Abstract: The invention provides methods for predicting, diagnosing or monitoring acute cardiac disorders, cardiac transplant rejection, or distinguishing acute cardiac disorders from pulmonary disorders, by measuring BNP signal peptide levels in a sample taken from a subject shortly after onset of, or presentation with the disorder or transplant rejection.

Abstract: The invention provides binding agents and assays for ghrelin signal peptide. The agents and assays are useful in methods for predicting, diagnosing, assessing or monitoring acute cardiac disorders, glucose handling disorders and diabetes in a subject. Also provided are nucleotides, polypeptides, and kits useful in the methods of the invention.

Abstract: Compounds and compositions comprising a B-type natriuretic signal peptide fragment agent, and methods of use thereof, are provided for the treatment or prevention of cardiovascular diseases, disorders, and conditions.

Abstract: The invention relates to a translational recoding reporter construct comprising: a first fluorescent protein coding sequence; a second fluorescent protein coding sequence encoding a fluorescent protein different from the first fluorescent protein; and a linker sequence interposed between the first and second fluorescent protein coding sequence; wherein the first fluorescent protein coding sequence and the second fluorescent protein coding sequence are out-of-frame with respect to each other but are co-expressed as a single fusion polypeptide upon recoding. The invention also relates to methods of use of the construct in screening modulators of recoding.

Abstract: The invention provides methods for predicting, diagnosing or monitoring acute cardiac disorders, cardiac transplant rejection, or distinguishing acute cardiac disorders from pulmonary disorders, by measuring BNP signal peptide levels in a sample taken from a subject shortly after onset of, or presentation with the disorder or transplant rejection.

Abstract: An intra-oral stabilisation device has an upper tray (101), a lower tray a lower tray (201), and at least two spacers (217) to provide a spacing between the anterior portions of the upper and lower trays. Spacers (217) provide a spacing between anterior portions of the trays, and are positioned between corresponding posterior portions of the trays. Engagement features (301) are provided for engaging undersides of the posterior portions of the upper tray with upper sides of the posterior potions of the lower tray, and minimise lateral movement of the trays relative to one another once the trays are engaged with one another. In an alternative embodiment, the device may have only the lower tray, and may have a locator (219) for stabilising an endotracheal tube 401 relative to the lower tray. The upper or lower tray can be used to stabilise fracture segments of a fractured jaw.

Abstract: The present invention relates to methods of detecting, monitoring and treating prostate cancer (PRC) OR prostatic intraepithelial neoplasia (PIN) or a predisposition to same. Provided for use in the methods is a novel cancer marker, PSPU43, as well as bioassays and kits.

Abstract: A means of measuring and monitoring skeletal growth rate using a plasma analyte, amino-terminal C-type natriuretic peptide (NT-CNP). Plasma NT-CNP concentrations reflect the potential for further growth of the immature skeleton. Measurement of plasma NT-CNP in a subject, when related to the mean of an appropriate age and gender matched set of control subjects, provides an index of the severity of a growth disorder not otherwise available and facilitates diagnosis in children with undetected osteo-chondrodysplasias or other intrinsic disorders of the growth plate. The invention also provides a means of detecting and monitoring potentially harmful effects of drugs and other factors on skeletal growth long before they are evident using current methods in clinical practice.

Abstract: This invention relates to methods for modulating neuronal cell death or impairment, and methods for the treatment, prevention, and/or amelioration of symptoms of one or more conditions or diseases in a mammal caused by neuronal cell death or dysfunction.

Abstract: Oil obtained from the liver of hoki fish is a potent inhibitor of angiogenesis and inflammation, and a modulator of the immune system. Compositions containing hoki liver oil, or fractions thereof, are useful for treating diseases or disorders associated with angiogenesis and inflammation. Certain oil fractions are potent stimulants of the immune system whereas other fractions are potent suppressants of the immune system.

Abstract: The use of a citrus fruit skin extract for promoting angiogenesis, or treating a disease or disorder where it is desirable to promote angiogenesis. Such diseases include coronary heart disease, stroke, or ulcers. A composition comprising an extract of citrus fruit skin suitable for use in promoting angiogenesis, or treating a disease or disorder where it is desirable to promote angiogenesis. A process for preparing a citrus fruit skin extract. The citrus fruit may be grapefruit, orange, lemon, lime, mandarin, tangelo, tangerine or uglis, preferably grapefruit (Citrus paradisii).

Abstract: An apparatus for remote gas sensing comprising a light source, a photodetector, a gas cell containing gas or a zone through which the gas passes and through which light from the light source passes and is reflected back to the photodetector, wherein the light source, photodetector and gas cell are connected by a single polarization preserving optical fiber through which light from the light source passes to the gas cell, which light reflected back from the cell passes back through the optical fiber with a different polarization to that to the light transmitted by the light source. In one form the gas cell comprises a resonant optical cavity.