Patents Assigned to Peking University
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Publication number: 20250143953Abstract: A physical method for regulating molecular transport within a brain extracellular space includes: applying an external pressure to brain tissue of an animal, wherein a rhythm of applying the external pressure is related to intrinsic rhythmicity of the animal. An apparatus for regulating molecular transport within a brain extracellular space includes: a detection mechanism (10), a pressurization mechanism (30), and a control mechanism (50). The detection mechanism (10) is capable of detecting intrinsic rhythmicity of an animal. The pressurization mechanism (30) is capable of applying an external pressure to brain tissue of the animal. The control mechanism (50) is capable of control the pressurization mechanism (10) based on a detection result of the detection mechanism (30), such that a rhythm of applying the external pressure by the pressurization mechanism (30) is related to the intrinsic rhythmicity of the animal.Type: ApplicationFiled: December 15, 2021Publication date: May 8, 2025Applicant: Peking University Third HospitalInventor: Hongbin Han
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Patent number: 12277486Abstract: The present disclosure discloses a defect location method and device based on coverage information, the method including: characterizing program structure information and test case coverage information of a target program in a graph to obtain a graph-characterized structure; generating a node attribute sequence and an adjacency matrix based on the graph-characterized structure; and inputting the node attribute sequence and the adjacency matrix to a trained graph neural network model, so that the graph neural network model outputs a suspicious degree list of the target program based on the node attribute sequence and the adjacency matrix. Through the graph-based unified information characterization, the coverage information can be saved without loss and compression, and the structure information may also be considered, thereby improving the accuracy of defect location.Type: GrantFiled: August 20, 2021Date of Patent: April 15, 2025Assignee: Peking UniversityInventors: Lu Zhang, Yiling Lou, Qihao Zhu, Jinhao Dong, Zeyu Sun, Dan Hao
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Patent number: 12260216Abstract: The present disclosure discloses a conflict detection method for Internet of Things (IoT) device scheduling, relating to the technical field of the IoT, and specific steps include: acquiring data of a device model; converting a device scheduling instruction into a conditional instruction according to the data of the device model; determining a scheduling conflict rule according to device scheduling conflicts in historical data; detecting whether the conditional instruction is in a conflict state based on the scheduling conflict rule; if the conditional instruction is in a conflict state, performing a first conflict resolution, or if the conditional instruction is in a non-conflict state or after a conflict is resolved, performing a second detection; converting, in the second detection, the conditional instruction into an SMT formula, inputting the SMT formula into an SMT solver for detection, and determining whether the conditional instruction is in a conflict state; and if the conditional instruction is in aType: GrantFiled: March 17, 2022Date of Patent: March 25, 2025Assignees: Peking University, East China Normal UniversityInventors: Zhi Jin, Xiaohong Chen, Han Bian
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Patent number: 12254592Abstract: A direct structured illumination microscopy (dSIM) reconstruction method is provided. First, a time domain modulation signal is extracted through a wavelet. Then, an incoherent signal is converted into a coherent signal. Next, an accumulation amount at each pixel is calculated. Finally, a super-resolution image is generated by using a correlation between signals at different spatial positions. An autocorrelation algorithm of dSIM is insensitive to an error of a reconstruction parameter. dSIM bypasses a complex frequency domain operation in structured illumination microscopy (SIM) image reconstruction, and prevents an artifact caused by the parameter error in the frequency domain operation. The dSIM algorithm has high adaptability and can be used in laboratory SIM, nonlinear SIM imaging systems, or commercial systems.Type: GrantFiled: August 20, 2020Date of Patent: March 18, 2025Assignee: Peking UniversityInventors: Peng Xi, Shan Jiang, Hui Qiao, Qionghai Dai
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Publication number: 20250082746Abstract: Provided are circular RNAs (circRNAs) encoding an antigenic polypeptide of a SARS-CoV-2 variant. Provided are circRNA vaccines against a SARS-CoV-2 variant, such as a Delta or Omicron variant. The circRNA vaccine comprises a circRNA comprising a nucleic acid sequence encoding an antigenic polypeptide comprising a Spike(S) protein or a fragment thereof of a SRAS-CoV-2 variant. Also provided are methods of treating or preventing a SARS-CoV-2 infection using the circRNAs or compositions thereof.Type: ApplicationFiled: January 9, 2023Publication date: March 13, 2025Applicant: Peking UniversityInventors: Wensheng WEI, Liang QU, Zongyi YI, Yong SHEN, Liangru LIN, Feng CHEN
