent number: 4731244
    Abstract: A method of seriatim administration to a patient of a plurality of ligands, each of which contains an antigen combining site of a monoclonal antibody of distinct idiotype, is disclosed. This method is useful for therapeutic as well as diagnostic purposes.
    Type: Grant
    Filed: November 13, 1985
    Date of Patent: March 15, 1988
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Mary A. Talle, Walter Newman, Patricia E. Rao, Gideon Goldstein
  • Process for preparing 2-acyl-3,4-dialkoxyanilines
    Patent number: 4731480
    Abstract: A process for preparing 2-acyl-3,4-dialkoxyanilines is described. The 2-acyl-3,4-dialkoxyanilines are useful intermediates in the preparation of 5,6-dialkoxy-4-alkyl-2(1H)-quinazolinones. The substituted quinazolinones are active as cardiotonic agents.
    Type: Grant
    Filed: July 29, 1985
    Date of Patent: March 15, 1988
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Richard A. Conley, Donald L. Barton
  • 2- Or 3- aryl substituted imidazo [1,2-a]pyridines
    Patent number: 4727145
    Abstract: Novel 2- or 3- aryl substituted imidazo[1,2-a]pyridines and their synthesis are described. The compounds have local anesthetic properties and are useful as local anesthetic agents.
    Type: Grant
    Filed: September 22, 1986
    Date of Patent: February 23, 1988
    Assignee: Ortho Pharmaceutical Corporation
    Inventor: Jeffery B. Press
  • 6-benzoxazinyl-2,3,4,5-tetrahydropyridazin-3-ones
    Patent number: 4721784
    Abstract: The synthesis of benzoxazinyl-pyridazinone compounds is described. The novel compounds are cardiotonic agents and inhibitors of phosphodiesterase fraction III. In addition, the compounds are useful as smooth muscle relaxants and bronchodilators.
    Type: Grant
    Filed: December 22, 1986
    Date of Patent: January 26, 1988
    Assignee: Ortho Pharmaceutical Corporation
    Inventor: Donald W. Combs
  • 4-nitrogen substituted isoquinolinol compounds having cardiotonic, phosphodiesterase fraction III inhibiting properties and/or renal vasodilating properties
    Patent number: 4714705
    Abstract: Substituted 3-isoquinolinol compounds of the general formula ##STR1## that exhibit cardiotonic and/or phosphodiesterase fraction III inhibiting properties and/or renal vasodilating are pharmacologically active in the treatment of cardiac conditions. Methods for synthesizing and using those compounds are described.
    Type: Grant
    Filed: July 7, 1986
    Date of Patent: December 22, 1987
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Ramesh M. Kanojia, Robert Falotico, Alfonso J. Tobia, Jeffery B. Press
  • Method for the production of crystalline amino-protected-beta-benzyl-L-aspartic acid
    Patent number: 4713480
    Abstract: An amino-protected L-aspartic acid, such as t-butyloxycarbonyl-beta-benzyl-L-aspartic acid, is prepared by first forming the amino-protected compound in the presence of a tertiary amine base having a pK.sub.a value of about 9 to about 12, water, and a water-immiscible polar organic solvent so as to produce a non-aqueous solution containing a salt form of amino-blocked-beta-benzyl-L-aspartic acid. The thus produced non-aqueous solution is then isolated, or next acidified and treated further to ultimately recover therefrom the amino-protected L-aspartic acid in crystalline form.
    Type: Grant
    Filed: January 7, 1987
    Date of Patent: December 15, 1987
    Assignee: Ortho Pharmaceutical Corporation
    Inventor: John M. Pascone
  • Substituted 3-(4-phenyl-1-piperazinyl)alkylquinazolin-2,4-(1H,3H) diones, methods of preparation, compositions and method of use
    Patent number: 4711883
    Abstract: Novel substituted-3-(4-phenyl-1-piperazinyl)alkyl quinazolin-2,4-(1H,3H)diones are described. These compounds are useful as antihypertensive agents.
    Type: Grant
    Filed: September 30, 1985
    Date of Patent: December 8, 1987
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Victor T. Bandurco, Charles F. Schwender, Robert Falotico, Alfonso J. Tobia
  • Monoclonal antibody to human suppressor T cells
    Patent number: 4709015
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on normal human suppressor T cells. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8Ul myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: August 9, 1984
    Date of Patent: November 24, 1987
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • N-(substituted thienyl)-N'-(substituted piperazinyl)-ureas
    Patent number: 4707550
    Abstract: The synthesis of thienopyrimidine-2,4-dione derivatives and their urea intermediates is described. The novel urea intermediates and thienopyrimidine-2,4-dione derivatives are general vasodilating agents and anti-hypertensive agents. The compounds are useful as cardiovascular agents.
    Type: Grant
    Filed: January 21, 1987
    Date of Patent: November 17, 1987
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Jeffery B. Press, Ronald K. Russell
  • Substituted thiacycloalkeno (3,2-b) pyridines and pharmaceutical compositions and method of use
    Patent number: 4705785
    Abstract: Novel substituted thiacycloalkeno [3,2-b] pyridines are described. These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstrictor activity.
    Type: Grant
    Filed: April 9, 1986
    Date of Patent: November 10, 1987
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Charles F. Schwender, John H. Dodd
  • Furo(3,4-d)pyrimidine-2,4-dione derivatives and intermediates thereof
    Patent number: 4703120
    Abstract: The synthesis of furo[3,4-d]pyrimidine-2,4-dione derivatives and their urea intermediates is described. The novel urea intermediates and furo[3,4-d]pyrimidine-2,4-dione derivatives are general vasodilating agents and anti-hypertensive agents. The compounds are useful as cardiovascular agents.
    Type: Grant
    Filed: April 28, 1986
    Date of Patent: October 27, 1987
    Assignee: Ortho Pharmaceutical Corporation
    Inventor: Jeffery B. Press
  • Hybrid cell line for producing monoclonal antibody to a human early thymocyte antigen, antibody, and methods
    Patent number: 4691010
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on approximately 10% of normal human thymocytes. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8Ul myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: August 9, 1984
    Date of Patent: September 1, 1987
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Hydroxamic acids and esters
    Patent number: 4681894
    Abstract: The synthesis of amido substituted naphthalenes and their intermediates is described. The intermediates and amido substituted naphthalenes are useful as anti-inflammatory agents.
    Type: Grant
    Filed: September 26, 1986
    Date of Patent: July 21, 1987
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: William V. Murray, Michael P. Wachter
  • Rioprostil-PVP complex
    Patent number: 4681759
    Abstract: A rioprostil/PVP complex is disclosed which is formed by lyophilization, evaporation or spray drying processes, and formed into improved solid dosage form for oral administration of cytoprotection and gastrointestinal lesions.
    Type: Grant
    Filed: May 8, 1985
    Date of Patent: July 21, 1987
    Assignee: Ortho Pharmaceutical Corporation
    Inventor: Linda S. Porubcan
  • Substituted 5,6-dialkoxyquinazoline derivatives
    Patent number: 4672116
    Abstract: Quinazoline derivatives having an oxy substituent in 5 and 6 positions are described. The novel quinazoline derivatives are useful as cardiotonic agents.
    Type: Grant
    Filed: December 20, 1985
    Date of Patent: June 9, 1987
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Victor T. Bandurco, Stanley C. Bell, John H. Dodd, Robert Falotico, Charles F. Schwender, Alfonso J. Tobia