Patents Assigned to OSLO
  • Tertiary amines for use in the treatment of cardiac disorders
    Patent number: 9951033
    Abstract: The present invention relates to tertiary amines of formula (I) for use in therapy, particularly for use in treating cardiovascular disorders. The compounds have been found to regulate phospholamban phosphorylation by interfering with the A-kinase anchor protein 18delta (AKAP18?) binding to the PKA substrate phospholamban. The compounds share a tri(alkylaryl/alkylheteroaryl) amine structure.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: April 24, 2018
    Assignee: UNIVERSITETET I OSLO
    Inventors: Kjetil Tasken, Birgitte Lygren, Ellen Ostensen, Jo Klaveness
  • Network security
    Patent number: 9954853
    Abstract: There is described a method for enabling a user of a client computer to securely access a remote server via a network, which is preferably the Internet, by authenticating the user. The method comprises providing a portable apparatus to the user which may communicate with the client computer. It further involves storing on the portable apparatus user credentials required to enable the user to be authenticated at the server and performing an authentication protocol between the client and the server. The authentication protocol includes the transmission to the server of a digest based at least partially on the user credentials; and the user credentials are stored on the portable apparatus in the form of a digest.
    Type: Grant
    Filed: September 25, 2013
    Date of Patent: April 24, 2018
    Assignee: Universitetet I Oslo
    Inventors: Audun Jøsang, Henning Klevjer
  • Multi-mode computer with selector
    Patent number: 9876802
    Abstract: There is disclosed a computing apparatus including a first context within which first processing activity may be performed and a second context within which second processing activity may be performed independent of the first processing activity, the apparatus further may include input and/or output channels with which the first and second contexts may communicate and a switch function operated by a selector; whereby operation of the selector by a user selectively allows communication between the first context and/or the second context (of the first part) and the input and/or output channels (of the second part). An indicator is provided to indicate which context is in communication with the input/output channels.
    Type: Grant
    Filed: October 11, 2013
    Date of Patent: January 23, 2018
    Assignee: UNIVERSITETET I OSLO
    Inventors: Audun Jøsang, Eric Fouchard
  • METHODS FOR IDENTIFYING, DIAGNOSING, AND PREDICTING SURVIVAL OF LYMPHOMAS
    Publication number: 20180011106
    Abstract: Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.
    Type: Application
    Filed: June 22, 2017
    Publication date: January 11, 2018
    Applicants: The United States of America, as represented by he Secretary, Department of Health and Human Servi, Board of Regents of the University of Nebraska, University of Rochester, Arizona Board of Regents on Behalf of the University of Arizona, Universitat de Barcelona, Fundacio Clinic, Hospital Clinic de Barcelona, Julius-Maximilians-University of Wurzburg, British Columbia Cancer Agency Branch, Oslo University Hospital HF, Queen Mary and Westfield College, University of London
    Inventors: Louis M. Staudt, George Wright, Sandeep Dave, Bruce Tan, John I. Powell, Wyndham Wilson, Elaine S. Jaffe, Wing C. Chan, Timothy C. Greiner, Dennis Weisenburger, James Armitage, Kai Fu, Richard I. Fisher, Lisa M. Rimsza, Thomas Miller, Thomas Grogan, Elias Campo Guerri, Silvia M. Bea, Itziar Salaverria, Armando Lopez-Guillermo, Emilio Montserrat, Victor Moreno, Andreas Zetti, German Ott, Hans-Konrad Muller-Hermelink, Andreas Rosenwald, Julie Vose, Randy Gascoyne, Joseph Connors, Erlend B. Smeland, Stein Kvaloy, Harald Holte, Jan Delabie, T. Andrew Lister
  • Methods and biomarkers for analysis of colorectal cancer
    Patent number: 9822417
    Abstract: The present invention relates to methods and biomarkers (e.g., gene expression biomarkers) for detection of colorectal cancer in biological samples (e.g., tissue samples, biopsy samples, stool samples, blood samples, plasma samples, serum samples). In some embodiments, methods and biomarkers of the present invention find use in detection of colon cancer, providing a prognosis to colorectal cancer patients, and in companion diagnostics.
