Patents Assigned to Pacesetter, Inc.
  • Publication number: 20230293083
    Abstract: Described herein are methods, devices, and systems that improve arrhythmia episode detection specificity, such as, but not limited to, atrial fibrillation (AF) episode detection specificity. Such a method can include obtaining an ordered list of R-R intervals within a window leading up to a detection of a potential arrhythmia episode, determining a measure of a dominant repeated R-R interval pattern within the window, and comparing the measure of the dominant repeated R-R interval pattern to a pattern threshold. If the measure of the dominant repeated R-R interval pattern is below the pattern threshold, that is indicative of a regularly irregular pattern being present, and there is a determination that the detection of the potential arrhythmia episode does not correspond to an actual arrhythmia episode. Such embodiments can beneficially be used to significantly reduce the number of false positive arrhythmia detections.
    Type: Application
    Filed: March 28, 2023
    Publication date: September 21, 2023
    Applicant: Pacesetter, Inc.
    Inventors: Nima Badie, Fujian Qu, Jong Gill
  • Publication number: 20230293085
    Abstract: Described herein are apparatuses and methods to detect tachycardias and selectively reject false tachycardia detections due to T-wave oversensing or noise. An apparatus includes electrodes, a sensing circuit coupled to at least two of the electrodes and configured to sense a signal indicative of cardiac electrical activity, and a smoothing filter configured to filter to the sensed signal indicative of cardiac electrical activity to thereby produce a filtered signal indicative of cardiac electrical activity. The apparatus produces a difference signal indicative of cardiac electrical activity by determining a difference between the sensed and filtered signals indicative of cardiac electrical activity. The apparatus also includes at least one processor configured to detect a tachycardia, or to determine whether or not to reject a tachycardia detection, based on the difference signal. The smoothing filter and/or difference circuitry can be implemented by the at least one processor, and/or other circuitry.
    Type: Application
    Filed: February 3, 2023
    Publication date: September 21, 2023
    Applicant: Pacesetter, Inc.
    Inventor: Fujian Qu
  • Publication number: 20230285757
    Abstract: A leadless biostimulator has a housing including an electronics compartment, an electronics assembly mounted in the electronics compartment, a proximal electrode that disposed on and/or integrated into the housing, and an electrical feedthrough assembly. The electrical feedthrough assembly includes a distal electrode and a flange. The flange is mounted on the housing. The distal electrode is electrically isolated from the flange by an insulator and configured to be placed in contact with target tissue to which a pacing impulse is to be transmitted by the leadless biostimulator. A mount is mounted on the flange and thereby mounted on the electrical feedthrough assembly. A fixation element is mounted on the mount and configured to facilitate fixation of the leadless biostimulator to tissue of a patient.
    Type: Application
    Filed: May 17, 2023
    Publication date: September 14, 2023
    Applicant: Pacesetter, Inc.
    Inventors: Paul Paspa, Thomas B. Eby, Matthew G. Fishler, Carl Lance Boling, Thomas Robert Luhrs, Russell Klehn, Tyler J. Strang, Arees Garabed, Kavous Sahabi, Brett Villavicencio, Wes Alleman, Alex Soriano, Matthew R. Malone, Conor P. Foley
  • Publication number: 20230233868
    Abstract: Methods and systems for terminating a pacemaker mediated tachycardia (PMT) are described herein. During a period that a PMT is not detected, an implantable system delivers an atrial pacing pulse to an atrial cardiac chamber in response to a PA interval expiring without an intrinsic atrial event being detected during the PA interval. The systems performs atrial sensing to thereby monitor for intrinsic atrial events in the atrial cardiac chamber, performs ventricular sensing to thereby monitor for intrinsic ventricular events in a ventricular cardiac chamber, and detects the PMT. Additionally, the system, in response to the PMT being detected, initiates a PMT PA interval that is shorter than the PA interval that the system would otherwise use for atrial pacing if the PMT was not detected.
    Type: Application
    Filed: April 4, 2023
    Publication date: July 27, 2023
    Applicant: Pacesetter, Inc.
    Inventors: Chunlan Jiang, Matthew G. Fishler
  • Publication number: 20230233867
    Abstract: Embodiments described herein relate to implantable medical devices (IMDs) and methods for use therewith. Such a method includes using an accelerometer of an IMD (e.g., a leadless pacemaker) to produce one or more accelerometer outputs indicative of the orientation of the IMD. The method can also include the IMD using an accelerometer to identify when the orientation of the IMD is such that the IMD will likely be able to successfully communicate with another IMD via one or more communication pulses sent from the IMD to the other IMD. The method also includes the IMD sending of the one or more communication pulses, that are used to communicate with the other IMD, when the orientation of the IMD is such that the IMD will likely be able to successfully communicate with the other IMD via one or more communication pulses sent from the IMD to the other IMD.
