Abstract: cis-2,6-Dimethyl-.alpha.,.alpha.-diphenyl-1-piperidinebutanol; and acid-addition salts. The compounds are pharmacological agents, especially antiarrythmic agents. The compounds can be produced by reacting phenyl lithium or phenylmagnesium halide with cis-.gamma.-(2,6-dimethylpiperidino)butyrophenone or a lower alkyl ester of cis-2,6-dimethyl-1-piperidinebutyric acid; by reacting .alpha.-(3-halopropyl)-.alpha.-phenylbenzyl alcohol with cis-2,6-dimethylpiperidine, or by reacting cis-1- (3-lithiopropyl)-2,6-dimethylpiperidine with benzophenone.

Abstract: New tetrapeptides having the formula A-Pro-Pro-Tyr(benzyl)-Ser(benzyl)-R.sub.1 wherein A is t-butoxycarbonyl, cyclohexylcarbonyl, benzyloxycarbonyl and p-nitrobenzyloxycarbonyl; Pro is D-Pro or L-Pro; Tyr(benzyl) is D-Tyr(benzyl) or L-Tyr(benzyl); Ser(benzyl) is D-Ser(benzyl) or L-Ser(benzyl) and R.sub.1 is lower alkoxy, hydrazino, amino, lower alkylamino or di(lower alkyl)amino.

Abstract: New tetrapeptides having the formula A-R.sub.1 -Ser(benzyl)-Tyr(benzyl)-R.sub.2 -R.sub.3 wherein A is t-butoxycarbonyl, cyclohexylcarbonyl, benzyloxycarbonyl and p-nitrobenzyloxycarbonyl; R.sub.1 is L-Trp, L-Thr(benzyl), L-Met or Gly; Ser(benzyl) is D-Ser(benzyl) or L-Ser(benzyl); Tyr(benzyl) is D-Tyr(benzyl) or L-Tyr(benzyl); R.sub.2 is D-Ala, .beta.-Ala, D-Leu or D-Val; and R.sub.3 is lower alkoxy, hydrazino, amino, lower alkylamino or di(lower alkyl)amino.

Abstract: New tetrapeptides having the formula A-R.sub.1 -R.sub.2 -Ser(benzyl)-Tyr(benzyl)-R.sub.3 wherein A is t-butoxycarbonyl, cyclohexylcarbonyl, benzyloxycarbonyl and p-nitrobenzyloxycarbonyl; R.sub.1 is L-Trp or L-His(benzyl); R.sub.2 is L-Trp or L-His(benzyl); Ser(benzyl) is D-Ser(benzyl) or L-Ser(benzyl); Tyr(benzyl) is D-Tyr(benzyl) or L-Tyr(benzyl); and R.sub.3 is lower alkoxy, hydrazino, amino, lower alkylamino or di(lower alkyl)amino.

Abstract: New tetrapeptides having the formula A-Ser(benzyl)-Try(benzyl)-D-Ala-Leu-R.sub.1 wherein A is t-butoxycarbonyl, cyclohexylcarbonyl, benzyloxycarbonyl and p-nitrobenzyloxycarbonyl; Ser(benzyl) is D-Ser(benzyl) or L-Ser(benzyl); Tyr(benzyl) is D-Tyr(benzyl) or L-Tyr(benzyl); Leu is D-Leu or L-Leu, and R.sub.1 is lower alkoxy, hydrazino, amino, lower alkylamino or di(lower alkyl)amino.

Abstract: 2H(1)Benzothiopyrano[4,3,2-cd]indazole N-oxides, 2H(1)benzopyrano[4,3,2-cd]indazole N-oxides and acid addition salts thereof are disclosed. These compounds can be produced by oxidation of the corresponding amines with oxidizing agents capable of forming an N-oxide derivative. The compounds are parasiticidal agents useful in the treatment of schistosome infections.

Abstract: New tripeptides having the formula A-R.sub.1 -Tyr(benzyl)-Ser(benzyl)-R.sub.2 wherein A is t-butoxycarbonyl or cyclohexylcarbonyl, R.sub.1 is Trp, His(benzyl), Cys(benzyl) or Pro and R.sub.2 is lower alkoxy, hydrazino, amino, lower alkylamino, di(lower alkyl)amino, benzylamino, allylamino, (diethoxyphosphinyl)methylamino, 2-(diethoxyphosphinyl)ethylamino or 2-[[(phenylmethyl)amino]sulfonyl]ethylamino, methods for their production, and the use of said tripeptides as luteinizing hormone releasing factor antagonists.