    Type: Grant
    Filed: January 9, 2013
    Date of Patent: November 21, 2017
    Assignee: OSLO UNIVERSITETSSYKEHUS HF
    Inventors: Ragnhild A. Lothe, Anita Sveen, Trude Holmeide Agesen, Guro Elisabeth Lind, Arild Nesbakken, Rolf Inge Skotheim
  • Biomarkers for subtypes of cervical cancer
    Patent number: 9809859
    Abstract: The present invention relates to biomarkers for chemoradioresistant subtypes of cervical cancer. In particular the present invention relates to a method for predicting a predisposition to a chemoradioresistant cervical cancer in a subject, a method for diagnosing a chemoradioresistant cervical cancer in a subject, a method for predicting the likelihood of recurrence of cervical cancer in a cervical cancer patient under treatment, and a method for predicting the prognosis for a patient with a chemoradioresistant cervical cancer.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: November 7, 2017
    Assignee: OSLO UNIVERSITETSSYKEHUS HF
    Inventors: Heidi Lyng, Malin Lando
  • Methods and biomarkers for detection of bladder cancer
    Patent number: 9797016
    Abstract: The invention relates to methods and biomarkers (e.g., epigenetic biomarkers) for detection of bladder cancer in biological samples (e.g., tissue samples, urine samples, urine sediments). In some embodiments, methods and biomarkers of the present invention find use in discriminating between bladder cancer, prostate cancer and renal epithelial tumors.
    Type: Grant
    Filed: October 19, 2011
    Date of Patent: October 24, 2017
    Assignee: OSLO UNIVERSITETSSYKEHUS HF
    Inventors: Guro Elisabeth Lind, Ragnhild A. Lothe, Rolf Inge Skotheim, Carmen Jeronimo, Vera L. Costa, Rui Henrique, Manuel R. Teixeira
  • DETERMINING BIOLOGICAL TISSUE TYPE
    Publication number: 20170296090
    Abstract: A method is described for determining biological tissue type based on a complex impedance spectra obtained from a probe with a conducting part adjacent a tissue region of interest, wherein the impedance spectra includes data from a number of frequencies. The method may include: obtaining, from the complex impedance spectra, a first data set representative of impedance modulus values, or equivalent admittance values, at one or more frequencies, obtaining, from the complex impedance spectra, a second data set representative of impedance phase angle values, or equivalent admittance values, at one or more different frequencies, applying a first discrimination criterion to the first data set, applying a second discrimination criterion to the second data set, and thereby determining if the tissue region of interest is a tissue type characterised by the discrimination criteria.
    Type: Application
    Filed: October 12, 2015
    Publication date: October 19, 2017
    Applicant: OSLO UNIVERSITETSSYKEHUS HF
    Inventors: Håvard KALVØY, Axel SAUTER, Audum STUBHAUG, Sverre GRIMENES, Ørjan G. MARTINSEN
  • Phenazine derivatives as anti-neoplastic agents and anti-infective agents
    Patent number: 9745273
    Abstract: Novel phenazine derivatives, methods for their preparation and their medical use, in particular as anti-neoplastic agents and anti-infective agents, are provided. Novel methods for the preparation of iodinin and myxin are also provided.
    Type: Grant
    Filed: November 3, 2014
    Date of Patent: August 29, 2017
    Assignees: Universitetet I Oslo, Bergen Teknologioverføring AS, Université Claude Bernard Lyon 1
    Inventors: Stein Ove Døskeland, Pål Rongved, Lars Herfindal, Marc Le Borgne, Elvar Örn Viktorsson, Ove Alexander Høgmoen Åstrand
  • Antibacterial polypeptides and use thereof
    Patent number: 9676829
    Abstract: The present invention discloses polypeptides with antibacterial properties and use said polypeptides and/or polynucleotides encoding said polypeptides in the preparation of medicament for the treatment of infectious diseases. The inventors also provide vectors encoding and adapted for expression of the polypeptides and polynucleotides of the invention. The vectors may be used in the preparation of a medicament for the treatment of bacterial infections. Further, the vector of the invention may be used to reduce the load of bacteria in food and/or feed.
