Patents Assigned to Oxyrane UK Limited
  • Yeast strains producing mammalian-like complex n-glycans
    Patent number: 11225646
    Abstract: Described herein are methods and genetically engineered fungal cells useful for producing target molecules containing mammalian-like complex N-glycans or containing intermediates in a mammalian glycosylation pathway.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: January 18, 2022
    Assignee: Oxyrane UK Limited
    Inventors: Steven Christian Jozef Geysens, Wouter Vervecken
  • Methods and materials for treatment of Pompe's disease
    Patent number: 10648044
    Abstract: This document relates to molecular complexes having acid alpha glucosidase activity and at least one modification that results in enhanced ability of the molecular complex to be transported to the interior of a mammalian cell.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: May 12, 2020
    Assignee: Oxyrane UK Limited
    Inventors: Wouter Vervecken, Kathleen Camilla Telesphore Alida Maria Piens, Jan Robert Ludo Stout, Gwenda Noëlla Pynaert
  • Hydrolysis of mannose-1-phospho-6-mannose linkage to phospho-6-mannose
    Patent number: 10392609
    Abstract: Described herein are methods and genetically engineered cells useful for uncapping a mannose-6-phosphate residue on an oligosaccharide.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: August 27, 2019
    Assignees: Oxyrane UK Limited, VIB vzw, Universiteit Gent, Vrije Universiteit Brussel
    Inventors: Nico Luc Marc Callewaert, Wouter Vervecken, Petra Sophie Tiels, Han Karel Remaut, Kathleen Camilla Telesphore Alida Maria Piens
  • De-mannosylation of phosphorylated N-glycans
    Patent number: 10344310
    Abstract: Methods for demannosylating phosphorylated N-glycans on a glycoprotein are described that use a mannosidase capable of hydrolyzing a terminal alpha-1,2 mannose linkage when the underlying mannose is phosphorylated.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: July 9, 2019
    Assignees: Oxyrane UK Limited, VIB vzw, Universiteit Gent
    Inventors: Kathleen Camilla Telesphore Alida Maria Piens, Wouter Vervecken
  • Yeast strains producing mammalian-like complex N-glycans
    Patent number: 10287557
    Abstract: Described herein are methods and genetically engineered fungal cells useful for producing target molecules containing mammalian-like complex N-glycans or containing intermediates in a mammalian glycosylation pathway.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: May 14, 2019
    Assignee: Oxyrane UK Limited
    Inventors: Steven Christian Jozef Geysens, Wouter Vervecken
  • Microorganisms genetically engineered to have modified N-glycosylation activity
    Patent number: 10023854
    Abstract: Described herein are methods and genetically engineered cells useful for producing an altered N-glycosylation form of a target molecule. Also described are methods and molecules with altered N-glycosylation useful for treating a variety of disorders such as metabolic disorders.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: July 17, 2018
    Assignees: Oxyrane UK Limited, VIB vzw, Universiteit Gent
    Inventors: Nico Luc Marc Callewaert, Wouter Vervecken, Karen Jacqueline Marcel De Pourcq, Steven Christian Jozef Geysens, Mouna Guerfal
  • Mannosidases capable of uncapping mannose-1-phospho-6-mannose linkages and demannosylating phosphorylated N-glycans and methods of facilitating mammalian cellular uptake of glycoproteins
    Patent number: 10011857
    Abstract: The invention provides mannosidases capable of uncapping mannose-1-phospho-6-mannose moieties and demannosylating phosphorylated N-glycans, methods of using such mannosidases, glycoproteins produced using the methods, as well as methods of facilitating mammalian cellular uptake of glycoproteins.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: July 3, 2018
    Assignee: Oxyrane UK Limited
    Inventors: Kathleen Camilla Telesphore Alida Maria Piens, Wouter Vervecken, Albena Vergilieva Valevska, Gwenda Noëlla Pynaert
  • De-mannosylation of phosphorylated N-glycans
    Patent number: 9689015
    Abstract: Methods for demannosylating phosphorylated N-glycans on a glycoprotein are described that use a mannosidase capable of hydrolyzing a terminal alpha-1,2 mannose linkage when the underlying mannose is phosphorylated.
