Patents Assigned to Otsuka Kagaku Kabushiki Kaisha
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Patent number: 5241027Abstract: A compound comprising 0.001 to 100 mole percent of a structural unit of the formula ##STR1## wherein W is --CMe.sub.2 -- or --Se--, R.sup.1 is C.sub.1 -C.sub.20 alkyl or aralkyl, R.sup.2 to R.sup.5 each represents H, C.sub.1 -C.sub.6 alkyl, etc., R.sup.6 and R.sup.7 each represents H, C.sub.1 -C.sub.6 alkyl, etc., X is O or S, provided that when W is --CMe.sub.2 --, X is S, and 0 to 99.999 mole percent of a structural unit of the formula ##STR2## wherein Y is H or Me and Z represents alkoxycarbonyl, phenyl, etc.Type: GrantFiled: October 7, 1991Date of Patent: August 31, 1993Assignee: Otsuka Kagaku Kabushiki KaishaInventor: Akira Miyashita
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Patent number: 5240753Abstract: The present invention provides a molded article for holding wafers which is made of a thermoplastic resin reinforced with whiskers. The present invention provides wafer holding molded articles, such as transport baskets, storage cases and carriers, for use in handling wafers and glass plates for liquid crystal televisions. These articles are useful for cleaning, drying, transporting or storing semiconductor wafers free of contamination.Type: GrantFiled: February 22, 1991Date of Patent: August 31, 1993Assignee: Otsuka Kagaku Kabushiki KaishaInventors: Akira Tabuchi, Morihiko Nakamura
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Patent number: 5236958Abstract: The present invention provides a photochromic compound of the formula (Ia) ##STR1## wherein R.sup.1 is a C.sub.1 -C.sub.20 alkyl group or an aralkyl group; R.sup.2, R.sup.3, R.sup.4 and R.sup.5 each represents H, a C.sub.1 -C.sub.6 alkyl group, an aryl group, an aralkyl group, a C.sub.1 -C.sub.5 alkoxy group, a halogen atom, a cyano group, a trichloromethyl group, a trifluoromethyl group or a nitro group; R.sup.6 and R.sup.7 each represents H, a C.sub.1 -C.sup.6 alkyl group, an aryl group, an aralkyl group, a halogen atom, a cyano group or a nitro group; and X is an oxygen atom or a sulfur atom, and a homopolymer of the above compound or a copolymer of the above compound and a vinyl compound represented by the formulaC H.sub.2 .dbd.C (Y) (Z)wherein Y is H or CH.sub.3 ; and Z is a carboxyl group, an alkoxy-carbonyl group, a cyano group, a carbamoyl group, an N,N-dimethylcarbamoyl group, an acetoxy group, a phenyl group or a methylphenyl group.Type: GrantFiled: October 17, 1991Date of Patent: August 17, 1993Assignee: Otsuka Kagaku Kabushiki KaishaInventor: Akira Miyashita
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Patent number: 5206361Abstract: The present invention provides a thiazolinoazetidinone derivative represented by the formula ##STR1## wherein R.sup.1 is phenyl having or not having substituent(s), methyl having or not having substituent(s) or ##STR2## group, R.sup.3 being phenyl having or not having substituent(s), and R.sup.2 is a hydrogen atom or carboxylic acid protective group, and a process for preparing the same.The present invention further provides a process for preparing a 2-exo-methylenepenam derivative characterized by hydrolyzing the thiazoline ring of a thiazolinoazetidinone derivative of the above formula (1) to effect recyclization and obtain a 2-exo-methylenepenam derivative represented by the formula ##STR3## wherein R.sup.1 and R.sup.2 are as defined above.Type: GrantFiled: March 7, 1991Date of Patent: April 27, 1993Assignee: Otsuka Kagaku Kabushiki KaishaInventors: Sigeru Torii, Hideo Tanaka, Masatoshi Taniguchi, Michio Sasaoka, Takashi Shiroi, Yutaka Kameyama
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Patent number: 5204458Abstract: The present invention provides a process for preparing a cephem derivative characterized in that an allenyl .beta.-lactam compound represented by the formula (1) ##STR1## wherein R.sup.1 is amino or protected amino, R.sup.2 is a hydrogen atom or lower alkoxyl, R.sup.3 is a hydrogen atom or carboxylic acid protecting group and X is the group --SO.sub.2 R.sup.4 or --SR.sup.4, R.sup.4 being substituted or unsubstituted aryl or substituted or unsubstituted nitrogen-containing aromatic heterocyclic group is reacted with a nucleophilic agent to obtain the derivative, the cephem derivative being represented by the formula (2) ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined above, and Y is the residue of the nucleophilic agent.Type: GrantFiled: March 10, 1992Date of Patent: April 20, 1993Assignee: Otsuka Kagaku Kabushiki KaishaInventors: Sigeru Torii, Hideo Tanaka, Masatoshi Taniguchi, Michio Sasaoka, Takashi Shiroi, Yutaka Kameyama
