Patents Assigned to Osaka University
  • Publication number: 20210371818
    Abstract: The present invention relates to a method for inducing the differentiation of corneal epithelial cells from pluripotent stem cells. More specifically, the present invention relates to a method for autonomously differentiating pluripotent stem cells, such as human iPS cells, into ectodermal cell lineage in a serum-free medium without using feeder cells and inducing the differentiation of the resultant ocular surface ectodermal lineage cells into corneal epithelial cells.
    Type: Application
    Filed: June 15, 2021
    Publication date: December 2, 2021
    Applicant: Osaka University
    Inventors: Kohji NISHIDA, Ryuhei HAYASHI, Yuki ISHIKAWA
  • Publication number: 20210371477
    Abstract: Provided is a method for causing a subject including a luminescent protein to emit light. The method provided is a method for causing a subject to emit light, wherein the subject is a plant body that has a fusion luminescent protein in a cell wall thereof, or a processed product of the same; the method includes the step of bringing a substrate composition into contact with the fusion luminescent protein; the fusion luminescent protein is a protein that includes a chemiluminescent protein moiety, a fluorescent protein moiety, and a moiety that connects the chemiluminescent protein moiety and the fluorescent protein moiety so that resonance energy transfer can occur from the chemiluminescent protein moiety to the fluorescent protein moiety; and the substrate composition contains a substrate of the chemiluminescent protein.
    Type: Application
    Filed: June 4, 2019
    Publication date: December 2, 2021
    Applicant: Osaka University
    Inventors: Takeharu Nagai, Megumi Iwano
  • Patent number: 11187984
    Abstract: A resist patterning method includes a resist layer forming step, a patterned exposure step, a flood exposure step, and a developing step. In the resist layer forming step, a resist layer is formed on a substrate. In the patterned exposure step, a sensitizer is produced from a sensitizer precursor in the resist layer. In the flood exposure step, flood exposure is performed on the resist layer in which the sensitizer has been produced to produce an acid from a strong acid generator. In the developing step, the resist layer is developed. The patterned exposure step includes: producing a strong acid from the strong acid generator; producing the sensitizer through a reaction between the strong acid and the sensitizer precursor; producing a weak acid through a reaction between the strong acid and a base; and producing the sensitizer through a reaction between the weak acid and the sensitizer precursor.
    Type: Grant
    Filed: November 25, 2016
    Date of Patent: November 30, 2021
    Assignee: OSAKA UNIVERSITY
    Inventor: Seiichi Tagawa
  • Patent number: 11189392
    Abstract: An X-ray microscope includes at least one of an X-ray source, a sample holding part, a concave Kirkpatrick-Baez mirror, a convex Kirkpatrick-Baez mirror, and a light receiving part located at a position in an imaging relation to a position of the sample holding part in this order along an optical axis.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: November 30, 2021
    Assignee: OSAKA UNIVERSITY
    Inventors: Satoshi Matsuyama, Jumpei Yamada
  • Patent number: 11186618
    Abstract: The purpose of the present invention is to provide a peptide that is capable of efficiently delivering an antigen to dendritic cells and improving the vaccine effects of the antigen. A peptide that has at least one motif sequence comprising the amino acid sequence of sequence listing 1, or an amino acid sequence comprising the aforementioned amino acid sequence, but in which a mutation has been induced in the amino acid residue at the first and/or second position of the amino acid sequence, is bound to an antigen protein or an antigen peptide to efficiently deliver the antigen protein or antigen peptide to dendritic cells, allowing for significantly superior vaccine effects to be exhibited.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: November 30, 2021
    Assignee: THE RESEARCH FOUNDATION FOR MICROBIAL DISEASES OF OSAKA UNIVERSITY
    Inventor: Yasuo Yoshioka
  • Publication number: 20210361549
    Abstract: Provided is an antiperspirant which serves to control secretion of sweat secreted from sweat glands and is capable of doing so by acting on sweat glands without closing sweat pores, the antiperspirant containing, as an active ingredient to control secretion of sweat secreted from sweat glands, at least one type of pentacyclic compound selected from the group consisting of compounds represented by formula (I): and derivatives thereof, and compounds represented by formula (VII): and derivatives thereof.