    Type: Application
    Filed: March 22, 2023
    Publication date: July 27, 2023
    Applicant: Pacesetter, Inc.
    Inventors: Xiaoyi Min, David Ligon, Weiqun Yang, Shawn Chen, Matthew G. Fishler
  • Patent number: 11684789
    Abstract: A biostimulator, such as a leadless pacemaker, including a header assembly having an electrical feedthrough assembly incorporating a helix mount, is described. The header assembly includes a fixation element mounted on the helix mount. The helix mount is mounted on a flange of the electrical feedthrough assembly, and thus, the fixation element can attach the leadless biostimulator to a target tissue. An electrode of the electrical feedthrough assembly is mounted within the flange to deliver a pacing impulse to the target tissue. A ceramic portion of the helix mount is disposed between the flange and the electrode to block an electrical path between the electrode and the flange. Accordingly, the helix mount both retains the fixation element on the leadless biostimulator and electrically isolates the flange and electrode components of the electrical feedthrough. Other embodiments are also described and claimed.
    Type: Grant
    Filed: January 26, 2021
    Date of Patent: June 27, 2023
    Assignee: PACESETTER, INC.
    Inventors: Bei Ning Zhang, Brett C. Villavicencio, Perry Li
  • Patent number: 11684350
    Abstract: A lead delivery catheter having a slittable pull ring is described. The lead delivery catheter includes a deflection wire attached to the slittable pull ring to deflect the catheter. The slittable pull ring has several ring holes arranged in a pattern. The pull ring is located distal to a tubular braid of the lead delivery catheter, and a size and pattern of the ring holes can be similar to a size and pattern of holes in the tubular braid. The structural similarity between the pull ring and the tubular braid facilitates use of a consistent cutting force to slit through the tubular braid and the pull ring of the lead delivery catheter. Other embodiments are also described and claimed.
    Type: Grant
    Filed: May 20, 2019
    Date of Patent: June 27, 2023
    Assignee: PACESETTER, INC.
    Inventors: Adam Weber, Jennifer Heisei
  • Patent number: 11672992
    Abstract: A valve for use in manufacturing of implantable medical devices is insertable into a bore of the medical device during a manufacturing process. The valve is configured to remain closed while the pressure differential between an internal volume of the implantable medical device and a surrounding environment is below a particular threshold and to open when the threshold is reached, thereby allowing air or other fluids to escape from the internal volume into the surrounding environment. The valves are particularly useful during certain types of coating processes that must be performed at or near vacuum and provide an effective way to prevent ingress of coating material into the internal volume of the implantable medical device.
    Type: Grant
    Filed: May 29, 2019
    Date of Patent: June 13, 2023
    Assignee: PACESETTER, INC.
    Inventors: Gabriella Dweck, Adrian Baima
  • Patent number: 11672949
    Abstract: A delivery system for an intracorporeal device includes a sheath defining one or more lumens shaped to receive a delivery catheter or shaft and a guidewire. The system may include a delivery shaft having a distal coupling feature adapted to releasably couple with a proximal coupling feature of the intracorporeal device. The delivery system may further include a hub through which the delivery shaft and guidewire are passed. The delivery shaft may be coupled to a feature, such as a knob, that enables manipulation of the delivery shaft to decouple the distal fixation feature from the proximal fixation feature of the intracorporeal device in order to deploy the intracorporeal device within a patient.
    Type: Grant
    Filed: December 14, 2020
    Date of Patent: June 13, 2023
    Assignee: Pacesetter, Inc.
    Inventors: Tracee Eidenschink, Jin Woo Park, Jason A. White
  • Publication number: 20230173284
    Abstract: Implantable medical devices (IMDs), systems, and methods for use therewith are disclosed. One such method is for use by a leadless pacemaker (LP) configured to perform conductive communication with another implantable medical device (IMD). The method includes the LP storing information that specifies when, within a cardiac cycle, the LP and the other IMD implanted in a patient are likely oriented relative to one another such that conductive communication therebetween should be successful. The method also includes the LP sensing a signal indicative of cardiac activity of the patient over a plurality of cardiac cycles, and outputting one or more conductive communication pulses, during a portion of at least one of the cardiac cycles, wherein the portion of the at least one of the cardiac cycles is identified based on the signal that is sensed and the information that is stored.
    Type: Application
    Filed: January 31, 2023
    Publication date: June 8, 2023
    Applicant: Pacesetter, Inc.