Abstract: New tripeptides having the formula A-R.sub.1 -Ser(benzyl)-Tyr (benzyl)-R.sub.2 wherein A is t-butoxycarbonyl or cyclohexyl carbonyl, R.sub.1 is Trp, His(benzyl), Cys(benzyl) or Pro and R.sub.2 is lower alkoxy, hydrazino, amino, lower alkylamino, di(lower alkyl)amino, benzylamino, allylamino, (diethoxyphosphinyl)methylamino, 2-(diethoxyphosphinyl)ethylamino or 2-[[(phenylmethyl)amino]sulfonyl]ethylamino, methods for their production, and the use of said tripeptides as luteinizing hormone releasing factor antagonists.

Abstract: New tripeptides having the formula A-R.sub.1 -Tyr(benzyl)-Thr(benzyl)-R.sub.2 wherein A is t-butoxycarbonyl or cyclohexylcarbonyl, R.sub.1 is Trp, His(benzyl), Cys(benzyl) or Pro and R.sub.2 is lower alkoxy, hydrazino, amino, lower alkylamino, di(lower alkyl)amino, benzylamino, allylamino, (diethoxyphosphinyl)methylamino, 2-(diethoxyphosphinyl)ethylamino or 2-[[(phenylmethyl)amino]sulfonyl]ethylamino, methods for their production, and the use of said tripeptides as luteinizing hormone releasing factor antagonists.

Abstract: A medicament-dispensing package for use with a parenteral solution container, including an open-ended transfer tube having a spike at one end and a bi-functional dispensing or loading configuration at the other end, a closure for a medicament container having a transfer chamber rotatably engageable with the loading end of the transfer tube and having means in the form of first and second access openings in the closure and transfer tube, respectively, which can be aligned by rotation for transfer of liquid and/or solid to and from the medicament container by way of the transfer tube.

Abstract: A work fixture is provided for testing leak-proof wearing apparel such as rubber gloves. The fixture comprises a leak-proof pneumatic clamp for mounting each article of apparel. The fixture also comprises means for folding the article while removing it from the fixture.

Abstract: A process is provided for freeze-drying an aqueous liquid product which comprises distributing the liquid product in containers closely fitted in cavities of a tray-shaped heat-conducting solid metal block having relatively high heat transfer, subjecting the block to accelerated cooling such that the liquid in each container is frozen thereby freezing the liquid in each container at substantially the same rate, and drying the frozen product under vacuum while in the block so that the frozen product in each container is dried at substantially the same rate.

Abstract: Actuator apparatus comprising a metal body or magnet adapted to be carried in a fixed cyclical path on a pivot arm which in turn is adapted to be actuated over a wide frequency range by a second resiliently mounted pivot arm in tandem, and further comprising a field-sensitive element (such as a reluctance effect element, Hall effect device, proximity switch, reed switch or the like) in proximity to the path of the body for path-responsive high fidelity control of an operation such as switching, the field-sensitive element being sensitive to discrete change in magnetic force caused by the cyclical movement for production of an electronic control signal or pulse in phase with each cycle.

Abstract: A work fixture is provided for testing leak-proof wearing apparel such as rubber gloves. The fixture comprises a leak-proof pneumatic clamp for mounting each article of apparel. The fixture also comprises means for folding the article while removing it from the fixture.

Abstract: O-2,6-diamino-2,4,6-trideoxy-.alpha.-D-xylo-hexopyranosyl-(1.fwdarw.4)-O-[5 -amino-5-deoxy-.beta.-D-xylofuranosyl-(1.fwdarw.5)]-N.sup.1 -[(S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxystreptamine, also named 5"-amino-4',5"-dideoxybutirosin A and acid addition salts of said compounds. These compounds exhibit a wide spectrum of antibacterial activity.The above compounds can be produced from O-2,6-dideoxy-2,6-bis(Z-amino)-.alpha.-D-glucopyranosyl-(1.fwdarw.4)-O-[2, 3-di-O-acetyl-5-deoxy-5-(Z-amino)-.beta.-D-xylofuranosyl-(1.fwdarw.5)]-6-O- acetyl-N.sup.1 -[(S)-2-acetyloxy-1-oxo-4-(Z-amino)butyl]-2-deoxy-N.sup.3 -streptamine, also named protected 5"-aminodeoxybutirosin A by treating said compound with trifluoromethanesulfonic anhydride and pyridine to yield a mixture containing the 4'-O-(trifluoromethanesulfonyl) compound. The mixture is reacted with the sodium salt of an arylmercaptan and the resulting 4'-arylthio compound is purified and treated with ammonia, thus deprotecting the four hydroxy groups.

