Patents Assigned to Osaka University
  • Patent number: 11560421
    Abstract: The present invention provides a new antibody against ECSA type Chikungunya virus, WA type Chikungunya virus, and Asian type Chikungunya virus or an antigen-binding fragment of the antibody. The antibody against Chikungunya virus or the antigen-binding fragment of the antibody of the present invention includes a heavy chain variable region or a heavy chain (1), (2), or (3) and a light chain variable region or a light chain (4).
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: January 24, 2023
    Assignees: Osaka University, Mahidol University
    Inventors: Tatsuo Shioda, Emi Nakayama, Tadahiro Sasaki, Orapim Puiprom, Aekkachai Tuekprakhon, Pornsawan Leaungwutiwong, Natthanej Luplertlop
  • Patent number: 11559196
    Abstract: A flexible endoscope of the present invention includes a catheter portion and a connection plug. The catheter portion includes an image guide, a light guide, and a catheter tube that surrounds the image guide and the light guide in a longitudinal direction, and the connection plug includes a hollow cover that accommodates the proximal end of the catheter tube, a flexible tube that protrudes from the hollow cover and through which the catheter tube is passed, a first connection terminal that is connected to the light guide extending from the proximal end of the catheter tube, and a second connection terminal that is connected to the image guide extending from the proximal end of the catheter tube. The image guide and the light guide are slidable inside the catheter tube, and at least one of the image guide and the light guide is arranged curved inside the hollow cover of the connection plug.
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: January 24, 2023
    Assignees: OSAKA UNIVERSITY, SUMITA OPTICAL GLASS, INC.
    Inventors: Keita Okayama, Shinsuke Nanto, Hiroya Hoshi
  • Patent number: 11559603
    Abstract: To provide a collagen sponge excellent in mechanical strength and a production method for the collagen sponge. A collagen sponge including a porous construct having a pore structure, the collagen sponge having a tensile strength of 1 N or more and 5 N or less in every direction including a length direction and a width direction. The collagen sponge may be produced by a production method including the following steps: (1) a step of subjecting a collagen solution obtained by mixing collagen and a solvent to stirring and deaeration treatment; (2) a step of subjecting the collagen solution to freeze-dry treatment; and (3) a step of subjecting a dried collagen product after the freeze-dry treatment to insoluble treatment.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: January 24, 2023
    Assignees: KOKEN CO., LTD., OSAKA UNIVERSITY
    Inventors: Ken Nakata, Gaku Kanno
  • Publication number: 20230014347
    Abstract: This disclosure provides a method for producing a hydrofluoroolefin (HFO) or fluoroolefin (FO), which is a target compound, with high selectivity, without requiring a high temperature and a catalyst in a synthesis process of the target compound. Specifically, the present disclosure provides a method for producing a hydrofluoroolefin or fluoroolefin having two, three, or four carbon atoms, comprising irradiating at least one starting material compound selected from the group consisting of hydrofluorocarbons having one or two carbon atoms and hydrofluoroolefin As having two or three carbon atoms with ionizing radiation and/or an ultraviolet ray having a wavelength of 300 nm or less, with the proviso that when the at least one starting material compound is the hydrofluoroolefin A, the resulting hydrofluoroolefin is different from the hydrofluoroolefin A.
    Type: Application
    Filed: August 25, 2022
    Publication date: January 19, 2023
    Applicants: DAIKIN INDUSTRIES, LTD., OSAKA UNIVERSITY
    Inventors: Yuuta HASUMOTO, Tatsuya TAKAKUWA, Osamu YAMAMOTO, Hideki NAKAYA, Masao NOUMI, Kazuyuki SATOU, Kohei YAMANOI, Akihiro OSHIMA
  • Patent number: 11558952
    Abstract: A BID includes: a discharger (2) including a dielectric pipe (8) and a pair of electrodes (14, 16) attached on an outer wall of the dielectric pipe, the pair of electrodes (14, 16) being arranged at a distance from each other in a direction along a central axis of the dielectric pipe (8), the discharger (2) being arranged so that plasma generating gas is introduced from a first end of the dielectric pipe (8) and configured to generates dielectric barrier discharge inside the dielectric pipe (8) to generate plasma; a detection section (4) including a sample gas introduction section (31) and a collection electrode (26) for collecting ions, the detection section (4) being configured to ionize components in the sample gas using light emitted from the plasma generated in the discharger (2) and to detect the generated ions by collecting them using the collection electrode (26); and a voltage supply (6; 6?) for generating a potential difference between the pair of electrodes (14, 16).