    Type: Grant
    Filed: September 29, 2011
    Date of Patent: June 27, 2017
    Assignee: Oxyrane UK Limited
    Inventors: Kathleen Camilla Telesphore Alida Maria Piens, Wouter Vervecken
  • Hydrolysis of mannose-1-phospho-6-mannose linkage to phospho-6-mannose
    Patent number: 9598682
    Abstract: Described herein are methods and genetically engineered cells useful for uncapping a mannose-6-phosphate residue on an oligosaccharide.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: March 21, 2017
    Assignees: VIB vzw, Universiteit Gent, Oxyrane UK Limited, Vrije Universiteit Brussel
    Inventors: Nico Luc Marc Callewaert, Wouter Vervecken, Petra Sophie Tiels, Han Karel Remaut, Kathleen Camilla Telesphore Alida Maria Piens
  • Hydrolysis of mannose-1-phospho-6-mannose linkage to phospho-6-mannose
    Patent number: 9493756
    Abstract: Described herein are methods and genetically engineered cells useful for uncapping a mannose-6-phosphate residue on an oligosaccharide.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: November 15, 2016
    Assignees: VIB vzw, Universiteit Gent, Oxyrane UK Limited, Vrije Universiteit Brussel
    Inventors: Nico Luc Marc Callewaert, Wouter Vervecken, Petra Sophie Tiels, Han Karel Remaut, Kathleen Camilla Telesphore Alida Maria Piens
  • Mannosidases capable of uncapping mannose-1-phospho-6-mannose linkages and demannosylating phosphorylated N-glycans and methods of facilitating mammalian cellular uptake of glycoproteins
    Patent number: 9347050
    Abstract: The invention provides mannosidases capable of uncapping mannose-1-phospho-6-mannose moieties and demannosylating phosphorylated N-glycans, methods of using such mannosidases, glycoproteins produced using the methods, as well as methods of facilitating mammalian cellular uptake of glycoproteins.
    Type: Grant
    Filed: September 29, 2011
    Date of Patent: May 24, 2016
    Assignee: Oxyrane UK Limited
    Inventors: Kathleen Camilla Telesphore Alida Maria Piens, Wouter Vervecken, Albena Vergilieva Valevska, Gwenda Noëlla Pynaert
  • Methods and materials for treatment of pompe's disease
    Patent number: 9249399
    Abstract: This document relates to molecular complexes having acid alpha glucosidase activity and at least one modification that results in enhanced ability of the molecular complex to be transported to the interior of a mammalian cell.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: February 2, 2016
    Assignee: Oxyrane UK Limited
    Inventors: Wouter Vervecken, Kathleen Camilla Telesphore Alida Maria Piens, Jan Robert Ludo Stout, Gwenda Noëlla Pynaert
  • Microorganisms genetically engineered to have modified N-glycosylation activity
    Patent number: 9222083
    Abstract: Described herein are methods and genetically engineered cells useful for producing an altered N-glycosylation form of a target molecule. Also described are methods and molecules with altered N-glycosylation useful for treating a variety of disorders such as metabolic disorders.
    Type: Grant
    Filed: April 27, 2011
    Date of Patent: December 29, 2015
    Assignees: Oxyrane UK Limited, VIB vzw, Universiteit Gent
    Inventors: Nico Luc Marc Callewaert, Wouter Vervecken, Karen Jacqueline Marcel De Pourcq, Steven Christian Jozef Geysens, Mouna Guerfal
  • Microorganisms genetically engineered to have modified N-glycosylation activity
    Patent number: 9206408
    Abstract: Described herein are methods and genetically engineered cells useful for producing an altered N-glycosylation form of a target molecule. Also described are methods and molecules with altered N-glycosylation useful for treating a variety of disorders such as metabolic disorders.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: December 8, 2015
    Assignees: Oxyrane UK Limited, VIB vzw, Universiteit Gent
    Inventors: Nico Luc Marc Callewaert, Wouter Vervecken, Karen Jacqueline Marcel De Pourcq, Steven Christian Jozef Geysens, Mouna Guerfal
  • Glycosylation of molecules
    Patent number: 8597906
    Abstract: Described herein are methods and genetically engineered cells useful for producing an altered N-glycosylation form of a target molecule. Also described are methods and molecules with altered N-glycosylation useful for treating a variety of disorders such as metabolic disorders.
