Abstract: The use of compounds of the following formula I: ##STR1## for treating psoriasis is disclosed.

Abstract: 1-Arylsulphonyl, arylcarbonyl and arylthiocarbonyl pyridazino derivatives and processes for making said derivatives are described. The novel derivatives are non-steroidal heterocyclic compounds which act as selective progestins and/or antiprogestins having a high in-vitro affinity for either the uterine, breast or bone progestin receptor. As such, the non-steroidal heterocyclic derivatives are useful in contraception, menopause, osteoporosis or endometriosis.

Abstract: This application relates to the use of topiramate and related sulfonamides for the treatment of manic-depressive bipolar disorder.

Abstract: The invention relates to cyclohexenyl antibacterial compounds of the formula I: ##STR1## and pharmaceutical compositions containing the compounds, methods for their production and use.

Abstract: Disclosed herein is a method of treating amyotrophic lateral sclerosis with topiramate and related compounds.

Abstract: Described herein are 4-?(thien-3-yl)methyl!-imidazoles of the formula: ##STR1## wherein R is hydrogen or methyl, andX is C.sub.1-4 alkyl, bromine or chlorine; or ##STR2## wherein Y is hydrogen, C.sub.1-4 alkyl, bromine or chlorine, andZ is C.sub.1-4 4alkyl, bromine or chlorine which have exceptional analgesic activity.

Abstract: The invention relates to a method of manufacturing pulmonary surfactant protein by solubilizing the protein in ethanol by treatment with a fluorinated alcohol so that the protein may be formulated into liposomes by ethanolic injection.

Abstract: The invention relates to benzoxazine and pyrido-oxazine antibacterial compounds of the general formula: ##STR1## wherein the moiety Q is a fused phenyl or fused pyridyl moiety and R is a substituted amine or substituted thio moiety as herein described, pharmaceutical compositions containing the compounds, methods for their production and their use in treating bacterial infections.

Abstract: The invention relates to benzoxazine and pyrido-oxazine antibacterial compounds of the general formula: ##STR1## wherein the moiety Q is a fused phenyl or fused pyridyl moiety as herein described, pharmaceutical compositions containing the compounds, methods for their production and their use in treating bacterial infections.

Abstract: A method and apparatus for identifying authorized users of a secure system. A user of the secure system is prompted to enter a personal identification code which is then received into the secure system. The personal identification code entered by the user is then compared against a list of authorized personal identification codes. The user is identified to be an authorized user of the secure system only if the personal identification code entered by the user is present in the list of authorized personal identification codes. Each personal identification code on the list of authorized personal identification codes is arranged in a personal identification code format that includes a plurality of core digits and a plurality of check digits.

Abstract: Disclosed are progestin agonists having the following formula: ##STR1## W is absent or --CH.dbd.CH--; R.sup.1 are independently selected from the group consisting of halogen, --CF.sub.3, and NO.sub.2, or both R.sup.1 may be joined to form a bi-radical which is --CH.dbd.CHCH.dbd.CH--;R.sup.3 are independently selected from the group consisting of hydrogen, C.sub.1-6 branched or linear alkyl, halogen and --CF.sub.3, with the proviso that R.sup.3 at the 3-position must be H where R.sup.3 at the 4-position is H, or both R.sup.3 may be joined to form a bi-radical selected from the group consisting of --CH.dbd.CHCH.dbd.CH--, --C(NC.sub.1-4 alkyl.sub.2)=CHCH.dbd.CH-- and --(CH.sub.2).sub.4 --;R.sup.5 is selected from the group consisting of H and Me;with the proviso that only one of R.sup.1 and R.sup.3 forms the fused bi-radical; and the stereoisomers.

Abstract: Shelf stable formulations of 2-CdA in water are disclosed which contain benzyl alcohol and, optionally, propylene glycol.

Abstract: This invention relates to substituted thiazole derivatives of the following general formula, the substituent groups of which are as defined in the specification herein: ##STR1## These compounds are useful as inhibitors of platelet aggregation and inhibitors of adhesion molecules and may be provided in pharmaceutical compositions and in methods of treating reperfusion thrombosis injury in patients. Also included are novel intermediates for preparing the compounds of the invention.

Abstract: The present invention is directed to a self-actuating dispenser for a regimen of pills satisfying the needs discussed herein above. A self-actuating dispenser having the features of the present invention comprises a base, a pill container, and a means for cyclically indexing the pill container with respect to the base. The base has a pill exit aperture. The pill container, which houses the pills in individual compartments or cells, is movably attached to the base such that any pill cell can be aligned with the pill exit aperture. The pill cells are provided with open bottoms for loading and dispensing which are covered over by the base when attached thereto. The means for cyclically indexing provides that each pill cell in turn is brought into alignment with the pill exit aperture thereby singly dropping the resident pills in a series of dispensing cycles.

Abstract: A regimen for the therapeutic management of a gonadal-steroid dependent condition in a mammal constitutes reducing the estrogen supply thereof by means of administration of a GnRH antagonist in an amount effective to inhibit proliferation of endometrial tissue without substantially stopping the production of endogenous estrogen. A method of determining whether the reduced estrogen supply in an individual is such that the concentration of estradiol has been suppressed to an optimized level appropriate to the therapeutic management of the gonadal-steroid dependent condition such as endometriosis in that individual by the administration of a GnRH antagonist at a given dosage level involves titering the dosage, e.g., by conducting a progesterone challenge test and optimal regimen doses of a GnRH antagonist.

Abstract: This invention relates to a novel method of manufacturing a lyophilized suppository composition wherein said suppository is made in situ in an applicator cartridge.

Abstract: This invention is directed to a multilayered controlled release pharmaceutical dosage form. More particularly the dosage form is adapted for water soluble drugs and comprises a plurality of coated particles wherein each has multiple layers about a core containing a drug active whereby the drug containing core and at least one other layer of drug active is overcoated with a controlled release barrier layer and preferably an outer layer of additional drug is adapted for immediate release to preferably provide one immediate releasing layer and at least two controlled releasing layers of a water soluble drug from the multilayered coated particle.

Abstract: The invention relates to triphenylalkyl antibacterial compounds of the general formula: ##STR1## pharmaceutical compositions containing the compounds, and methods for their production and use. These compounds are effective in inhibiting the action of a bacterial histidine protein kinase and are thus useful as anti-infective agents against a variety of bacterial organisms, including organisms which are resistant to other known antibiotics.

Abstract: This invention relates to aqueous gel retinoid compositions and their methods of use. More specifically, the aqueous gel retinoid compositions of the invention utilize micronized particles of retinoids, particularly tretinoin, to provide an aqueous gel for topical application of such retinoids to the skin which minimizes skin irritation while retaining drug efficacy.

Abstract: An apparatus and method for automatically identifying, handling, tracking, and processing dried blood samples in HIV-1 testing are disclosed. Dried blood samples are punched from test cards into incubation receptacles for incubation and further testing. Optionally, the location on the test card to be punched may be manually, semi-automatically or automatically selected, ranked, and punched in order of preference. Test results corresponding to a particular test subject are automatically tracked and reported while maintaining the anonymity of the subject.