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: January 17, 2023
    Assignees: Shimadzu Corporation, OSAKA UNIVERSITY
    Inventors: Kei Shinada, Katsuhisa Kitano
  • Patent number: 11548882
    Abstract: The present invention provides a compound, a salt thereof, or a prodrug thereof as a compound effective for preventing and/or treating fibrosis, the compound being represented by formula (1) (wherein A is an optionally substituted benzene ring; B is optionally substituted aryl or optionally substituted heteroaryl; X is an oxygen atom or a sulfur atom; Y is a nitrogen atom or a carbon atom; of Y is a single or double bond when Y is a carbon atom, or of Y is a single bond when Y is a nitrogen atom; each R1 independently represents lower alkyl, or two R1s may be bound to each other to form a spiro ring or a crosslinked structure, or two R1s may be bound to each other to form a saturated fused heterocycle together with nitrogen and carbon atoms constituting a ring containing Y; p is 0, 1, or 2; or (R1)p is oxo).
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: January 10, 2023
    Assignees: Osaka University, Kyoto University, Inter-University Research Institute Corporation National Institutes of Natural Sciences
    Inventors: Ryu Nagata, Yasuo Mori, Masayuki Mori, Motohiro Nishida, Takuro Tomita
  • Patent number: 11549880
    Abstract: An electromagnetic wave detecting device comprising: an emission unit configured to emit electromagnetic waves having coherence; an electromagnetic wave modulating unit configured to modulate one or both of a phase and an amplitude of the emitted electromagnetic waves and to change a state of the modulation relative to an imaging target; and a post-modulation electromagnetic wave intensity detecting unit configured to detect an intensity of post-modulation electromagnetic waves, which are the modulated electromagnetic waves acquired by modulating the electromagnetic waves emitted from the emission unit using the imaging target and the electromagnetic wave modulating unit, using one pixel.
    Type: Grant
    Filed: August 15, 2019
    Date of Patent: January 10, 2023
    Assignees: OSAKA UNIVERSITY, The University of Tokyo
    Inventors: Ryoichi Horisaki, Jun Tanida, Sadao Ota
  • Publication number: 20220411750
    Abstract: The present invention relates to a cell structure including cells containing at least hepatocytes and vascular endothelial cells, and extracellular matrix component, wherein the extracellular matrix components are disposed between the cells, and a liver sinusoidal network is provided between the cells.
    Type: Application
    Filed: November 17, 2020
    Publication date: December 29, 2022
    Applicants: TOPPAN INC., Osaka University
    Inventors: Yasuyuki HIRAOKA, Shiro KITANO, Shinji IRIE, Michiya MATSUSAKI
  • Patent number: 11534854
    Abstract: Provided are a long-life and inexpensive friction stir welding tool that is not dependent on the mode of friction stir welding or the type of material to be welded, and a friction stir welding method using the friction stir welding tool. The friction stir welding tool comprises a body portion having a shoulder portion, and a probe portion disposed on a bottom surface of the body portion, and is characterized in that the probe portion is spherical-crown shaped. Preferably, the shoulder portion is flat or convex, and preferably the hardness of the shoulder portion is greater than the hardness of the probe portion.
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: December 27, 2022
    Assignee: OSAKA UNIVERSITY
    Inventors: Hidetoshi Fujii, Yoshiaki Morisada, Yasuhiro Aoki, Akihiko Ikuta
  • Patent number: 11535691
    Abstract: Provided are a macromolecular material that exhibits high toughness and self-healing properties, and that can be produced by a simple process, as well as a method for producing the material. The macromolecular material contains a crosslinked polymer crosslinked by the interaction between a host group and a guest group. The crosslinked polymer contains a repeating structural unit represented by the following formula (1a) and a repeating structural unit represented by the following formula (2a).
