Abstract: A three-component knee joint prosthesis is disclosed including femoral, tibial and patellar components. During flexion of the prosthetic knee, the patellar component, which has a convex bearing surface, cooperates with and is guided by a patellar track defined by the anterior plate portion, lateral condylar bearing portion and medial condylar bearing portion of the femoral component and a web portion joining the two femoral condylar bearing portions. The inner regions of the two femoral condylar bearing portions are steeply sloped towards the web portion to permit the patellar component to "ride deeply" upon the femoral component at high degrees of flexion, thereby reducing quadriceps tension and expanding the permissible range of motion in flexion.

Abstract: Hypoglycemic thiazolidine-2,4-derivatives ##STR1## wherein the dotted line represents a bond or no bond; V is --CH.dbd.CH--, --N.dbd.CH--, --CH.dbd.N-- or S;W is CH.sub.2, CHOH, CO, C.dbd.NOR or --CH.dbd.CH--;X is S, O, NR.sup.1, --CH.dbd.N-- or --N.dbd.CH--;Y is CH or N;Z is hydrogen, (C.sub.1 -C.sub.7)alkyl, (C.sub.3 -C.sub.7)cycloalkyl, phenyl, naphtyl, pyridyl, furyl, thienyl or phenyl mono- or disubstituted with the same or different groups which are (C.sub.1 -C.sub.3)alkyl, trifluoromethyl, (C.sub.1 -C.sub.3)alkoxy, fluoro, chloro or bromo;Z.sup.1 is hydrogen or (C.sub.1 -C.sub.3)alkyl;R is hydrogen or methyl; andn is 1, 2 or 3;a pharamceutically acceptable cationic salt thereof; or a pharmaceutically acceptable acid addition salt thereof when the compound contains basic nitrogen.

Abstract: Process and intermediates for isopropyl 3S-amino-4-cyclohexyl-2R-hydroxybutyrate and 3S-amino-2R-hydroxy-5-methylhexanoate from R-malic acid. These products are of known utility in the synthesis of certain renin inhibitors.

Abstract: Polypeptides and derivatives thereof containing nor-statine and nor-cyclostatine are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin.

Abstract: Substantially homogeneous (meth)acrylic acid/itaconic acid copolymers of number average molecular weight of 500 to 7000 are prepared by copolymerizing in aqueous solution 5 to 90 mole percent acrylic or methacrylic acid monomer with 95 to 10 mole percent itaconic acid monomer at 80.degree. to 120.degree. C. in the presence of a polymerization initiator, the acrylic or methacrylic acid monomer and at least half of the initiator being added separately and continuously to the itaconic acid monomer throughout the polymerization period. The copolymers are employed at a level of from about 0.1 to 100 ppm for prevention of alkaline calcium and magnesium scale formation, such as during seawater evaporative desalination.

Abstract: A series of novel spiro-substituted glutaramide derivatives have been prepared, including the pharmaceutically acceptable salts thereof and bioprecursors therefor, wherein the spiro-substituent completes a 5- or 6-membered carbocycyclic ring and is located at the carbon atom adjacent to the carbamoyl group. These particular compounds are inhibitors of the neutral endopeptidase E.C.3.4.24.11 enzyme and are therefore useful in therapy as diuretic agents for the treatment of hypertension, heart failure, renal insufficiency and other disorders. Methods for preparing these compounds from known starting materials are provided.

Abstract: This invention relates to devices useful for the controlled delivery of one or more beneficial agents to an environment of use. More specifically, this invention concerns such devices which are powered by lyotropic liquid crystals. This inventioin also relates to the controlled delivery of one or more beneficial agents to an aqueous environment of use through the use of such lyotropic liquid crystal powered dispensing devices. Also disclosed are methods for the controlled delivery of one or more beneficial agents to an aqueous environment of use which comprise administering to or otherwise placing the devices of this invention in the environment of use.

Abstract: 2-Guanidino-4-arylthiazole compounds of the formula ##STR1## a pharmaceutically acceptable cationic or acid addition salt thereof whereinR.sup.1 is hydrogen, (C.sub.1 -C.sub.10)alkyl, optionally substituted phenyl or certain optionally substituted aralkyl groups;R.sup.2 is hydrogen or (C.sub.1 -C.sub.4)alkyl, andAr is certain optionally substituted pyrrolyl or indolyl groups; method for their use in treatment of gastric ulcers, by inhibition of parietal cell H.sup.+ /K.sup.+ ATPase, and antiinflammatory conditions in combination with piroxicam, for use in mammals, and pharmaceutical compositions containing said compounds.

Abstract: An apparatus for draining fluids, for example, from a chest or pleural cavity, includes a collection chamber for collecting fluids through an inlet port for entry of the fluids. Also included is a dry or waterless suction control chamber in fluid communication with the collection chamber for regulating the degree of vacuum imposed in the collection chamber. If desired, a seal chamber can also be provided between the dry suction control chamber and the collection chamber so as to prevent any ambient or atmospheric air from passing into the collection chamber. The suction control chamber has a first inlet which is coupled to a suction source and a second inlet communicates with the ambient. A waterless regulator is provided for regulating the degree of suction imposed in the collection chamber at a plurality of predetermined preset levels of suction. This regulator is positioned between the suction inlet and the ambient inlet.