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Publication number: 20250078881Abstract: The present disclosure provides a method and an apparatus for operating an in-memory computing architecture applied to a neural network and a device, the method includes: generating a mono-pulse input signal based on discrete time coding; inputting the mono-pulse input signal into a memory array of the in-memory computing architecture to generate a bit line current signal corresponding to the memory array; and controlling a neuron circuit of the in-memory computing architecture to output a mono-pulse output signal based on discrete time coding according to the bit line current signal, wherein the mono-pulse output signal is configured as a mono-pulse input signal of a memory array of the next layer of neural network in the next in-memory computing cycle.Type: ApplicationFiled: June 17, 2022Publication date: March 6, 2025Applicant: Peking UniversityInventors: Peng HUANG, Lixia HAN, Xiaoyan LIU, Jinfeng KANG
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Publication number: 20250081574Abstract: Embodiments of the present application provides a method for improving the short-circuit capability of an enhancement-mode (E-mode) GaN HEMT and its device structure. This is achieved by depositing metal in the active region between the gate and the source, adjacent to the source region of a conventional E-mode GaN HEMT, the metal is directly connected with the source of the conventional E-mode GaN HEMT. The conventional E-mode GaN HEMT is combined with a gate-source-shorted depletion-mode (D-mode) GaN HEMT to form a complete E-mode GaN HEMT with improved short-circuit capability. By clamping the saturation current of the complete device through the D-mode GaN HEMT, the saturation current density of the E-mode GaN HEMT can be reduced, and the purpose of improving the short-circuit capability is finally realized.Type: ApplicationFiled: August 30, 2024Publication date: March 6, 2025Applicant: Peking UniversityInventors: Jin WEI, Jingjing YU
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Publication number: 20250057450Abstract: An intelligent deformable microneedle includes a supporting seat; a counter electrode provided above the supporting seat; an elastic object with a compressed state and a natural state, where a working electrode is provided on an outer surface of the elastic object, and a specific enzyme that can react with an analyte to be detected is provided on the working electrode; a soluble needle-shaped body fixed on the supporting seat, where the soluble needle-shaped body completely wraps the counter electrode and the elastic object from the outside, and the soluble needle-shaped body has an inner cavity structure that enables the elastic object to be in the compressed state. The microneedle is internally provided with the elastic object, after penetrating into skin, the soluble needle-shaped body is dissolved, the elastic object inside is exposed, length becomes longer, and the working electrode of an electrochemical sensor is attached to the elastic object.Type: ApplicationFiled: August 6, 2024Publication date: February 20, 2025Applicant: Peking UniversityInventor: Yue CUI
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Publication number: 20250027936Abstract: The present disclosure provides an immunoassay device, and a preparation method and use thereof, and belongs to the technical field of biological detection. In the present disclosure, the immunoassay device includes a test strip and a thin film pump, where a driving component in the thin film pump is connected to a printed circuit board (PCB) or a chip outside the thin film pump through a wire, to control starting or turning off of the thin film pump; and a liquid outlet of the thin film pump is closely attached to a top of a conjugate pad of the test strip, or a top of a sample pad of the test strip, or a top of a middle part between the conjugate pad and the sample pad.Type: ApplicationFiled: January 9, 2024Publication date: January 23, 2025Applicants: Peking University, PEKING UNIVERSITY FIRST HOSPITALInventors: Yue CUI, Li YANG
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Patent number: 12206041Abstract: Disclosed is a method for monolithic integration preparation of a full-color nitride semiconductor micro light-emitting diode (micro-LED) array.Type: GrantFiled: August 9, 2022Date of Patent: January 21, 2025Assignee: Peking UniversityInventors: Xinqiang Wang, Fang Liu, Zhaoying Chen, Yucheng Guo, Bowen Sheng, Duo Li, Bo Shen
