Abstract: A liquid crystal element (100) includes a plurality of unit electrodes (10), a liquid crystal layer (LQ), and a plurality of wall members (WL). Each of the unit electrodes (10) includes a first electrode (1) and a second electrode (2). A voltage is applied to the liquid crystal layer (LQ) from each of the unit electrodes (10). The wall members (WL) are arranged in the liquid crystal layer (LQ). The liquid crystal layer (LQ) has a waveform retardation (RT). Two or more of a plurality of peaks (P1) in the retardation (RT) correspond to positions of respective wall members (WL).

Abstract: The quantum circuit learning device includes a signal input unit that provides a quantum circuit including plural quantum bits with an input signal, a signal acquisition unit that observes states of quantum bits that the quantum circuit includes and acquires an output signal based on the observed states, and an adjustment unit that adjusts a circuit parameter that defines a circuit configuration of the quantum circuit, using an output signal that the signal acquisition unit acquires and a cost function that is set based on a teacher signal corresponding to the output signal.

Abstract: An analysis device includes an analysis unit configured to receive scattered light, transmitted light, fluorescence, or electromagnetic waves from an observed object located in a light irradiation region light-irradiated from a light source and analyze the observed object on the basis of a signal extracted on the basis of a time axis of an electrical signal output from a light-receiving unit configured to convert the received light or electromagnetic waves into the electrical signal.

Abstract: The present invention provides a liposome preparation containing a population of liposomes containing a CD1d ligand compound, wherein the average particle size of the population of liposomes is 90 to 110 nm and the polydispersity index of particle size distribution is 0.2 or less. and the polydispersity index of the particle size distribution is 0.2 or less. The present invention also provides the use of the liposome preparation in the prevention or treatment of graft-versus-host disease and organ transplant rejection.

Abstract: A semiconductor nanoparticle includes a core and a shell covering a surface of the core. The shell has a larger bandgap energy than the core and is in heterojunction with the core. The semiconductor nanoparticle emits light when irradiated with light. The core is made of a semiconductor that contains M1, M2, and Z. M1 is at least one element selected from the group consisting of Ag, Cu, and Au. M2 is at least one element selected from the group consisting of Al, Ga, In and Tl. Z is at least one element selected from the group consisting of S, Se, and Te. The shell is made of a semiconductor that consists essentially of a Group 13 element and a Group 16 element.

Abstract: To provide a collagen sponge excellent in mechanical strength and a production method for the collagen sponge. A collagen sponge including a porous construct having a pore structure, the collagen sponge having a tensile strength of 1 N or more and 5 N or less in every direction including a length direction and a width direction. The collagen sponge may be produced by a production method including the following steps: (1) a step of subjecting a collagen solution obtained by mixing collagen and a solvent to stirring and deaeration treatment; (2) a step of subjecting the collagen solution to freeze-dry treatment; and (3) a step of subjecting a dried collagen product after the freeze-dry treatment to insoluble treatment.

Abstract: According to one embodiment, a liquid crystal optical element includes a first liquid crystal layer including a first cholesteric liquid crystal and a second liquid crystal layer including a second cholesteric liquid crystal, a helical pitch of each of the first cholesteric liquid crystal and the second cholesteric liquid crystal changing continuously. The first cholesteric liquid crystal including a first portion having a first helical pitch and a second portion having a second helical pitch different from the first helical pitch. The second cholesteric liquid crystal including a third portion having a third helical pitch and a fourth portion having a fourth helical pitch different from the third helical pitch.

Abstract: Provided is a means for identifying cells suitable for transplantation into a cornea, or a means for producing a cell population suitable for transplantation into a cornea using the same. A method for producing a cell population suitable for transplantation into a cornea, the method comprising the steps of (1) preparing a cell population cultured under conditions suitable for inducing differentiation into corneal endothelial cells, and (2) measuring the expression of at least one gene selected from the group consisting of POU6F2, LMX1B, and TFAP2B in the cell population.

Abstract: The present invention relates to a method for freezing a cell structure including freezing a cell structure including fragmented extracellular matrix components, cells and fibrin and having a three-dimensional tissue structure.

Abstract: In order to increase the order of a frequency of an AC signal to be applied between a vibration section and a sample to an order at substantially the same level as the order of a vibration frequency of the vibration section in measuring a vibration component of the vibration control section, a vibration component measuring device (2) includes: a vibration section (4); a first AC signal generator (20) configured to generate a first AC signal; a second AC signal generator (44) configured to generate a second AC signal having a frequency which is (a) more than one time and less than two times or (b) more than two times and less than three times as high as a frequency of the first AC signal; a signal applying section (14, 56) configured to apply the second AC signal between the vibration section and a sample (X); a vibration control section (10) configured to cause the vibration section to vibrate; and a measuring section (16, 18, 20, 22, 42, 44, 50) configured to measure a varying component of vibration of the v

Abstract: A joint evaluation apparatus includes an inertial sensor unit that is attached in a vicinity of a joint with joint axes of the joint to connect bones on both sides parallel to a detection axis and detects motion of a bone of a joint axis of which a range of motion of joint movement is limited, among the joint axes, as a waveform signal, a load detection unit that detects a load applied to the joint, a data obtaining unit that, when detecting generation of the load, obtains the waveform signal to be detected by the inertial sensor unit, in a time direction and an intensity direction, and a feature amount calculation unit that analyzes the waveform signal and calculates a feature amount that evaluates movement quality of the joint.

