Patents Assigned to Osaka University
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Publication number: 20240082637Abstract: An exercise support apparatus includes an information processing unit that supports a setting of a next exercise menu for improvement to a targeted body, based on prior body motion information on a subject detected by a motion sensor.Type: ApplicationFiled: December 13, 2021Publication date: March 14, 2024Applicant: OSAKA UNIVERSITYInventors: Ken NAKATA, Takashi KANAMOTO
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Publication number: 20240086756Abstract: An information processing apparatus determines a combination of a first data qubit and a second data qubit that further reduces the energy represented by an energy equation. The energy equation includes first to third energy terms. The first energy term is used to identify the first data qubit on which a Z error has occurred. The second energy term is used to identify the second data qubit on which an X error has occurred. The third energy term reduces the energy as the number of data qubits each being a third data qubit on which both a Z error and an X error have simultaneously occurred increases. The information processing apparatus determines that a Y error has occurred on the third data qubit.Type: ApplicationFiled: July 27, 2023Publication date: March 14, 2024Applicants: Fujitsu Limited, OSAKA UNIVERSITYInventors: Jun FUJISAKI, Hirotaka OSHIMA, Keisuke FUJII
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Patent number: 11926853Abstract: Provided is a botulinum toxin producing method which is simple achieves a high toxin yield, and obtains a toxin having high specific activity. This botulinum toxin producing method includes: (A) a step in which a botulinum toxin is produced from botulinum toxin-producing bacteria in a medium, and a mixture a is obtained which contains a botulinum toxin, a bacterial component, and a nucleic acid component derived from the botulinum toxin; (B) a step in which the mixture a is subjected to the removal of the bacterial component, and a mixture b is obtained which contains a nucleic acid component and a botulinum toxin; (C) a step in which an endonuclease is added to the mixture b and a mixture c is obtained which contains a nucleic acid degradation product and a botulinum toxin; and (D) a step in which the mixture c is subjected to removal of the nucleic acid degradation product, and an isolated botulinum toxin liquid d is obtained.Type: GrantFiled: December 17, 2019Date of Patent: March 12, 2024Assignee: The Research Foundation For Microbial Diseases of Osaka UniversityInventors: Daisuke Yokouchi, Akiko Miura, Ryu Okada, Yuzo Yamashita, Yuya Sasaki, Shogo Nishihata
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Patent number: 11920161Abstract: Provided are a cell population substantially consisting of mammalian cells that are positive for cell surface markers CD31 and CD200 and negative for CD45; a cell population substantially consisting of mammalian cells that are positive for cell surface markers CD31, CD157 and CD200 and negative for CD45; a mammalian vascular endothelial stem cell that is positive for the cell surface marker CD31, positive for at least one of CD157 and CD200, and negative for CD45; and a medicament for vascular regeneration, comprising any of the cell populations or the vascular endothelial stem cells as an active ingredient.Type: GrantFiled: November 15, 2018Date of Patent: March 5, 2024Assignee: Osaka UniversityInventors: Nobuyuki Takakura, Hisamichi Naito, Taku Wakabayashi
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Patent number: 11922277Abstract: A high accuracy information extracting device construction system includes: a feature quantity extraction expression list generating unit for generating a feature quantity extraction expression list; a feature quantity calculating unit for calculating feature quantities of teacher data by means of respective feature quantity extracting expressions; a teacher data supply unit for supplying teacher data; an evaluation value calculating unit for generating information extracting expressions by means of machine learning on the basis of the calculated feature quantities of teacher data and the teacher data, and calculating evaluation values for the respective feature quantity extracting expressions; and a synthesis unit for constructing a high accuracy information extracting device using T weak information extracting parts F(X)t output from the evaluation value calculating unit 15 and confidence levels Ct corresponding thereto.Type: GrantFiled: July 6, 2018Date of Patent: March 5, 2024Assignee: OSAKA UNIVERSITYInventor: Aya Nakae
