Abstract: The present invention relates to an universal method for the large scale production of high-purity carrier free or non carrier added radioisotopes by applying a number of “unit operations” which are derived from physics and material science and hitherto not used for isotope production. A required number of said unit operations is combined, selected and optimized individually for each radioisotope production scheme. The use of said unit operations allows a batch wise operation or a fully automated continuous production scheme. The radioisotopes produced by the inventive method are especially suitable for producing radioisotope-labelled bioconjugates as well as particles, in particular nanoparticles and microparticles.

Abstract: A single photon counting detector system has a layer of photosensitive material and an N×M array of photo-detector diodes. Each photo-detector diode has a bias potential interface and a diode output interface. The bias potential interface is connected to bias potential. An N×M array of high gain, low noise readout unit cells is provided, one readout unit cell for each photo-detector diode. Each readout unit cell has an input interface connected to the diode output interface, a high-gain voltage amplifier with an integration capacitor at least two parallel lines of digital counters, each having a comparator with an individually selectable threshold and a gateable section to determine the counting intervals of the digital counters. A multiplexer allows access to the readout cell unit either on a per pixel basis or for several pixels in parallel to read out the digital counter to a data processor transferring the data off chip.

Abstract: An image fusion method combines absorption, differential phase contrast and dark-field (scattering) signals obtained with X-ray phase contrast sensitive techniques, such as an arrangement of gratings. The process fuses the absorption and dark-field signals by principal component analysis. Further the differential phase contrast is merged into the PCA fused image to obtain an edge enhancement effect. Due to its general applicability and its simplicity in usage, the proposed process is usable as a standard method for image fusion scheme using phase contrast imaging, in particular on medical scanners (for instance mammography), inspection at industrial production lines, non-destructive testing, and homeland security.

Abstract: A system and a method improve a quality of beam delivery in proton therapy by pencil beam scanning of a predeterminable volume within a patient that minimizes beam position errors. The system has a proton source generating a proton beam, a number of proton beam bending/focusing units, a beam nozzle having an outlet for the proton beam to penetrate the predetermined volume, a beam bending magnet, and a couple of sweeper magnets to sweep the proton beam in both lateral directions. A position-sensitive detector is aligned with the nozzle to control the position of the proton beam and control logic controls the position and the energy of the proton beam and has a beam steering data set. A correction logic is aligned with the control logic for correcting beam position errors by comparing an expected beam position with the actual beam position detected and generates beam position correction data.

Abstract: An X-ray detector contains a layer of photosensitive material and an N×M array of photo-detector diodes disposed in the photosensitive material. Each of the diodes has a bias potential interface and a diode output interface. The bias potential interface is connected to a bias potential. The X-ray detector further has an N×M array of high gain, low noise readout unit cells, one readout unit cell for each diode. Each cell contains an input interface connected to the diode output interface, a high-gain voltage amplifying device having an integration capacitor, a first switch in parallel to the integration capacitor and a sample/hold capacitor disposed between a second switch and third switch. The sample/hold capacitor is connectable to the voltage amplifying device via the second switch and is connectable to a signal output line. A multiplexer contains a row select and a column select circuit allowing access to each readout cell unit.

Abstract: An X-ray arrangement is suitable to record absorption, phase contrast, and dark field images of an object. The visibility of low absorbing specimens is improved and required radiation dose is reduced. The assembly includes an X-ray source; two or more gratings; a position-sensitive detector with spatially modulated detection sensitivity; a recorder for recording the images; an evaluator for evaluating the intensities for each pixel to identify the characteristic of the object for each individual pixel as an absorption and/or a differential phase contrast and/or an x-ray scattering dominated pixel. Images are collected by rotating from 0 to n or 2n either the sample or the assembly. The gratings are produced with planar geometry. The X-rays pass through the gratings parallel to the substrate. The grating structures extend along the X-ray path which determines the phase shift.