Abstract: O-2,6-diamino-2,3,6-trideoxy-.alpha.-D-ribo-hexo-pyranosyl-(1.fwdarw.4)-O-[ 5-amino-5-deoxy-.beta.-D-xylofuranosyl-(1.fwdarw.5)]-N.sup.1 -[(S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxystreptamine), also named 5"-amino-3',5"-dideoxybutirosin A and acid addition salts of said compounds. These compounds exhibit a wide spectrum of antibacterial activity.The above compounds can be produced from O-2,6-dideoxy-2,6-bis(Z-amino)-.alpha.-D-glucopyranosyl-(1.fwdarw.4)-O-[2, 3-di-O-acetyl-5-deoxy-5-(Z-amino)-.beta.-D-xylofuranosyl-(1.fwdarw. 5)]-6-O-acetyl-N.sup.1 -[(S)-2-acetyloxy-1-oxo-4-(Z-amino)butyl]-2-deoxy-N.sup. 3 -streptamine, also named protected 5"-amino-deoxybutirosin A by treating said compound with trifluoromethanesulfonic anhydride and pyridine to yield the 3'-O-(trifluoromethanesulfonyl) compound. The product is reacted with the sodium salt of an arylmercaptan and the resulting 3'-arylthio compound is purified and treated with ammonia, thus deprotecting the four hydroxy groups.

Abstract: A disposable incontinent pad such as an adult diaper or the like is provided comprising a fluid absorbent matrix with facing and backing sides, a facing sheet, and a water-impervious backing sheet in layered relation having the matrix infolded at its lateral edges onto the facing side in a C-fold configuration with the backing sheet overlapping the fold lines onto the facing sheet such that the pad when worn in a holder garment in fluid-absorbing relation with the body is resistant to lateral run-off of body fluid.

Abstract: 2H(1)Benzothiopyrano[4,3,2-cd]indazole N-oxides, 2H(1)benzopyrano[4,3,2-cd]indazole N-oxides and acid addition salts thereof are disclosed. These compounds can be produced by oxidation of the corresponding amines with oxidizing agents capable of forming an N-oxide derivative. The compounds are parasiticidal agents useful in the treatment of schistosome infections.

Abstract: O-2,6-Diamino-2,3,4,6-tetradeoxy-.alpha.-D-erythro-hexopyranosyl-(1.fwdarw. 4)-O-[5-amino-5-deoxy-.beta.-D-xylofuranosyl-(1.fwdarw.5)]-N.sup.1 -[(S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxystreptamine, also known as aminotrideoxybutirosin A, and acid-addition salts. They have a wide spectrum of antibacterial activity.The above compounds can be produced from aminodeoxybutirosin A by the sequence of reactions which comprises protecting the five primary amino groups by converting them to arylmethoxycarbonyl derivatives, converting the 3',4'-hydroxyl groups to an acetal, acylating the remaining four hydroxyl groups, and hydrolyzing the acetal to produce a key intermediate which is an O-2,6-dideoxy-2,6-bis[[(arylmethoxy)carbonyl]amino]-.alpha.-D-glucopyranos yl-(1.fwdarw.4)-O-[2,3-di-O-acyl-5-deoxy-5-[[(arylmethoxy)carbonyl]amino]-. beta.-D-xylofuranosyl-(1.fwdarw.5)]-6-O-acyl-N.sup.1 -[(S)-2-acyloxy-1-oxo-4-[[(arylmethoxy)carbonyl]amino]-butyl]-2-deoxy-N.su p.

Abstract: Novel organic amide compounds which are N-[6-[(substituted amino)phenyl]-1,2-dihydro-2-oxonicotinyl]penicillin and cephalosporin type compounds having broad spectrum antibacterial utility are provided by (a) reacting the free amino acid of the appropriate penicillin or cephalosporin or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding N-6-[(substituted amino)phenyl]-1,2-dihydro-2-oxonicotinic acid or (b) reacting the free amino acid 6-amino-penicillanic acid, 7-aminocephalosporanic acid, 7-amino-3-methylceph-3-em-4-carboxylic acid or a related compound or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding D-N-[6-[(substituted amino)phenyl]-1,2-dihydro-2-oxonicotinyl]-2-substituted glycine. Pharmaceutical compositions containing said compounds and methods for treating infections using said compositions are also disclosed.