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Patent number: 5196530Abstract: The present invention provides a process for preparing a 2-exo-methylenepenam derivative represented by the formula (2), the process being characterized by reacting an allenyl .beta.-lactum compound represented by the formula (1) with a metallic reducing agent, in which R.sup.1, R.sup.2, R.sup.3 and X are defined in the specification.Type: GrantFiled: March 10, 1992Date of Patent: March 23, 1993Assignee: Otsuka Kagaku Kabushiki KaishaInventors: Sigeru Torii, Hideo Tanaka, Masatoshi Taniguchi, Michio Sasaoka, Takashi Shiroi, Yutaka Kameyama
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Patent number: 5183716Abstract: A solid-state battery having a solid electrolyte represented by [A].sub.u.({[=N(Z).sub.2 ].(MX).sub.v }.sub.w), a positive electrode, and a negative electrode. A is a single ionic polymer of at least one of an oligoethylene oxypolyphosphazene compound having a sulfone group and an oligoalkylene oxpolyphosphazene compound having a fluorolakylsulfone group. The respective oxypolyphosphazenes have the structure of one of formulas (I) to (IV): ##STR1## R is at least one of methyl, ethyl and propyl. R' is hydrogen or methyl. h, k, h' and k' are each the average number of repeating ethyleneoxy unite or alkyleneoxy units and are each a real number from 0 to 20. l, n, l' and n' are each an integer of 0 or greater in the range of 3.ltoreq.l+n+l'+n'.ltoreq.200,000. Z is a group represented by Y--(OCH.sub.2 CH.sub.2).sub.y --O--. Y is at least one of methyl, ethyl and propyl. y is a real number from 1 to 30.Type: GrantFiled: February 21, 1990Date of Patent: February 2, 1993Assignee: Otsuka Kagaku Kabushiki KaishaInventors: Yoshifumi Nakacho, Akiyoshi Inubushi, Yuji Tada
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Patent number: 5153080Abstract: An all solidstate secondary battery comprising an oxide of layer structure represented by the formula(V.sub.2 O.sub.5)x *(A)y *zH.sub.2 Oserving as a cathode active material, lithim or a lithium alloy serving as a negative electrode active substance, and an oligoalkyleneoxypolyphosphazene polymer serving as an electrolyte, contains no solvent, is excellent in charge-discharge characteristics and usable with safety over a wide temperature range of from low to high temperatures.Type: GrantFiled: August 15, 1990Date of Patent: October 6, 1992Assignee: Otsuka Kagaku Kabushiki KaishaInventors: Akiyoshi Inubushi, Toshifumi Nakacho, Yuji Tada
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Patent number: 5151524Abstract: A process for preparing an imidazolidine-2,5-dione derivative of the formula ##STR1## includes reacting a phenyl isocyanate compound of the formula ##STR2## with methylhydantoin of the formula ##STR3## in the presence of a basic catalyst, wherein X is a halogen atom, lower alkyl, lower alkoxyl, lower haloalkyl, nitro cyano or alkoxycarbonyl, and n is an interger of 0 or 1 to 4. A second process for preparing an imidazolidine-2,5-dione derivative of formula IV includes reacting phosgene or trichloromethyl chloroformate with methylhydantoin of formula VI in the presence of a dehydrogen chloride agent, and further reacting the resulting product with an aniline derivative of formula VII ##STR4## in the presence of a dehydrogen chloride agent, wherein X is same as above.Type: GrantFiled: July 18, 1990Date of Patent: September 29, 1992Assignee: Otsuka Kagaku Kabushiki KaishaInventor: Tetuya Imai
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Patent number: 5142040Abstract: The present invention provides a process for preparing a 3-formylcephem derivative represented by the formula (2) ##STR1## which comprises oxidizing in the presence of oxygen a 3-halomethylcephem derivative represented by the formula (1) ##STR2## wherein R.sup.1 is amino group or protected amino group, R.sup.2 is hydrogen atom or a carboxylic acid protective group, X is halogen atom.Type: GrantFiled: March 7, 1991Date of Patent: August 25, 1992Assignee: Otsuka Kagaku Kabushiki KaishaInventors: Sigeru Torii, Hideo Tanaka, Masatoshi Taniguchi, Michio Sasaoka, Takashi Shiroi, Ryo Kikuchi, Yutaka Kameyama