Abstract: Phase sensitive X-ray imaging methods provide substantially increased contrast over conventional absorption based imaging, and therefore new and otherwise inaccessible information. The use of gratings as optical elements in hard X-ray phase imaging overcomes some of the problems impairing the wider use of phase contrast in X-ray radiography and tomography. To separate the phase information from other contributions detected with a grating interferometer, a phase-stepping approach has been considered, which implies the acquisition of multiple radiographic projections. Here, an innovative, highly sensitive X-ray tomographic phase contrast imaging approach is presented based on grating interferometry, which extracts the phase contrast signal without the need of phase stepping. Compared to the existing phase step approach, the main advantage of this new method dubbed “reverse projection” is the significantly reduced delivered dose, without degradation of the image quality.

Abstract: A novel approach based on the increase of the intrinsic oxidative stability of uncrosslinked membranes is addressed. The co-grafting of styrene with methacrylonitrile (MAN), which possesses a protected ?-position and strong dipolar pendant nitrile group, onto 25 ?m ETFE base film is disclosed. Styrene/MAN co-grafted membranes were compared to styrene based membrane in durability tests in single H2/O2 fuel cells. The incorporation of MAN improves the chemical stability dramatically. The membrane preparation based on the copolymerization of styrene and MAN shows encouraging results and offers the opportunity of tuning the MAN and crosslinker content to enhance the oxidative stability of the resulting fuel cell membranes.

Abstract: A tensile strain state in semiconductor components is adjusted. A pretensioned (tensile strain) layer is applied to a substrate (FIG. 1, (A)). Bridge structures (FIG. 1, (B)) are introduced in the layers by lithography and etching. The bridges are connected to the layer on both sides and are thus continuous. The geometric shape of the bridges, formed with a cross-section modulation, is determined by the windows (FIG. 1 (C)) in the layer. When the substrate is etched selectively, the bridge is undercut through the windows. The geometric structuring of the cross-section (FIG. 1, (D)) causes a redistribution of the originally homogeneous strain when the bridges are detached from the substrate, with the larger cross-sections relaxing at the expense of the smaller cross-sections, where the pretension is increased. Only a multiplication of stresses (or strain) originally present in the sample is possible, with the multiplication factor determined by lengths, widths and depths, and/or the relationships thereof.

Abstract: A single photon counting pixel detector chip has a negligible dead time and consequentially high frame rates. The detector chip contains: a) a layer of photosensitive material; b) an N×M array of photo-detector diodes arranged in the layer of photosensitive material; and c) a N×M array of readout unit cells. The readout unit cell contains an input interface connected to a diode output interface, a high-gain charge to voltage amplifying device and a pixel counter being connected to an output of the high-gain voltage amplifying device. The pixel counter is split into a first number of nibble counters. The basic counter cell contains a counting element, a switch, a temporary storage element and an output stage. Additionally, the detector chip has a side shift register to read out the nibble counters row-wise with a predetermined number of nibble row selections.

Abstract: A single photon counting detector system has a layer of photosensitive material and an N×M array of photo-detector diodes. Each photo-detector diode has a bias potential interface and a diode output interface. The bias potential interface is connected to bias potential. An N×M array of high gain, low noise readout unit cells is provided, one readout unit cell for each photo-detector diode. Each readout unit cell has an input interface connected to the diode output interface, a high-gain voltage amplifier with an integration capacitor at least two parallel lines of digital counters, each having a comparator with an individually selectable threshold and a gateable section to determine the counting intervals of the digital counters. A multiplexer allows access to the readout cell unit either on a per pixel basis or for several pixels in parallel to read out the digital counter to a data processor transferring the data off chip.

Abstract: An image fusion method combines absorption, differential phase contrast and dark-field (scattering) signals obtained with X-ray phase contrast sensitive techniques, such as an arrangement of gratings. The process fuses the absorption and dark-field signals by principal component analysis. Further the differential phase contrast is merged into the PCA fused image to obtain an edge enhancement effect. Due to its general applicability and its simplicity in usage, the proposed process is usable as a standard method for image fusion scheme using phase contrast imaging, in particular on medical scanners (for instance mammography), inspection at industrial production lines, non-destructive testing, and homeland security.