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Publication number: 20250009662Abstract: A nanoparticle drug based on a small interfering RNA (siRNA) targeting JFK and use thereof are provided. Nucleotide sequences of the sense strand and the antisense strand of the siRNA targeting JFK are set forth in SEQ ID NO: 1 and SEQ ID NO: 2, respectively. Liposomes can be used to encapsulate the complex of the siRNA and a protamine to produce a nanoparticle drug targeting JFK, which may be used to treat a disease related to abnormally-high expression of JFK. In this disclosure, breast cancer 4T1 cell-based tumor-bearing mice serve as the model for evaluating the anti-tumor activity of combined therapy involving the nanoparticle drug targeting JFK and radiotherapy. The results reveal that this combined therapy exhibits superior anti-tumor activity compared to the control group.Type: ApplicationFiled: July 3, 2024Publication date: January 9, 2025Applicant: Peking UniversityInventors: Luyang SUN, Zhaofei Liu, Lin He, Yongfeng Shang, Chao Gao, Shimiao Yu
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Publication number: 20240408055Abstract: The present invention relates to a use of a natural compound Anisomelic acid extracted from Anisomeles indica O. Kuntze in the preparation of pharmaceutical compositions for inhibiting the infection and replication of novel coronaviruses and the mutant strains (SARS-CoV-2 variants) thereof, the Anisomelic acid is a compound comprising a chemical structural Formula I, the pharmaceutical composition includes a safe and effective amount of Anisomelic acid, that is, the pharmaceutical composition is a combination of a safe and effective amount of Anisomelic acid and its pharmaceutically acceptable salt or carrier thereof.Type: ApplicationFiled: October 21, 2021Publication date: December 12, 2024Applicants: Peking University Shenzhen Graduate School, CNS BIOTEK CORP., Gansu Evergreen Pharmaceuticals Co.,Ltd.Inventors: Zhen Yang, Yew-Min Tzeng, Jun-Min Quan, Qing Chang, Chi-Tai Yeh
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Patent number: 12156778Abstract: A self-ligating bracket, a double-wing spacing adjustable bracket and a dental appliance are described. The self-ligating bracket includes a bracket base plate, a first elastic support, a bracket body, and a position-limited member. A first end of the first elastic support is connected to the bracket base plate. The bracket body has a hollow structure. A second end of the first elastic support is connected to a distal end of the bracket body. The distal end of the bracket body is provided with a distal-end gap. The distal end of the bracket body is expanded radially by the second end of the first elastic support. The position-limited member is movable in an axial direction of the bracket body, and the position-limited member is sleeved on an outside of the bracket body for overcoming elastic force provided by the first elastic support and making the bracket body contract in a radial direction.Type: GrantFiled: September 14, 2022Date of Patent: December 3, 2024Assignees: Peking University School of Stomatology, Center of Huanzhengduowei Education & Science and Technology, BeijingInventors: Tian Min Xu, Kai Yuan Xu
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Patent number: 12159407Abstract: An optimization and enhancement method for medical health physical examination big data includes following steps: all closed edges and all feature corner points in an anteroposterior spinal X-ray image are obtained, an internal difference coefficient of each closed edge relative to each other closed edge is obtained based on a positional distribution difference coefficient of each feature corner point within each closed edge relative to each feature corner point within each other closed edge, and the vertebral body edge probability of each closed edge is obtained by combing a rectangularity degree of each closed edge; the vertebral body edge confidence probability is obtained based on the rectangularity degree and the number of the feature corner points within each closed edge to select a reference vertebral body edge; all spinal vertebral bodies are obtained by a feature matching algorithm and grayscale enhancement is performed on all spinal vertebral bodies.Type: GrantFiled: July 16, 2024Date of Patent: December 3, 2024Assignee: Peking UniversityInventors: Jue Liu, Liyuan Tao
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Publication number: 20240384433Abstract: The present invention provides a method for scalable fabrication of ultra-flat polycrystalline diamond membranes, the method comprising: (1) performing chemical vapor deposition on a growth substrate having diamond seeds thereon to grow a polycrystalline diamond membrane, wherein an exposed surface of the polycrystalline diamond membrane is a grown surface having a first roughness; and a surface bonded to the growth substrate is a buried surface; (2) bonding the grown surface to a transfer substrate using an adhesive; and (3) removing the growth substrate to expose the buried surface of the polycrystalline diamond membrane, wherein the buried surface has a second roughness after exposure, and the second roughness is less than the first roughness.Type: ApplicationFiled: May 14, 2024Publication date: November 21, 2024Applicants: The University of Hong Kong, Dongguan Institute of Opto-electronics, Peking University, Southern University of Science and TechnologyInventors: Zhiqin CHU, Jixiang Jing, Qi WANG, Zhongqiang WANG, Kwai Hei LI
