Abstract: The invention provides methods and materials related to a gene expression-based survival predictor for diffuse large B cell lymphoma (DLBCL) patients.

Abstract: The invention relates to segmenting blood vessels in perfusion MR images, more particularly, the invention relates to automated vessel removal in identified tumor regions prior to tumor grading. Pixels from a perfusion related map from dynamic contrast enhancement (DCE) MR images are clustered into arterial pixels and venous pixels by e.g. a k-means class cluster analysis. The analysis applies parameters representing the degree to which the tissue entirely consists of blood (such as relative blood volume (rBV), peak enhancement (?R2max) and/or post first-pass enhancement level (?R2p)) and parameters representing contrast arrival time at the tissue (such as first moment of the area (fmAUC) and/or contrast arrival time (T0)). The artery and venous pixels are used to form a vessel mask. The invention also relates to a computer aided diagnostic (CAD) system for tumor grading, comprising automated tumor segmentation, vessel segmentation, and tumor grading.

Abstract: A method of matching message elements, including a reading step of reading a contents of a first message and a second message and a determining step that determines whether the content of the first message is the same as the content of the second message, wherein if the content of the first message matches the content of the second message, a new pair is formed that includes the content of the first message and the content of the second message. The method further includes a matching table lookup step of reading a matching table, which stores one or more pairs of matching elements, a consistency check step to determine whether the new pair is consistent with the one or more pairs of matching elements stored in the matching table, and a storage step for storing the new pair to the matching table based on the result of the consistency check step.

Abstract: The present invention discloses a method for the formation of lithium comprising layer on a substrate using an atomic layer deposition method. The method comprises the sequential pulsing of a lithium precursor through a reaction chamber for deposition upon a substrate. Using further oxidising pulses and or other metal containing precursor pulses, an electrolyte suitable for use in thin film batteries may be manufactured.

Abstract: The invention relates to a method and a post-operative care unit for analysing and quantifying an ultrasound tissue Doppler imaging (TDI) signal from a transducer fastened on the myocardium to obtain a parameter indicating regional cardiac ischaemia or correlates with global hypokinetic heart function. This has the advantage over manually operated probes that it can be automated and used continuously over long time. According to the method, a TDI signal trace corresponding to at least one of tissue velocity, strain or strain rate is extracted and correlated with an electrocardiogram to define subsections within a cardiac cycle in the extracted trace corresponding to the early systolic phase and the post-systolic phase. Then, a velocity, strain or strain rate is read in at least the post-systolic phase of the extracted trace, and a parameter which is a function of one of these readings and which indicates ischaemia or global hypokinetic function is generated.

Abstract: A zone location system with ultrasound US transmitters S1, S2, S3 located in respective zones Z1, Z2, Z3 such as rooms of a building B. Preferably, the US transmitters are time-multiplexed so that each of them in turn transmits a US signal US with a unique ID code USID represented therein. The portable tag PT includes an ultrasound receiver USR arranged to receive the US signal. Based on the received US signal, the portable tag PT measures a strength of the received US signal. The portable tag PT also measures a parameter related to a movement of the portable tag PT, e.g. a Doppler shift based on the received US signal. Further, the portable tag extracts the USID. Then it transmits a wireless Radio Frequency signal RFS with its own ID PTID, the USID and first and second data values D1, D2 representing the signal strength and the movement related parameters.

Abstract: The present invention relates to a microarray comprising a chimeric probe for an intergenic exon-to-exon junction of a fusion gene and at least two intragenic probes for a fusion gene partner of the fusion gene. The invention further relates to a method of detecting a fusion gene and a kit suitable for detecting fusion genes.

Abstract: The present invention provides the use of an LXR antagonist, or a physiologically-acceptable pro-drug therefor, in the manufacture of a medicament for combating insulin resistance or a disorder associated therewith. Further provided is a compound being an ester or carbamate of a hydroxycholesterol, a pharmaceutical composition of such a compound or its use in therapy.

Abstract: A method of detecting intrusion in a computer program which has number of defined libraries and includes cross border instructions which cause execution to branch from a source library to a target library. The method comprises the step of determining whether execution of the program is in an area consistent with normal execution of the program, by checking whether the source library of a cross border instruction is the expected current execution library of the program. Each cross border instruction has a code stub identifying the source library, and when a legal cross border instruction is executed the target library becomes the current execution library. The method also checks that the target address of a cross border instruction is a legal address. In another arrangement, areas of the program are set so that a cross border instruction will generate page protection fault which is intercepted by the intrusion detection system so that the cross border instruction can be checked.

Abstract: The present invention relates to novel markers for hypermethylation of gene promoters in cancers. In particular the present invention relates to a method of determining whether a tumour is developing in the aero-digestive system, or whether a subject is relapsing after treatment of such a tumour. The method comprises determining the methylation level, the number of methylated CpG sites or the methylation state of CpG sites in a nucleic acid sequence in the promoter region, first exon or intron, of one or more genes selected from the group consisting of CNRIP1, MAL, FBN1, SPG20, SNCA, and INA. The method further relates to a diagnostic kit for detecting tumours in the aero-digestive tract.