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Patent number: 5131827Abstract: This invention relates to a resin composition for scroll compressor parts which comprises(A) about 40 to 70 parts by weight of at least one thermoplastic resin selected from the group consisting of polyphenylene sulfide, polyetheretherketone, polyetherketone, all-aromatic polyester, nylon-4,6, nylon-MXD6, polysulfone, polyarylsulfone, polyethersulfone, polyetherimide, polyamide-imide and polyimide,(B) about 15 to 45 parts by weight of whisker with an average fiber diameter of not more than about 3 .mu.m and a tensile modulus of not less than about 10,000 kgf/mm.sup.2 ;(C) about 10 to 25 parts by weight of heat-resistant fiber with an average fiber diameter of not more than about 30 .mu.m and a tensile modulus of not less than about 6,500 kgf/mm.sup.2 ; and(D) about 5 to 20 parts by weight of a finely divided solid lubricant, the sum total of components (A) to (D) being 100 parts by weight and a method of manufacturing scroll compressor parts characterized in that the above composition is injection molded.Type: GrantFiled: October 31, 1990Date of Patent: July 21, 1992Assignee: Otsuka Kagaku Kabushiki KaishaInventor: Takio Tasaka
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Patent number: 5126447Abstract: A process for preparing a .beta.-lactam derivative of formula (2) and/or the corresponding enol tautomer, which includes oxidizing an alkenyl-substituted .beta.-lactam derivative of formula (1) in the presence of a ruthenium catalyst or a rhenium catalyst using a periodic acid: ##STR1## wherein R.sup.1 is a hydrogen atom, a C.sub.1-4 alkyl group or a C.sub.1-4 haloalkyl group, R.sup.2 is a hydrogen atom, a C.sub.1-4 alkyl group or a phenyl group which may have a substituent, A is a group selected from ##STR2## wherein R.sup.3 is an amino group or a protected amino group, and R.sup.4 -R.sup.8 are as defined in the application.Type: GrantFiled: March 1, 1991Date of Patent: June 30, 1992Assignee: Otsuka Kagaku Kabushiki KaishaInventors: Sigeru Torii, Hideo Tanaka, Masatoshi Taniguchi, Michio Sasaoka, Takashi Shiroi, Ryo Kikuchi, Yutaka Kameyama
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Patent number: 5114809Abstract: The present invention provides an all solid-state lithium secondary battery comprising an oxide of layer structure serving as a positive electrode active substance and represented by the formula(V.sub.2 O.sub.5)x.cndot.(A)y.cndot.zH.sub.2 Owherein x+y=1, y=0.03 to 0.5, z=0.1 to 1.6, A is at least one oxide seleced from among GeO.sub.2, SiO.sub.2, B.sub.2 O.sub.3, MoO.sub.3, WO.sub.3, Nb.sub.2 O.sub.5, TeO.sub.2, Bi.sub.2 O.sub.3, Cr.sub.3 O.sub.8 and ZrO.sub.2, lithium or a lithium alloy serving as a negative electrode active substance, and a compound serving as an electrolyte and represented by the formula{[N=P(E).sub.2 ].cndot.(LiX)a}bwhereini) [N=P(E).sub.Type: GrantFiled: October 19, 1990Date of Patent: May 19, 1992Assignee: Otsuka Kagaku Kabushiki KaishaInventors: Yoshifumi Nakacho, Akiyoshi Inubushi, Yuji Tada
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Patent number: 5070194Abstract: This invention provides a method of producing a .beta.-lactam derivative represented by the formula (I): ##STR1## said method consisting essentially of the step of reacting a .beta.-lactam derivative represented by the formula (II): ##STR2## with a phenol in a reaction system which consists essentially of said .beta.-lactam derivative of formula (II) and said phenol.Type: GrantFiled: April 5, 1989Date of Patent: December 3, 1991Assignee: Otsuka Kagaku Kabushiki KaishaInventors: Michio Sasaoka, Nori Saito, Takashi Shiroi, Shigemitsu Nagao, Ryo Kikuchi, Yutaka Kameyama
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Patent number: 4958018Abstract: Disclosed is a method of producing a 3-exomethylenecepham of the formula ##STR1## wherein R.sup.1 is amino or substituted amino and R.sup.2 is a carboxy-protecting group comprising reacting a cephem of the formula ##STR2## wherein R.sup.1 and R.sup.2 are as defined above and X is halogen with lead metal while maintaining the pH of the reaction system at about 0.1 to 8. The cephem (I) may be reacted with a catalytic amount of lead metal or a lead compound in the presence of a metal having a greater ionization tendency than lead.Type: GrantFiled: May 4, 1989Date of Patent: September 18, 1990Assignee: Otsuka Kagaku Kabushiki KaishaInventors: Sigeru Torii, Hideo Tanaka, Masatoshi Taniguchi, Michio Sasaoka, Norio Saito, Takashi Shiroi, Shigemitsu Nagao, Ryo Kikuchi, Yutaka Kameyama
