Abstract: An array substrate and a manufacturing method therefor, and a display panel are provided. The manufacturing method includes: forming a scan line and a gate on a substrate; forming a first insulating layer covering the scan line and the gate on the substrate; forming a metal oxide semiconductor layer above the first insulating layer, the metal oxide semiconductor layer including a source, a drain and an active layer; coating an upper surface of the metal oxide semiconductor layer with a photosensitive material layer; photoetching the photosensitive material layer from the back side of the substrate by using a first metal layer as a mask to form a channel protection layer; performing conductorization treatment on the metal oxide semiconductor layer to enable the source and the drain to be conductive; forming a data line above the first insulating layer; and forming a pixel electrode above the first insulating layer.

Abstract: The present disclosure provides an immunoassay device, and a preparation method and use thereof, and belongs to the technical field of biological detection. In the present disclosure, the immunoassay device includes a test strip and a thin film pump, where a driving component in the thin film pump is connected to a printed circuit board (PCB) or a chip outside the thin film pump through a wire, to control starting or turning off of the thin film pump; and a liquid outlet of the thin film pump is closely attached to a top of a conjugate pad of the test strip, or a top of a sample pad of the test strip, or a top of a middle part between the conjugate pad and the sample pad.

Abstract: The present disclosure provides a carborane-phospholipid conjugate, in which carboranyl is introduced at the end of the arm of a phospholipid. The present disclosure also provides a liposome composition including the carborane-phospholipid conjugate, and a use of the composition in delivering at least one therapeutic agent and/or at least one diagnostic agent.

Abstract: Disclosed is a method for monolithic integration preparation of a full-color nitride semiconductor micro light-emitting diode (micro-LED) array.

Abstract: Provided is a preparation method for an ultrahigh-conductivity multilayer single-crystal laminated copper material, where multiple layers of single-crystal copper foils are laminated together to form a laminate, and the laminate is pressurized and annealed as one piece by performing pressurizing and high-temperature annealing at the same time, or the laminate is pressed as one piece by means of direct hot rolling, thereby obtaining an ultrahigh-conductivity multi-layer single-crystal laminated copper material, whereby, according to the method, multiple layers of single-crystal copper foils are used as raw materials, an ultrahigh-conductivity multi-layer single-crystal laminated copper material is prepared by means of hot rolling or pressing and annealing, and the conductivity of the copper material is greater than or equal to 105% IACS.

Abstract: A method and a device for encoding or decoding based on an inter-frame prediction. The method includes steps of: determining a temporal motion vector prediction value of a to-be-processed coding unit, where the temporal motion vector prediction value is a temporal motion vector prediction value of a sub-block, a temporal motion vector of which is obtainable through prediction, in sub-blocks adjacent to the to-be-processed coding unit and/or sub-blocks in the to-be-processed coding unit; determining a motion vector residual prediction value of the to-be-processed coding unit according to the temporal motion vector prediction value; determining a motion vector of a sub-block in the to-be-processed coding unit according to the temporal motion vector prediction value and the motion vector residual prediction value and performing a motion compensation according to the motion vector of the sub-block in the to-be-processed coding unit to determine a prediction block of the to-be-processed coding unit.

Abstract: A method for processing time series data comprises: dividing time series data into a plurality of data fragments according to an objective function, the plurality of data fragments having a greatest similarity; in response to determining that at least one data fragment does not satisfy an iteration termination condition, performing following iteration operations on the at least one data fragment; and constructing a time series base pattern library by using a plurality of time series base patterns. The iteration operations includes: using the at least one data fragment as at least one update time series fragment; dividing each update time series fragment into a plurality of update data fragments; using each update data fragment that does not satisfy the iteration termination condition as a new update time series fragment; and using each update data fragment that satisfies the iteration termination condition as a time series base pattern.

Abstract: A nanoparticle drug based on a small interfering RNA (siRNA) targeting JFK and use thereof are provided. Nucleotide sequences of the sense strand and the antisense strand of the siRNA targeting JFK are set forth in SEQ ID NO: 1 and SEQ ID NO: 2, respectively. Liposomes can be used to encapsulate the complex of the siRNA and a protamine to produce a nanoparticle drug targeting JFK, which may be used to treat a disease related to abnormally-high expression of JFK. In this disclosure, breast cancer 4T1 cell-based tumor-bearing mice serve as the model for evaluating the anti-tumor activity of combined therapy involving the nanoparticle drug targeting JFK and radiotherapy. The results reveal that this combined therapy exhibits superior anti-tumor activity compared to the control group.

Abstract: A method for clonal-growth of a single-crystal metal, including: using copper as an example, placing an existing small-sized single-crystal copper foil with a plane of any index on a copper foil that needs to be single-crystallized, and performing annealing to obtain, by cloning, a large-area (in meters) single-crystal copper foil with the same surface index as that of the parent facet. The method solves the difficult problem of large-area single-crystal copper foil preparation. By performing annealing, a parent single-crystal copper foil with a very small size (˜0.25 cm2) can be cloned to produce a large-area (˜700 cm2) single-crystal copper foil, which is an increase in area of about 3000 times.

Abstract: The present disclosure provides an image sensing computing unit and its operating method, an image sensing computer and an electronic device. Among them, the image sensing computing unit includes a first photosensitive unit and a second photosensitive unit. The second photosensitive unit is connected in series with the first photosensitive unit. The changing direction of the first threshold voltage of the first photosensitive unit when receiving light is opposite to the changing direction of the second threshold voltage of the second photosensitive unit when receiving light, so as to implement an in-situ logical operation between light input signals.