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Publication number: 20240065992Abstract: An aortic aneurysm has few noticeable symptoms and is at high risk of rupture without a sign of abnormality. Further, if the aortic aneurysm ruptures, it causes a shock state due to massive blood loss and results in a very low survival rate. Thus, when the aortic aneurysm is found by physical examination or the like, surgery with a stent graft or the like needs to be performed according to the state of its progression. A pharmaceutical composition for preventing and treating an aortic aneurysm including a medium chain fatty acid as a main component has an effect of inhibiting the occurrence and progression of the aortic aneurysm. Thus, when the aortic aneurysm is found, continuous intake of the composition can not only inhibit the progression of the aortic aneurysm but also mediate the regression of the aortic aneurysm, thereby producing the effect of improving vital prognosis.Type: ApplicationFiled: December 10, 2021Publication date: February 29, 2024Applicants: KINKI UNIVERSITY, YASHIRO CO., LTD., OSAKA UNIVERSITYInventors: Nobuhiro ZAIMA, Hirona KUGO, Motohiro KITANO, Yoshinori HIROTA, Ken-ichi HIRANO
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Patent number: 11914009Abstract: An NMR apparatus includes a depressurizing device for depressurizing an NMR probe, a gas supply device for supplying gas into the NMR probe to thereby pressurize the NMR probe, and a control device. The control device alternately repeats depressurization of the NMR probe, using the depressurizing device, and pressurization of the NMR probe, using the gas supply device. This replaces the gas in the NMR probe.Type: GrantFiled: August 11, 2022Date of Patent: February 27, 2024Assignees: JEOL Ltd., OSAKA UNIVERSITYInventors: Hiroki Takahashi, Yuki Endo, Toshimichi Fujiwara, Yoh Matsuki
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Publication number: 20240058365Abstract: [Object] It is an object to provide a highly safe and easy-to-administer pharmaceutical preparation for treating epilepsy, pharmaceutical preparation for treating an autism spectrum disorder, and/or pharmaceutical preparation for treating an anxiety disorder. [Solving Means] A topical preparation containing as an active ingredient at least one selected from the group consisting of sirolimus and a sirolimus derivative is a pharmaceutical preparation that is easy to administer, and is highly safe as a therapeutic agent for epilepsy, an autism spectrum disorder, and/or an anxiety disorder. Suitable examples of the active ingredient include sirolimus, everolimus, temsirolimus, ridaforolimus, and zotarolimus.Type: ApplicationFiled: October 7, 2020Publication date: February 22, 2024Applicant: OSAKA UNIVERSITYInventor: Mari KANEDA
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Publication number: 20240060878Abstract: An objection is to provide a method for characterizing a molecule delivery particle, the method comprising determining a molar concentration thereof. The method for characterizing a molecule delivery particle, the method comprising subjecting a molecule delivery particle comprising a first particle and a second particle to particle separation with optical measurement to determine an increment in refractive index of each of the first particle and the second particle; and determining a molar concentration of each of the first particle and the second particle based on the increment in refractive index, a molecular weight, and a specific refractive index increment of each of the first particle and the second particle.Type: ApplicationFiled: March 24, 2022Publication date: February 22, 2024Applicant: OSAKA UNIVERSITYInventors: Susumu UCHIYAMA, Takahiro MARUNO, Tetsuo TORISU
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Publication number: 20240063334Abstract: Provided is a method for manufacturing a semiconductor nanoparticle, the method includes performing a heat treatment of a first mixture containing a silver (Ag) salt, an alkali metal salt, a salt containing at least one of indium (In) and gallium (Ga), a sulfur source, and an organic solvent. A ratio of the number of atoms of an alkali metal to the total number of atoms of Ag and the alkali metal in the first mixture is greater than 0 and less than 1.Type: ApplicationFiled: July 25, 2023Publication date: February 22, 2024Applicants: National University Corporation Tokai National Higher Education and Research System, OSAKA UNIVERSITY, NICHIA CORPORATIONInventors: Tsukasa TORIMOTO, Tatsuya KAMEYAMA, Yuki MORI, Hiroki YAMAUCHI, Susumu KUWABATA, Taro UEMATSU, Daisuke OYAMATSU
