Abstract: A series of [N-alkyl-N-(nitro-, alkylsulphonamido, or amino-phenalkyl)amino]-alkyl, alkoxy or alkylthio phenyl derivatives having utility as anti-arrhythmic agents.

Abstract: A steerable catheter having a Doppler crystal at the tip to measure the velocity of blood in vivo--and inferentially the blood flow. The catheter includes two passageways, one passageway being exposed to the blood stream with the other passageway containing the electrical leads to the Doppler crystal. The one passageway is dimensioned for receiving a wire guide for accurately manipulating the catheter. Preferably, the catheter incorporates an inflatable angio-balloon operable to distend the blood vessel in the region of a stenosis. Thus, blood flow can be determined in the region of the stenosis before and/or after the vessel is distended. The passageways are preferably defined by a pair of generally concentric tubes with the Doppler crystal doughnut-shaped and sealingly disposed at the tip of the catheter.

Abstract: Dihydropyridines having unsaturated side chains are disclosed. The compounds are useful anti-ischemic and antihypertensive agents.

Abstract: An antibiotic complex, containing three major components, has been isolated from fermentations of a new strain of the microorganism Streptomyces hirautus. The major components are new, neutral, macrolide antibiotic compounds, which are useful as antibacterial agents against certain gram-positive bacteria.

Abstract: A series of novel N-alkyl-N-(alkanesulphonamidoheterocyclicmethyl)-4-alkanesulphonamidophene tyl mines have been prepared, including their pharmaceutically acceptable salts and various key novel intermediates therefor. The heterocyclic moiety present in these compounds is a benzo-fused heterocyclic group derived from either benzofuran, benzothiophene, benzoxazole or quinoline, and it is attached to the adjacent methyl group of the molecule by means of the available ring carbon atom which is situated alpha to the hetero atom. These particular compounds are useful in therapy as highly effective anti-arrhythmic agents and therefore, are of value in the treatment of various cardiac arrhythmias. Preferred member compounds include N-methyl-N-(5-methanesulphonamidobenzofur-2-ylmethyl)-4-methanesulphonamid op henethylamine and N-methyl-N-(6-methanesulphonamidoquinol-2-ylmethyl)-4-methanesulphonamidop hen thylamine. Methods for preparing all these compounds from known starting materials are provided.

Abstract: A drainage device, particularly adapted for use in medical procedures for draining fluids from a body cavity of a patient, incorporating a suction control chamber dimensioned and configured to provide an enhanced air and liquid flow pattern within the chamber. The suction control chamber might also include a baffle plate for air and noise control. The drainage device might further include a seal chamber and an improved high negativity relief valve. The present invention also includes a device, having an integral sampling or injection port, for coupling tubing.

Abstract: A support stand, particularly suitable for use in securing an article against overturn, being coupled to the article in a locked article stabilizing position. Preferably, the stand is rotatively coupled to the article for selective location of the stand in either an inoperative position or in a locked operative article stabilizing position.

Abstract: A new glycopeptide antibiotic UK-68,597 can be prepared by submerged aerobic propagation in aqueous nutrient media of Actinoplanes sp. ATCC 53533. The antibiotic and its cationic salts are active against a variety of microorganisms and are effective in controlling coccidiosis, enteritis, swine dysentery and theileriosis as well as being effective in promotion of growth and/or improving efficiency of feed utilization in poultry, swine and ruminants.

Abstract: Intermediates and a stepwise process for the conversion of D-methionine or certain of its derivatives to optically active compounds of the formula ##STR1## wherein R is (C.sub.1 -C.sub.3)alkyl, phenyl or tolyl. The latter compounds are in turn useful as an intermediate in the preparation of penem antibiotic 5R,6S-6-(1R-hydroxyethyl)-2-(1R-oxo-3S-thiolanylthio)-2-penem-3-carboxylic acid and corresponding pharmaceutically acceptable salts and esters.

Abstract: Oxophthalazinyl acetic acids having benzothiazole side chains are prepared by reacting an oxophthalazinyl thioacetamide acetate with hydrogen sulfide and a nitrophenyl compound having a reactive group such that the benzothiazole side chain may be formed by ring closure involving the thioacetamide group. The oxophthalazinyl thioacetamide may be prepared by reacting the corresponding cyanomethyloxophthalazinyl acetate with hydrogen sulfide in the presence of tertiary amines. Analogous indazole and oxopyridopyridazinone acetic acids may be prepared similarly, as well as oxophthalazinyl, indazole and oxopyridopyridazinone acetic acids having thiazolopyridinyl side chains.

