Abstract: Surgically implantable shaped materials, e.g., sheets, are fabricated from elongate bone particles, advantageously those that have been demineralized. The materials when applied to a bone repair site enhance or accelerate new bone ingrowth by any one of a variety of biological and/or mechanical mechanisms.

Abstract: Fibrous connective tissue for surgical implantation is made substantially antigen-free by contact with one or more extraction agents. Solutions or mixtures of molecules having bipolar regions act as antigen removing permeation enhancers. Cationic, anionic, non-ionic or amphoteric surfactants are suitable bipolar permeation enhancers. One or more extraction agents can be combined to form extraction mixtures.

Abstract: A device for preventing adhesions or binding of tissue to tissue or of tissue to bone which comprises a composite of a first layer and a second layer, each of which comprises a biodegradable polymer. The first layer is selected from the group consisting of a non-porous layer and a porous layer having a pore size no greater than 3.mu.. The second layer has pores which have a pore size of from about 30.mu. to about 250.mu.. Such a composite device provides for tissue growth into the second layer, while the first layer acts as an adhesion-preventing barrier, and enables attachment of the device to tissue without suturing. Alternatively, the device comprises the first layer hereinabove mentioned and a second layer which is an adherence layer and which adheres to tissue and/or bone.

Abstract: A flowable demineralized bone powder composition is provided for use in surgical bone repair.

Abstract: A device for preventing adhesions or binding of tissue to tissue or of tissue to bone which comprises a composite of a first layer and a second layer, each of which comprises a biodegradable polymer, such as, for example, a polyethylene glycol/polybutylene terephthalate copolymer. The first layer is selected from the group consisting of a non-porous layer and a porous layer having a pore size no greater than 3.mu.. The second layer has pores which have a pore size of from about 30.mu. to about 250.mu.. The device is placed between two tissues or between tissue and bone. Such a composite device provides for tissue growth into the second layer, while the first layer acts as an adhesion-preventing barrier, and enables attachment of the device to tissue without suturing. Alternatively, the device comprises the first layer hereinabove mentioned and a second layer which is an adherence layer and which adheres to tissue and/or bone.

Abstract: A shaped piece of swollen demineralized bone which can also be plasticized is provided for use in surgical bone repair.

Abstract: An osteogenic composition is obtained from demineralized bone tissue.

Abstract: Demineralized bone particles having a median length to median thickness ratio of at least about 10:1 are incorporated in an osteogenic composition useful for repairing bone defects.

Abstract: A process for treating musculoskeletal tissue which comprises contacting musculoskeletal tissue with both an effective amount of at least one treating agent selected from the class consisting of antibiotics and disinfectants, and an agent to increase diffusion of the treating agent into the tissue, such as a surfactant or a permeation enhancer. The disinfectant and/or antibiotic function in killing bacteria, vegetative organisms, and viruses (including HIV virus) which may be remaining in the musculoskeletal tissue. A preferred disinfectant is ethanol.

Abstract: A shaped piece of swollen demineralized bone which can also be plasticized is provided for use in surgical bone repair.

Abstract: A flowable demineralized bone powder composition is provided for use in surgical bone repair.

Abstract: Swollen demineralized bone particles are formulated into a flowable osteogenic composition which is useful in the repair of osseous defects.

Abstract: An osteogenic composition is obtained from demineralized bone tissue.

Abstract: Bone is enzymatically debrided prior to undergoing further processing which renders the bone suitable for osteoprosthetic use.

Abstract: A process for cryopreserving a biological material which comprises contacting the biological material with both an effective amount at least one cryopreservation agent, and an agent to increase diffusion of the cryopreservation agent into the biological material, such as a surfactant or a permeation enhancer.

Abstract: A flowable demineralized bone powder composition is provided for use in surgical bone repair.

Abstract: At least a portion of the surface of an osteoprosthetic implant is provided with demineralized bone powder adhering thereto. Sorption of the bone particles is accompanied by rapid and deep bone in-growth which firmly anchors the prosthesis to the host bone repair site.

Abstract: A kit and process for reconstituting human bone and/or related tissue is disclosed. The kit comprises a pre-formulated sterilized reconstitution medium and double ended transfer needle.

Abstract: Bone is enzymatically debrided prior to undergoing further processing which renders the bone suitable for osteoprosthetic use.

Abstract: A prosthesis for replacing bone extracted from a cadaver. A preferred prosthesis is formed of two tubes of differing diameter, the larger-diameter tube beng slidable over the smaller-diameter tube to provide a telescoping assembly. A stop is provided on the smaller tube, and is adjustably positioned thereon for operatively contacting an end of the larger tube to resist contraction of the assembly after insertion within a cadaver. Threaded pins are provided at the ends of the assembly for engagement within bone of a skeleton of the cadaver. The prosthesis retains the physical appearance of a cadaver after extraction of bone for use in surgical and other therapeutic purposes on living organisms.