    Inventors: Xiaoyi Min, David Ligon, Weiqun Yang, Shawn Chen, Matthew G. Fishler
  • Patent number: 11666765
    Abstract: A biostimulator, such as a leadless pacemaker, has electrode(s) coated with low-polarization coating(s). A low-polarization coating including titanium nitride can be disposed on an anode, and a low-polarization coating including a first layer of titanium nitride and a second layer of platinum black can be disposed on a cathode. The anode can be an attachment feature used to transmit torque to the biostimulator. The cathode can be a fixation element used to affix the biostimulator to a target tissue. The low-polarization coating(s) impart low-polarization to the electrode(s) to enable an atrial evoked response to be detected and used to effect automatic output regulation of the biostimulator. Other embodiments are also described and claimed.
    Type: Grant
    Filed: March 11, 2021
    Date of Patent: June 6, 2023
    Assignee: PACESETTER, INC.
    Inventors: Gene A. Bornzin, Wesley Alleman, Tyler J. Strang, Keith Victorine, Nicole Cooper
  • Patent number: 11670843
    Abstract: Methods for manufacturing implantable electronic devices include forming an antenna of the implantable electronic device by delivering an antenna trace within a dielectric antenna body. The antenna trace includes a first trace portion disposed in a first transverse layer and defining a first trace path and a second trace portion disposed in a second transverse layer longitudinally offset from the first transverse layer and defining a second trace path. If projected to be coplanar, the first trace path defines a trace boundary and the second trace path is within the trace boundary.
    Type: Grant
    Filed: October 27, 2021
    Date of Patent: June 6, 2023
    Assignee: Pacesetter, Inc.
    Inventors: Armando M. Cappa, Jorge N. Amely-Velez, Alan B. Vogel, Wisit Lim, John R. Gonzalez, Alexander Robertson, Alex Soriano, Evan Sheldon, Perry Li, Jeffery Crook
  • Publication number: 20230171130
    Abstract: Described herein is a fully-differential receiver for use with an implantable medical device (IMD) and configured to receive conducted communication signals that are transmitted by another IMD or an external device. The fully-differential receiver includes a fully-differential preamplifier, a fully-differential buffer, a first comparator, a second comparator, and an AC coupling network coupled between differential outputs of the fully-differential buffer and a coupled together differential pair of inputs of the first and second comparators. A differential pair of inputs of the fully-differential receiver comprise the differential pair of inputs of the fully-differential preamplifier, and a differential pair of outputs of the fully-differential receiver comprise a first output of the first comparator and a second output of the second comparator. In order to conserve power, the fully-differential receiver is selectively changed from operating in a first mode to operating in a second mode, and vice versa.
    Type: Application
    Filed: November 30, 2021
    Publication date: June 1, 2023
    Applicant: Pacesetter, Inc.
    Inventors: Eric C. Labbe, Benjamin T. Persson
  • Publication number: 20230170863
    Abstract: Described herein is a fully-differential preamplifier comprising an input differential pair, an output current load, and a current source. The current source is coupled between the input differential pair and a low voltage rail and configured to control whether the fully-differential preamplifier is operating in a first mode or a second mode, wherein the preamplifier draws more current when operating in the second mode compared to when operating in the first mode. The input differential pair is coupled between the output current load and the current source. The output current load is coupled between a high voltage rail and the input differential pair. The input differential pair comprise positive and negative inputs of the fully-differential preamplifier. Nodes where the input differential pair and the output current load are coupled to one another comprise positive and negative outputs of the fully-differential preamplifier.
    Type: Application
    Filed: November 30, 2021
    Publication date: June 1, 2023
    Applicant: Pacesetter, Inc.
    Inventors: Eric C. Labbe, Benjamin T. Persson
  • Patent number: 11660452
    Abstract: In one embodiment, the present disclosure is directed to a method for providing a neural stimulation therapy to treat chronic pain of a patient. The method comprises: recording, using a neural sensing system, neural activity of the patient at one or more sites within the nervous system of the patient related to the chronic pain of the patient, modifying a computational neural modeling system to model the sensed neural activity of the patient; computing a respective neural response of the patient for each of a plurality of different temporal stimulation patterns using the modified computational neural modeling system; selecting, based on the respective neural responses, one of the plurality of temporal stimulation patterns; and programming an implantable stimulation system to provide the selected one of the plurality of temporal stimulation patterns to the patient to treat the chronic pain of the patient.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: May 30, 2023
    Assignee: Pacesetter, Inc.