Abstract: Antiparasitic milbemycin derivatives having at the C.25 position a substituted 2-propenyl group --C(CH.sub.3).dbd.CH--R.sup.2 wherein R.sup.2 is a C.sub.3 -C.sub.8 alkyl, alkenyl or alkynyl group which may optionally contain an oxygen or sulphur atom as part of the chain, or a C.sub.3 -C.sub.8 cycloalkyl or cycloalkenyl group, or a 3 to 6 membered oxygen or sulphur containing heterocyclic ring which may optionally be substituted by one or more alkyl groups or halogen atoms; and process for their preparation.

Abstract: An intraoperative blood recovery system and method for salvaging operative blood while simultaneously delivering previously collected blood to a reinfusion system. A blood collection and transfer reservoir, having multiple compartments which can be separated by vacuum or pressure barriers, is designed to maintain a continuous suction for blood inflow while blood previously collected can be simultaneously transported through the reservoir to achieve the uninterrupted flow of blood into and delivery of blood out of the reservoir.

Abstract: The invention provides triazole antifungal compounds of the formula: ##STR1## wherein R is either (a) a phenyl group optionally substituted with 1 to 3 substituents, each selected independently from halo and CF.sub.3 ; or(b) a 5-chloropyridin-2-yl group; and R.sup.

Abstract: Transdermal flux enhancers such as oleic acid and 1-dodecylazacycloheptan-2-one are used in combination with iontophoresis in the topical administration of pharmaceutical agents.

Abstract: A sensor for the determination of the concentration of a dissolved substance in an aqueous medium comprising an optical fiber having on the distal end thereof an adherent, water-insoluble organic polymer having a plurality of fluorescent organic substituents, which may be the same or different, covalently bonded to said polymer through ester or amide linkages.

Abstract: A blood washing and plasma separation device and method are disclosed, which utilize lumen-side fed hollow fiber membranes in multiple separation passes in conjunction with countercurrent flow wash injection.

Abstract: Beta-lactamase inhibiting compounds of the formula ##STR1## or a pharmaceutically acceptable acid addition or carboxylate salt thereof; where n is zero, 1 or 2; X.sub.3 is H or Br, R.sup.1 is H, the residue of certain carboxy-protecting groups or the residue of an ester group readily hydrolyzable in vivo; one of R.sup.12 and R.sup.13 is H and the other is vinyl, certain aryl, alkylthio, alkylsulfonyl or certain heterocyclyl, aminomethyl, thiocarboxyamido or amidino groups; one of R.sup.2 and R.sup.3 is H and the other is as disclosed for the other of R.sup.12 and R.sup.13, or is Cl or CH.sub.2 OH, and R.sup.18 is H or certain acyl groups; intermediates useful in their production, methods for their preparation and use, and pharmaceutical compositions containing them.

Abstract: A method of converting alpha acids to hop flavors by exposing the alpha acids to an environment capable of substantially simultaneously isomerizing and reducing the alpha acids to form either THIAA or HHIAA. Another aspect of this invention is directed to a method of reducing hop flavors by exposing an isoalpha acid, a dihydroisoalpha acid or a mixture thereof to conditions suitable to reduce said acids to produce THIAA, HHIAA or a mixture thereof at a pH of about 5 to about 12 in a reaction inert, protic solvent. Yet another aspect of this invention is directed to a method of reducing hop flavors comprising exposing an isoalpha acid, a dihydroisoalpha acid or a mixture thereof to conditions suitable to reduce said acids to produce THIAA, HHIAA or a mixture thereof in a reaction inert, aprotic solvent.

Abstract: A method of removing objectionable impurities from a hop flavor so that the impurities will not cause a fruity aroma of the beer. The method comprises steam stripping the odor forming impurities from the hop flavor at a pH such that the steam stripping is effective in removing the impurities to produce the purified hop flavor.

Abstract: An apparatus for mixing and spraying a slurry. The apparatus comprises a mixing chamber and a screw means, disposed within the chamber, for mixing and transporting material downstream to an air atomization nozzle. Another aspect of this invention is a method for mixing and spraying a slurry. The method comprises introducing and propelling a particulate solid along a mixing chamber. A liquid is introduced downstream from the introduction of the solid, a sufficient distance such that no substantial liquid backs up to the introduction of the solid. The solid and liquid are mixed to form a slurry, substantially in the absence of air. The slurry is propelled downstream, substantially in the absence of air, and atomized.

Abstract: This invention concerns methods for improving the mobility and pipeline transport of a viscous crude oil and the productivity of viscous crude oil producing wells by forming an oil-in-water emulsion with said oil and from 20 to 80% by weight of water in the presence of 100 to 1500 parts by weight of a surfactant blend per million parts by weight of said emulsion, said blend comprising from 15 to 85 parts by weight of an anionic or amphoteric surfactant (A) selected from those of the formula Ar(OCH.sub.2 CH.sub.2).sub.n OSO.sub.3 H, ##STR1## a sodium and ammonium salt thereof, and from 85 to 15 parts by weight of a nonionic surfactant selected from (B) of the formulae Ar(OCH.sub.2 CH.sub.2).sub.p OH or (C) of the formula ##STR2## the latter having an HLB value of from 10 to 20; where Ar is octylphenyl or nonylphenyl,n is 2 to 10,p is 10 to 100,a is 10 to 40, b is 15 to 55, c is 10 to 40, R.sup.1 is C.sub.8 to C.sub.18 alkyl and R.sup.2 is C.sub.12 to C.sub.18 alkyl; and said emulsion.