Abstract: The present disclosure provides a compound function prediction method based on a neural network and a connectivity map (CMAP) algorithm. The compound function prediction method is used to predict an efficacy of a compound, and the compound function prediction method includes the following steps: constructing a compound molecule-encoding vector neural network; constructing and training an encoding vector-marker gene expression variation deep neural network; constructing and training a marker gene expression level or gene expression variation-whole genome gene expression level or gene expression variation neural network; constructing upregulated and downregulated gene sets of a disease or a phenotype; and evaluating a correlation between the compound and the disease or the phenotype.

Abstract: The application relates to a strongly-polarized molecule of the following general formula: wherein A denotes a group having a polarizability greater than 2 C·m2/V; R1 and R2 are respectively hydrogen, halogen, a hydroxyl group, an amino group, a cyano group, a nitro group, a carboxyl group, a C1-12 alkyl group, a C1-12 alkoxy group, a halogenated C1-12 alkyl group, a halogenated C1-12 alkoxy group, a hydroxyl C1-12 alkyl group, a hydroxyl C1-12 alkoxy group, or a C1-12 alkyl amino group; x1 and x2 denote 0 or an integer no less than 1, respectively; and y1 and y2 denote 0 or an integer no less than 1, respectively. The application further relates to a strongly-polarized molecule-graphene molecule heterojunction, and a single molecule field effect transistor comprising a substrate, a gate, a dielectric layer and the strongly-polarized molecule-graphene molecule heterojunction; and the dielectric layer is located between the gate and the strongly-polarized molecule-graphene molecule heterojunction.

Abstract: The present invention relates to a use of a natural compound Anisomelic acid extracted from Anisomeles indica O. Kuntze in the preparation of pharmaceutical compositions for inhibiting the infection and replication of novel coronaviruses and the mutant strains (SARS-CoV-2 variants) thereof, the Anisomelic acid is a compound comprising a chemical structural Formula I, the pharmaceutical composition includes a safe and effective amount of Anisomelic acid, that is, the pharmaceutical composition is a combination of a safe and effective amount of Anisomelic acid and its pharmaceutically acceptable salt or carrier thereof.

Abstract: A bacterial capsular oligosaccharide derivative, a preparation method therefor, a pharmaceutical composition and a use thereof. The derivative is as shown in formula (I), and the substituent is described in detail in the description. The derivative has anti-inflammatory activity and can be used for treating sepsis.

Abstract: The present invention belongs to the field of medicine. Provided is a pharmaceutical composition for enhancing the anti-tumor effect of an EZH2 inhibitor. The pharmaceutical composition comprises an EZH2 inhibitor and a PPAR?agonist, wherein the PPAR? agonist enhances the anti-solid tumor effect of the EZH2 inhibitor. Further provided in the present invention are a related preparation of the pharmaceutical composition and the use thereof in the preparation of an anti-tumor drug. Experimental results show that when the EZH2 inhibitor GSK126 and the PPAR? agonist fenofibrate are used in combination to treat B16F10 cells, SMMC7721 cells and GL261 cells, it is found that the use thereof in combination with fenofibrate can significantly enhance the inhibitory effect of GSK126 on cell proliferation.

Abstract: An optimization and enhancement method for medical health physical examination big data includes following steps: all closed edges and all feature corner points in an anteroposterior spinal X-ray image are obtained, an internal difference coefficient of each closed edge relative to each other closed edge is obtained based on a positional distribution difference coefficient of each feature corner point within each closed edge relative to each feature corner point within each other closed edge, and the vertebral body edge probability of each closed edge is obtained by combing a rectangularity degree of each closed edge; the vertebral body edge confidence probability is obtained based on the rectangularity degree and the number of the feature corner points within each closed edge to select a reference vertebral body edge; all spinal vertebral bodies are obtained by a feature matching algorithm and grayscale enhancement is performed on all spinal vertebral bodies.

Abstract: The industrial geographical information system relates to the field of industrial production intelligent management and control and comprises a device acquisition control end, a spatio-temporal big data processing end and an industrial geographical information system platform end. Based on a spatial data unified management and analysis framework of the geographic information system, various sensors, monitoring devices and mobile devices in an industrial production environment are acquired to perceive real-time data, and the real-time data are cleaned, denoised, cached, distributed, stored and processed permanently.

Abstract: A curved electric laryngoscope is provided. The curved electric laryngoscope includes a handle and a display screen, where the display screen is rotationally provided at an upper part of the handle; a lower end of the handle is connected to a curved outer tube; the handle is provided therein with an inner tube and an inner tube position adjustment assembly; the inner tube includes an upper end connected to the inner tube position adjustment assembly and a lower end inserted into the curved outer tube; the inner tube position adjustment assembly includes a drive motor, a lead screw, a slide rail, a slider, and a slider bracket; the slide rail is provided along a length direction of the handle; and the lead screw is parallel to the slide rail; the drive motor is fixed at an upper end inside the handle.

Abstract: A self-ligating bracket, a double-wing spacing adjustable bracket and a dental appliance are described. The self-ligating bracket includes a bracket base plate, a first elastic support, a bracket body, and a position-limited member. A first end of the first elastic support is connected to the bracket base plate. The bracket body has a hollow structure. A second end of the first elastic support is connected to a distal end of the bracket body. The distal end of the bracket body is provided with a distal-end gap. The distal end of the bracket body is expanded radially by the second end of the first elastic support. The position-limited member is movable in an axial direction of the bracket body, and the position-limited member is sleeved on an outside of the bracket body for overcoming elastic force provided by the first elastic support and making the bracket body contract in a radial direction.

Abstract: The present invention relates to the field of biomedicine, in particular regenerative medicine. In particular, the present invention relates to a method for producing cardiomyocytes from differentiated cells, such as fibroblasts, by means of reprogramming using a Tyk2 inhibitor and/or a TGF? inhibitor, and optionally a cardiomyocyte-inducing transcription factor.