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: December 27, 2022
    Assignee: Osaka University
    Inventors: Akira Harada, Yoshinori Takashima, Kazuhisa Iwaso
  • Publication number: 20220403437
    Abstract: Glucuronosyltransferase 1 gene which catalyzes glucuronic acid transfer to the hydroxyl group at the 3-position in an oleanane-type triterpenoid is identified. Glucuronosyltransferase 1 gene having a desired activity, derived from a Fabaceae plant (soybean, Glycyrrhiza, and Lotus japonicus), and containing nucleotide sequences represented by SEQ ID Nos: 2, 4, and 6, respectively, is provided.
    Type: Application
    Filed: October 16, 2020
    Publication date: December 22, 2022
    Applicants: OSAKA UNIVERSITY, NATIONAL AGRICULTURE AND FOOD RESEARCH ORGANIZATION
    Inventors: Toshiya MURANAKA, Hikaru SEKI, Soo Yeon CHUNG, Masao ISHIMOTO, Susumu HIRAGA, Yukiko SATOU
  • Patent number: 11532767
    Abstract: Provided is a method of producing semiconductor nanoparticles that exhibit a band-edge emission, and are superior in quantum yield. The method includes raising the temperature of a first mixture containing a silver (Ag) salt, a salt containing at least one of indium (In) and gallium (Ga), a solid compound that serves as a supply source of sulfur (S), and an organic solvent to a temperature in a range of from 125° C. to 175° C., and heat-treating, subsequent to the raising of the temperature, the first mixture at a temperature in a range of from 125° C. to 175° C. for three seconds or more to obtain a solution containing semiconductor nanoparticles, and decreasing the temperature of the solution containing semiconductor nanoparticles. The solid compound that serves as a supply source of S contains thiourea.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: December 20, 2022
    Assignees: OSAKA UNIVERSITY, National University Corporation Tokai National Higher Education and Research System, NICHIA CORPORATION
    Inventors: Susumu Kuwabata, Taro Uematsu, Kazutaka Wajima, Tsukasa Torimoto, Tatsuya Kameyama, Daisuke Oyamatsu
  • Patent number: 11527761
    Abstract: Provided are (i) a catalyst that has a core-shell structure and is highly active in an oxygen reduction reaction, which is a cathode reaction of a fuel cell, and (ii) a reaction acceleration method in which the catalyst is used. A core-shell catalyst for accelerating an oxygen reduction reaction, contains: silver or palladium as a core material; and platinum as a shell material, the core-shell catalyst having, on a surface thereof, a (110) surface of a face centered cubic lattice.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: December 13, 2022
    Assignees: TANAKA KIKINZOKU KOGYO K.K., OSAKA UNIVERSITY
    Inventors: Koichi Matsutani, Takeshi Kaieda, Yasushi Masahiro, Hideaki Kasai, Hiroshi Nakanishi, Koji Shimizu
  • Patent number: 11510980
    Abstract: The invention relates to brartemicin analogues of Formula (IV) and their uses. These compounds are potent Mincle agonists and Th1-stimulating vaccine adjuvants.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: November 29, 2022
    Assignees: VICTORIA LINK LTD., OSAKA UNIVERSITY
    Inventors: Amy Jane Foster, Bridget Louise Stocker, Mattheus Simon Maria Timmer, Sho Yamasaki
  • Publication number: 20220371120
    Abstract: A dissimilar material solid phase bonding method is disclosed wherein one member and another member having different compositions are brought into contact with one another by way of an insert material to form an interface (1) to be bonded, at which the one member and the insert material are in contact with one another, and an interface (2) to be bonded, at which the other member and the insert material are in contact with one another; the temperature of the interface (1) to be bonded and the interface (2) to be bonded is raised by means of frictional heat and/or by electrical heating; a bonding pressure (1) is applied substantially perpendicular to the interface (1) to be bonded; a bonding pressure (2) is applied substantially perpendicular to the interface (2) to be bonded; and the bonding pressure (1) and the bonding pressure (2) are set to different values.