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Publication number: 20240384233Abstract: The present invention relates to the field of biomedicine, in particular regenerative medicine. In particular, the present invention relates to a method for producing cardiomyocytes from differentiated cells, such as fibroblasts, by means of reprogramming using a Tyk2 inhibitor and/or a TGF? inhibitor, and optionally a cardiomyocyte-inducing transcription factor.Type: ApplicationFiled: July 29, 2021Publication date: November 21, 2024Applicants: Plastech Pharmaceutical Technology Co., Ltd., Peking UniversityInventors: Yang Zhao, Yanmeng Tao, Jingdong Wu, Hao Wang
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Patent number: 12144543Abstract: Provided are a controllably self-deformable optical fiber, a multifunctional laser scalpel and a laser processing device including the same. The controllably self-deformable optical fiber drives the protective layer and the optical fiber to deform through controllable deformation of a deformation portion on an outer surface of the protective layer. In addition, the optical fiber also has multiple functions, and can be applied in the treatment of complex lacunae in medical and other related fields.Type: GrantFiled: March 7, 2021Date of Patent: November 19, 2024Assignee: Peking University School of StomatologyInventors: Fusong Yuan, Peijun Lyu, Shanshan Liang
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Patent number: 12126523Abstract: This application provides a method for multiplexing HTTP channels. The method includes: sending, by the terminal, a first HTTP request to a first server through a first HTTP channel, to request first data; after receiving a first HTTP response returned by the first server, receiving, through the first HTTP channel, a first part that is of the first data and that is sent by the first server; and if a size that is of the first data and that is carried in the first HTTP response is greater than a first threshold, generating a second HTTP request, and sending a second HTTP request to a second server through a second HTTP channel, to request a second part of the first data; and after receiving the first part of the first data, sending control signaling to the first server, to disconnect the first HTTP channel.Type: GrantFiled: June 13, 2022Date of Patent: October 22, 2024Assignees: Huawei Technologies Co., Ltd., Peking UniversityInventors: Hao Wang, Zheng Hu, Chenren Xu, Shuo Chen, Xingmin Guo, Xiaojin Li
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Patent number: 12120331Abstract: A system and a method for compressing an image based on a FLASH in-memory computing array are provided. The system includes: a convolutional neural network for encoding of the FLASH in-memory computing array, a convolutional neural network for decoding based on the FLASH in-memory computing array, and a quantization module; the convolutional neural network for encoding based on the FLASH in-memory computing array is configured to encode an original image to obtain a feature image; the quantization module is configured to quantize the feature image to obtain a quantized image; the convolutional neural network for decoding based on the FLASH in-memory computing array is configured to decode the quantized image to obtain a compressed image.Type: GrantFiled: December 31, 2019Date of Patent: October 15, 2024Assignee: Peking UniversityInventors: Jinfeng Kang, Yachen Xiang, Peng Huang, Xiaoyan Liu, Runze Han
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Publication number: 20240319129Abstract: A methane sensor includes a substrate, a conductive connection electrode, and a sensing electrode, the conductive connection electrode is arranged on the substrate, and the sensing electrode is covered on the conductive connection electrode, the sensing electrode is a layer of conductive polymer film, and the conductive connection electrode is coated with an insulating layer in addition to the sensing area. The sensing electrode adopts one of poly (3,4-ethylenedioxythiophene): poly (styrene sulfonic acid), polyaniline, polythiophene and polypyrrole, which is made into a film by a screen printing, inkjet printing or other coating method in the form of liquid or paste. The present invention adopts the above methane sensor, with a small and stable sensor, realizing sensitive and rapid detection of methane, and solving the problems of high power consumption of methane sensors in the prior art, high working temperature, expensive and bulky casing of the equipment, and high price.Type: ApplicationFiled: December 25, 2023Publication date: September 26, 2024Applicant: Peking UniversityInventor: Yue CUI