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Patent number: 11905308Abstract: The present invention aims to provide a nucleic acid compound that hardly forms non-Watson-Crick base pairs, and an oligonucleotide containing the nucleic acid compound and showing reduced non-specific binding with nucleic acids other than the target nucleic acid. The nucleic acid compound according to the present invention is characterized in that the 2-position carbonyl group of the pyrimidine base is functionally converted (X1 and X2 are each independently S or Se), and that the 2?-position and the 4?-position are bridged in a particular structure. The oligonucleotide according to the present invention is characterized in that at least one of thymidine and uridine is the nucleic acid compound.Type: GrantFiled: February 9, 2022Date of Patent: February 20, 2024Assignee: OSAKA UNIVERSITYInventors: Satoshi Obika, Kosuke Ito, Takaki Habuchi, Masahiko Horiba
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Patent number: 11906722Abstract: An electromagnetic wave detecting device comprising: an emission unit configured to emit electromagnetic waves having coherence; an electromagnetic wave modulating unit configured to modulate one or both of a phase and an amplitude of the emitted electromagnetic waves and to change a state of the modulation relative to an imaging target; and a post-modulation electromagnetic wave intensity detecting unit configured to detect an intensity of post-modulation electromagnetic waves, which are the modulated electromagnetic waves acquired by modulating the electromagnetic waves emitted from the emission unit using the imaging target and the electromagnetic wave modulating unit, using one pixel.Type: GrantFiled: November 17, 2022Date of Patent: February 20, 2024Assignees: OSAKA UNIVERSITY, The University of TokyoInventors: Ryoichi Horisaki, Jun Tanida, Sadao Ota
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Publication number: 20240050481Abstract: The present disclosure includes a composition for use in the treatment of dystrophic epidermolysis bullosa, comprising a blister-derived cell of a patient with dystrophic epidermolysis bullosa that is genetically modified to produce type VII collagen.Type: ApplicationFiled: July 21, 2021Publication date: February 15, 2024Applicants: OSAKA UNIVERSITY, STEMRIM INC.Inventors: Katsuto TAMAI, Yasushi KIKUCHI, Tomoki TAMAKOSHI, Takehiko YAMAZAKI
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Patent number: 11899019Abstract: Methods are provided for predicting a response to an anti-PD-1 antibody or anti-PD-L1 antibody therapy based on a new biomarker and for evaluating a malignancy of cancer. The method for predicting a response of a subject to an anti-PD-1 antibody or anti-PD-L1 antibody therapy includes measuring an expression level of LAT1 in a sample collected from a cancer tissue of the subject; and predicting a response of the subject to the anti-PD-1 antibody or anti-PD-L1 antibody therapy based on the expression level of LAT1. The method for evaluating a malignancy of cancer in a subject includes staining a sample collected from a cancer tissue of the subject with an anti-LAT1 antibody and an anti-PD-L1 antibody; and evaluating a malignancy of the cancer in the subject based on a presence or absence of a LAT1-positive and PD-L1-positive site.Type: GrantFiled: November 7, 2018Date of Patent: February 13, 2024Assignees: J-PHARMA CO., LTD., NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY, OSAKA UNIVERSITYInventors: Hitoshi Endou, Goshi Ishihara, Kyoichi Kaira, Yoshikatsu Kanai
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Patent number: 11899336Abstract: A liquid crystal element is provided that can inhibit occurrence of voltage drop between one end and the other end of each electrode. A liquid crystal element (100) includes a liquid crystal layer LQ, a plurality of first arcuate electrodes (1), and a plurality of second arcuate electrodes (2). The first arcuate electrodes (1) are disposed concentrically about an optical axis (AX) of the liquid crystal element (100) and applies first voltage (V1) to the liquid crystal layer (LQ). The second arcuate electrodes (2) are disposed concentrically about the optical axis (AX) and applies second voltage (V2) to the liquid crystal layer (LQ).Type: GrantFiled: April 17, 2020Date of Patent: February 13, 2024Assignee: OSAKA UNIVERSITYInventors: Giichi Shibuya, Sunri Lee, Hiroyuki Yoshida, Masanori Ozaki
