Abstract: The present invention relates to the field of biomedicine, in particular regenerative medicine. In particular, the present invention relates to a method for producing cardiomyocytes from differentiated cells, such as fibroblasts, by means of reprogramming using a Tyk2 inhibitor and/or a TGF? inhibitor, and optionally a cardiomyocyte-inducing transcription factor.

Abstract: Provided are a controllably self-deformable optical fiber, a multifunctional laser scalpel and a laser processing device including the same. The controllably self-deformable optical fiber drives the protective layer and the optical fiber to deform through controllable deformation of a deformation portion on an outer surface of the protective layer. In addition, the optical fiber also has multiple functions, and can be applied in the treatment of complex lacunae in medical and other related fields.

Abstract: A method for continuous epitaxy of a carbon film, including the following steps: Si, providing a foil, wherein the foil is selected from a nickel foil or a copper-nickel alloy foil and has a first surface and a second surface; and S2, using the foil as a substrate and placing it on a solid carbon source, wherein the first surface of the foil is positioned close to the solid carbon source, while the second surface of the foil is positioned away from the solid carbon source, and then heating the foil and the solid carbon source, so that a carbon film is formed by continuous epitaxy on the second surface of the foil.

Abstract: Disclosed is a DNA sequencing method. The DNA sequencing method of this invention comprises: (1) adding a tag sequence at the 3? terminus of the DNA to be sequenced so as to form a DNA to be sequenced including the tag sequence, the nucleotide sequence of said tag sequence being the reverse complement of the nucleotide sequence of the sequencing primer; (2) mixing the DNA to be sequenced including the tag sequence and the sequencing primer so as to form a product having a 5? terminus double strand and a single main strand; (3) after step (2) is completed, the product is mixed separately with dATP, dCTP, dTTP, and dGTP to obtain four systems, each system is separately added to a single-molecule device modified by a DNA polymerase, and electric signals are read. Experiments verify that the method of this invention performs DNA sequencing and has important application value.

Abstract: This application provides a method for multiplexing HTTP channels. The method includes: sending, by the terminal, a first HTTP request to a first server through a first HTTP channel, to request first data; after receiving a first HTTP response returned by the first server, receiving, through the first HTTP channel, a first part that is of the first data and that is sent by the first server; and if a size that is of the first data and that is carried in the first HTTP response is greater than a first threshold, generating a second HTTP request, and sending a second HTTP request to a second server through a second HTTP channel, to request a second part of the first data; and after receiving the first part of the first data, sending control signaling to the first server, to disconnect the first HTTP channel.

Abstract: A system and a method for compressing an image based on a FLASH in-memory computing array are provided. The system includes: a convolutional neural network for encoding of the FLASH in-memory computing array, a convolutional neural network for decoding based on the FLASH in-memory computing array, and a quantization module; the convolutional neural network for encoding based on the FLASH in-memory computing array is configured to encode an original image to obtain a feature image; the quantization module is configured to quantize the feature image to obtain a quantized image; the convolutional neural network for decoding based on the FLASH in-memory computing array is configured to decode the quantized image to obtain a compressed image.

Abstract: Provided is a pharmaceutical composition for enhancing the anti-tumor effect of an EZH2 inhibitor. The pharmaceutical composition includes an EZH2 inhibitor and an SCD1 inhibitor. The SCD1 inhibitor enhances the effect of the EZH2 inhibitor on a solid tumor. Further provided are a related preparation of the pharmaceutical composition and the use thereof in the preparation of an anti-tumor drug.

Abstract: A core-shell nanocomposite is formed by co-assembly of an amphiphilic polymer and hydrophobically modified magnetic nanoparticles, with its core being a hydrophobically modified magnetic nanomaterial and its shell being the amphiphilic polymer, wherein hydrophilic segments in the amphiphilic polymer are located at an outermost layer of the shell. The above composite can be used as additives in the crystallization of conglomerates and obtain optically pure crystals of both enantiomers in a single process. The key thereof is that the composite is used to enrich molecules with the same configuration while inhibit the crystallization of the other enantiomer in a supersaturated solution of conglomerates, such that a non-magnetic crystal and a magnetic crystal (which are enantiomers of each other) are generated in a unit operation. Optically pure crystals of both enantiomers with over 90 ee % can be obtained by one-time crystallization, and the total yield can be as high as 40%.

Abstract: A method for piloting from bypass in a network based on a satellite load platform can unify the influence of distance change and Doppler frequency shift of satellite ground stations in the whole network, and realize accurate quasi synchronization between the clock of the whole network and the clock of the satellite. The method includes transmitting a pilot signal from bypass based on a satellite load platform in a satellite communication system, taking a spaceborne high stability timing clock source as a reference, and transmitting the pilot signal to all downlink beams to provide the pilot signal for all satellite stations covered by the satellite.

Abstract: Disclosed are a root canal fluid filling device and method. The root canal fluid filling device includes a root canal filling device box, including an upper box body and a lower box body which are arranged in upper and lower partitions and detachable; a positive and negative pressure generating apparatus, arranged in the lower box body; an air pressure monitoring apparatus, arranged in the lower box body and connected to the positive and negative pressure generating apparatus; an air pressure recovery apparatus, arranged in the lower box body; an auxiliary positioning apparatus, including an auxiliary positioning crown which is respectively connected to the positive and negative pressure generating apparatus, the air pressure monitoring apparatus and the air pressure recovery apparatus and is to be sleeved outside and cemented to a tooth to be subjected to root canal therapy; a control display apparatus; and a power supply apparatus.

