Abstract: A device for detecting properties of soft tissue. The device comprises a probe coupled to drive means to urge the probe against the soft tissue, a detector for determining applied stress to the soft tissue, and an ultrasonic transmitter configured to, in use, transmit ultrasound waves through at least a portion of the probe and through the soft tissue. A system including the device is also provided along with a corresponding method.

Abstract: The invention relates to pharmaceutical compositions comprising combinations of flavonoids that may be used to treat and/or prevent diabetes and associated diseases, conditions and/or disorders. The invention also relates to methods of treating diabetes and associated diseases, conditions and/or disorders using the pharmaceutical compositions.

Abstract: The invention provides novel quinoline sulfonamide compounds of Formula I: and their use for the treatment or prevention of bacterial infections caused by both Gram positive and Gram negative bacteria such as, for example, infections caused by one or more bacteria from the Enterobactericeae, Staphylococcaceae, or Streptococcaceae families. The compounds described and claimed herein may be formulated in one or more pharmaceutical or veterinary compositions for use in animal husbandry, and in particular in relation to the treatment of mastitis by directly targeting mastitis causing bacteria in a bovine herd. In certain embodiments described herein the pharmaceutical or veterinary compositions are formulated as a spray for direct administration to the udder of the bovine animal such as a cow.

Abstract: The present invention provides organic compounds which are capable of releasing carbon monoxide under physiological conditions or pH trigger, and to the use of such compounds for conditioning a cell, tissue or organ, for example, to protect against ischaemic injury during a transplant event.

Abstract: A method for preparing a hydrogel comprising mixing a solution of a polymer with a photoinitiator, where the polymer comprises multiple subunits each having a non-aromatic unsaturated functional group, and irradiating the mixture with visible light to produce the hydrogel.

Abstract: In one embodiment, there is provided an apparatus for converting an analogue radio-frequency (RF) signal to an optical signal. The apparatus may include: a vapor cell enclosing a gas of atoms; a probing light source configured to propagate a probing light beam through the vapor cell, a frequency of the probing light beam being tuned across a range in which the atoms transition from a first quantum state to a second quantum state; and, a coupling light source configured to propagate a coupling light beam through the vapor cell, a frequency of the coupling light beam being resonant or off-resonant with transition of the atoms from the second quantum state to a Rydberg state; wherein the vapor cell is configured such that on exposure thereof to an RF field carrying information from the RF signal, the apparatus is configured to encode the RF signal into the probing light beam.

Abstract: The present invention provides organic compounds which are capable of releasing carbon monoxide under physiological conditions or pH trigger, and to the use of such compounds for conditioning a cell, tissue or organ, for example, to protect against ischaemic injury during a transplant event.

Abstract: A gel comprising nano-sized particles of metallic silver (Ag), a polymer comprising carboxylate groups, carboxylate molecules comprising at least one group capable of binding to Ag, and metal ions, where the gel is useful as a topically applied antimicrobial agent.

Abstract: An assembly of micelle aggregates, wherein each aggregate comprises micelles of an anionic surfactant and nano-sized particles of metallic silver. A product comprising such assemblies for use in treating or preventing bacterial infections.

Abstract: The present disclosure relates to methods for the prognosis and/or diagnosis of vascular-related disorders in a subject and in particular pregnancy-related vascular disorders. The present disclosure is based on the finding that a positive correlation exists between positive prediction of a vascular disorder event in a subject and the concentration of the circulating marker NTproCNP (also referred to as NT-CNP) in humans and animals. In addition, the present disclosure is based on the finding that there is also a positive correlation between the occurrence of a vascular related adverse event during pregnancy and the concentration of the circulating marker NT-proCNP in the maternal circulation.

Abstract: The present invention relates generally to assays, methods and kits for the prognosis and/or diagnosis of cardiac disorders. The present invention also provides, for example, binding agents to a novel class of circulating cardiac troponin T upstream open reading frame (TnTuORF) peptide biomarkers for use in predicting or diagnosing a cardiac disorder other than myocardial infarction or unstable angina. In addition, the binding agents of the present invention may be used to enhance the sensitivity and false positive performance of cardiac troponins in the prognosis and diagnosis of myocardial infarction.

Abstract: Compounds and compositions comprising a B-type natriuretic signal peptide fragment agent, and methods of use thereof, are provided for the treatment or prevention of cardiovascular diseases, disorders, and conditions.

Abstract: The invention provides binding agents and assays for insulin signal peptide. The agents and assays are useful in methods for predicting, diagnosing, assessing or monitoring acute cardiac disorders, glucose handling disorders and diabetes in a subject. Also provided are nucleotides, polypeptides, and kits useful in the methods of the invention.

Abstract: Viral VEGF and viral anti-inflammatory cytokine compositions, methods of treatment using them, and kits containing them for use in the promotion and/or improvement of wound healing and/or tissue repair, and for anti-scarring, anti-inflammatory, anti-fibrosis and anti-adhesion indications.

Abstract: The invention provides methods for predicting, diagnosing or monitoring acute cardiac disorders, cardiac transplant rejection, or distinguishing acute cardiac disorders from pulmonary disorders, by measuring BNP signal peptide levels in a sample taken from a subject shortly after onset of, or presentation with the disorder or transplant rejection.

Abstract: Viral VEGF and viral anti-inflammatory cytokine compositions, methods of treatment using them, and kits containing them for use in the promotion and/or improvement of wound healing and/or tissue repair, and for anti-scarring, anti-inflammatory, anti-fibrosis and anti-adhesion indications.

Abstract: A reaction vessel holder (120) receives a reaction vessel (110). The reaction vessel (110) has a portion that is substantially optically transparent to light of a first range of wavelengths. The reaction vessel holder (120) comprises a body having a high thermal conductivity that is thermally coupled to and supports the reaction vessel (120). The body is further thermally coupled to a thermal device (130) for heating or cooling the reaction vessel holder (120) and thereby the reaction vessel (110). The body comprises a transparent portion that is substantially optically transparent to the light of the first range of wavelengths. The optically transparent portion of the reaction vessel (110) faces the transparent portion of the body such that light of the first range of wavelengths to and/or from the sample in the reaction vessel (120) can pass through the transparent portion.

Abstract: The invention provides methods for predicting, diagnosing or monitoring acute cardiac disorders, cardiac transplant rejection, or distinguishing acute cardiac disorders from pulmonary disorders, by measuring BNP signal peptide levels in a sample taken from a subject shortly after onset of, or presentation with the disorder or transplant rejection.

Abstract: Diagnostics relating to C-type natriuretic and erythropoietin signal peptides and fragments, and kits, uses and applications therefore.

Abstract: Diagnostics relating to C-type natriuretic and erythropoietin signal peptides and fragments, and kits, uses and applications therefor.