    Type: Grant
    Filed: September 25, 2014
    Date of Patent: June 13, 2017
    Assignee: Oslo Universitetssykehus HF
    Inventors: Ragnhild Weel-Sneve, James Alexander Booth, Magnar Bjørås, Knut Ivan Kristiansen
  • Methods and kits for detection of 5-hydroxymethylcytosine
    Patent number: 9677128
    Abstract: The present invention relates to methods and kits for the detection of 5-hydroxymethylcytosme (5hmC). In some embodiments, the present invention relates to methods and kits for detection of 5hmC in nucleic acid (e.g., DNA, RNA). In some embodiments, the present invention relates to detection of 5hmC in genomic DNA, e.g., mammalian genomic DNA.
    Type: Grant
    Filed: October 20, 2011
    Date of Patent: June 13, 2017
    Assignee: OSLO UNIVERSITETSSYKEHUS HF
    Inventors: Adam Brian Robertson, John Arne Dahl, Arne Klungland
  • ENGINEERED INVARIANT CHAIN MOLECULE FOR IMPROVED MHC CLASS I LOADING
    Publication number: 20170106066
    Abstract: The present invention relates to peptides presented on the cell surface of cells in the MHC class I (MHC I) context in which the invariant chain has been engineered to favor loading of specific antigens and generate CD8+ T-cell activation
    Type: Application
    Filed: June 10, 2015
    Publication date: April 20, 2017
    Applicant: UNIVERSITETET I OSLO
    Inventors: Sebastien P. WÄLCHLI, Tone Fredsvik GREGERS, Else Marit Suso INDERBERG, Gustav GAUDERNACK, Gunnar KVALHEIM, Oddmund BAKKE
  • Multivalent phage display systems and methods
    Patent number: 9598692
    Abstract: The present invention relates to vectors, methods and systems for polypeptide display and selection. Specifically, the present invention relates to vectors, methods, and systems for multivalent phage display using pIX protein of filamentous phage and helper phage.
    Type: Grant
    Filed: September 21, 2010
    Date of Patent: March 21, 2017
    Assignee: University of Oslo
    Inventors: Geir Age Loset, Inger Sandlie
  • Cyclic amino compounds for use in the treatment of cardiac disorders
    Patent number: 9585880
    Abstract: The present invention relates to tertiary amines of formula (I) for use in therapy, particularly for use in treating cardiovascular disorders. The compounds have been found to regulate phospholamban phosphorylation by interfering with the A-kinase anchor protein 18delta (AKAP18?) binding to the PKA substrate phospholamban. The compounds share a tri(alkylaryl/alkylheteroaryl) amine structure.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: March 7, 2017
    Assignee: Universitetet I Oslo
    Inventors: Jo Klaveness, Kjetil Tasken
  • Detection of saxitoxin-producing dinoflagellates
    Patent number: 9580759
    Abstract: The current disclosure generally relates to the field of saxitoxins and the identification of microorganisms capable of producing them. In particular, the saxitoxin A (sxtA) gene comprising catalytic domain sequences saxitoxin A1 (sxtA1) and saxitoxin A4 (sxtA4) is identified in a number of dinoflagellate species. The disclosure relates to methods of detection of saxitoxin-producing dinoflagellates by amplification and detection of the sxtA gene (in particular by PCR) and kits and primers for use in the method are also disclosed. Saxitoxin-producing dinoflagellate genera detected by the method include Alexandrium, Pyrodinium or Gymnodinium.