    Type: Application
    Filed: March 18, 2019
    Publication date: November 25, 2021
    Applicants: MANDOM CORPORATION, OSAKA UNIVERSITY
    Inventors: Kie Nakashima, Ryuichiro Kurata, Fumitaka Fujita, Fumihiro Okada
  • Publication number: 20210366627
    Abstract: A method for synthesizing a copper-silver alloy includes an ink preparation step, a coating step, a crystal nucleus formation step and a crystal nucleus synthesis step. In the ink preparation step, a copper salt particle, an amine-based solvent, and a silver salt particle are mixed, thereby preparing a copper-silver ink. In the coating step, a member to be coated is coated with the copper-silver ink. In the crystal nucleus formation step, at least one of a crystal nucleus of copper having a crystal grain diameter of 0.2 ?m or less and a crystal nucleus of silver having a crystal grain diameter of 0.2 ?m or less is formed from the copper-silver ink. In the crystal nucleus synthesis step, the crystal nucleus of copper and the crystal nucleus of silver are synthesized.
    Type: Application
    Filed: August 9, 2021
    Publication date: November 25, 2021
    Applicants: SENJU METAL INDUSTRY CO., LTD., OSAKA UNIVERSITY
    Inventors: Jinting JIU, Minoru UESHIMA, Katsuaki SUGANUMA, Wanli LI
  • Publication number: 20210363338
    Abstract: An object is to provide a macromolecular composite material that can be produced by a simple process, and that has excellent mechanical properties. The macromolecular composite material of the present invention contains a polymer component and a cyclodextrin compound, the polymer component containing a thermoplastic resin, and the cyclodextrin compound being at least one member selected from the group consisting of cyclodextrin and cyclodextrin derivatives. The macromolecular composite material of the present invention can be produced by a simple process, and has excellent mechanical properties.
    Type: Application
    Filed: May 20, 2021
    Publication date: November 25, 2021
    Applicant: Osaka University
    Inventors: Yoshinori Takashima, Akira Harada, Motofumi Osaki, Kensaku Takahashi, Junsu Park
  • Patent number: 11183187
    Abstract: The present invention provides a dialog system comprising a speech receiving step in which the dialog system receives input of a speech of a human, a first speech determination step in which the dialog system determines a first speech which is a speech in response to the speech of the human, a first speech presentation step in which the first speech is presented by a first agent, a reaction acquisition step in which the dialog system acquires a reaction of the human to the first speech, a second speech determination step in which the dialog system determines, when the reaction of the human is a reaction indicating that the first speech is not a speech in response to the speech of the human, a second speech which is different from the first speech, and a second speech presentation step in which the second speech is presented by the second agent.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: November 23, 2021
    Assignees: NIPPON TELEGRAPH AND TELEPHONE CORPORATION, OSAKA UNIVERSITY
    Inventors: Hiroaki Sugiyama, Toyomi Meguro, Junji Yamato, Yuichiro Yoshikawa, Hiroshi Ishiguro
  • Patent number: 11179495
    Abstract: Disclosed is a three-dimensional tissue comprising cells and collagen including endogenous collagen, wherein at least a portion of the cells is adhered to the collagen, and the content of the collagen is from 10 wt % to 90 wt % based on the three-dimensional tissue.
    Type: Grant
    Filed: January 31, 2018
    Date of Patent: November 23, 2021
    Assignees: TOPPAN PRINTING CO., LTD., OSAKA UNIVERSITY
    Inventors: Michiya Matsusaki, Shinji Irie, Shiro Kitano
  • Publication number: 20210347953
    Abstract: Provided is a method for producing low-molecular-weight polytetrafluoroethylene which is less likely to generate C6-C14 perfluorocarboxylic acids and salts thereof. The disclosure relates to a method for producing low-molecular-weight polytetrafluoroethylene having a melt viscosity at 380° C. of 1.0×102 to 7.0×105 Pa·s. The method includes (1) irradiating high-molecular-weight polytetrafluoroethylene with radiation in a substantially oxygen-free state and decomposing the high-molecular-weight polytetrafluoroethylene into a low-molecular-weight component and (2) deactivating, in a substantially oxygen-free state, at least part of main-chain radicals and end radicals generated by the irradiation and providing the low-molecular-weight polytetrafluoroethylene.