Abstract: An X-ray arrangement is suitable to record absorption, phase contrast, and dark field images of an object. The visibility of low absorbing specimens is improved and required radiation dose is reduced. The assembly includes an X-ray source; two or more gratings; a position-sensitive detector with spatially modulated detection sensitivity; a recorder for recording the images; an evaluator for evaluating the intensities for each pixel to identify the characteristic of the object for each individual pixel as an absorption and/or a differential phase contrast and/or an x-ray scattering dominated pixel. Images are collected by rotating from 0 to n or 2n either the sample or the assembly. The gratings are produced with planar geometry. The X-rays pass through the gratings parallel to the substrate. The grating structures extend along the X-ray path which determines the phase shift.

Abstract: An energy filter allows, particularly at lower beam energies, a determined spread of the beam energies in order to preserve the beam edges and to spread the Bragg peak at each individual beam energy. The energy filter behaves similarly to a ridge filter and spreads out the Bragg peak of a low energy proton beam (70-100 MeV) so that energy modulation of the beam can be done with steps of 5 mm in one go over the full range of 235-70 MeV. Due to its mechanical flexibility, the energy filter can be placed on the skin of the patient which minimizes the effect of scattering in the filter due to the short distance behind a layer of a plurality of metal particles within a flexible soft plastic sheet to the skin of the patient.

Abstract: A laser interferometer and a method for operating a laser interferometer perform a differential position measurement by laser interferometry of two elements while offering a rotational degree of freedom to one of the elements using a reflecting sphere as a mirror for the laser beam. The laser interferometer and method do not require the object to be aligned with the rotation axis, but instead can track the object in off-centered geometries. This is achieved by employing the pointing of the reflected beam from the sphere as a feedback signal to realign the interferometer which then has a constant beam pointing to the center of the sphere in all cases. The laser interferometer and method keep the direction of the measurement constant. The laser interferometer and method are suitable for homodyne and heterodyne types of laser interferometer technology.

Abstract: A self-contained system for the generation of electrical energy from biomass by gasification combines several process units in one self-contained system. The global properties are greater than the sum of the individual properties of the process units.

Abstract: To generate methane from biomass, a biomass pulp is produced from the biomass with a desired dry mass content being set, and the biomass pulp is placed under pressure. The biomass pulp is heated under pressure in order to liquefy the solid organic components of the biomass pulp. The pressurized and heated biomass pulp is heated further to at least the critical temperature of the biomass pulp. Solids precipitated under pressure and increased temperature are separated from the fluid phase. At least a part of the remaining fluid phase is gasified under pressure and increased temperature by means of a reactor to form a methane-rich gas.

Abstract: A method for evaluating radiation model data in particle beam radiation applications, in particular in proton beam therapy of a determined target volume of malignant tissue within a patient, includes the following steps: a) gaining diagnostic data for a determined target volume to be irradiated; b) calculating a particle range in the predetermined target volume based on the diagnostic data for the determined target volume; c) designing a radiation model with particle beam characteristics based on the calculated particle range and optionally on a calculated dose depth distribution; d) applying a single pencil beam shot to the determined target volume at an elevated beam energy as compared to the particle beam characteristics of the radiation model; e) measuring the beam range of the single pencil beam shot downstream of the determined target volume; and f) comparing the measured beam range to a reference beam range calculated on the basis of the radiation model.

Abstract: An energy filter allows, particularly at lower beam energies, a determined spread of the beam energies in order to preserve the beam edges and to spread the Bragg peak at each individual beam energy. The energy filter behaves similarly to a ridge filter and spreads out the Bragg peak of a low energy proton beam (70-100 MeV) so that energy modulation of the beam can be done with steps of 5 mm in one go over the full range of 235-70 MeV. Due to its mechanical flexibility, the energy filter can be placed on the skin of the patient which minimizes the effect of scattering in the filter due to the short distance behind a layer of a plurality of metal particles within a flexible soft plastic sheet to the skin of the patient.

Abstract: A method is provided for achieving specific magnetic states with a given vortex chirality in artificial kagome spin ice building block structures containing one or more hexagonal rings of ferromagnetic islands created with electron beam lithography, where a subgroup of the ferromagnetic islands have a smaller width and therefore higher switching field than the other normal (wider) islands and are placed at specific positions in each of the rings. The positioning of the islands determines the magnetic state of the building block structure during magnetization reversal, and determines the chirality of the magnetic vortices that occur in each ring.