Abstract: A methane sensor includes a substrate, a conductive connection electrode, and a sensing electrode, the conductive connection electrode is arranged on the substrate, and the sensing electrode is covered on the conductive connection electrode, the sensing electrode is a layer of conductive polymer film, and the conductive connection electrode is coated with an insulating layer in addition to the sensing area. The sensing electrode adopts one of poly (3,4-ethylenedioxythiophene): poly (styrene sulfonic acid), polyaniline, polythiophene and polypyrrole, which is made into a film by a screen printing, inkjet printing or other coating method in the form of liquid or paste. The present invention adopts the above methane sensor, with a small and stable sensor, realizing sensitive and rapid detection of methane, and solving the problems of high power consumption of methane sensors in the prior art, high working temperature, expensive and bulky casing of the equipment, and high price.

Abstract: A chemiluminescent lateral flow immunoassay method is provided for reducing cross reactions and false positives when detecting protein analytes. The detection method involves a lateral flow immunoassay strip, the strip includes a sample pad, a conjugate pad, a nitrocellulose membrane, and an absorbent pad. The capture antibody of the analyte on the nitrocellulose membrane is used as the test line, and the IgG antibody is used as the control line. The lateral flow immunoassay is performed on the strip by the Au nanoparticle-antibody-horseradish peroxidase-polyethylene glycol (AuNP-Ab-RP-PEG) conjugate to detect the specific analyte. During the detection, the conjugate is prepared in the strip and then added to the analyte for detection, or the conjugate is mixed with the analyte and then added to the strip for detection.

Abstract: The present disclosure provides a method for assessing GCS capacity. The method includes: determining scores of a plurality of geologic indicators of a target region belonging to a target type of geologic body for the GCS; and determining an assessment result of the GCS capacity of the target region based on the scores of the plurality of geologic indicators and weights of the plurality of geologic indicators.

Abstract: Disclosed are an optical instrument, an imaging system, and an imaging method for a miniature multi-photon microscope, relating to the optical configuration field. The optical instrument is configured to have a fluorescence excitation optical path and a fluorescence collection optical path. The optical instrument includes a condenser, and the condenser includes a first lens group and a second lens group separately disposed. The first lens group is located in the fluorescence collection optical path, the second lens group is located in the fluorescence excitation optical path and the fluorescence collection optical path. A relative distance the second lens group and a miniature objective is less than a first preset distance threshold. A collection efficiency of scattered fluorescence of the miniature multi-photon microscope may be improved, thereby improving an imaging signal-to-noise ratio and an imaging depth when a sample to be test with a scattering characteristic is observed.

Abstract: Disclosed is an embedded semiconductor random access memory structure, including a hafnium oxide-based ferroelectric storage element suitable for storing information, and a tunneling field effect transistor connected to the storage element. The tunneling field effect transistor is suitable for controlling the hafnium oxide-based ferroelectric storage element to perform read and write operations. A semiconductor memory array can be formed by repeating the above memory structures. A control method for the memory structure includes steps of writing 0, writing 1, reading, and writing back.

Abstract: Provided in the present application are an end-edge-cloud coordination system and method based on a digital retina, and a device. The coordination system may include, but is not limited to, a front-end device, an edge device, and a cloud device. The front-end device is used for extracting, from collected video data, features having universality, and is used for generating analysis and recognition tasks on the basis of the features. The front-end device is also used for processing the analysis and recognition tasks, so as to obtain a first intermediate result to be sent to the edge device. The edge device is used for processing the analysis and recognition tasks on the basis of the first intermediate result, so as to obtain a second intermediate result to be sent to the cloud device. The cloud device is used for processing the analysis and recognition tasks on the basis of the second intermediate result, so as to obtain an analysis and recognition result for video data.

Abstract: A flexible permanent magnetic material, a preparation method and an application thereof in magnetic biological effect products are provides, relating to the technical field of medical equipment. Raw materials of the flexible permanent magnetic material of the application include the following components in parts by weight: 0-70 parts of anisotropic neodymium iron boron powder and 0-40 parts of anisotropic samarium iron nitrogen powder and 3-20 parts of binder.

Abstract: A method for low frequency somatic cell mutation identification and quantification, relating specifically to a method for transposon copy number and genome location identification. Specific sites of different transposon families are used, transposon insertion sequences are specifically enriched via library construction, high-throughput sequencing and bioinformatics analysis are used, and genome locations, copy numbers and types of transposons within samples are accurately identified. The method economically and accurately identifies copy numbers and genome locations of transposons.

Abstract: A method and a system are for non-contact determination of a detection boundary. A Wi-Fi receiving device simultaneously receives data packets by using any two antennas, and measures channel state information; conjugate multiplication is performed on the CSI measured at a moment corresponding to reception of the two antennas, to obtain a new CSI signal stream; a time window with the length M is selected from the new CSI signal stream, and M CSI samples in the time window are collected, to form a conjugate set; the mean of the conjugate set is subtracted from all the samples in the conjugate set, to obtain a zero-mean conjugate set; N zero-mean conjugate sets are obtained for CSI on N sub-carriers simultaneously transmitted; and probability distribution fitting is performed on the absolute values of all elements in the N zero-mean conjugate sets, to calculate a boundary detection feature.

Abstract: A method for quasi-synchronous code division multiple access based on synchronization clock by piloting can make CDMA operate in quasi-synchronous conditions, so it is suitable for open wireless channels with relay nodes, such as satellite communication systems, and open wireless channels without relay nodes. The method includes: adopting a mode of CDMA spread spectrum transmission to share power resources to transmit signals at multiple transmitting stations in open wireless channels; adopting an external pilot signal to provide synchronization clock for the CDMA signals transmitted by multiple terminal stations in the open wireless channels, eliminating path delay differences from the multiple terminal stations to a relay node or receiving station, and making multi-channel CDMA signals received at the relay node or receiving station clock synchronized and phase aligned. The method can realize the quasi-synchronous reception of multi-channel CDMA signals.