    Type: Application
    Filed: July 12, 2019
    Publication date: November 11, 2021
    Applicants: OSAKA UNIVERSITY, DAIKIN INDUSTRIES, LTD.
    Inventors: Akihiro OSHIMA, Takayuki TANAKA, Hideki NAKAYA, Kazuyuki SATOH, Ryosuke SENBA
  • Patent number: 11166436
    Abstract: A health condition estimation device capable of accurately estimating the health condition of a cow includes: a three-dimensional coordinates acquisition unit which acquires a group of three-dimensional coordinates representing the three-dimensional shape of a cow extracted from a distance image of the cow; a feature amount extraction unit which extracts the feature amount of the cow according to the group of three-dimensional coordinates acquired by the three-dimensional coordinates acquisition unit; and a score calculation unit which calculates a score that indicates the health condition of the cow, according to the feature amount extracted by the feature amount extraction unit.
    Type: Grant
    Filed: February 13, 2017
    Date of Patent: November 9, 2021
    Assignee: OSAKA UNIVERSITY
    Inventors: Yasushi Yagi, Fumio Okura, Yasushi Makihara, Daigo Muramatsu
  • Patent number: 11166995
    Abstract: The present invention provides an anticancer agent containing the following (1) and (2): (1) HVJ-E (hemagglutinating virus of Japan envelope), (2) an inhibitor of an immune checkpoint protein.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: November 9, 2021
    Assignees: OSAKA UNIVERSITY, GENOMIDEA INC.
    Inventors: Yasufumi Kaneda, Kazuma Sakura, Tomoyuki Nishikawa, Masanori Fukushima, Toshihiro Nakajima
  • Patent number: 11169071
    Abstract: In a method for analyzing samples involving the use of a device for analyzing samples, the device for analyzing samples includes at least a movement part through which a sample moves, and a measurement unit that is formed in a middle of the movement part and that measures a value of an ion current when the sample passes through the movement part. The analysis method includes at least a measurement step for measuring the value of the ion current when the sample passes through the movement part, and a determination step for determining a change over time in a quantity of ions from the value of the ion current measured in the measurement step. The quantity of ions includes a quantity of ions that have leaked from the sample during movement of the sample through the movement part.
    Type: Grant
    Filed: October 4, 2017
    Date of Patent: November 9, 2021
    Assignees: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY, OSAKA UNIVERSITY, KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION
    Inventors: Hirotoshi Yasaki, Takao Yasui, Noritada Kaji, Yoshinobu Baba, Tomoji Kawai, Satoyuki Kawano, Kentaro Doi, Takeshi Yanagida, Mao Fukuyama
  • Patent number: 11169132
    Abstract: A purpose is to provide a monitoring system to monitor whether there is a substance to be monitored in the air, and a detecting device used in the monitoring system. The monitoring system includes a detecting device, an analyzing device, and an abnormality notification system. The detecting device determines whether the air is in an abnormal state on the basis of an output signal from an abnormality detection sensor, pours liquid to be inspected, into which the air is sucked and liquefied, into a previously-installed reagent container when determining the abnormal state, generates mixed liquid in which a reactant in the reagent container and the poured liquid to be inspected are mixed, and drops the generated mixed liquid to an electrode of the analyzing device.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: November 9, 2021
    Assignees: OSAKA UNIVERSITY, ALLIED TELESIS HOLDINGS K.K.
    Inventors: Noriyasu Katoh, Minoru Aoki, Eiichi Tamiya
  • Publication number: 20210338798
    Abstract: Provided is a method of producing reassortant influenza virus containing an antigenic protein of the first influenza virus strain, the method including the following steps: 1) a step of irradiating the first influenza virus strain with ultraviolet light in such an irradiation dose that the first influenza virus strain has initial infection ability and loses or is reduced in virus growth potential; 2) a step of infecting a host with the first influenza virus strain and the second influenza virus strain; 3) a step of culturing the host infected with the first influenza virus strain and the second influenza virus strain, to obtain culture product; 4) a step of inactivating influenza virus strain having an antigenic protein of the second influenza virus strain in the culture product obtained in the step 3); and 5) a step of collecting reassortant influenza virus after the step 4).