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Patent number: 4933444Abstract: Disclosed is a process for preparing 2.beta.-substituted-methylpenicillin derivative of the formula ##STR1## wherein R is H or carboxyl protecting group, R.sub.1 is H or halo, R.sub.2 is H, lower alkyl, lower alkoxy, halogen, azido, lower alkylthio, phthalimide or a group --NHR.sub.3 (wherein R.sub.3 is H or acyl), and --N Y is an optionally substituted monocyclic or bicyclic heterocyclic group having 1 to 4 nitrogen atoms in the ring structure, the process comprising reacting a compound of the formula ##STR2## wherein X is Cl or Br, and R, R.sub.1 and R.sub.2 are as defined above with a heterocyclic compound of the formula ##STR3## wherein --N Y is as defined above.Type: GrantFiled: June 26, 1989Date of Patent: June 12, 1990Assignees: Taiho Pharmaceutical Co., Ltd., Otsuka Kagaku Kabushiki KaishaInventors: Sigeru Torii, Hideo Tanaka, Motoaki Tanaka, Shozo Yamada, Akira Nakai, Hisashi Ohbayashi
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Patent number: 4925934Abstract: The invention provides a process for preparing a .beta.-lactam derivative represented by the formula ##STR1## the process comprising reacting a .beta.-lactam derivative represented by the following formula (II) and having a protected carboxyl group with a cresol; ##STR2## wherein R represents a benzyl group having an electron-donating group as a substituent on the phenyl ring, a diphenylmethyl group which may have an electron-donating group as a substituent on the phenyl ring or a tert-butyl group.Type: GrantFiled: March 1, 1989Date of Patent: May 15, 1990Assignees: Otsuka Kagaku Kabushiki Kaisha, Taiho Pharmaceutical Co., Ltd.Inventors: Masatoshi Taniguchi, Michio Sasaoka, Kiyotoshi Matsumura, Ichiro Kawahara, Kenji Kaze, Daisuke Suzuki, Akihiro Shimabayashi
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Patent number: 4920142Abstract: This invention provides an imidazole derivative represented by the formula ##STR1## wherein R is lower alkyl, lower alkoxyalkyl, lower alkoxycarbonylmethyl or cyanomethyl, and X.sup.1 and X.sup.2 are each a hydrogen atom or halogen atom, process for preparing the derivative, and a fungicidal compositions comprising the derivative for use in agriculture and horticulture.Type: GrantFiled: February 1, 1989Date of Patent: April 24, 1990Assignee: Otsuka Kagaku Kabushiki KaishaInventors: Tetsuya Imai, Hisashi Takao
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Patent number: 4912213Abstract: The present invention provides a process for preparing a penicillanic acid derivative of the formula ##STR1## which comprises reacting lead with a halogenated penicillanic acid derivative of the formula ##STR2## wherein X, Y, Z and R.sup.1 are as defined in the specification. The reaction is advantageously conducted in the presence of a metal having higher ionization tendency than lead such as aluminum, iron, magnesium or a mixture thereof.Type: GrantFiled: September 7, 1988Date of Patent: March 27, 1990Assignees: Otsuka Kagaku Kabushiki Kaisha, Taiho Pharmaceutical Company, LimitedInventors: Masatoshi Taniguchi, Michio Sasaoka, Kiyotoshi Matsumura, Ichiro Kawahara, Kenji Kase, Daisuke Suzuki, Shigeru Torii, Hideo Tanaka, Motoaki Tanaka, Akira Nakai
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Patent number: 4906623Abstract: A cephalosporin compound substituted by imidazolium ring in 3-position of cephem having the following formula (I), and pharmaceutically acceptable salt thereof, ##STR1## wherein R.sup.1 is an organic residue known in .beta.-lactam antibiotics, R.sup.2 is hydrogen atom or methoxy, n is 0 or 1, A is a nitrogen-containing group constituting imidazolium ring, is useful as an agent for preventing and treating bacterial infections.Type: GrantFiled: March 25, 1988Date of Patent: March 6, 1990Assignee: Otsuka Kagaku Kabushiki KaishaInventors: Kiyotoshi Matsumura, Hiroshi Akagi, Daisuke Suzuki, Akihiro Shimabayashi