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Publication number: 20240046819Abstract: A heart model includes a main body formed from an elastic material and including a left atrium and a left ventricle, with a mitral valve installed at a boundary portion between the left atrium and the left ventricle; and a vena cava provided in the main body, wherein the mitral valve includes an anterior leaflet and a posterior leaflet, both the leaflets extending to the left ventricle side and capable of opening and closing, and the anterior leaflet and the posterior leaflet are each provided on a tip side with a plurality of string-shaped members extending into the left ventricle.Type: ApplicationFiled: October 20, 2023Publication date: February 8, 2024Applicants: OSAKA UNIVERSITY, JMC CORPORATIONInventors: Keita OKAYAMA, Yasushi SAKATA, Daichi WATANABE, Makoto INADA
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Patent number: 11883200Abstract: A biosignal measurement apparatus is used by being affixed on a living body. The apparatus includes an affixed part that is a sheet, in which a signal-acquiring section of multiple electrodes and wiring connected to each of the electrodes are formed, and which can be freely expanded, contracted and bent and is adhesive; and a substrate that is connected to the wiring and on which a signal-processing circuit for wirelessly transmitting biosignals obtained through the wiring is mounted. The signal-acquiring section is exposed on the surface of the affixed part and the affixed part and the substrate are stacked so that the back surface of the affixed part faces the substrate.Type: GrantFiled: January 28, 2022Date of Patent: January 30, 2024Assignee: Osaka UniversityInventors: Tsuyoshi Sekitani, Takafumi Uemura, Teppei Araki, Shusuke Yoshimoto
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Patent number: 11883141Abstract: A biological information measurement apparatus includes: a pressure sensor including a pressure detecting element; a pressing mechanism which presses the pressure sensor against an artery in a living body; a press controller which controls a pressing force of the pressing mechanism; a blood flow sensor; a blood flow information measurer which measures blood flow information based on output of the blood flow sensor; a pressing force decider which decides a first pressing force based on blood flow information measured during a pressing force control time period when the pressing force is changed in one direction, and information of a pressure pulse wave detected during the pressing force control time period; and a record controller which records a pressure pulse wave detected in a first state where the pressing force is controlled to the first pressing force, and blood flow information measured in the first state.Type: GrantFiled: March 8, 2018Date of Patent: January 30, 2024Assignees: OMRON HEALTHCARE Co., Ltd., OSAKA UNIVERSITYInventors: Yuki Kato, Shingo Yamashita, Toshihiko Ogura, Shunsuke Yoshimoto, Masataka Imura, Osamu Oshiro
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Publication number: 20240025873Abstract: An object of the present invention is to provide a novel method for producing a ketone derivative, and more specifically, a method for producing a ketone derivative (I) represented by formula (I), including mixing a thioester derivative (II) represented by formula (II), a Grignard reagent (III) represented by formula (III) and a copper salt to form a ketone derivative (I).Type: ApplicationFiled: October 1, 2021Publication date: January 25, 2024Applicants: TOKUYAMA CORPORATION, OSAKA UNIVERSITYInventors: Masahiko SEKI, Kazushi MASHIMA, Hayato TSURUGI, Daiki KATO, Tomoya MURASE, Jalindar Bhausaheb TALODE
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Patent number: 11880374Abstract: A device to support work of searching document data for interpreting an information analysis result of analysis data obtained by analyzing a sample containing an analyte, includes: an acquisition unit to acquire first information for identifying the analyte from the analysis data; a reception unit to receive input of second information for searching data of a document for interpreting the information analysis result of the analysis data; an extraction unit to extract, based on the first and second information, terms relevant to the information analysis result, from among terms in data of documents in a database; a calculation unit to calculate, for each relevant term, relevance scores indicating a relevance degree between the relevant term and the first information, and a relevance degree between the relevant term and the second information; and a processing unit to obtain an index value of statistical likelihood from the relevance scores.Type: GrantFiled: May 9, 2022Date of Patent: January 23, 2024Assignees: Shimadzu Corporation, OSAKA UNIVERSITYInventors: Shinji Kanazawa, Satoshi Shimizu, Fumio Matsuda