    Type: Application
    Filed: July 11, 2017
    Publication date: November 4, 2021
    Applicant: The Research Foundation for Microbial Diseases of Osaka University
    Inventors: Takao Fujimoto, Junji Fujita
  • Publication number: 20210343908
    Abstract: Semiconductor nanoparticles including Ag, In, Ga, and S are provided. In the semiconductor nanoparticles, a ratio of a number of Ga atoms to a total number of In and Ga atoms is 0.95 or less. The semiconductor nanoparticles emit light having an emission peak with a wavelength in a range of from 500 nm to less than 590 nm, and a half bandwidth of 70 nm or less, and have an average particle diameter of 10 nm or less.
    Type: Application
    Filed: July 14, 2021
    Publication date: November 4, 2021
    Applicants: NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM, OSAKA UNIVERSITY, NICHIA CORPORATION
    Inventors: Tsukasa TORIMOTO, Tatsuya KAMEYAMA, Marino KISHI, Chie MIYAMAE, Susumu KUWABATA, Taro UEMATSU, Daisuke OYAMATSU, Kenta NIKI
  • Publication number: 20210340540
    Abstract: A method of reducing the level of a transcription product in a cell comprising contacting with the cell a composition comprising a double-stranded nucleic acid complex comprising a first nucleic acid strand annealed to a second nucleic acid strand, wherein: (i) the first nucleic acid strand hybridizes to the transcription product and comprises (a) a region consisting of at least 4 consecutive nucleotides that are recognized by RNase H when the strand is hybridized to the transcription product, (b) one or more nucleotide analogs located on 5? terminal side of the region, (c) one or more nucleotide analogs located on 3? terminal side of the region and (d) a total number of nucleotides and nucleotide analogs ranging from 8 to 35 nucleotides and (ii) the second nucleic acid strand comprises (a) nucleotides and optionally nucleotide analogs and (b) at least 4 consecutive RNA nucleotides.
    Type: Application
    Filed: May 27, 2021
    Publication date: November 4, 2021
    Applicants: National University Corporation Tokyo Medical and Dental University, Osaka University
    Inventors: Takanori Yokota, Kazutaka Nishina, Satoshi Obika, Hidehiro Mizusawa
  • Patent number: 11161199
    Abstract: Provided are a simple and effective friction welding method that can suppress increases in hardness of the welded part and reductions in hardness (strength) in the heat affected zone regardless of the composition of ferrous material, and a welded structure obtained with the same. The present invention relates to a friction welding method wherein surfaces to be welded of two metal members (2, 4) to be welded are made to slide in contact with each other. The friction welding method is characterized in that at least one of the metal members (2, 4) to be welded is a ferrous material, and the maximum temperature reached during welding is equal to or less than the A3 point or equal to or less than the Acm point of the ferrous material. The maximum temperature reached during welding is preferably equal to or less than the A1 point of the ferrous material.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: November 2, 2021
    Assignee: OSAKA UNIVERSITY
    Inventors: Hidetoshi Fujii, Rintaro Ueji, Yoshiaki Morisada
  • Patent number: 11162162
    Abstract: A steel with high hardness and excellent toughness contains, in mass %, 0.40-1.00% C, 0.10-2.00% Si, 0.10-1.00% Mn, 0.030% or less P, 0.030% or less S, 1.10-3.20% Cr, 0.010-0.10% Al, and 0.15-0.50% V, and further contains at least one or two of 2.50% or less Ni and 1.00% or less Mo, with an amount of (C+V) being 0.60% or more in mass %, with the balance consisting of Fe and unavoidable impurities. The steel has a microstructure which is a martensitic structure with finely dispersed Fe-based ? carbides, with its prior austenite grain size being 20 ?m or less.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: November 2, 2021
    Assignees: OSAKA UNIVERSITY, KOMATSU LTD.
    Inventors: Yoritoshi Minamino, Koji Hagihara, Koji Yamamoto, Shohei Ikurumi, Yusuke Hiratsuka, Takeshi Fujimatsu, Toshiyuki Sugimoto