    Type: Application
    Filed: October 28, 2020
    Publication date: November 24, 2022
    Applicant: OSAKA UNIVERSITY
    Inventors: Hidetoshi Fujii, Yoshiaki Morisada, Yasuhiro Aoki, Masayoshi Kamai
  • Publication number: 20220376294
    Abstract: A solid electrolyte which contains a garnet-type composite metal oxide phase (L) and shows an excellent lithium ion conductivity is provided. The solid electrolyte contains a garnet-type composite metal oxide phase (L) and a phase (D) different from the phase (L). The phase (L) contains Li, La, Zr, O, and Ga, and an Li site in the phase (L) is substituted with the Ga. A lattice constant of the solid electrolyte is not smaller than 12.96 ?. The phase (D) contains at least one of LiF, BaZrO3, YF3, SrF2, and ScF3.
    Type: Application
    Filed: August 3, 2022
    Publication date: November 24, 2022
    Applicants: KANEKA CORPORATION, OSAKA UNIVERSITY
    Inventors: Kazuaki Kanai, Makio Naito
  • Publication number: 20220372437
    Abstract: A method for producing a fibrin sheet containing at least one selected from the group consisting of cells and drugs in a fibrin gel, the method comprising: a step 1 of applying a fibrinogen solution containing at least one selected from the group consisting of cells and drugs and fibrinogen dropwise onto a surface of a substrate made of a gelatin hydrogel; a step 2 of adding thrombin to the fibrinogen solution on the surface of the substrate; a step 3 of placing a support film on and in contact with a top surface of the fibrinogen solution to which the thrombin has been added; a step 4 of forming a fibrin sheet containing the at least one selected from the group consisting of cells and drugs in a fibrin gel between the substrate and the support film by a reaction between the fibrinogen and the thrombin; and a step 5 of melting the substrate at a temperature not lower than a melting temperature of the gelatin hydrogel to separate, from the substrate, the fibrin sheet supported by the support film.
    Type: Application
    Filed: September 9, 2020
    Publication date: November 24, 2022
    Applicant: OSAKA UNIVERSITY
    Inventors: Takaaki SAMURA, Shigeru MIYAGAWA, Yoshiki SAWA, Junya YOKOYAMA
  • Patent number: 11505605
    Abstract: It was discovered that antigen-binding molecules comprising (i) a domain that binds to a molecule expressed on the surface of cells having immune response-suppressing functions, and (ii) a T cell receptor complex-binding domain exhibit more superior antitumor effects than conventional antigen-binding molecules by crosslinking T cells with cells having immune response-suppressing functions, and damaging the cells having immune response-suppressing functions.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: November 22, 2022
    Assignees: Chugai Seiyaku Kabushiki Kaisha, Osaka University
    Inventors: Tomoyuki Igawa, Takahiro Ishiguro, Shimon Sakaguchi, Hiroyoshi Nishikawa
  • Patent number: 11505774
    Abstract: A sample storage apparatus includes: a lid member; a sample storage container; first and second fluid sucking sections; first and second fluid discharging sections; first to fourth flow paths; and a first fluid identification sensor. The first flow path is connected to the first fluid sucking section, the second flow path is connected to the second fluid sucking section, the third flow path is connected to the first fluid discharging section, and the fourth flow path is connected to the second fluid discharging section. The first fluid identification sensor for identifying a fluid is disposed in the first flow path.
    Type: Grant
    Filed: October 22, 2019
    Date of Patent: November 22, 2022
    Assignees: NIHON KOHDEN CORPORATION, OSAKA UNIVERSITY
    Inventors: Hodaka Makino, Hirotsugu Kubo, Tetsuya Ogawa, Masahiro Kinooka
  • Patent number: 11509123
    Abstract: A wiring sheet includes one or more carbon wires each of which is one of a signal line and a power supply line, and which are conductors including carbon as a main material and have flexibility; and an insulation sheet that encloses substantially an entirety of the one or more carbon wires, includes an electrical insulator as a main material, and has flexibility.
    Type: Grant
    Filed: July 25, 2017
    Date of Patent: November 22, 2022
    Assignee: OSAKA UNIVERSITY
    Inventors: Tsuyoshi Sekitani, Takafumi Uemura, Shusuke Yoshimoto, Teppei Araki, Yuki Noda, Takayasu Sakurai, Tokihiko Mori, Makoto Takamiya