    Inventors: Alexander Kent, Jeffery M. Kramer
  • Patent number: 11654288
    Abstract: A system and method are provided for managing atrial-ventricular (AV) delay adjustments. An AV interval is measured that corresponds to an interval between an atrial paced (Ap) event or an atrial sensed (As) event and a sensed ventricular (Vs) event. A candidate AV delay is set based on the AV interval and a bundle branch adjustment (BBA) value. A QRS characteristic of interest (COI) is measured while utilizing the candidate AV delay in connection with delivering a pacing therapy. The BBA value is adjusted and the candidate AV delay is reset based on the BBA value as adjusted. A collection of QRS COIs and corresponding candidate AV delays are obtained and one of the candidate AV delays is selected as a BBA AV delay. The pacing therapy is managed, based on the BBA AV delay.
    Type: Grant
    Filed: August 10, 2020
    Date of Patent: May 23, 2023
    Assignee: Pacesetter, Inc.
    Inventors: Wenwen Li, Nima Badie, Luke C. McSpadden, Yun Qiao, Avi Fischer, Kyungmoo Ryu
  • Patent number: 11648408
    Abstract: A method of manufacturing a filtered feedthrough assembly for use with an implantable medical device. The method may include gold brazing an insulator to a flange at first braze joint, and gold brazing a plurality of feedthrough wire to the insulator at second braze joints. The method may further include applying a first non-conductive epoxy to the first braze joint, and applying a second non-conductive epoxy to the second braze joint. The method may further include grit blasting a face of the flange, applying a conductive epoxy to the face of the flange, and attaching an EMI filter to the conductive epoxy such that it is grounded to the flange via the conductive epoxy and not via the first braze joint or the second braze joints.
    Type: Grant
    Filed: November 6, 2019
    Date of Patent: May 16, 2023
    Assignee: Pacesetter, Inc.
    Inventor: Haytham M. Hussein
  • Patent number: 11647940
    Abstract: Described herein are methods, devices, and systems that improve arrhythmia episode detection specificity, such as, but not limited to, atrial fibrillation (AF) episode detection specificity. Such a method can include obtaining an ordered list of R-R intervals within a window leading up to a detection of a potential arrhythmia episode, determining a measure of a dominant repeated R-R interval pattern within the window, and comparing the measure of the dominant repeated R-R interval pattern to a pattern threshold. If the measure of the dominant repeated R-R interval pattern is below the pattern threshold, that is indicative of a regularly irregular pattern being present, and there is a determination that the detection of the potential arrhythmia episode does not correspond to an actual arrhythmia episode. Such embodiments can beneficially be used to significantly reduce the number of false positive arrhythmia detections.
    Type: Grant
    Filed: April 9, 2021
    Date of Patent: May 16, 2023
    Assignee: Pacesetter, Inc
    Inventors: Nima Badie, Fujian Qu, Jong Gill
  • Patent number: 11648404
    Abstract: A system and method for designating between types of activation by a pulse generator configured to deliver a left ventricular (LV) pacing pulse at an LV pacing site as part of a cardiac resynchronization therapy (CRT) are provided. The system includes a sensing channel configured to collect cardiac activity (CA) signals along at least one sensing vector extending through a septal wall between the LV and right ventricle (RV). The CA signals are indicative of one or more beats and include a pre-LV pacing segment indicative of cardiac activity preceding the LV pacing pulse and a post-LV pacing segment indicative of cardiac activity following the LV pacing pulse. The system includes memory to store program instructions. One or more processors are configured to implement the program instructions to analyze the pre-LV pacing segment to identify a first myocardium activation (MA) characteristic of interest (COI).
    Type: Grant
    Filed: October 7, 2020
    Date of Patent: May 16, 2023
    Assignee: Pacesetter, Inc.
    Inventors: Jan O. Mangual-Soto, Nima Badie, Luke C. McSpadden
  • Patent number: 11648407
    Abstract: An implantable system including an atrial leadless pacemaker (aLP) and a ventricular leadless pacemaker (vLP), and methods for use therewith, are configured or used to terminate a pacemaker mediated tachycardia (PMT). In an embodiment, in response to the aLP detecting a PMT, the aLP initiates a PMT PA interval, and the aLP does not inform the vLP, via an i2i communication, of an atrial sensed event that caused the PMT to be detected, thereby preventing the vLP from initiating a PV interval during the PMT PA interval. The aLP selectively terminates the PMT PA interval. Additionally, the aLP informs the vLP, via an i2i communication, of an intrinsic atrial event being detected during the PMT PA interval, or of an atrial paced event being performed in response to the PMT PA interval expiring without an intrinsic atrial event being detected during the PMT PA interval.
    Type: Grant
    Filed: March 23, 2021
    Date of Patent: May 16, 2023
    Assignee: Pacesetter, Inc.
    Inventors: Chunlan Jiang, Matthew G. Fishler