Abstract: A non-invasive and accurate vagina evaluation device and uterine evaluation devices are provided that measure the receptivity (uterine implantation capacity) of the mother's body to a fertilized egg implanting itself into the uterus. A first vagina evaluation device includes: a main body stretchable and expandable after insertion into a vagina, followed by air injection thereinto; four electrodes brought into contact with the vagina wall as the main body expands and stretches; and fixation means configured to fix the interval of arrangement of the electrodes. Second and third uterine evaluation device include: a flexible and rod-shaped main body for insertion into a uterine cavity; and four or two impedance electrodes arranged with a predetermined interval therebetween in an insertion direction of the main body and brought into contact with an endometrium of the uterine cavity to measure a uterine endometrial impedance generated between the endometrium and each of the electrodes.

Abstract: The present invention is intended to provide a method that can produce an oxidation reaction product of a hydrocarbon or a derivative thereof in an aqueous phase using a hydrocarbon or a derivative thereof as a raw material. In order to achieve the above object, the method for producing an oxidation reaction product of a hydrocarbon or a derivative thereof of the present invention includes the step of: irradiating a reaction system with light in a presence of a raw material and a halogen oxide radical to react, wherein the raw material is a hydrocarbon or a derivative thereof, the reaction system is a reaction system containing an aqueous phase, the aqueous phase contains the raw material and the halogen oxide radical, and in the reaction step, the raw material is oxidized to produce an oxidation reaction product of the raw material.

Abstract: The present inventors have found that HMGB1 fragment peptides having a particular amino acid sequence exhibit the effects of improvement of cardiac function, inhibition of cardiomyocyte hypertrophy, inhibition of myocardial fibrosis, and promotion of angiogenesis in an animal model of dilated cardiomyopathy, that the particular HMGB1 fragment peptides also exhibit the effects of improvement of cardiac function, inhibition of cardiomegaly, inhibition of cardiomyocyte hypertrophy, inhibition of myocardial fibrosis, and promotion of angiogenesis in an animal model of ischemic cardiomyopathy caused by old myocardial infarction, and that the particular HMGB1 fragment peptides exhibit the effects of inhibition of cardiomyocyte hypertrophy and inhibition of myocardial fibrosis in an animal model of hypertensive cardiomyopathy.

Abstract: According to one embodiment, a liquid crystal optical element comprises a transparent substrate comprising a first main surface and a second main surface opposed to the first main surface, an alignment film disposed on the second main surface, and a liquid crystal layer overlapping the alignment film and comprising a cholesteric liquid crystal and an additive exhibiting a liquid crystalline property. Refractive anisotropy of the additive is greater than refractive anisotropy of the liquid crystal layer.

Abstract: Provided are preventive or therapeutic agents for fibrotic diseases and cancer. A Wnt signaling pathway inhibitor or a preventive and therapeutic agent for fibrotic diseases or cancer, both comprising an oligopeptide consisting of an amino acid sequence containing a DE loop sequence of RANKL protein and a ?-strand sequence of RANKL protein placed adjacent to the N-terminal side of the DE loop sequence.

Abstract: According to one embodiment, a liquid crystal optical element includes a transparent substrate including a main surface, an alignment film disposed on the main surface, and a liquid crystal layer overlapping the alignment film and including a cholesteric liquid crystal including liquid crystal molecules stacked helically and an additive exhibiting a liquid crystalline property. In the liquid crystal layer, a reflective surface along which alignment directions of the liquid crystal molecules are identical is inclined with respect to the main surface.

Abstract: The present invention provides a preventive or therapeutic method for an inflammatory skin disease, such as psoriasis, the method comprising administering an oligopeptide as an active ingredient. More specifically, the invention provides a preventive or therapeutic method for an inflammatory skin disease, the method comprising administering an oligopeptide consisting of an amino acid sequence containing a DE loop sequence of RANKL protein and a ?-strand D sequence of RANKL protein placed adjacent to the N-terminal side of the DE loop sequence.

Abstract: The present invention addresses the problem of providing a fluorine-containing aromatic polymer; a method for producing the fluorine-containing aromatic polymer; etc. The problem can be solved by: a polymer having a monomer unit represented by formula (1) (wherein R1 in each occurrence is independently a halogen atom, NR11R12 (wherein R11 and R12 are independently a hydrogen atom or an organic group), or an organic group; n1 is an integer of 0 to 4; two R1s that can be present in the ortho-positions may form a ring together with two carbon atoms on the adjacent benzene ring, wherein the formed ring may have an organic group as a substituent; and L1 is a single bond, an oxygen atom, a sulfur atom, -L11-O—, —O-L12-O—, -L13-S—, or —S-L14-S— (wherein L11 to L14 are each independently an alkylene group optionally having one or more substituents); etc.

Abstract: A friction stir welding tool member according to the present embodiment has a shoulder portion and a probe portion concentrically projecting from an upper surface of the shoulder portion. The shoulder portion includes a curved surface processed portion that is curved to have a curved shape on an outer peripheral edge of the shoulder portion. A space occupancy occupied by the two-dimensional space in which neither the shoulder portion nor the probe portion exists is in a range of 30% to 70%, the space occupancy being determined based on a projection drawing of a side surface region surrounded from a tip of the probe portion to the curved surface processed portion of the shoulder portion.