Abstract: Method for preparing a high strength, low modulus, ductile, biocompatible titanium base alloy containing one or more isomorphous beta stabilizers, eutectoid beta stabilizers and optional alpha stabilizers, characterized by a modulus of elasticity not exceeding 100 GPa; comprising blending pre-selected amounts of the alloying ingredients, melting the blend in a plasma arc furnace, allowing the melt to cool and solidify, vaccum arc remelting and thermomechanically processing the resulting solid to provide the desired alloy.

Abstract: A novel three-step process for resolving a racemic spiro-hydantoin compound into its optical antipodes is disclosed, which involves (1) reacting said racemic compound with an optically-active asymmetric isocyanate of the formula RNCO, wherein R is (S)- or (R)-1-phenylethyl or (S) or (R)-1-(1-naphthyl)ethyl, to form the corresponding diastereomeric uredio compound; (2) separating the resulting diastereomeric mixture into its component parts, and (3) thereafter converting the separated ureido diastereomers obtained in step (b) to the corresponding asymmetric hydantoin compounds by treatment with an alkali metal lower alkoxide (C.sub.1 -C.sub.4), followed by acidification, whereupon the desired optical isomer is obtained.

Abstract: Preparation of 2-oxindole-1-carboxamides by reaction of 2-oxindoles with trichloracetyl isocyanate to produce novel N-trichloroacetyl-2-oxindole-1-carboxamides which are then hydrolyzed to 2-oxindole-1-carboxamides useful as analgesic and anti-inflammatory agents and/or intermediates for such agents.

Abstract: Compounds of the formula ##STR1## where HET is a heterocyclic group, n is an integer of 0 to 2 and R.sup.1 is hydrogen or lower alkyl are protease inhibitors useful as anti-plasmin and antithrombin agents.

Abstract: A catheter for facilitating the exchange of guidewires during the course of a transluminal angioplasty or related procedure which comprises an elongated, flexible, tubular member having at least one lumen running the full length thereof from its proximal end to its distal end and which at least three apertures or ports extending through the wall thereof at longitudinally spaced locations near the distal end of the tubular member. These ports communicate with the lumen of the tubular member and a longitudinal slit is also provided through the wall of the tubular member connecting the most proximal port to the next proximal port. The exchange catheter may also include a proximal hub connected to the proximal end of the elongated plastic tube.

Abstract: A series of novel polypeptide derivatives, containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues, which are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin. Particularly valuable precursors for many of these compounds are certain other 5-amino-2,5-disubstituted-4-hydroxypentanoic acid derivatives.

Abstract: Compounds of the formula ##STR1## where Het is a heterocyclic group, n is an integer of 0 to 2 and R.sup.1 is hydrogen or lower alkyl are protease inhibitors useful as anti-plasmin and anti-thrombin agents.

Abstract: The hemostasis valve gasket for use in an introducer which is integrally formed from an elastomeric material so as to exhibit resiliency and which is designed to close about small diameter objects such as a guide wire and about larger diameter objects such as a working catheter or guide catheter to prevent air or blood leakage. The gasket includes a cylindrical base with a central bore therethrough and a hollow convex domed shaped member projecting therefrom. The hollow dome shaped member terminates in a concave section. The concave section of the dome shaped member has at least one arcuate slit formed in the external surface which extends inwardly toward the hollow chamber to form a central, self-sealing passage aligned with the central bore of the cylindrical base member.

Abstract: A three-component knee joint prosthesis is disclosed including femoral, tibial and patellar components. During flexion of the prosthetic knee, the patellar component, which has a convex bearing surface, cooperates with and is guided by a patellar track defined by the anterior plate portion, lateral condylar bearing portion and medial condylar bearing portion of the femoral component and a web portion joining the two femoral condylar bearing portions. The inner regions of the two femoral condylar bearing portions are steeply sloped towards the web portion to permit the patellar component to "ride deeply" upon the femoral component at high degrees of flexion, thereby reducing quadriceps tension and expanding the permissible range of motion in flexion.

Abstract: A novel method for replacing a previously implanted knee joint prosthesis in a patient is disclosed in which the previously implanted femoral component is replaced with a revision femoral component having thicker distal and posterior bearing portions so as to restore the natural anatomic transverse joint plane and collateral ligamentous balance in extension and flexion of the prosthetic joint. Instrumentation for use in this method includes a novel revision cutting jig which is used in the preparation of the distal end of the femur for the implantation of the revision femoral component.