Abstract: A process for the preparation of active surfaces terminated by a desired form of organic, organic-inorganic, or inorganic nature comprising growing with a gas phase deposition technique preferable the ALCVD (atomic layer chemical vapour deposition) technique. As an example, trimethylaluminium (TMA), hydroquinone (Hq) and phloroglucinol (Phl) have been used as precursors to fabricate surfaces that are terminated by hydroxyl groups attached to aromates. Further types of active surfaces are described. These surfaces can be used to produce surfaces: suitable for adhesion through the use of glue or other adhesive, providing receptors for biological molecules, making the surfaces biocompatible, of catalytically active materials, where upon subsequent types of chemical reactions can take place, with different degrees of wetting properties.

Abstract: Celiac Sprue and/or dermatitis herpetiformis are treated by interfering with HLA binding of immunogenic gluten peptides. The antigenicity of gluten oligopeptides and the ill effects caused by an immune response thereto are decreased by administration of an HLA-binding peptide inhibitor. Such inhibitors are analogs of immunogenic gluten peptides and (i) retain the ability to bind tightly to HLA molecules; (ii) retain the proteolytic stability of these peptides; but (iii) are unable to activate disease-specific T cells.

Abstract: Proton conductivity has been shown in acceptor-doped rare earth orthoniobates and tantalates (LnNbO4 and LnTaO4) at high temperatures and in a humid atmosphere. The use of the materials as an electrolyte in a laboratory-scale fuel cell and water vapour sensor has been demonstrated. Results for Ca-doped LaNbO4 are given as examples.

Abstract: The surface recombination velocity of a silicon sample is reduced by deposition of a thin hydrogenated amorphous silicon or hydrogenated amorphous silicon carbide film, followed by deposition of a thin hydrogenated silicon nitride film. The surface recombination velocity is further decreased by a subsequent anneal. Silicon solar cell structures using this new method for efficient reduction of the surface recombination velocity is claimed.

Abstract: The invention relates to a porous heterogeneous catalyst material comprising frameworks of inorganic cornerstones connected by organic bridges, characterized in that as organic bridges are used ligands having a complexed catalytically active metal. The metals are preferably palladium and platinum. The ligands preferably contain nitrogen donor groups for complexing the catalytically active metal and carboxylate groups connecting to the inorganic cornerstones.

Abstract: A method of estimating the impulse response of a channel is disclosed. The method includes transmitting an impulse signal to the channel, detecting a received signal from the channel, and calculating an estimate of the impulse response of the channel by applying a calculated inverse matrix of the impulse signal to the received signal.

Abstract: A process for the preparation of thin films of an organic-inorganic nature comprising growing with a gas phase deposition technique preferable the ALCVD (atomic layer chemical vapour deposition) technique. As an example, trimethylaluminium (TMA), hydroquinone (Hq) and phloroglucinol (PhI) have been used as precursors to fabricate thin films of aluminium benzene oxides constructing a hybrid type film. Further thin films with a hybrid nature are described. These films can be used as an optical material, a pressure sensor, a gas sensor, temperature sensor, magnetic field sensor, electric field sensor, a piezoelectric material, a magnetic material, a semiconductor material and as an electric insulating material.

Abstract: A method of assigning a set of resources to multiple agents using the resources, including an initial stage, consisting in setting up a collaborative network between agents, which expresses all the relations between agents liable to share at least one given resource through one or more coordinated actions, the network evaluating a degree of satisfaction for each agent according to all the validity verdicts ascribed by each agent to the relations in which they are engaged, and a resolution stage including a series of iterative basic stages during which each agent: perceives a satisfaction rating ascribed to each relation by all the agents linked by the relation, alters the satisfaction rating, and validates or invalidates the relation in question, wherein the series of basic stages continues until a predefined state of resolution is achieved.

Abstract: A process for the preparation of a water soluble unsaturated fatty acid salt from a crude composition comprising at least one non-water soluble or sparingly water soluble unsaturated fatty acid or salt thereof, said process comprising: adding to said crude composition in the presence of water at least one amino alcohol compound so as to form a water soluble amino alcohol salt of said acid or salt; separating an aqueous phase; and optionally isolating said salt from said aqueous phase.

Abstract: A laminar label (7) which comprises a base label (4), which is attached to a release web (3) by means of a glue layer (5) on top of which base label a supplement (13) is applied, which is covered by a top label (11). The base label with a matching release web is made of the same starting material (40, 41) as the top label with a matching release web (9) and the base label and the top label are brought together on the release web (3) of the base label in a relative displaced position and with a special treatment, e.g., a removal of portions through punching of said starting material in order to form a base label and a top label, respectively. Also a method and an apparatus for providing laminar labels (7), base labels (4) being applied on a release web (3), supplements (13) being positioned on top of the base labels and top labels (11) being positioned in such a way that they overlap the supplements.