    Type: Grant
    Filed: May 16, 2012
    Date of Patent: February 28, 2017
    Assignees: UNIVERSITETET I OSLO, NEWSOUTH INNOVATIONS PTY LIMITED
    Inventors: Brett A. Neilan, Shauna Ann Murray, Anke Corinna Stüken, Kjetill S. Jakobsen, Russel J. S. Orr, Ralf Kellmann
  • Tertiary amines for use in the treatment of cardiac disorders
    Patent number: 9556111
    Abstract: The present invention relates to tertiary amines of formula (I) for use in therapy, particularly for use in treating cardiovascular disorders. The compounds have been found to regulate phospholamban phosphorylation by interfering with the A-kinase anchor protein 18delta (AKAP185) binding to the PKA substrate phospholamban. The compounds share a tri(alkylaryl/alkylheteroaryl)amine structure.
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: January 31, 2017
    Assignee: UNIVERSITETET I OSLO
    Inventors: Kjetil Tasken, Birgitte Lygren, Ellen Ostensen, Jo Klaveness
  • Methods and biomarkers for detection and prognosis of cervical cancer
    Patent number: 9506117
    Abstract: The present invention relates to methods and biomarkers for detection of cervical cancer in biological samples, and in particular to markers associated with hypoxia related to the cervical cancer.
    Type: Grant
    Filed: February 20, 2013
    Date of Patent: November 29, 2016
    Assignee: Oslo universitetssykehus HF
    Inventors: Heidi Lyng, Cathinka Halle Julin
  • OUTER MEMBRANE VESICLES AND USES THEREOF
    Publication number: 20160279222
    Abstract: The disclosure relates to outer membrane vesicles from Francisella and Piscirickettsia, and their use in vaccine compositions. In particular, the present disclosure relates to compositions and methods useful in inducing protective immunity against francisellosis or salmon rickettsial septicaemia (SRS) in fish.
    Type: Application
    Filed: November 13, 2014
    Publication date: September 29, 2016
    Applicant: UNIVERSITY OF OSLO
    Inventors: Hanne WINTHER-LARSEN, Espen BRUDAL, Duncan COLQUHOUN
  • Inhibitors of Metallo-Beta-Lactamase (MBL) Comprising a Zinc Chelating Moiety
    Publication number: 20160244431
    Abstract: Compounds according to formula I are provided: A-L-B wherein A represents a lipophilic chelating moiety which is selective for Zn2+ions; L is a covalent bond or a linker; and B is a vector which is either a moiety capable of interacting with one or more biological structures found in a bacterium (preferably in a bacterial cell wall), for example a penicillin-binding protein such as a metallo-?-lactamase or DD-transferase, or a moiety capable of enhancing transport of the compound across a bacterial cell membrane. A method of treating and/or preventing a bacterial infection in a human or non-human mammal employing such compounds are also provided. In such a method, the compound of formula I may be administered in combination with (either simultaneously, separately, or sequentially) a ?-lactam antibiotic.
    Type: Application
    Filed: October 6, 2014
    Publication date: August 25, 2016
    Applicant: Universitetet I Oslo
    Inventors: Pål RONGVED, Ove Alexander Høgmoen ÅSTRAND, Annette BAYER, Hanna-Kirsti Schrøder LEIROS, Ørjan SAMUELSEN, Kine Susann Waade EDVARDSEN
  • Formation of a lithium comprising structure on a substrate by ALD
    Patent number: RE46610
    Abstract: A method for the formation of lithium includes a layer on a substrate using an atomic layer deposition method. The method includes the sequential pulsing of a lithium precursor through a reaction chamber for deposition upon a substrate. Using further oxidizing pulses and or other metal containing precursor pulses, an electrolyte suitable for use in thin film batteries may be manufactured.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: November 14, 2017
    Assignee: Universitetet I Oslo
    Inventors: Ola Nilsen, Helmer Fjellvåg, Mari Endresen Alnes, Titta Aaltonen, Matti Putkonen