    Type: Grant
    Filed: April 26, 2011
    Date of Patent: December 3, 2013
    Assignees: Oxyrane UK Limited, VIB vzw, Universiteit Gent
    Inventors: Nico Luc Marc Callewaert, Wouter Vervecken, Karen Jacqueline Marcel De Pourcq, Steven Christian Jozef Geysens, Mouna Guerfal
  • De-mannosylation of phosphorylated N-glycans
    Publication number: 20130295603
    Abstract: Methods for demannosylating phosphorylated N-glycans on a glycoprotein are described that use a mannosidase capable of hydrolyzing a terminal alpha-1,2 mannose linkage when the underlying mannose is phosphorylated.
    Type: Application
    Filed: September 29, 2011
    Publication date: November 7, 2013
    Applicant: OXYRANE UK LIMITED
    Inventors: Kathleen Camilla Telesphore Alida Maria Piens, Wouter Vervecken
  • METHODS AND MATERIALS FOR TREATMENT OF POMPE'S DISEASE
    Publication number: 20130243746
    Abstract: This document relates to molecular complexes having acid alpha glucosidase activity and at least one modification that results in enhanced ability of the molecular complex to be transported to the interior of a mammalian cell.
    Type: Application
    Filed: March 14, 2013
    Publication date: September 19, 2013
    Applicant: OXYRANE UK LIMITED
    Inventors: Wouter Vervecken, Kathleen Camilla Telesphore Alida Maria Piens, Jan Robert Ludo Stout, Gwenda Noëlla Pynaert
  • Glycosylation of Molecules
    Publication number: 20130195835
    Abstract: Described herein are methods and genetically engineered cells useful for producing an altered N-glycosylation form of a target molecule. Also described are methods and molecules with altered N-glycosylation useful for treating a variety of disorders such as metabolic disorders.
    Type: Application
    Filed: September 14, 2012
    Publication date: August 1, 2013
    Applicants: OXYRANE UK LIMITED, UNIVERSITEIT GENT, VIB VZW
    Inventors: Nico Luc Marc Callewaert, Wouter Vervecken, Karen Jacqueline Marcel De Pourcq, Steven Christian Jozef Geysens, Mouna Guerfal
  • Glycosylation of Molecules
    Publication number: 20130190253
    Abstract: Described herein are methods and genetically engineered cells useful for producing an altered N-glycosylation form of a target molecule. Also described are methods and molecules with altered N-glycosylation useful for treating a variety of disorders such as metabolic disorders.
    Type: Application
    Filed: September 14, 2012
    Publication date: July 25, 2013
    Applicants: OXYRANE UK LIMITED, UNIVERSITEIT GENT, VIB VZW
    Inventors: Nico Luc Marc Callewaert, Wouter Vervecken, Karen Jacqueline Marcel De Pourcq, Steven Christian Jozef Geysens, Mouna Guerfal
  • HYDROLYSIS OF MANNOSE-1-PHOSPHO-6-MANNOSE LINKAGE TO PHOSPHO-6-MANNOSE
    Publication number: 20130158239
    Abstract: Described herein are methods and genetically engineered cells useful for uncapping a mannose-6-phosphate residue on an oligosaccharide.
    Type: Application
    Filed: September 29, 2010
    Publication date: June 20, 2013
    Applicants: UNIVERSITEIT GENT, VRIJE UNIVERSITEIT BRUSSEL, OXYRANE UK LIMITED, VIB VZW
    Inventors: Nico Luc Marc Callewaert, Wouter Vervecken, Petra Sophie Tiels, Han Karel Remaut, Kathleen Camilla Telesphore Alida Maria Piens